Multivitamin complex-loaded electrospun polyvinyl alcohol core/shell structure fibers for transdermal delivery system: In-silico and experimental studies

作者: Betancourt Galindo, Rebeca ; Carrillo Cabrera, Yeslie ; Matinez Perez, Carlos ; Garcia-Casillas, Perla E. ; Nicolas Vazquez, Maria Ines ; Escobedo-Gonzalez, Rene Gerardo ; Camacho Montes, Hector ; Espinosa Neira, Roberto

Transdermal delivery systems offer a controlled and targeted environment for releasing drugs compared to other delivery systems.This study presents the fabrication of polyvinyl alc. (PVA) fibers with a multivitamin complex (MV) using the electrospinning technique (ES).The research focuses on understanding how various fiber structures, such as core/shell, simple fibers, and ES parameters, affect the MC release mechanism and cell viability behavior.The vitamin complexes were uniformly encapsulated within the polymeric chains in all structure fibers.PVA simple fibers with and without the vitamin complex don't significantly differ in diameter size.However, the core/Shell fiber has a notable decrease in fiber diameter of 45%.The fiber with a core/shell structure resulted in a slower release rate of the vitamin complex than simple fiber.According to the Korsmeyer-Peppas model, the release mechanism observed in our study for the simple fibers is classical Fickian diffusion.Instead, core/shell fibers indicate a more anomalous or non-Fickian behavior.The structural configurations of the fibers do not result in statistically significant differences in cell viability.This could be attributed to the identical nature of materials used, including the polymer and MV, across all cases.Finally, a computational chem. study was used to examine the interaction between polyvinyl alc. (PVA) and vitamins K3 and B3, like a model of MV.The anal. showed four strong hydrogen bonds between PVA and vitamin B3, whereas the interaction between PVA and vitamin K3 only had one hydrogen bond.Furthermore, the PVA and vitamin B3 interaction had higher energy and was more exothermic and spontaneous than the PVA-vitamin K3 interaction.On the other hand, the PVA-vitamin K4 interaction displayed higher reactivity due to its lower separation energy.In contrast, the PVA-vitamin B3 interaction was more stable.

2023-12-01·European journal of nutrition

The effect of vitamin K4 supplementation on insulin resistance in individuals with type 2 diabetes: a double-blind randomised placebo-controlled clinical trial.

Article

作者: Ali, Amani M ; Abbassi, Maggie M ; Fawzi, May ; Sabry, Nirmeen A ; Mousa, Shrook

PURPOSEThe purpose of this study was to assess the possible clinical effects of vitamin K4 supplementation in individuals with type 2 diabetes namely insulin resistance, glycaemic control, and lipid profile.METHODSThis was a prospective randomised double-blind placebo-controlled clinical trial. A total of 106 patients were randomised to receive either 1 mg of vitamin K4 (menadiol diacetate) or placebo for 24 weeks.RESULTSNinety patients (n = 45 in each study group) were included in the final analysis. After 24 weeks, homeostatic model assessment of insulin resistance (HOMA-IR) (16.54 ± 7.81 vs. 29.09 ± 36.56, P = 0.027) and fasting serum insulin (FSI) (6.86 ± 3.45 vs. 11.13 ± 12.66 µU/ml, P = 0.032) were significantly lower in the vitamin K group compared to placebo. Additionally, triglycerides (TG) (144.94 ± 50.7 vs. 172.8 ± 101.5 mg/dl, P = 0.031) and very low-density lipoproteins (VLDL) levels (28.9 ± 9.88 vs. 34.6 ± 20.30 mg/dl, P = 0.027) decreased significantly in the vitamin K group after 24 weeks compared to baseline. Moreover, more patients in the vitamin K group (35.6%) had their antidiabetic medication doses reduced after 24 weeks compared to placebo (13.3%, P = 0.029).CONCLUSIONVitamin K4 supplementation for 24 weeks is capable of improving insulin resistance and TG levels in individuals with type 2 diabetes. In addition, the improvement in insulin resistance was reflected in the decrease in antidiabetic medication doses. However, it did not affect fasting plasma glucose (FPG) or glycated haemoglobin (HbA₁c).TRIAL REGISTRATIONThe study was registered on clinicaltrials.gov with ID: NCT04285450.

2023-04-13·Journal of Chemical & Engineering Data

Determination and Simulation of Menadiol Diacetate Solubility in 14 Solvents at Temperatures from 283.15 to 323.15 K

作者: Zhao, Zhong ; Lu, Xinyi ; Wu, Xiaoli ; Wang, Jidong ; Yang, Xiaotong

In this paper, the solubility of menadiol diacetate in nine alcs. (methanol, ethanol, n-propanol, i-propanol, n-butanol, i-butanol, n-amyl alc., i-amyl alc., and cyclohexanol) and five n-alkyl acetates (Me acetate, Et acetate, Pr acetate, Bu acetate, and amyl acetate) was exptl. measured with the aid of a laser dynamic device at temperatures from 283.15 to 323.15 K.The solubility of menadiol diacetate as a function of temperature was regressed in terms of three semiempirical solubility models (Apelblat, van't Hoff, and λh), two activity coefficient solubility models (Wilson and NRTL), and the Jouyban model.The thermodn. mixing properties (mixing Gibbs energy, entropy, and enthalpy) of the solutions were estimated in terms of the measured solubility data and the regressed parameters of the Wilson model.

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