作者: Hideki Ishikawa ; Hideaki Tsukuma ; Isaburo Fujimoto ; Akira Oshima ; Yoshiyuki Fudemoto ; Ryosuke Murakami ; Nobuo Miki ; Torn Otani ; Katsumi Nakanishi ; Tomohiko Hiyama

In order to estimate the diagnostic validity of chemical fecal occult blood tests, i.e. orthotolidine (Shionogi A) and guajac (Shionogi B) slides for detecting cancers of the esophagus, stomach and colorectum, the authors followed up all the examinees (n=3,449) of comprehensive medical check‐ups at the Center for Adult Diseases, Osaka, by means of record linkage to the Osaka Cancer Registry's files. Then, diagnostic validity was calculated based on the results of two years’ follow‐up. Sensitivity for the respective cancers was 20.0%, 11.8% and 62.5% for Shionogi A, and 20.0%, 5.9% and 43.8% for Shionogi B slides. Likelihood ratio for the respective cancers was 1.4, 0.8 and 4.5 for Shionogi A, and 3.3, 1.0 and 7.5 for Shionogi B. Specificity was analogous among the three cancer sites, being 86% for Shionogi A and 94% for Shionogi B. These results suggest that the diagnostic validity of chemical occult blood tests for detecting cancers of the esophagus and the stomach is very poor, and therefore imply that close examinations of these sites for screening positives is unnecessary in mass screenings for colorectal cancer.

1986-07-01·Gan to kagaku ryoho. Cancer & chemotherapy

[Occult blood screening for colorectal cancer].

Article

作者: Fujita, M ; Kumanishi, Y ; Taguchi, T

Because of the recent increase in the incidence of colorectal cancer in Japan, attempts were made to find an effective method for screening asymptomatic patients with this cancer. In current mass screening, guaiac-impregnated slides such as the Shionogi and Hemoccult types are widely used. A screening system consisting of examination with Shionogi B slides for 3 consecutive days under mild restricted diet and a medical questionnaire, followed by re-examination under a restricted diet for persons showing a partially positive result is accepted as the most reliable screening method. As these slide tests are based on peroxidase-like activity in hemoglobin, dietary fiber, meat, peroxidase-containing foods and drugs influence the sensitivity and specificity of the test. Recently, immunological fecal occult blood tests with high sensitivity and specificity such as RPHA or Feca-EIA have been developed. We have evaluated the RPHA method and compared it with the Shionogi B slide. The positive rate of the RPHA method was rather lower than that of the Shionogi test and the detection rate of Colorectal cancer was equivalent to that of Shionogi. We are now applying the RPHA method to mass screening, and the Feca-EIA Test is also under consideration for practical use.

100 项与 Hepatitis B vaccine(Shionogi) 相关的药物交易

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