This study aimed to investigate the relationship between administration of probiotics and improvement in quality of life in women with functional constipation.

开始日期2018-02-24

申办/合作机构

Fakultas Kedokteran, Universitas Indonesia

100 项与 Lactobacillus plantarum IS-10506(Fakultas Kedokteran, Universitas Indonesia) 相关的临床结果

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100 项与 Lactobacillus plantarum IS-10506(Fakultas Kedokteran, Universitas Indonesia) 相关的转化医学

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100 项与 Lactobacillus plantarum IS-10506(Fakultas Kedokteran, Universitas Indonesia) 相关的专利（医药）

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项与 Lactobacillus plantarum IS-10506(Fakultas Kedokteran, Universitas Indonesia) 相关的文献（医药）

2022-04-03·Journal of Dermatological Treatment4区 · 医学

Beneficial effect of Lactobacillus plantarum IS-10506 supplementation in adults with atopic dermatitis: a randomized controlled trial

4区 · 医学

Article

作者: Umborowati, M. A. ; Surono, I. S. ; Prakoeswa, C. R. S. ; Bonita, L. ; Setyaningrum, T. ; Hidayati, A. N. ; Karim, A. ; Herwanto, N.

INTRODUCTIONAlthough the therapeutic effects of probiotics in atopic dermatitis (AD) are known, the limited findings in adults are inconsistent. Lactobacillus plantarum (LP) IS-10506 was found to improve AD symptoms due to its immunomodulatory effects.OBJECTIVETo assess the Scoring Atopic Dermatitis Index (SCORAD), the serum immunoglobulin E (IgE), interleukin (IL)-4, interferon-gamma (IFN-γ), forkhead box P3 (Foxp3+), and IL-17 levels in adults with mild and moderate AD after LP IS-10506 supplementation.METHODSA randomized double-blind placebo-controlled trial comparing the microencapsulated probiotic (2 × 10¹⁰ CFU/day) and placebo (skim milk-Avicel) was conducted at an outpatient clinic on 30 adults with mild and moderate AD. The patients were divided into 2 groups with 15 patients each: intervention and control.RESULTThe SCORAD score was significantly lower in the probiotic than the placebo group on the 8th week. The IL-4 and IL-17 levels were significantly lower in the probiotic than the placebo group. The IFN-γ and Foxp3+ levels were significantly higher in the probiotic than the placebo group. However, the IgE levels remained significantly unchanged.CONCLUSIONThe administration of LP IS-10506 is effective for alleviating AD symptoms in adults owing to its immunomodulatory effects.

2020-02-19·Beneficial Microbes3区 · 医学

Lactobacillus plantarum IS-10506 promotes renal tubular regeneration in pyelonephritic rats

3区 · 医学

Article

作者: Rauf, S. ; Soemyarso, N.A. ; Prasetyo, R.V. ; Noer, M.S. ; Surono, I. ; Djojodimedjo, T. ; Sudarmo, S.M.

Lactobacillus plantarum IS-10506 is a novel probiotic isolated from Indonesian traditional fermented buffalo milk dadih. Probiotics are clinically proven to be effective in accelerating recovery after urinary tract infection (UTI) and in decreasing recurrent UTI in children with or without structural disorders of the urinary tract. This study aimed to investigate the role of the probiotic L. plantarum IS-10506 in activating and regenerating renal epithelial stem cells in pyelonephritic rats. Fifty-five 20-weeks-old male Sprague-Dawley rats were randomised into control, lipopolysaccharide (LPS) and treatment (LPS and probiotic) groups. Pyelonephritis was induced with Escherichia coli ATCC 25922 LPS administered via a urethral catheter on the first experimental day to the LPS and treatment groups. Microencapsulated L. plantarum IS-10506 was orally administered once daily for up to 14 days to the treatment group. On days 3, 5, 7, 10 and 14, five rats per group were sacrificed and their kidneys were immunohistochemically analysed for production of interleukin (IL)-10, lipocalin-2 and Ki-67 in the renal tubular cells. IL-10 production was upregulated starting from day 3 through day 14 in the treatment group (P<0.05) compared with that in the control and LPS groups. Moreover, treatment with the probiotic led to increased activation of renal tubular stem cell, as indicated by a higher lipocalin-2 production, and further proliferation of renal tubular stem cells was documented by a higher Ki-67 production. Taken together, these results indicate that the anti-inflammatory probiotic L. plantarum IS-10506 improves renal injury in pyelonephritic rats by activating endogenous renal tubular stem cells to proliferate into mature renal tubular epithelial cells.

2019-04-19·Beneficial Microbes3区 · 医学

Lactobacillus plantarum IS-10506 supplementation increases faecal sIgA and immune response in children younger than two years

3区 · 医学

Article

作者: Surono, I.S. ; Bela, B. ; Wibowo, H. ; Kusumo, P.D. ; Munasir, Z.

The immature intestinal immune system in young children develops as it comes into contact with dietary and microbial antigens in the gut. Intestinal microbiota plays a significant role in host defence mechanisms as shown by inflammatory responses towards potential pathogens. We investigated the probiotic function of Lactobacillus plantarum IS-10506 of ‘dadih’ origin in modulating immune response in young children. We aimed to assess its effect on their immune response by assessing transforming growth factor-β1 (TGF-β1) and tumour necrosis factor-α (TNF-α) responses and faecal secretory immunoglobulin A (sIgA) titre in a randomised, double-blinded placebo-controlled trial in 12-24-month-old children (n=38). We used four treatment groups for a 90-day supplementation period: placebo (n=11), probiotic (n=9), zinc (n=8) and probiotic and zinc (n=10). Faecal sIgA, plasma TGF-β1 and TNF-α titre were evaluated using the enzyme-linked immunosorbent assay standard technique. Statistical analysis divided the results (pre/post treatment) into high (>1) and low (<1) ratios. The results showed that faecal sIgA titre increased in all treatment groups compared with the control (placebo) and significantly increased in the probiotic group (P=0.05). In addition, the TGF-β1 ratio in the zinc group was significantly higher (P=0.05) than that in the placebo group. We observed a significant positive correlation between TGF-β1/TNF-α and faecal sIgA (r=0.27, P=0.04). Post hoc test results revealed that zinc supplementation has a significant effect on body-weight gain. Taken together, probiotic L. plantarum IS-10506 supplementation stimulates TGF-β1, which in turn increases the production of sIgA, in line with the significant correlation between TGF-β1/TNF-α and faecal sIgA.

100 项与 Lactobacillus plantarum IS-10506(Fakultas Kedokteran, Universitas Indonesia) 相关的药物交易

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