Delving into the Latest Updates on Fakultas Kedokteran, Universitas Indonesia with Synapse

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排名前五的药物类型	数量

益生菌	1

关联

1

项与 Fakultas Kedokteran, Universitas Indonesia 相关的药物

Lactobacillus plantarum IS-10506(Fakultas Kedokteran, Universitas Indonesia)

靶点-

作用机制

细菌替代物 [+1]

在研机构

Fakultas Kedokteran, Universitas Indonesia [+1]

原研机构

Fakultas Kedokteran, Universitas Indonesia

在研适应症

便秘

非在研适应症-

最高研发阶段临床3期

首次获批国家/地区-

首次获批日期-

51

项与 Fakultas Kedokteran, Universitas Indonesia 相关的临床试验

NCT06510257 / Not yet recruiting临床2期

Safety and Efficacy of Reconyl for Cough With/Without Sore Throat: A Preliminary Study

This study is a prospective, randomized, double-blind and placebo-controlled study to find out if reconyl may relieve the acute cough with/without sore throat.

开始日期2024-10-01

申办/合作机构

PT Dexa Medica

[+1]

NCT06497439 / Not yet recruiting临床2期

Efficacy and Safety of Silfamin for Common Cold With or Without Sore Throat: Preliminary Study

This is a 2-arm, prospective, randomized, double-blind, placebo-controlled, and three-days-treatment clinical study comparing the efficacy and safety of Silfamin at a dose of 2 tablets@150 mg twice daily in subjects with common cold.

开始日期2024-08-01

申办/合作机构

PT Dexa Medica

[+1]

NCT06558006 / Recruiting临床2期

Safety and Efficacy of Predimenol for Headache: A Preliminary Study

This is a prospective, double-blind, placebo-controlled and randomized study aimed to obtain a description of the efficacy and safety of Predimenol in alleviating headache.

开始日期2024-06-19

申办/合作机构

PT Dexa Medica

[+1]

100 项与 Fakultas Kedokteran, Universitas Indonesia 相关的临床结果

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0 项与 Fakultas Kedokteran, Universitas Indonesia 相关的专利（医药）

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40

项与 Fakultas Kedokteran, Universitas Indonesia 相关的文献（医药）

2024-04-01·International Archives of Otorhinolaryngology

Types of Epiglottic Collapse in Breathing Sleep Disorder and Their Impact in Clinical Practice

Article

作者: Tamin, Susyana ; Wardani, Retno S. ; Putranto, Fikri Mirza ; Yunizaf, Rahmanofa ; Rachmawati, Elvie Zulka Kautzia ; Fardizza, Fauziah ; Rizki, Niken Ageng

Abstract Introduction Obstructive sleep apnea (OSA) is a severe form of sleep-disordered breathing (SDB) that is strongly correlated with comorbidities, in which epiglottic collapse (EC) and other contributing factors are involved. Objectives To evaluate the occurrence of EC in OSA patients through drug-induced sleep endoscopy (DISE) and to determine the factors contributing to EC. Methods A retrospective study of 37 adult patients using medical history. Patients were assessed for laryngopharyngeal reflux (LPR) and lingual tonsil hypertrophy (LTH) using reflux symptom index and reflux finding score (RFS); for OSA using polysomnography, and for airway collapse through DISE. An independent t-test was performed to evaluate risk factors, including the involvement of three other airway structures. Results Most EC patients exhibited trap door epiglottic collapse (TDEC) (56.8%) or pushed epiglottic collapse (PEC) (29.7%). Lingual tonsil hypertrophy, RFS, and respiratory effort-related arousal (RERA) were associated with epiglottic subtypes. Laryngopharyngeal reflux patients confirmed by RFS (t(25) = −1.32, p = 0.197) tended to suffer PEC; LTH was significantly associated (X2(1) = 2.5, p = 0.012) with PEC (odds ratio [OR] value = 44) in grades II and III LTH patients; 11 of 16 TDEC patients had grade I LTH. Pushed epiglottic collapse was more prevalent among multilevel airway obstruction patients. A single additional collapse site was found only in TDEC patients. Conclusion Laryngopharyngeal reflux causes repetitive acid stress toward lingual tonsils causing LTH, resulting in PEC with grade II or III LTH. Trap door epiglottic collapse requires one additional structural collapse, while at least two additional collapse sites were necessary to develop PEC. Respiratory effort-related arousal values may indicate EC.

2024-01-01·Plasmatology

Platelet Transfusion Refractoriness

作者: Baskoro, Muhammad Orri ; Yasmin, Amirah ; Lubis, Anna Mira

Platelet transfusion refractoriness (PTR) is a conditioikb1n where platelet counts fail to increase adequately in several transfusions, often found in hemato-oncological situations. PTR poses life-threatening risks to patients, especially in cases when the platelet is very low, and transfusion is life-saving. It can be differentiated into immune or non-immune causes. While non-immune causes predominate, immune factors, particularly anti-HLA antibodies, are also notable in many cases. Accurately determining if platelet transfusion failure originates from an immune or non-immune cause is vital due to differing treatments, particularly the need for HLA-compatible platelets with immune causes. Yet, a lack of consensus exists regarding the diagnostic methods and treatment modalities. Therefore, this review aims to explore the origins, mechanisms, diagnostic criteria, and management approaches concerning PTR.

2023-12-01·In Vitro Cellular & Developmental Biology - Animal

Liver organoids cocultured on decellularized native liver scaffolds as a bridging therapy improves survival from liver failure in rabbits

Article

作者: Ayudyasari, Wulan ; Gunardi, Hardian ; Pawitan, Jeanne Adiwinata ; Balachander, Gowri Manohari ; Septiana, Wahyunia Likhayati ; Yu, Hanry ; Antarianto, Radiana Dhewayani

The present study aimed to develop viable liver organoids using decellularized native liver scaffolds and evaluate the efficacy of human liver organoid transplantation in a rabbit model of cirrhosis. Liver organoids were formed by coculture of hepatocyte-like cells derived from the human-induced pluripotent stem cells with three other cell types. Twelve 3-mo-old New Zealand White Rabbits underwent a sham operation, bile duct ligation, or biliary duct ligation followed by liver organoid transplantation. Liver organoid structure and function before and after transplantation were evaluated using histological and molecular analyses. A survival analysis using the Kaplan-Meier method was performed to determine the cumulative probability of survival according to liver organoid transplantation with significantly greater overall survival observed in rabbits that underwent liver organoid transplantation (P = 0.003, log-rank test). The short-term group had higher hepatic expression levels of ALB and CYP3A mRNA and lower expression levels of AST mRNA compared to the long-term group. The short-term group also had lower collagen deposition in liver tissues. Transplantation of human liver organoids cocultured in decellularized native liver scaffold into rabbits that had undergone bile duct ligation improved short-term survival and hepatic function. The results of the present study highlight the potential of liver organoid transplantation as a bridging therapy in liver failure; however, rejection and poor liver organoid function may limit the long-term efficacy of this therapeutic approach.

100 项与 Fakultas Kedokteran, Universitas Indonesia 相关的药物交易

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100 项与 Fakultas Kedokteran, Universitas Indonesia 相关的转化医学

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