Randomized, Double Blind, Placebo Controlled Study of Parallel Groups to Evaluate the Effect of Chronic Supplementation of L-arginine in the Muscular Performance.

The primary purpose of this study is to evaluate the effect of oral administration of L-arginine in the muscular fatigue of the quadriceps, expressed in terms of the Fatigue Resistance Factor (FRF). The secondary purpose of this study is to evaluate the effect of oral administration of L-arginine in the muscular force the quadriceps.

开始日期2008-10-01

申办/合作机构

Sanofi

100 项与 L-Arginine/L-Aspartate 相关的临床结果

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100 项与 L-Arginine/L-Aspartate 相关的转化医学

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100 项与 L-Arginine/L-Aspartate 相关的专利（医药）

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661

项与 L-Arginine/L-Aspartate 相关的文献（医药）

2024-04-01·Biomaterials Advances

Co-release of nitric oxide and L-arginine from poly (β-amino ester)-based adhesive reprogram macrophages for accelerated wound healing and angiogenesis in vitro and in vivo

Article

作者: Kharazi, Anousheh Zargar ; Javanmard, Shaghayegh Haghjooy ; Varshosaz, Jaleh ; Heydari, Parisa ; Kharaziha, Mahshid

Recently, insufficient angiogenesis and prolonged inflammation are crucial challenges of chronic skin wound healing. The sustained release of L-Arginine (L-Arg) and nitric oxide (NO) production can control immune responses, improve angiogenesis, enhance re-epithelialization, and accelerate wound healing. Here, we aim to improve wound healing via the controlled release of NO and L-Arg from poly (β-amino ester) (PβAE). In this regard, PβAE is functionalized with methacrylate poly-L-Arg (PAMA), and the role of PAMA content (50, 66, and 75 wt%) on the adhesive properties, L-Arg, and NO release, as well as collagen deposition, inflammatory responses, and angiogenesis, is investigated in vitro and in vivo. Results show that the PAMA/ PβAE could provide suitable adhesive strength (~25 kPa) for wound healing application. In addition, increasing the PAMA content from 50 to 75 wt% results in an increased release of L-Arg (approximately 1.4-1.7 times) and enhanced NO production (approximately 2 times), promoting skin cell proliferation and migration. The in vitro studies also show that compared to PβAE hydrogel, incorporation of 66 wt% PAMA (PAMA 66 sample) reveals superior collagen I synthesis (~ 3-4 times) of fibroblasts, controlled pro-inflammatory and improved anti-inflammatory cytokines secretion of macrophages, and accelerated angiogenesis (~1.5-2 times). In vivo studies in a rat model with a full-thickness skin defect also demonstrate the PAMA66 sample could accelerate wound healing (~98 %) and angiogenesis, compared to control (untreated wound) and Tegaderm™ commercial wound dressing. In summary, the engineered multifunctional PAMA functionalized PβAE hydrogel with desired NO and L-Arg release, and adhesive properties can potentially reprogram macrophages and accelerate skin healing for chronic wound healing.

2024-04-01·Neurotoxicity Research

Effects of Exercise Training and L-Arginine Loaded Chitosan Nanoparticles on Hippocampus Histopathology, β-Secretase Enzyme Function, APP, Tau, Iba1and APOE-4 mRNA in Aging Rats

Article

作者: Aghaei, Fariba ; Falahi, Farshad ; Wong, Alexei ; Zargani, Mehdi ; Ali Askari, Ali ; Dehghannayeri, Zahra ; Sarshin, Amir ; Arabzadeh, Ehsan ; Feizolahi, Foad

The objective of this study was to evaluate the combined and independent effects of exercise training and L-Arginine loaded chitosan nanoparticles (LA CNPs) supplementation on hippocampal Tau, App, Iba1, and ApoE gene expression, oxidative stress, β-secretase enzyme activity, and hippocampus histopathology in aging rats. Thirty-five male Wistar rats were randomly assigned to five groups (n = 7 in each): Young (8 weeks old), Old (20 months old), old + L-arginine supplementation (Old Sup), old + exercise (Old Exe) and old + L-arginine supplementation + exercise (Old Sup + Exe). LA CNPs were administered to the supplement groups through gavage at a dosage of 500 mg/kg/day for 6-weeks. Exercise groups were subjected to a swimming exercise program five days/week for the same duration. Upon the completion of their interventions, the animals underwent behavioral and open-field task tests and were subsequently sacrificed for hippocampus genetic and histopathological evaluation. For histopathological analysis of brain, Cresyl violet staining was used. Congo Red staining was employed to confirm amyloid plaques in the hippocampus. Expressions of Tau, App, Iba1, and ApoE genes were determined by real-time PCR. In contrast to the Old group, Old Exe and Old Sup + Exe groups spent more time in the central space in the open field task (p < 0.05) and have more live cells in the hippocampus. Old rats (Old, Old Sup and Old Exe groups) exhibited a significant Aβ peptide accumulation and increases in APP, Tau, Iba1, APOE-4 mRNA and MDA, along with decreases in SOD compared to the young group (p < 0.05). However, LA CNPs supplementation, exercise, and their combination (Old Sup, Old Exe and Old Sup + Exe) significantly reduced MDA, Aβ plaque as well as APP, Tau, Iba1, and APOE-4 mRNA compared to the Old group (p < 0.05). Consequently, the administration of LA CNPs supplements and exercise might regulate the risk factors of hippocampus cell and tissue.

2024-02-01·animal

Characterization of taste sensitivities to amino acids and sugars by conditioned taste aversion learning in chickens

Article

作者: Yoshida, Yuta ; Fujishiro, Shu ; Kawabata, Fuminori ; Kawai, Ryota

Taste plays an essential role in regulating the feeding behaviors of animals. The present study aimed to characterize the taste sensory profiles of amino acids and sugars in chickens. To achieve this, we employed a conditioned taste aversion learning method, which is characterized by a specific pairing of gastrointestinal malaise and taste perception. Our findings revealed that chickens were able to learn to avoid L-Val, L-Lys, and L-His through conditioned taste aversion learning, and exhibited a strong aversion to L-Arg. These results suggest that chickens are primarily sensitive to basic amino acids, including L-Lys, which is a crucial limiting amino acid in feeds. Interstingly, this sensitivity to basic amino acids in chickens contrasts with humans, who are mainly sensitive to acidic amino acids as umami taste. Furthermore, despite the absence of a mammalian sweet taste receptor gene in the chicken genome, we demonstrated that chickens learned to avoid glucose, galactose, sucrose, and maltose by conditioned taste aversion learning. Taken together, the present study provides the idea that chickens possess a gustatory perception toward specific amino acids and sugars for the detection of beneficial nutrients in their feeds.

100 项与 L-Arginine/L-Aspartate 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
牙周炎	临床3期	乌克兰	Ukrainian Medical Stomatological Academy	2017-10-20
炎症	药物发现	乌克兰	Ukrainian Medical Stomatological Academy	2017-10-20

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ESC2018	N/A	代谢综合征	62	L-Arginine aspartate	壓獵顧鹽憲廠蓋夢願鬱(網築鹽選蓋夢廠糧齋糧) = 蓋艱鑰糧鏇窪積積醖繭窪觸齋遞衊壓獵遞範醖 (遞鬱積獵衊鬱鏇襯壓艱 ) 更多	-	2018-08-26
				l-arginine aspartate	壓獵顧鹽憲廠蓋夢願鬱(網築鹽選蓋夢廠糧齋糧) = 膚積壓壓齋製觸廠繭鹹窪觸齋遞衊壓獵遞範醖 (遞鬱積獵衊鬱鏇襯壓艱 ) 更多
EULAR2015	N/A	类风湿关节炎 \| 高血压	42	L-Arginine aspartate + standard treatment	(憲範網餘鏇觸獵糧衊壓) = 鑰襯窪鏇窪艱壓廠壓餘簾選憲壓窪壓觸遞蓋襯 (選繭築鹽願醖選齋築獵 )	积极	2015-06-10
				Standard treatment	(憲範網餘鏇觸獵糧衊壓) = 鏇憲壓廠範鹽簾壓鹹餘簾選憲壓窪壓觸遞蓋襯 (選繭築鹽願醖選齋築獵 )
FP098 (ERA2015)	N/A	肾功能不全 \| 类风湿关节炎 \| 高血压	27	L-Arginine aspartate 30 ml/day	(齋壓範夢鏇糧製艱積膚) = 繭齋範衊膚觸窪鏇膚鏇衊繭鑰遞顧鬱選窪獵糧 (鬱壓顧鏇積壓鏇積襯窪 ) 更多	积极	2015-05-21
				Standard treatment	(齋壓範夢鏇糧製艱積膚) = 簾簾糧遞齋憲簾餘膚鑰衊繭鑰遞顧鬱選窪獵糧 (鬱壓顧鏇積壓鏇積襯窪 ) 更多
EULAR2011	N/A	类风湿关节炎	40	Methotrexatum	範鹹餘餘顧蓋齋鏇遞顧(夢顧製膚艱艱獵蓋膚醖) = 範鏇糧夢鹽襯窪鑰蓋選鏇網獵簾鬱壓餘醖築襯 (構簾廠壓艱繭齋觸窪繭 ) 更多	积极	2011-05-25
				NO-donators (Arginine hydrochloride and L-Arginine aspartate)	範鹹餘餘顧蓋齋鏇遞顧(夢顧製膚艱艱獵蓋膚醖) = 窪網簾齋遞鏇壓艱壓糧鏇網獵簾鬱壓餘醖築襯 (構簾廠壓艱繭齋觸窪繭 )