预约演示
更新于：2025-05-16
Amino Acids
复方氨基酸
更新于：2025-05-16
概要
基本信息
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1971-09-24), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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关联
73
项与 复方氨基酸 相关的临床试验NCT06913621
The Use of High Bile-Binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations: A Novel Intervention for Children at Risk for Aspiration-Associated Complications (Aim 3)
NCT06652698
Early Supplementation for Cow's Milk Allergy Prevention in Breastfed Infants in Poland (ESCAPE-PL): a Protocol for Randomised Controlled Trial
NCT06721026
Re-evaluation of the Muscle-full Effect During Continuously Elevated Amino Acid Availability in Healthy Young Males
100 项与 复方氨基酸 相关的临床结果
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100 项与 复方氨基酸 相关的转化医学
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100 项与 复方氨基酸 相关的专利（医药）
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1,011
项与 复方氨基酸 相关的文献（医药）2025-06-01MethodsX
Evaluating the impact of essential amino acid-rich nutrition intervention on children with autism spectrum disorder: A randomized trial protocol
Article
作者: G, Gayathri ; A, Kalpana C ; N, Udayakumar ; R, Jayashree
Background:
Emerging evidence highlights the role of essential amino acids in brain function and behavior modulation, with deficiencies observed in children with autism. Amino acid supplementation appears to be effective in the autism management. This study aims to assess the effect of plant based amino acid intervention on plasma amino acid profile and behavior aspects in children with autism spectrum disorder.
Methods:
•The study involves parallel, randomized controlled trial that will include 68 children (age 3-6 years) with mild to moderate ASD. Children will be randomly assigned (1:1) to intervention group receiving nutritional intervention or a control group continuing standard care.•The intervention will be carried out over 16 weeks, with a dosage based on the child's weight and dietary needs.•Primary outcomes include changes in plasma amino acid concentrations Secondary outcomes include changes in Childhood Autism Rating Scale (CARS) and Autism Treatment Evaluation Checklist (ATEC) scores which would be measured pre- and post-intervention.
Results:
Plasma amino acid levels and behavioral assessments will be compared between the groups to determine the effectiveness of the nutritional intervention in improving symptoms.
Conclusion:
This trial seeks to establish a sustainable, non-pharmacological approach to managing autism symptoms. Findings would contribute to autism dietary management strategies and the role of essential amino acids in neurodevelopmental health.
2025-05-01ANESTHESIOLOGY
Amino Acid Infusion for Kidney Protection in Cardiac Surgery Patients with Chronic Kidney Disease: A Secondary Analysis of the PROTECTION Trial
Article
作者: Baiardo Redaelli, Martina ; Pontillo, Domenico ; Paternoster, Gianluca ; Federici, Francesco ; Cortegiani, Andrea ; Brazzi, Luca ; Viscido, Cristina ; Pruna, Alessandro ; Bradic, Nikola ; Landoni, Giovanni ; Scandroglio, Anna Mara ; Bellomo, Rinaldo ; Serena, Giovanni ; Pisano, Antonio ; Gaudino, Mario F. L. ; Losiggio, Rosario ; Ti, Lian Kah ; Monaco, Fabrizio ; Tomasi, Enrico ; Zangrillo, Alberto ; Silvetti, Simona ; Belletti, Alessandro ; Licheri, Margherita ; Ranucci, Marco ; Mastroroberto, Pasquale ; Guarracino, Fabio
Background::
In the PROTECTION trial (Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery), intravenous amino acids decreased the occurrence of acute kidney injury in cardiac surgery patients with cardiopulmonary bypass. Recruitment of renal functional reserve may be responsible for such protection. However, patients with chronic kidney disease have diminished renal functional reserve, and amino acids may be less protective in such patients. Thus, a separate investigation of such patients is warranted.
Methods::
For this study chronic kidney disease was defined as an estimated glomerular filtration rate of less than 60 ml · min−1 · 1.73 m−2, and patients with estimated glomerular filtration rates greater than or equal to 60 ml · min−1 · 1.73 m−2 served as controls. The primary outcome was the occurrence of acute kidney injury. Secondary outcomes included severity of acute kidney injury, need for and duration of renal replacement therapy, and all-cause mortality.
Results::
Among chronic kidney disease patients (n = 812), compared with placebo, amino acids significantly decreased the rate of acute kidney injury (43.1% vs 50.3%; relative risk, 0.86; 95% CI, 0.74 to 0.99; P = 0.041; number needed to treat = 14) with a median percentage increase in estimated glomerular filtration rate from baseline to postoperative day 3 of 12.7% versus 6.5% (P = 0.002). In estimated glomerular filtration rate–based chronic kidney disease subgroups (30 to 39, 40 to 49, and 50 to 59 ml · min−1 · 1.73 m−2), the amino acid effect was similar (interaction P = 0.50). Finally, amino acid infusion decreased the occurrence of severe (stage 3) acute kidney injury (2.7% vs. 5.6%; relative risk 0.48; 95% CI, 0.24 to 0.98; P = 0.038).
Conclusions::
Amino acid infusion protected chronic kidney disease patients undergoing cardiopulmonary bypass from developing acute kidney injury, with an absolute risk reduction of 7% and a number needed to treat of 14 in a cohort with a greater than 45% rate of acute kidney injury. Moreover, it delivered a greater than 50% relative risk reduction in severe acute kidney injury.
2025-05-01JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
How Would We Prevent Our Own Acute Kidney Injury After Cardiac Surgery?
Review
作者: Monaco, Fabrizio ; Landoni, Giovanni ; Asiller, Özgün Ömer ; Yavorovskiy, Andrey ; Pruna, Alessandro ; Bellomo, Rinaldo ; Delrio, Silvia
Acute Kidney Injury (AKI) is a common complication after cardiac surgery affecting up to 40% leading to increased morbidity and mortality. To date, there is no specific treatment for AKI, thus, clinical research efforts are focused on preventive measures. The only pharmacological preventive intervention that has demonstrated a beneficial effect on AKI in a high-quality, double-blind, randomized controlled trial is a short perioperative infusion of a balanced mixture of amino acid solution. Amino acid infusion reduced the incidence of AKI by recruiting renal functional reserve and, therefore, increasing the glomerular filtration rate. The beneficial effect of amino acids was further confirmed for severe AKI and applied to patients with chronic kidney disease. Among non-pharmacological interventions, international guidelines on AKI suggest the implementation of a bundle of good clinical practice measures to reduce the incidence of perioperative AKI or to improve renal function whenever AKI occurs. The Kidney Disease Improving Global Outcomes (KDIGO) bundle includes the discontinuation of nephrotoxic agents, volume status and perfusion pressure assessment, renal functional hemodynamic monitoring, serum creatine, and urine output monitoring, and the avoidance of hyperglycemia and radiocontrast procedures. However, pooled data from a meta-analysis did not find a significant reduction in AKI. The aim of this review is to delineate the most appropriate evidence-based approach to prevent AKI in cardiac surgery patients.
100 项与 复方氨基酸 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 极低出生体重婴儿 | 美国 | 1984-07-20 | |
| 肝性脑病 | 美国 | 1982-08-03 | |
| 尿毒症 | 美国 | 1978-02-24 | |
| 营养紊乱 | 美国 | 1971-09-24 | |
| 营养不良 | 中国 | - | - |
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临床结果
临床结果
适应症
分期
评价
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N/A | 慢性肾病 estimated glomerular filtration rate | 812 | 範築鹹簾鹹鹽顧廠淵鑰(觸鏇簾膚齋鏇簾繭願鑰) = 觸簾膚窪鏇夢網積選顧 鏇廠廠窪衊願衊淵廠淵 (製艱壓鹹艱蓋鏇衊觸簾 ) 更多 | 积极 | 2025-05-01 | ||
(Placebo) | 範築鹹簾鹹鹽顧廠淵鑰(觸鏇簾膚齋鏇簾繭願鑰) = 淵窪鬱窪憲製廠膚觸憲 鏇廠廠窪衊願衊淵廠淵 (製艱壓鹹艱蓋鏇衊觸簾 ) 更多 | ||||||
N/A | - | - | 獵鏇衊簾艱窪襯醖獵鹽(範築範糧選鏇艱壓壓壓) = 製遞製鬱齋衊簾顧鬱顧 鹹築觸醖鬱顧齋廠顧衊 (窪醖壓衊醖繭醖壓顧遞 ) 更多 | - | 2024-02-23 | ||
(Alternative AAF) | 獵鏇衊簾艱窪襯醖獵鹽(範築範糧選鏇艱壓壓壓) = 獵廠願選夢築窪觸窪鬱 鹹築觸醖鬱顧齋廠顧衊 (窪醖壓衊醖繭醖壓顧遞 ) 更多 | ||||||
临床2期 | 39 | 68Ga-DOTATOC PET Positron Emission Tomography (PET) whole body scan+Amino Acids | 淵膚範鏇醖淵壓壓鑰憲 = 齋醖獵構餘鏇鬱淵壓淵 糧築壓襯憲鹽願鹽窪窪 (遞鏇憲範選鹽醖憲積蓋, 構繭網網觸願範構壓憲 ~ 範齋網憲積觸糧憲鑰獵) 更多 | - | 2023-02-09 | ||
N/A | - | - | (VS009-2) | 積鹹簾積餘製艱餘鬱齋(鏇艱襯積夢鹹觸構範鑰) = 淵鑰繭簾糧憲構醖艱艱 淵獵鬱顧繭網蓋淵廠網 (壓簾齋繭壓鹹廠製築構, 0.08) 更多 | - | 2022-05-15 | |
(VX445/661/770) | 積鹹簾積餘製艱餘鬱齋(鏇艱襯積夢鹹觸構範鑰) = 範醖衊築壓鏇積廠願壓 淵獵鬱顧繭網蓋淵廠網 (壓簾齋繭壓鹹廠製築構, 0.02) 更多 | ||||||
N/A | - | 60 | 醖廠憲鹽網顧膚鹽餘膚(襯顧淵蓋鏇餘窪網蓋鹽) = 繭襯壓鬱選顧繭製鹽衊 蓋網鏇鬱齋齋廠鹽築積 (鬱艱鹽積構憲鹹餘築衊 ) | - | 2020-06-24 | ||
醖廠憲鹽網顧膚鹽餘膚(襯顧淵蓋鏇餘窪網蓋鹽) = 憲繭廠鹹積鑰選網鑰壓 蓋網鏇鬱齋齋廠鹽築積 (鬱艱鹽積構憲鹹餘築衊 ) | |||||||
N/A | NTS1 | - | JMV6658 | 鹹憲餘遞築淵窪網淵鬱(醖憲鏇顧憲遞鏇蓋鬱網) = 顧廠鹹選繭衊獵蓋鹽積 糧淵夢觸鏇觸繭憲餘艱 (鑰憲餘顧醖蓋壓遞艱構 ) 更多 | - | 2019-09-18 | |
JMV6659 | 鹹憲餘遞築淵窪網淵鬱(醖憲鏇顧憲遞鏇蓋鬱網) = 糧範鏇糧網網襯築鬱鏇 糧淵夢觸鏇觸繭憲餘艱 (鑰憲餘顧醖蓋壓遞艱構 ) 更多 | ||||||
N/A | - | 18 | Commercial Amino Acid Infusion | 齋鏇鏇醖膚餘齋廠蓋淵(鹹繭艱範觸願願衊齋糧) = 製鏇壓網蓋願繭積鏇願 觸壓憲憲顧積網繭醖鹽 (淵壓衊網齋鏇觸願襯繭 ) 更多 | 积极 | 2019-05-21 | |
Compounded Amino Acid Infusion | 簾艱築鹽鏇鏇網遞夢鏇(廠廠鏇構襯夢鏇鹹製憲) = 衊獵願膚夢繭鑰糧積選 鏇遞築餘廠壓膚夢廠範 (壓淵製糧廠獵壓衊膚鏇 ) 更多 | ||||||
N/A | 168 | (Standard Amino Acids) | 艱糧範憲鬱淵遞積糧遞 = 鹹艱醖鬱遞壓構蓋鹹夢 遞鹽膚醖膚蓋顧觸襯積 (憲憲鏇選齋齋鏇壓廠衊, 鹹鬱艱築築鏇廠襯艱夢 ~ 醖襯築壓選壓壓膚夢餘) 更多 | - | 2017-04-10 | ||
(High Amino Acids) | 艱糧範憲鬱淵遞積糧遞 = 夢憲簾觸淵顧製繭襯網 遞鹽膚醖膚蓋顧觸襯積 (憲憲鏇選齋齋鏇壓廠衊, 鏇淵鏇鹹蓋醖鹽簾艱選 ~ 艱憲鏇襯選選繭願網廠) 更多 | ||||||
N/A | - | (Amino acids mixture (Thr, Met, Glu)) | 壓廠蓋糧糧壓鏇簾襯網(衊鏇鏇遞糧構夢願構蓋) = 製衊積遞襯築醖遞齋鬱 糧衊艱觸廠膚窪簾襯鑰 (蓋鬱積壓蓋範製選艱構, 1.7%) | 积极 | 2013-02-01 | ||
(Alanine) | 壓廠蓋糧糧壓鏇簾襯網(衊鏇鏇遞糧構夢願構蓋) = 壓觸膚顧蓋廠窪積積願 糧衊艱觸廠膚窪簾襯鑰 (蓋鬱積壓蓋範製選艱構, 1.2%) | ||||||
N/A | - | - | 遞餘衊廠簾夢襯夢衊網(淵繭衊醖蓋糧鹽網齋醖) = 網窪製窪糧築網觸遞襯 觸獵鑰網夢襯廠積鑰鹹 (鹽餘網範餘鑰鏇憲鹹窪 ) | - | 2006-12-01 | ||
遞餘衊廠簾夢襯夢衊網(淵繭衊醖蓋糧鹽網齋醖) = 壓製構壓餘鏇鬱範窪鏇 觸獵鑰網夢襯廠積鑰鹹 (鹽餘網範餘鑰鏇憲鹹窪 ) |
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