更新于：2024-11-21

Cancer vaccine(Sarepta Therapeutics, Inc.)

更新于：2024-11-21

概要

研发状态

概要

基本信息

药物类型

治疗性疫苗

别名

AVICINE、Cancer vaccine

+ [1]

靶点-

作用机制

免疫调节剂、免疫刺激剂

治疗领域

肿瘤消化系统疾病内分泌与代谢疾病+ [1]

在研适应症-

非在研适应症

结直肠癌胰腺癌前列腺癌

原研机构

Sarepta Therapeutics, Inc.

在研机构-

非在研机构

Sarepta Therapeutics, Inc.Supergen Bioenergy Hub

最高研发阶段终止临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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序列信息

Sequence Code 36183

关联

100 项与 Cancer vaccine(Sarepta Therapeutics, Inc.) 相关的临床结果

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100 项与 Cancer vaccine(Sarepta Therapeutics, Inc.) 相关的转化医学

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100 项与 Cancer vaccine(Sarepta Therapeutics, Inc.) 相关的专利（医药）

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项与 Cancer vaccine(Sarepta Therapeutics, Inc.) 相关的文献（医药）

2020-05-01·Bioorganic Chemistry2区 · 化学

Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Aβ1-42 aggregation

2区 · 化学

Article

作者: Hagenow, Stefanie ; Avila Murillo, Monica ; Plazas, Erika ; Cuca, Luis Enrique ; Stark, Holger

Multifactorial neurodegenerative disorders such as Alzheimer's disease (AD) are considered a growing public health problem due the rising incidence and low effectiveness of current treatments [6]. Since pharmacotherapy based on a single target has been insufficient for drug development in complex diseases, the emerging multi-target approach is a promising strategy for the search of new anti-AD drug candidates. Herein described natural isoquinoline alkaloids were investigated for multi-target activity on key mechanisms associated with the AD's pathogenesis, i.e. cholinergic depletion, beta amyloid (Aβ) aggregation and oxidative stress. Alkaloid isolation from root extract of Zanthoxylum rigidum was carried out using multi-step chromatography and TLC-bioautography against acetylcholinesterase (AChE) giving eight purified isoquinoline alkaloids. Isolated compounds were tested for inhibitory activity against cholinesterase (AChE and BChE), monoamine oxidase (MAO-A and B) and Aβ aggregation. Our study revealed two benzophenanthridine alkaloids, nitidine (5) and avicine (7), as the most potent multi-target candidates. Both showed dual cholinesterase inhibition, being more active against AChE over BChE, with IC₅₀ values in sub-micromolar range in AChE. Kinetic analysis with cholinesterase showed, that both compounds are reversible-mixed inhibitors, where avicine (7) presented highest potency with K_i values of 0.063 µM (EeAChE), 0.511 µM (HrAChE) and 0.123 µM (EqBChE). In addition, these alkaloids presented moderate Aβ_1-42 anti-aggregation activity and MAO-A inhibition with IC₅₀ values between 0.5 and 2 µM. Our findings suggest that avicine (7) is a promising natural compound and multifunctional candidate representing a suitable starting point for the development of new therapeutic agents for Alzheimer's disease.

2011-01-01·Organic & Biomolecular Chemistry3区 · 化学

Palladium-catalyzed tandem reaction to construct benzo[c]phenanthridine: application to the total synthesis of benzo[c]phenanthridine alkaloids

3区 · 化学

Article

作者: Longguan Xie ; Xiaohua Xu ; Pei Lv ; Kanglun Huang

A concise and efficient synthesis of benzo[c]phenanthridines was accomplished by the palladium-catalyzed ring-opening coupling of azabicyclic alkene with o-iodobenzoates, followed by tandem cyclization. The strategy was successfully applied in the total synthesis of benzo[c]phenanthridine alkaloids such as sanguinarine, chelerythrine, nitidine and avicine.

2006-07-01·Journal of Ethnopharmacology2区 · 医学

Validation of use of a traditional antimalarial remedy from French Guiana, Zanthoxylum rhoifolium Lam

2区 · 医学

Article

作者: Séverine Maurel ; Geneviève Bourdy ; Michel Sauvain ; S. Georges ; Valérie Jullian

Zanthoxylum rhoifolium bark (Rutaceae) is a medicinal plant, traditionally used in French Guiana to treat and prevent malaria. Bioassay-guided extractions of Zanthoxylum rhoifolium bark have shown that antiplasmodial activity is concentrated in the alkaloid fraction. Further fractionation of this extract has yielded seven benzophenanthridine alkaloids, dihydroavicine 1, dihydronitidine 2, oxyavicine 3, oxynitidine 4, fagaridine 5, avicine 6 and nitidine 7. Antimalarial activity of the last five compounds has been evaluated, and nitidine was the most potent, displaying an IC(50)<0.27microM against Plasmodium falciparum. Investigation of the traditional remedy, a trunk bark decoction in water, has shown that fagaridine 5, avicine 6 and nitidine 7 are also present in the decoction, therefore justifying the traditional use of Zanthoxylumrhoifolium bark as antimalarial.

100 项与 Cancer vaccine(Sarepta Therapeutics, Inc.) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
结直肠癌	临床3期	-	Supergen Bioenergy Hub	-
结直肠癌	临床3期	-	Sarepta Therapeutics, Inc.	-
胰腺癌	临床3期	-	Supergen Bioenergy Hub	-
胰腺癌	临床3期	-	Sarepta Therapeutics, Inc.	-
前列腺癌	临床3期	-	Supergen Bioenergy Hub	-
前列腺癌	临床前	-	Sarepta Therapeutics, Inc.	-