Subetta(Subetta) - 在研适应症：糖尿病_专利_临床

概要

基本信息

药物类型

多克隆抗体

别名-

靶点-

作用方式-

作用机制-

治疗领域

内分泌与代谢疾病

在研适应症

糖尿病

非在研适应症

葡萄糖耐受不良

原研机构

OOO NPF Materia Medica Holding

在研机构

OOO NPF Materia Medica Holding

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

关联

3

项与 Subetta 相关的临床试验

NCT03725033

/ Completed临床3期

Multicentre Double-blind Placebo-controlled Parallel Group Randomized Clinical Trial of Efficacy and Safety of Subetta in the Treatment of Impaired Glucose Tolerance

Purpose of the study:
* to assess the efficacy of Subetta in the treatment of impaired glucose tolerance
* to assess the safety of Subetta in the treatment of impaired glucose tolerance.

开始日期2018-10-10

申办/合作机构

OOO NPF Materia Medica Holding

NCT01868646

/ Completed临床4期

Multicentre Double-blind Placebo-controlled Parallel-group Randomized Clinical Trial of Efficacy and Safety of Subetta in the Combined Treatment of Patients With Type II Diabetes Mellitus

The purpose of this study is:
* to assess clinical efficacy of Subetta in the combined treatment of type II diabetes mellitus;
* to assess safety of Subetta in the combined treatment of type II diabetes mellitus.

开始日期2013-05-07

申办/合作机构

OOO NPF Materia Medica Holding

NCT01868594

/ Completed临床4期

Multicentre Double-blind Placebo-controlled Parallel-group Randomized Clinical Trial of Efficacy and Safety of Subetta in the Combined Treatment of Patients With Type I Diabetes Mellitus

The purpose of this study is:
* to assess clinical efficacy of Subetta in the combined treatment of type I diabetes mellitus;
* to assess safety of Subetta in the combined treatment of type I diabetes mellitus.

开始日期2013-05-07

申办/合作机构

OOO NPF Materia Medica Holding

100 项与 Subetta 相关的临床结果

登录后查看更多信息

100 项与 Subetta 相关的转化医学

登录后查看更多信息

100 项与 Subetta 相关的专利（医药）

登录后查看更多信息

9

项与 Subetta 相关的文献（医药）

2019-06-25·International journal of endocrinology4区 · 医学

Expression of Concern on “Subetta Treatment Increases Adiponectin Secretion by Mature Human Adipocytes In Vitro”

4区 · 医学

ArticleOA

作者: International Journal of Endocrinology

2019-06-16·Journal of diabetes research3区 · 医学

Expression of Concern on “The Novel Oral Drug Subetta Exerts an Antidiabetic Effect in the Diabetic Goto-Kakizaki Rat: Comparison with Rosiglitazone”

3区 · 医学

ArticleOA

作者: Journal of Diabetes Research

2015-08-01·Bulletin of experimental biology and medicine4区 · 医学

Subetta Enhances Sensitivity of Human Muscle Cells to Insulin

4区 · 医学

Article

作者: Tarasov, S A ; Myslivets, A A ; Nicoll, J ; Kachaeva, E V ; Gorbunov, E A

Addition of Subetta to insulin (10 nM) increased insulin-stimulated glucose uptake 43% (p<0.001). Moreover, glucose uptake stimulated by insulin (10 nM) in the presence of Subetta was similar to that stimulated by 300 nM insulin. These findings suggest that Subetta significantly enhanced insulin sensitivity of tissues through stimulation of glucose transport to myocytes mediated by glucose transporter 4.

100 项与 Subetta 相关的药物交易

登录后查看更多信息

研发状态

批准上市

10 条最早获批的记录,

登录

后查看更多信息

适应症	国家/地区	公司	日期
糖尿病	俄罗斯	OOO NPF Materia Medica Holding	-

未上市

10 条进展最快的记录,

登录

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
葡萄糖耐受不良	临床3期	俄罗斯	OOO NPF Materia Medica Holding	2018-10-10

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03725033 (Pubmed \| J Clin Med) 人工标引	临床3期	葡萄糖耐受不良	-	Subetta	遞簾獵製廠鑰艱積醖顧(廠鬱範壓糧範觸選醖網) = 糧遞遞網壓蓋獵糧獵襯窪選願淵憲蓋鑰齋鬱鹹 (齋積蓋築憲顧夢淵網選, 2.11) 更多	积极	2022-03-03
				Placebo	遞簾獵製廠鑰艱積醖顧(廠鬱範壓糧範觸選醖網) = 壓憲壓壓壓壓繭糧壓鬱窪選願淵憲蓋鑰齋鬱鹹 (齋積蓋築憲顧夢淵網選, 2.55)
NCT03725033 (CTgov)	临床3期	葡萄糖耐受不良	538	Subetta (Subetta)	範選憲鏇鏇網顧淵壓遞(齋製簾顧製窪選醖網夢) = 簾憲簾鬱範簾簾獵窪窪網顧衊鏇蓋鑰簾膚鹽鏇 (鏇範衊鏇製膚窪淵鹽憲, 0.88) 更多	-	2021-01-14
				Placebo (Placebo)	範選憲鏇鏇網顧淵壓遞(齋製簾顧製窪選醖網夢) = 餘簾憲蓋積衊齋襯襯築網顧衊鏇蓋鑰簾膚鹽鏇 (鏇範衊鏇製膚窪淵鹽憲, 0.86) 更多
NCT01868646 (CTgov)	临床4期	2型糖尿病	190	Subetta (Subetta)	鬱膚糧獵淵廠蓋觸鹹築(衊願窪鹽遞壓遞鑰壓製) = 簾鹹憲襯繭鏇膚糧襯願憲鬱積顧選襯簾鏇鬱襯 (襯鏇遞蓋夢淵鹹積積鹹, 1.06) 更多	-	2019-03-04
				Placebo (Placebo)	鬱膚糧獵淵廠蓋觸鹹築(衊願窪鹽遞壓遞鑰壓製) = 觸壓鹽膚獵餘膚壓鑰簾憲鬱積顧選襯簾鏇鬱襯 (襯鏇遞蓋夢淵鹹積積鹹, 1.06) 更多
NCT01868594 (CTgov)	临床4期	1型糖尿病	200	insulins+Subetta (Subetta)	鑰鹽積淵範蓋鏇觸製簾(願範願簾簾選構鏇鬱範) = 艱鑰網繭簾襯觸壓窪衊鬱壓廠齋遞簾餘觸鑰衊 (膚餘網鑰觸顧糧觸築壓, 0.91) 更多	-	2019-03-04
				Placebo (Placebo)	鑰鹽積淵範蓋鏇觸製簾(願範願簾簾選構鏇鬱範) = 淵鑰鏇窪築艱鹽餘艱築鬱壓廠齋遞簾餘觸鑰衊 (膚餘網鑰觸顧糧觸築壓, 1.02) 更多
NCT01868594 (Pubmed \| Diabetes Res Clin Pract)	临床4期	1型糖尿病追加	144	Subetta add-on therapy	艱簾選夢淵構襯獵願鏇(鹹積襯壓壓壓壓顧膚鑰) = 鑰鹹觸醖顧製築積鹽齋網淵淵鑰範網觸構淵衊 (膚繭艱願繭鬱觸製蓋憲, -0.84 ~ -0.37) 更多	积极	2018-08-01
				Placebo	艱簾選夢淵構襯獵願鏇(鹹積襯壓壓壓壓顧膚鑰) = 艱餘襯觸網蓋願積膚廠網淵淵鑰範網觸構淵衊 (膚繭艱願繭鬱觸製蓋憲, -0.44 ~ 0.11) 更多