多菌灵(Carbendazim) - 药物靶点：DNA-directed DNA polymerase x RT x Tubulin_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Benzimate

+ [5]

靶点

DNA-directed DNA polymerase x RT x Tubulin

作用机制

DNA-指导DNA聚合酶抑制剂、RT抑制剂(逆转录酶抑制剂)、微管蛋白抑制剂

治疗领域

肿瘤免疫系统疾病感染+ [1]

在研适应症-

非在研适应症

HIV感染肿瘤

原研机构

Procter & Gamble Co.

在研机构-

非在研机构

ImQuest BioSciences, Inc.Arisyn Therapeutics Inc

Procter & Gamble Co.

最高研发阶段无进展临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构

分子式C9H9N3O2

InChIKeyTWFZGCMQGLPBSX-UHFFFAOYSA-N

CAS号10605-21-7

关联

2

项与多菌灵相关的临床试验

NCT00023816 / Unknown status临床1期IIT

Third Phase I and Pharmacokinetic Study Of FB-642 Administered Orally To Patients With Advanced Solid Tumors

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
PURPOSE: Phase I trial to study the effectiveness of carbendazim in treating patients who have advanced solid tumors or lymphoma.

开始日期-

申办/合作机构

Jonsson Comprehensive Cancer Center

[+1]

NCT00003709 / Completed临床1期IIT

Phase I and Pharmacokinetic Study of FB-642 Administered Orally on a Weekly Schedule to Patients With Advanced Solid Tumors

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase I trial to study the effectiveness of carbendazim in treating patients who have advanced solid tumors.

开始日期1998-10-01

申办/合作机构

University of Texas Health Science Center At San Antonio

[+2]

100 项与多菌灵相关的临床结果

登录后查看更多信息

100 项与多菌灵相关的转化医学

登录后查看更多信息

100 项与多菌灵相关的专利（医药）

登录后查看更多信息

1,717

项与多菌灵相关的文献（医药）

2025-01-01·Talanta

Highly sensitive detection of carbendazim in agricultural products using colorimetric and photothermal lateral flow immunoassay based on plasmonic gold nanostars

Article

作者: Wu, Qi ; Zhang, Yaohai ; He, Yue ; Zhao, Qiyang ; Wang, Chengqiu ; Cui, Yongliang ; Zhang, Tian ; Xie, Longyingzi ; Liu, Lei

The wide use and high toxicity of carbendazim (CBD) in agriculture pose unprecedented demands for convenient, sensitive, and cost-effective on-site monitoring. Herein, we propose a novel colorimetric and photothermal dual-mode lateral flow immunoassay (LFIA) based on plasmonic gold nanostars (AuNSs) for CBD detection in agricultural products. The AuNSs were synthesized via a rapid seed-mediated growth method (with growth time of ∼5 s). A stable immunoprobe was formed by adsorbing CBD antibodies onto AuNSs. This immunoprobe exhibited high conversion efficiency and sensitivity in photothermal detection with a low limit of detection (LOD) of 0.28 ng mL^-1. The LOD of the colorimetric mode was higher (0.48 ng mL^-1). The results of CBD detection in various agricultural products aligned well with ultra-performance liquid chromatography tandem mass spectrometry. Overall, our LFIA shows excellent sensitivity, specificity, reproducibility, and rapidness in CBD detection, and thus is a highly potential on-site platform in resource-limited environments.

2025-01-01·Food Chemistry

Signal switching electrochemical and fluorescence dual-mode sensing platform for carbendazim determination based on “two-in-one” magneto-fluorescent Cdots

Article

作者: Yang, Huaixia ; Guo, Liang ; Ke, Yuanmeng ; Jia, Yuzhen ; Liu, Zhixiang ; Miao, Mingsan

An innovative method for carbendazim (CBZ) detection was developed, consisting of an electrochemical-fluorescence dual-mode biosensor based on magneto-fluorescent composite M-CDs. M-CDs, as the fluorescent probe of this sensor, could combine the electrical signal-ferrocene to achieve the "signal switching" by specifically recognizing CBZ through aptamers, of which magnetic property was used to quickly separate from complex substrates without interference. The dual-mode sensor based on M-CDs demonstrated excellent linear responses in both electrochemical and fluorescence assays. It achieved detection ranges of 10 fg/mL - 300 ng/mL and 60 fg/mL - 100 ng/mL with detection limits (LODs) of 1.4 fg/mL and 2.3 fg/mL. The sensor exhibited exceptional detection performance, stability and anti-interference. In addition, the results of the sensor in actual samples were consistent with those of enzyme-linked immunosorbent assay (ELISA), which further demonstrated that the sensor could accurately trace detecting CBZ in real samples and had a certain application prospect.

2025-01-01·Journal of Pharmaceutical and Biomedical Analysis

Method validation and determination of pesticides in Mikania glomerta Spreng tincture by direct injection and UPLC-MS/MS analysis

Article

作者: de Oliveira, Angélica Castanheira ; Ferraris, Fausto Klabund ; da Nobrega, Armi Wanderley ; de Brito, Thais Morais ; Amendoeira, Fabio Coelho ; da Nóbrega, Armi Wanderley ; Morelli Cardoso, Maria Helena Wohlers ; Bastos, Lucia Helena Pinto ; Rocha, Leandro Machado

Over the past two decades, concerns have arisen about the efficacy and safety of medicinal plants, highlighting good agricultural practices and quality control. This study aimed to validate a multi-residue analysis method for detecting 268 pesticides in Mikania glomerata tincture, using direct injection and UPLC-MS/MS, per SANTE guidelines. The validation of the method involved evaluating the linearity of analytical curves in terms of the determination coefficient r2 and residuals (%), as well as the limits of quantification (LOQ), matrix effects, precision (expressed as the coefficient of variation, CV), and accuracy (determined as the recovery percentage). The parameters and acceptance criteria were assessed based on SANTE guidelines. The method was then applied to analyse commercial samples of M. glomerata tincture, and traces of carbendazim and dimethomorph were detected. This study underscores the need for regulatory measures to enhance agricultural practices, thereby ensuring the safety and efficacy of medicinal plants.

100 项与多菌灵相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
-	多菌灵	-	DB13009

研发状态

10 条进展最快的记录,

登录

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
HIV感染	临床3期	-	Procter & Gamble Co.	-
HIV感染	临床3期	-	ImQuest BioSciences, Inc.	-
HIV感染	临床3期	美国	Arisyn Therapeutics Inc	-
肿瘤	临床3期	美国	Arisyn Therapeutics Inc	-