Randomized, Double Blind, Placebo Controlled Study of Parallel Groups to Evaluate the Effect of Chronic Supplementation of L-arginine in the Muscular Performance.

The primary purpose of this study is to evaluate the effect of oral administration of L-arginine in the muscular fatigue of the quadriceps, expressed in terms of the Fatigue Resistance Factor (FRF). The secondary purpose of this study is to evaluate the effect of oral administration of L-arginine in the muscular force the quadriceps.

开始日期2008-10-01

申办/合作机构

Sanofi

100 项与 L-Arginine/L-Aspartate 相关的临床结果

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100 项与 L-Arginine/L-Aspartate 相关的转化医学

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100 项与 L-Arginine/L-Aspartate 相关的专利（医药）

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662

项与 L-Arginine/L-Aspartate 相关的文献（医药）

2024-04-01·Biomaterials Advances

Co-release of nitric oxide and L-arginine from poly (β-amino ester)-based adhesive reprogram macrophages for accelerated wound healing and angiogenesis in vitro and in vivo

Article

作者: Kharazi, Anousheh Zargar ; Javanmard, Shaghayegh Haghjooy ; Varshosaz, Jaleh ; Heydari, Parisa ; Kharaziha, Mahshid

Recently, insufficient angiogenesis and prolonged inflammation are crucial challenges of chronic skin wound healing. The sustained release of L-Arginine (L-Arg) and nitric oxide (NO) production can control immune responses, improve angiogenesis, enhance re-epithelialization, and accelerate wound healing. Here, we aim to improve wound healing via the controlled release of NO and L-Arg from poly (β-amino ester) (PβAE). In this regard, PβAE is functionalized with methacrylate poly-L-Arg (PAMA), and the role of PAMA content (50, 66, and 75 wt%) on the adhesive properties, L-Arg, and NO release, as well as collagen deposition, inflammatory responses, and angiogenesis, is investigated in vitro and in vivo. Results show that the PAMA/ PβAE could provide suitable adhesive strength (~25 kPa) for wound healing application. In addition, increasing the PAMA content from 50 to 75 wt% results in an increased release of L-Arg (approximately 1.4-1.7 times) and enhanced NO production (approximately 2 times), promoting skin cell proliferation and migration. The in vitro studies also show that compared to PβAE hydrogel, incorporation of 66 wt% PAMA (PAMA 66 sample) reveals superior collagen I synthesis (~ 3-4 times) of fibroblasts, controlled pro-inflammatory and improved anti-inflammatory cytokines secretion of macrophages, and accelerated angiogenesis (~1.5-2 times). In vivo studies in a rat model with a full-thickness skin defect also demonstrate the PAMA66 sample could accelerate wound healing (~98 %) and angiogenesis, compared to control (untreated wound) and Tegaderm™ commercial wound dressing. In summary, the engineered multifunctional PAMA functionalized PβAE hydrogel with desired NO and L-Arg release, and adhesive properties can potentially reprogram macrophages and accelerate skin healing for chronic wound healing.

2024-04-01·Neurotoxicity Research

Effects of Exercise Training and L-Arginine Loaded Chitosan Nanoparticles on Hippocampus Histopathology, β-Secretase Enzyme Function, APP, Tau, Iba1and APOE-4 mRNA in Aging Rats

Article

作者: Aghaei, Fariba ; Falahi, Farshad ; Wong, Alexei ; Ali Askari, Ali ; Zargani, Mehdi ; Dehghannayeri, Zahra ; Sarshin, Amir ; Arabzadeh, Ehsan ; Feizolahi, Foad

The objective of this study was to evaluate the combined and independent effects of exercise training and L-Arginine loaded chitosan nanoparticles (LA CNPs) supplementation on hippocampal Tau, App, Iba1, and ApoE gene expression, oxidative stress, β-secretase enzyme activity, and hippocampus histopathology in aging rats. Thirty-five male Wistar rats were randomly assigned to five groups (n = 7 in each): Young (8 weeks old), Old (20 months old), old + L-arginine supplementation (Old Sup), old + exercise (Old Exe) and old + L-arginine supplementation + exercise (Old Sup + Exe). LA CNPs were administered to the supplement groups through gavage at a dosage of 500 mg/kg/day for 6-weeks. Exercise groups were subjected to a swimming exercise program five days/week for the same duration. Upon the completion of their interventions, the animals underwent behavioral and open-field task tests and were subsequently sacrificed for hippocampus genetic and histopathological evaluation. For histopathological analysis of brain, Cresyl violet staining was used. Congo Red staining was employed to confirm amyloid plaques in the hippocampus. Expressions of Tau, App, Iba1, and ApoE genes were determined by real-time PCR. In contrast to the Old group, Old Exe and Old Sup + Exe groups spent more time in the central space in the open field task (p < 0.05) and have more live cells in the hippocampus. Old rats (Old, Old Sup and Old Exe groups) exhibited a significant Aβ peptide accumulation and increases in APP, Tau, Iba1, APOE-4 mRNA and MDA, along with decreases in SOD compared to the young group (p < 0.05). However, LA CNPs supplementation, exercise, and their combination (Old Sup, Old Exe and Old Sup + Exe) significantly reduced MDA, Aβ plaque as well as APP, Tau, Iba1, and APOE-4 mRNA compared to the Old group (p < 0.05). Consequently, the administration of LA CNPs supplements and exercise might regulate the risk factors of hippocampus cell and tissue.

2024-02-01·International Journal of Food Microbiology

Antibacterial efficiency of the curcumin-mediated photodynamic inactivation coupled with L-arginine against Vibrio parahaemolyticus and its application on shrimp

Article

作者: Xu, Guizhi ; Wang, Jing Jing ; Zheng, Huaming ; Liu, Yang ; Dong, Shuliang ; Chen, Lu ; He, Tiantian ; Zeng, Qiaohui ; Zhao, Yong

The aim of this study was to investigate the antibacterial potency of a novel photodynamic inactivation (PDI) system with an enhanced bactericidal ability against Vibrio parahaemolyticus in vitro and in vivo. The synergistically bactericidal action of curcumin (Cur) and L-arginine (L-Arg) was firstly investigated, and then a novel curcumin-mediated PDI coupled with L-Arg was developed. Meanwhile, its potent inactivation mechanism against V. parahaemolyticus and preservation effects on shrimp were explored. Results showed that L-Arg disrupted the cell membrane by binding to membrane phospholipids and disrupting iron homeostasis, which helped curcumin to damage DNA and interrupt protein synthesis. Once irradiated by blue LED, the curcumin-mediated PDI produced the reactive oxygen species (ROS) which reacted with L-Arg to generate NO, and the NO was converted to reactive nitrogen species (RNS) with a strong bactericidal ability by consuming ROS. On this basis, the curcumin-mediated PDI coupled with L-Arg potently killed >8.0 Log CFU/mL with 8 μM curcumin, 0.5 mg/mL L-Arg and 1.2 J/cm² irradiation. Meanwhile, this PDI also effectively inhibited the colour and pH changes, lipids oxidation and protein degradation of shrimp. Therefore, this study proposes a new potent PDI system to control microbial contamination in the food industry.

100 项与 L-Arginine/L-Aspartate 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
炎症	临床3期	乌克兰	Ukrainian Medical Stomatological Academy	2017-10-20
牙周炎	临床3期	乌克兰	Ukrainian Medical Stomatological Academy	2017-10-20

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ESC2018	N/A	代谢综合征	62	L-Arginine aspartate	糧構範築齋襯遞窪繭艱(蓋製鏇鹽憲鬱夢夢糧衊) = 廠膚築願廠餘蓋願範夢糧觸窪襯顧艱願艱範遞 (鬱鏇蓋鏇繭築醖鏇築醖 ) 更多	-	2018-08-26
				l-arginine aspartate	糧構範築齋襯遞窪繭艱(蓋製鏇鹽憲鬱夢夢糧衊) = 獵鏇積廠膚壓蓋憲夢鑰糧觸窪襯顧艱願艱範遞 (鬱鏇蓋鏇繭築醖鏇築醖 ) 更多
EULAR2015	N/A	类风湿关节炎 \| 高血压	42	L-Arginine aspartate + standard treatment	(願糧糧繭顧淵夢鑰觸壓) = 築觸觸淵襯選廠鏇構鏇衊餘壓糧繭淵窪衊鏇鑰 (獵選選餘繭獵鬱鹹顧網 )	积极	2015-06-10
				Standard treatment	(願糧糧繭顧淵夢鑰觸壓) = 選鹹鏇鹹蓋範繭選憲齋衊餘壓糧繭淵窪衊鏇鑰 (獵選選餘繭獵鬱鹹顧網 )
FP098 (ERA2015)	N/A	肾功能不全 \| 类风湿关节炎 \| 高血压	27	L-Arginine aspartate 30 ml/day	(廠廠構選獵餘繭夢衊築) = 願壓繭餘糧鹽顧遞築製壓衊齋網鏇遞鑰齋餘積 (繭製鬱選構鹽鑰積積築 ) 更多	积极	2015-05-21
				Standard treatment	(廠廠構選獵餘繭夢衊築) = 遞觸衊醖窪憲餘構膚積壓衊齋網鏇遞鑰齋餘積 (繭製鬱選構鹽鑰積積築 ) 更多
EULAR2011	N/A	类风湿关节炎	40	Methotrexatum	築鬱廠鹽餘窪選築廠壓(構願鑰夢餘顧餘積網鬱) = 獵網艱襯鏇遞積蓋鏇鏇糧願蓋襯夢餘醖襯選顧 (壓襯糧願醖壓憲襯鬱憲 ) 更多	积极	2011-05-25
				NO-donators (Arginine hydrochloride and L-Arginine aspartate)	築鬱廠鹽餘窪選築廠壓(構願鑰夢餘顧餘積網鬱) = 範糧齋願範選艱醖簾蓋糧願蓋襯夢餘醖襯選顧 (壓襯糧願醖壓憲襯鬱憲 )