Acetylcysteine lysinate(Acetylcysteine lysinate)

概要

基本信息

药物类型

小分子化药

别名

L-Lysine-N-acetyl-L-cysteinate、N-acetylcysteine lysinate、Nacystelyn

靶点-

作用方式-

作用机制

溶菌剂

治疗领域

遗传病与畸形消化系统疾病呼吸系统疾病+ [2]

在研适应症-

非在研适应症

寻常痤疮囊性纤维化慢性阻塞性肺疾病

原研机构

Galephar Research, Inc.

在研机构-

非在研机构

Galephar Research, Inc.

Laboratoires S.M.B. SA

权益机构-

最高研发阶段终止临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评孤儿药 (欧盟)

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结构/序列

分子式C5H9NO3S

InChIKeyPWKSKIMOESPYIA-BYPYZUCNSA-N

CAS号616-91-1

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关联

3

项与 Acetylcysteine lysinate 相关的临床试验

EUCTR2010-018454-13-BE

/ Not yet recruiting临床3期

A Phase III, Multicentre, Randomised, Placebo-Controlled, Double Blind Study of the Incidence of Recurring Pulmonary Exacerbations in Cystic Fibrosis Patients using Two Different Doses of Inhaled Nacystelyn®

开始日期-

申办/合作机构

Laboratoires S.M.B. SA

EUCTR2020-005270-10-BG

/ Not yet recruiting临床2期

A randomized, partially blinded, parallel study to evaluate the effects of nacystelyn in combination with isotretinoin in the treatment of recalcitrant acne vulgaris.

开始日期2021-08-18

申办/合作机构-

EUCTR2019-001160-29-BE

/ Not yet recruiting临床2期

A single blind, placebo controlled, three period, chronic dosing (6 weeks), multicentre, exploratory study to evaluate the effects of Nacystelyn (20 mg BID and 40 mg BID) on Functional Respiratory Imaging (FRI) parameters in subjects with moderate to severe COPD

开始日期2019-06-24

申办/合作机构-

100 项与 Acetylcysteine lysinate 相关的临床结果

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100 项与 Acetylcysteine lysinate 相关的转化医学

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100 项与 Acetylcysteine lysinate 相关的专利（医药）

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20,970

项与 Acetylcysteine lysinate 相关的文献（医药）

2025-12-31·Journal of Enzyme Inhibition and Medicinal Chemistry

Natural product as a lead for impairing mitochondrial respiration in cancer cells

Article

作者: Pyrczak-Felczykowska, Agnieszka ; Kaczorowska, Anna-Karina ; Giełdoń, Artur ; Smoleński, Ryszard T. ; Reekie, Tristan A. ; Herman-Antosiewicz, Anna ; Braczko, Alicja ; Antosiewicz, Jędrzej

The impact of the isoxazole derivative of usnic acid, ISOXUS (formerly known as 2b) on cancer and non-cancerous cell metabolism was investigated. ISOXUS significantly reduced the utilisation of most metabolic substrates that produce NADH or FADH2, mitochondrial electron flow and oxygen consumption rate (OCR) in MCF-7 breast cancer cells in contrast to HB2 normal epithelial cells. Molecular docking revealed that ISOXUS inhibits mitochondrial respiratory chain complex II, which was confirmed experimentally. Disturbance of electron flow in MCF-7 cells resulted in increased reactive oxygen species (ROS) production. They appeared crucial for ISOXUS-induced cancer cell vacuolization and a drop in survival as an antioxidant, α-tocopherol, protected against these processes. These findings indicate that ISOXUS is a metabolic inhibitor that targets mitochondrial complex II in breast cancer cells resulting in diminished ATP production and increased ROS formation which translates into reduced cell viability.

2025-09-01·Talanta

An activatable β-diketonate europium(III) complex-based probe for time-gated luminescence detection and imaging of peroxynitrite in vitro and in vivo

Article

作者: Zou, Jinhua ; Dong, Zhiyuan ; Yuan, Jingli ; Song, Bo ; Liu, Qi

Peroxynitrite (ONOO^-), one of representative reactive nitrogen species with strong oxidative and nitrative properties, is known to be associated with various human diseases, such as Alzheimer's disease, drug-induced liver injury (DILI), inflammation, and cancer. Probing its fluctuations throughout diseases holds profound promise for advancing early diagnosis and enabling prompt intervention. In this work, we designed and synthesized a β-diketonate Eu³⁺ complex-based probe, [Eu(Cy-CDHH)₃(terpy)], for the time-gated luminescence (TGL) detection of ONOO^-. The probe, composed of a cyanine-dye-conjugated β-diketonate-Eu³⁺ coordination structure, is non-luminescent due to the intramolecular energy transfer from β-diketonate to cyanine-dye, which inhibits the energy transfer from β-diketonate to central Eu³⁺ ion. Upon reaction with ONOO^-, the unsaturated CC bond of cyanine-dye is cleaved. This process leads to the recovery of the intense long-lived luminescence of the β-diketonate-Eu³⁺ complex (ϕ = 17.3 %, τ = 436 μs), showcasing characteristics of rapid response (within 10 s), high selectivity, low detection limit (17.4 nM), and low cytotoxicity. These features enable the probe to be used for the quantitative TGL detection of ONOO^- in aqueous media as well as for the background-free TGL imaging of ONOO^- in living cells under assorted stimuli. Furthermore, the probe was effectively implemented for imaging of ONOO^- in livers of drug-induced liver injury mice, revealing the up-regulation of ONOO^- levels in this disease and the therapeutic efficacy of glutathione (GSH) via precluding the onset of reactive oxygen/nitrogen species. This research paves a new way for the fabrication of lanthanide complex bioprobes, providing a useful tool for understanding the interconnection between ONOO^- and disease-related physiological processes.

2025-07-01·Applied Catalysis B: Environment and Energy

Self-activated Au4Ni2 system with electronic antenna: Boosting photocatalytic oxidative coupling of amines and mechanistic insight

作者: Hu, Shu-Xian ; Sun, Xiaoyan ; Lin, ShanShan ; Sheng, Hongting ; Zhu, Manzhou ; Li, Tianrong ; Yun, Yapei ; Zhu, Kai ; Wei, Zhi-Yu ; Guo, Tingyu ; Li, Lin

Efficient and selective oxidative coupling of amines by Photocatalytic is highly desirable for scientific and industrial fields.A thorough understanding of photocatalytic mechanisms is a necessary condition for realizing the development of novel photocatalysts.Herein, we design a novel Au₄Ni₂(SR)₈ with precise at. structure for oxidative coupling of amines with TOF values up to 1666.7 h^-1.Based on systematic characterization and theor. simulations, we elaborated that the Ni-S site in Au₄Ni₂(SR)₈ system as an electron antenna to accelerate the attraction light carriers to the nanocluster (NC) surface for single electron transfer (SET) with amines.Meanwhile, a series of intermediates such as Au₄Ni₂(SR)₈+PhCH₂NH₂, PhCH=NH and PhCH(NH2)NHCH2Ph intermediates were successfully captured by paper spray mass spectrometry (PS-MS).Compared with Ag₄Ni₂(SR)₈, Au₄Pd₂(SR)₈ and Ag₄Pd₂(SR)₈, Au₄Ni₂(SR)₈ can significantly reduce the energy barrier of electron transfer during photocatalysis.In particular, the O₂ here is specifically activated to O₂^.- by stimulating amine C₆H₅CH₂NH₂^.- under the action of Au₄Ni₂(SR)₈, avoiding the generation of multi-component reactive oxygen species (ROS).This study provides an avenue to construct photocatalysts with high photo response to boost the solar-energy conversion.

100 项与 Acetylcysteine lysinate 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
寻常痤疮	临床3期	保加利亚	Laboratoires S.M.B. SA	2021-08-10
慢性阻塞性肺疾病	临床3期	比利时	Laboratoires S.M.B. SA	2019-07-14
囊性纤维化	临床3期	欧盟	-	-
囊性纤维化	临床3期	-	Galephar Research, Inc.	-
囊性纤维化	临床3期	-	Laboratoires S.M.B. SA	-