Abstract Purpose Radioiodine therapy (RIT) of benign thyroid diseases is an established therapy. This study aimed to identify factors predictive for outcome in patients with non-toxic goiter (NTG), unifocal (UFA), multifocal (MUFA) or diffuse autonomy (DISA) and Graves’ disease (GD). Methods Retrospective analysis of 205 patients with benign thyroid disease (54 NTG, 46 MUFA, 24 DISA, 26 UFA, 55 GD) who underwent RIT. Follow up time was 12 months for determining treatment outcome. Results The type of disease was predictive for volume reduction after 12 months (NTS 66%, DISA 67%, MUFA 58%, UFA 51%, GD 71%, p<0.001) and post-treatment hypothyroidism (NTS 48%, DISA 33%, MUFA 15%, UFA 15%, p=0.006). Initial volume, intra-therapeutic uptake and intra-therapeutic half-life were independent prognostic factors for volume reduction 12 months after RIT. In patients with NTG, UFA, MUFA, DISA post-treatment hypothyroidism was significantly correlated with extent of volume reduction 12 months after RIT, achieved dose, higher pre-therapeutic TSH values and younger age. Two different strategies for pre-therapeutic dosimetry used in MUFA showed no differences regarding the therapeutic outcome. In GD, effective half-life, initial volume and Graves’ ophthalmopathy were predictive for treatment failure. Conclusion Reduction of thyroid volume and the percentage of hypothyroid patients one year after RIT was primarily dependent on the type of disease. In MUFA and DISA we could identify volume reduction after 3 months as a reliable predictor for hypothyroidism while in patients with GD a short intra-therapeutic half-life, a large pre-therapeutic volume and active Graves’ ophtalmopathy were relevant predictors for treatment failure suggesting an intensified follow-up scheme in these patients.

2022-12-01·Annals of Nuclear Medicine

Development of a novel small-animal myocardial phantom can evaluate the image quality of dual-isotope simultaneous acquisition (DISA)

Article

作者: Shibutani, Takayuki ; Hiromasa, Tomo ; Wakabayashi, Hiroshi ; Onoguchi, Masahisa ; Kinuya, Seigo ; Kanno, Takayuki

BACKGROUNDMyocardial phantom studies are widely used as a tool to accurately assess the physical phenomenon of dual-isotope simultaneous acquisition (DISA) in the small-animal fields. However, the previous phantom did not reproduce the structures of rats or mice. The aim of this study was to develop a novel myocardial phantom simulating the structure of a small animal that can be evaluated using the image quality of DISA.METHODSA novel small-animal myocardial phantom that simulated a rat was constructed by the myocardium, liver, lung, spine, and torso. Normal and inferior wall defect myocardial phantoms were filled with ^99mTc or ¹⁸F solution to simulate single-isotope acquisition (SIA) and DISA. Phantom and small-animal images with no scatter correction (nonSC) and scatter correction (SC) were created.RESULTSThe ^99mTc DISA with SC showed a low %CV compared to that with nonSC. Although the ^99mTc DISA with nonSC had lower cavity contrast than that of ^99mTc SIA with nonSC, the cavity contrast of SC had similar values between SIA and DISA. The minimum %uptake of ^99mTc SIA with nonSC was a lower value compared to that of ^99mTc DISA with nonSC. The ^99mTc DISA was equivalent to the minimum %uptake of ^99mTc SIA by SC.CONCLUSIONWe have developed a novel myocardial phantom for the rat model to evaluate the image quality for reproducing the physical phenomenon associated with radiation attenuation and scattering. Furthermore, we could demonstrate the usefulness of the novel small-animal myocardial phantom by image quality evaluation of DISA with ^99mTc and ¹⁸F compared to SIA.

2021-09-01·Journal of Molecular Recognition4区 · 生物学

Investigations of Dianhydro‐D‐glucitol adsorbed on AuNPs surface: In silico and in vitro approach based on anticancer activity studies against A549 lung cancer cell lines

4区 · 生物学

Article

作者: V., Shyni ; Sajan, D. ; D. R., Leenaraj ; Joseph, Lynnette

AbstractThe adsorption behavior of a lung cancer agent, Dianhydro‐D‐glucitol (DIS) on gold nanoparticles (AuNPs) was studied using surface‐enhanced Raman scattering techniques. The stabilized geometry, inter‐ and intra‐molecular hydrogen bond, and harmonic vibrational wavenumbers of DIS and DIS adsorbed on AuNPs (DISA) surface have been investigated with the help of the density functional theory (DFT) method. The stability of the molecules arising from stereoelectronic interactions, leading to its bioactivity, has been confirmed using natural bond orbital (NBO) analysis, which was further substantiated by the narrow HOMO LUMO energy gap obtained for DISA, from frontier molecular orbital analysis as well as electronic spectral analysis. The molecular electrostatic potential analysis along with local and global reactivity descriptors predicts the reactive site of the molecules. Molecular docking study was performed to obtain information about protein‐ligand reactions for DIS and DISA, with different cancer proteins. This study enlightens the potential of SERS agents for targeted drug delivery and photothermal. The in vitro cytotoxic effects of DPH and DPHA molecules on lung cancer cell lines were analyzed using the MTT assay and the SERS method.

100 项与 DISA (Sprint Bioscience) 相关的药物交易

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