PB-01(PB-01) - 药物靶点：FST_专利_临床

概要

基本信息

药物类型

激素

别名

靶点

FST

作用机制

卵泡抑素激动剂

治疗领域

遗传病与畸形消化系统疾病呼吸系统疾病+ [1]

在研适应症-

非在研适应症

囊性纤维化

原研机构

Hudson Institute of Medical Research

在研机构-

非在研机构

Hudson Institute of Medical Research

Paranta Biosciences Ltd.

最高研发阶段无进展临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

2

项与 PB-01 相关的临床试验

ACTRN12616000496415 / Completed临床1期

A Phase I, double-blind, placebo-controlled, randomised, crossover study to assess the anti-inflammatory effects of orally inhaled PB01 following an inhaled lipopolysaccharide (LPS) challenge in healthy male volunteers.

开始日期2016-05-05

申办/合作机构

Paranta Biosciences Ltd.

ACTRN12615000984594 / Completed临床1期

Randomised, double-blind, placebo-controlled Phase I study to evaluate the safety, tolerability and pharmacokinetics of single and multiple doses of orally inhaled PB01 administered to healthy subjects.

开始日期2015-09-22

申办/合作机构

Paranta Biosciences Ltd.

100 项与 PB-01 相关的临床结果

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100 项与 PB-01 相关的转化医学

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100 项与 PB-01 相关的专利（医药）

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7

项与 PB-01 相关的文献（医药）

2023-08-01·Poultry Science

Enzymatic hydrolysis of minced chicken carcasses for protein hydrolysate production

Article

作者: Liu, Shao-Quan ; Zhang, Xing ; Li, Xinzhi

Animal and poultry processing generates significant volumes of by-products that can be further processed for other uses. In this study, we treated minced chicken carcasses with proteases to produce protein hydrolysates that can be used as nutritional and/or flavor-enhancing ingredients. Five different microbial proteases were investigated for their abilities to hydrolyse the minced chicken carcass: Flavourzyme, Protamex, PB01, PB02, and PB03, with PB02 demonstrating the highest degree of hydrolysis (DH) of the minced chicken carcass (43.95%) after 4 h of hydrolysis. The essential hydrolytic parameters were optimized using response surface methodology in conjunction with Box-Behnken design. The optimal conditions were found to be: enzyme/substrate ratio of 3:100 (w/w), temperature of 51.20°C, pH of 6.62 ± 0.05, and substrate/water ratio of 1:1 (w/v) for 4-h hydrolysis, which resulted in a maximum DH of 45.44%. The protein recovery was 50.45 ± 2.05%, and the protein hydrolysate was high in free amino acids (7,757.31 mg/100 mL), of which essential and taste-active amino acids accounted for 41.74% and 92.64%, respectively. The hydrolysate was comprised mainly of low molecular weight peptides (1-5 kDa, 0.5-1 kDa, and <0.5 kDa), which were potential taste substances and flavor precursors. The resulting hydrolysate might be employed as a nutritive product, an ingredient for flavoring generation or a component of fermentation media.

2021-10-01·Revista Iberoamericana de Micología4区 · 生物学

Differentially expressed proteins in the interaction of Paracoccidioides lutzii with human monocytes

4区 · 生物学

Article

作者: Mares, Joise Hander ; Freire, Herbert Pina Silva ; Oliveira, Flamélia Carla Silva ; Pirovani, Carlos Priminho ; Souza, Ednara Almeida de ; Pessoa, Wallace Felipe Blohem ; Romano, Carla Cristina

BACKGROUNDFungi of the genus Paracoccidioides are the etiological agents of paracoccidioidomycosis, a highly prevalent mycosis in Latin America. Infection in humans occurs by the inhalation of conidia, which later revert to the form of yeast. In this context, macrophages are positioned as an important line of defense, assisting in the recognition and presentation of antigens, as well as producing reactive oxygen species that inhibit fungal spreading.AIMSThe objective of this study was to identify differentially expressed proteins during the interaction between Paracoccidioides lutzii Pb01 strain and human U937 monocytes.METHODSTwo-dimensional electrophoresis, combined with mass spectrometry, was used to evaluate the differential proteomic profiles of the fungus P. lutzii (Pb01) interacting with U937 monocytes.RESULTSIt was possible to identify 25 proteins differentially expressed by Pb01 alone and after interacting with U937 monocytes. Most of these proteins are directly associated with fungal metabolism for energy generation, such as glyceraldehyde-3-phosphate dehydrogenase, and intracellular adaptation to monocytes. Antioxidant proteins involved in the response to oxidative stress, such as peroxiredoxin, cytochrome, and peroxidase, were expressed in greater quantity in the interaction with monocytes, suggesting their association with survival mechanisms inside phagocytic cells. We also identified 12 proteins differentially expressed in monocytes before and after the interaction with the fungus; proteins involved in the reorganization of the cytoskeleton, such as vimentin, and proteins involved in the response to oxidative stress, such as glioxalase 1, were identified.CONCLUSIONSThe results of this proteomic study of a P. lutzii isolate are novel, mimicking in vitro what occurs in human infections. In addition, the proteins identified may aid to understand fungal-monocyte interactions and the pathogenesis of paracoccidioidomycosis.

2018-08-01·Fungal Biology3区 · 生物学

Characterization of extracellular proteins in members of the Paracoccidioides complex

3区 · 生物学

Article

作者: Célia Maria de Almeida Soares ; Simone Schneider Weber ; Lucas Nojosa Oliveira ; Juliana Alves Parente-Rocha ; Edilânia Gomes Araújo Chaves ; Amanda Rodrigues de Oliveira ; Clayton Luiz Borges ; Alexandre Melo Bailão ; Lilian Cristiane Baeza

Paracoccidioides is a thermodimorphic fungus that causes Paracoccidioidomycosis (PCM) - an endemic systemic mycosis in Latin America. The genus comprises several phylogenetic species which present some genetic and serological differences. The diversity presented among isolates of the same genus has been explored in several microorganisms. There have also been attempts to clarify differences that might be related to virulence existing in isolates that cause the same disease. In this work, we analyzed the secretome of two isolates in the Paracoccidioides genus, isolates Pb01 and PbEpm83, and performed infection assays in macrophages to evaluate the influence of the secretomes of those isolates upon an in vitro model of infection. The use of a label-free proteomics approach (LC-MS^E) allowed us to identify 92 proteins that are secreted by those strains. Of those proteins, 35 were differentially secreted in Pb01, and 36 in PbEpm83. According to the functional annotation, most of the identified proteins are related to adhesion and virulence processes. These results provide evidence that different members of the Paracoccidioides complex can quantitatively secrete different proteins, which may influence the characteristics of virulence, as well as host-related processes.

100 项与 PB-01 相关的药物交易

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