作者: Asghar, Muhammad Adnan ; Ahmed, Nadeem ; Khalid, Muhammad ; Mubarak, Saman ; Alharthy, Rima D ; Yaqub, Muhammad ; Shafiq, Zahid ; Shafiq, Iqra ; Braga, Ataualpa Albert Carmo

A new series of sensors SM-1 to SM-3 was designed and synthesized using indole carboxaldehydes (2a-2c) and 2,4-dinitrophenyl hydrazine. Accompanied by the synthesis, density functional theory investigation was also accomplished at the M06-2X/6-311G+(d,p) functional. A reduction in band gap (ΔE = 4.702-4.230 eV) along with a bathochromic shift (λ_max = 433.223-471.584 nm) was seen in deprotonated chromophores than their neutral sensors. Further, significant charge transference from indole toward dinitrophenyl hydrazine was also examined. Global reactivity parameters also expressed the greater stability of sensors than that of their deprotonated form. SM-3 displayed high selectivity toward F ions as compared to SM-1 and SM-2, which respond to both F^- and CN^- ions. The electronic absorption spectrum was recorded in CH₃CN. The sensor SM-3 showed high selectivity toward F^- ions with a low detection limit (8.69 × 10^-8), and the binding constant for SM-3 was determined as 7.7 × 10⁵. The sensor displayed naked eye views as the color of solution changed from mustard to purple with a red shift of 96 nm. The mechanism suggests deprotonation from the NH group, which was confirmed by ¹H NMR. The sensor is found to be useful for detection of F^- ions in the real sample and for analytical application (test strip).

2019-02-01·Advanced Biosystems3区 · 生物学

Self‐Assembled Metal‐Phenolic Nanoparticles for Enhanced Synergistic Combination Therapy against Colon Cancer

3区 · 生物学

Article

作者: Xiao, Gao ; Liao, Xuepin ; Richardson, Joseph J. ; Huang, Wen ; Li, Ke ; Dai, Yunlu ; Shi, Bi ; Chen, Wen ; Yu, Kang ; Guo, Junling

AbstractEngineering functional nanomaterials to have both high therapeutic efficacy and minimal side‐effects has become a promising strategy for next‐generation cancer treatments. Herein, an adenosine triphosphate (ATP) depletion and reactive oxygen species‐enhanced combination chemotherapy platform is introduced whereby therapeutic samarium (Sm3+) ions and (−)‐epicatechin (EC) are integrated via a metal‐phenolic network (SmIII‐EC). The independent pathway between Sm3+ and EC can achieve a synergistic therapeutic effect through the mitochondrial dysfunction process. SmIII‐EC nanoparticles cause a significant reduction of viability of C26 murine colon carcinoma cells while with lower systemic toxic effects on normal cell lines. SmIII‐EC nanoparticles are used to directly compare with a clinic anticancer drug 5‐fluorouracil. SmIII‐EC nanoparticles not only decrease the tumor volume but also do not affect the body weight of mice and normal organs, showing significant advantages over clinic counterpart. These facts suggest that SmIII‐EC nanoparticles represent a clinically promising candidate for colon cancer treatment with a targeted therapeutic effect and minimum side toxicity.

2001-11-23·Journal of Applied Microbiology3区 · 生物学

Isolation of an aerobic denitrifying bacterial strain NS-2 from the activated sludge of piggery wastewater treatment systems in Taiwan possessing denitrification under 92% oxygen atmosphere

3区 · 生物学

Article

作者: C.-P. Yang ; B.-Y. Liu ; J.-J. Su ; J. Lin

AIMSTo isolate aerobic denitrifying bacteria which will be applied to piggery wastewater treatment facilities for enhanced nitrate and nitrite removal.METHODS AND RESULTSNitrate-supplemented basal medium in airtight, crimp-sealed serum bottles containing an atmosphere of 92% oxygen was inoculated with denitrifiers, strains NS-2 and SM-3, and incubated at 30 degrees C. After 20 h, the concentration of nitrate was decreased rapidly by both NS-2 and SM-3. Nitrite production was almost zero during the whole experimental period for both strains. Nitrogen gas production peaked at the 20 h for both NS-2 (8.20 +/- 1.03 mmol l(-1)) and SM-3 (3.93 +/- 0.16 mmol l(-1)).CONCLUSIONSStrain NS-2, which produced the highest N2 concentration in this work, was identified as Pseudomonas stutzeri. This strain is the most capable of aerobic and anaerobic conversion of nitrate to N2 without forming a nitrite intermediate.SIGNIFICANCE AND IMPACT OF THE STUDYStrain NS-2 is highly promising for future application in in situ piggery wastewater treatment.

100 项与 Monoclonal antibody SM-3(Cancer Research Technology) 相关的药物交易

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