Influenza virus vaccine(Japan Vaccine Co., Ltd.)(Influenza virus vaccine(Japan Vaccine Co., Ltd.))

概要

基本信息

药物类型

灭活疫苗、预防性疫苗

别名

靶点-

作用机制

免疫刺激剂

治疗领域

感染呼吸系统疾病

在研适应症-

非在研适应症

流感病毒感染

原研机构

Japan Vaccine Co., Ltd.

在研机构-

非在研机构

Japan Vaccine Co., Ltd.

Terumo Corp.

Daiichi Sankyo Co., Ltd.

最高研发阶段终止申请上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

8

项与 Influenza virus vaccine(Japan Vaccine Co., Ltd.) 相关的临床试验

JPRN-JapicCTI-152991 / Completed临床3期

Open study of quadrivalent VN-100 in healthy children

开始日期2015-09-26

申办/合作机构

Terumo Corp.

[+2]

JPRN-jRCT2080222939 / Completed临床3期

Open study of quadrivalent VN-100 in healthy children

开始日期2015-09-26

申办/合作机构

Terumo Corp.

[+2]

JPRN-JapicCTI-142613 / Completed临床3期

Open study of quadrivalent VN-100 in Japanese healthy volunteers

开始日期2014-10-29

申办/合作机构

Terumo Corp.

[+2]

100 项与 Influenza virus vaccine(Japan Vaccine Co., Ltd.) 相关的临床结果

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100 项与 Influenza virus vaccine(Japan Vaccine Co., Ltd.) 相关的转化医学

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100 项与 Influenza virus vaccine(Japan Vaccine Co., Ltd.) 相关的专利（医药）

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1

项与 Influenza virus vaccine(Japan Vaccine Co., Ltd.) 相关的文献（医药）

2013-12-01·BMC Complementary and Alternative Medicine

Effect of oral administration of ethanolic extract of Vitex negundo on thioacetamide-induced nephrotoxicity in rats

Article

作者: Mahmood A Abdulla ; Wageeh A Yehye ; Farkaad A Kadir ; Normadiah M Kassim

AbstractBackgroundOxidative stress due to abnormal induction of reactive oxygen species (ROS) molecules is believed to be involved in the etiology of many diseases. Evidences suggest that ROS is involved in nephrotoxicity through frequent exposure to industrial toxic agents such as thioacetamide (TAA). The current investigation was designed to explore the possible protective effects of the leaves of Vitex negundo(VN) extract against TAA-induced nephrotoxicity in rats.MethodsTwenty four Sprague Dawley rats were divided into four groups: (A) Normal control, (B) TAA (0.03% w/v in drinking water), (C) VN100 (VN 100 mg/kg + TAA) and (D) VN300 (VN 300 mg/kg + TAA). Blood urea and serum creatinine levels were measured,supraoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) levels of renal tissue were assayed. Histopathological analysis together with the oxidative stress nicotinamide adenine dinucleotide phosphate (NADPH) oxidase p22phox in kidney sections were examined in all experimental groups.ResultsBlood urea and serum creatinine levels were increased in TAA group as a result of the nephrotoxicity compared to the VN100 and VN300 groups where, the levels were significantly decreased (p < 0.05). Renal MDA level was significantly decreased (p < 0.05) in the VN-treated groups with increased CAT and SOD activities compared to the TAA group. Light microscopic examination of renal tissues stained by H&E stain and Masson’s Trichrome for TAA-treated groups revealed severe histopathological changes, whereas specimens obtained from VN-treated groups showed only mild changes. These findings were supported by immunohistochemical results.ConclusionsVN extract acts as a natural potent antioxidant to prevent ongoing TAA-induced nephrotoxicity in rats, both biochemically and morphologically.

100 项与 Influenza virus vaccine(Japan Vaccine Co., Ltd.) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
流感病毒感染	申请上市	-	Japan Vaccine Co., Ltd.	-
流感病毒感染	申请上市	-	Daiichi Sankyo Co., Ltd.	-
流感病毒感染	申请上市	-	Terumo Corp.	-