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更新于：2025-03-20

Carbocromen Hydrochloride

盐酸卡波罗孟

更新于：2025-03-20

概要

基本信息

药物类型

小分子化药

别名

Chromonar、卡波罗孟、延心痛

+ [2]

靶点-

作用方式-

作用机制-

治疗领域

神经系统疾病心血管疾病

在研适应症

心绞痛心律失常冠状动脉疾病+ [1]

非在研适应症-

原研机构

锦州九泰药业有限责任公司

在研机构

锦州九泰药业有限责任公司

非在研机构-

最高研发阶段批准上市

首次获批日期

中国 (1996-01-01),

心绞痛心律失常冠状动脉疾病+ [1]

最高研发阶段(中国)批准上市

特殊审评-

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结构/序列

分子式C20H27NO5

InChIKeyKLOIYEQEVSIOOO-UHFFFAOYSA-N

CAS号804-10-4

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关联

100 项与盐酸卡波罗孟相关的临床结果

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100 项与盐酸卡波罗孟相关的转化医学

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100 项与盐酸卡波罗孟相关的专利（医药）

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327

项与盐酸卡波罗孟相关的文献（医药）

2025-03-01·Journal of Molecular and Cellular Cardiology

Does coronary microvascular dysfunction play a role in heart failure with reduced ejection fraction?

Article

作者: Chilian, William ; Dong, Feng ; Yin, Liya ; Gadd, James ; Yun, June ; Kundu, Dipan ; Ohanyan, Vahagn ; Kolz, Christopher ; Shockling, Lindsay ; Goodwill, Adam ; Dinchman, Amber ; Shabani, Parisa ; Shin, Song Yi ; Pucci, Thomas

Heart failure (HF) is a conundrum in that, current therapies only slow the progression of the disease. We posit, if the causal mechanism were targeted, progression of the disease could be stopped and potentially reversed. We hypothesize that insufficient myocardial blood flow (MBF) produces minute areas of ischemia, that lead to an accumulating injury culminating in HF. Accordingly, we determined the relationship between MBF and cardiac work (wall stress-rate product [WSRP]) in control C57Bl6/J mice (Control), mice with transaortic constriction to produce HF (TAC-HF) and HF mice treated with the coronary vasodilator, chromonar (4 weeks of treatment, TAC-Chromonar). MBF and WSRP were measured during norepinephrine infusion in anesthetized mice. In Controls, MBF increased when work/WSRP was increased with norepinephrine, however, when cardiac work was increased in TAC-HF, MBF did not increase. After chromonar treatment, when work increased, MBF increased. Changes in cardiac function paralleled MBF, i.e., decrement in cardiac function occurred in TAC-HF (ejection fraction), but 4 weeks of chromonar treatment reversed this functional decline. We also found in a model of cardiac hypoxia fate-mapping, a 5-fold increase in the number of hypoxic cardiac myocytes (TAC-HF vs Control), which was reversed by chromonar. Capillary densities also followed this trend with a decrease from Control in TAC-HF, which was restored by Chromonar. We propose that a cause of HF is inadequate MBF to meet the metabolic demands of the working heart. Pharmacological coronary vasodilation with chromonar to increase MBF in HF can reverse the functional decline and improve cardiac function.

2024-01-01·Results in Chemistry

Anthelmintic and anti-filarial coumarins of natural and synthetic origin: Chemical and biological intervention

作者: Rout, Sudhanshu Sekhar ; Pattanayak, Priyabrata

Coumarin is a bicyclic system with a lactone-(hetero)aryl motif and a critical structural unit of many natural and synthetic pharmaceutical compoundsThe coumarins possess a broad spectrum of biol. activities and have successful clin. applications.Several coumarin-based natural compounds like osthol, isopimpinellin, umbelliferon, scopoletin, scopoline, cleomiscosin A to D, and inophyllum E have been isolated with anthelmintic and antifilarial activities.The ability of coumarin to interact with various active sites through noncovalent interactions like van der Waals forces, metal coordination, electrostatic and hydrophobic interaction, as well as hydrogen bonding, have led to the synthesis of different coumarins with significant anthelmintic and anti-filarial activities.The SAR studies of parasitic coumarins revealed that a hydroxy group at C-4 and C-7 positions has a deciding role in the anthelmintic and anti-filarial activity.The careful structure-activity studies could be effectively employed in the structural optimization of the bicyclic coumarin ring, allowing it to have many derivatives that could be screened for helminthiases.We hope this review will provide a structure-based input to researchers to design and develop novel coumarin hybrids to treat helminthiasis and filariasis.

2023-06-25·European Heart Journal

Takotsubo syndrome is a coronary microvascular disease: experimental evidence

Article

作者: Jeong, Lacey S ; Chandler, Selena ; Hakobyan, Tatevik ; Shockling, Lindsay ; Kimball, Kelly ; Hoff, Ellianna ; Chen, Yeong-Renn ; Kegecik, Karlina ; Srivastava, Geetika ; Kolz, Christopher ; Kang, Patrick T ; Pucci, Thomas ; Jabir, Abdur Rahman ; Dong, Feng ; Ohanyan, Vahagn ; Jia, Zhenyu ; Joshi, Hirva ; Shabani, Parisa ; Chilian, William M ; Chen, Chwen-Lih ; Sisakian, Hamayak ; Yin, Liya

AbstractBackground and aimsTakotsubo syndrome (TTS) is a conundrum without consensus about the cause. In a murine model of coronary microvascular dysfunction (CMD), abnormalities in myocardial perfusion played a key role in the development of TTS.Methods and resultsVascular Kv1.5 channels connect coronary blood flow to myocardial metabolism and their deletion mimics the phenotype of CMD. To determine if TTS is related to CMD, wild-type (WT), Kv1.5−/−, and TgKv1.5−/− (Kv1.5−/− with smooth muscle-specific expression Kv1.5 channels) mice were studied following transaortic constriction (TAC). Measurements of left ventricular (LV) fractional shortening (FS) in base and apex, and myocardial blood flow (MBF) were completed with standard and contrast echocardiography. Ribonucleic Acid deep sequencing was performed on LV apex and base from WT and Kv1.5−/− (control and TAC). Changes in gene expression were confirmed by real-time-polymerase chain reaction. MBF was increased with chromonar or by smooth muscle expression of Kv1.5 channels in the TgKv1.5−/−. TAC-induced systolic apical ballooning in Kv1.5−/−, shown as negative FS (P < 0.05 vs. base), which was not observed in WT, Kv1.5−/− with chromonar, or TgKv1.5−/−. Following TAC in Kv1.5−/−, MBF was lower in LV apex than in base. Increasing MBF with either chromonar or in TgKv1.5−/− normalized perfusion and function between LV apex and base (P = NS). Some genetic changes during TTS were reversed by chromonar, suggesting these were independent of TAC and more related to TTS.ConclusionAbnormalities in flow regulation between the LV apex and base cause TTS. When perfusion is normalized between the two regions, normal ventricular function is restored.

100 项与盐酸卡波罗孟相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	盐酸卡波罗孟	C01DX05	DB13279

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
心绞痛	中国	锦州九泰药业有限责任公司	1996-01-01
心律失常	中国	锦州九泰药业有限责任公司	1996-01-01
冠状动脉疾病	中国	锦州九泰药业有限责任公司	1996-01-01
心肌梗塞	中国	锦州九泰药业有限责任公司	1996-01-01