This is a dose-finding safety trial followed by a randomized pilot trial comparing administration of SARS-CoV2-specific T cells (SARS-CoVSTs) to standard of care treatment in hospitalized patients with COVID19 who are at high risk of requiring mechanical ventilation.
The SARS-CoVSTs lines have been made at Baylor College of Medicine from healthy donors who have made a full recovery from COVID19. These cell lines were frozen for later use and will be thawed and used to treat patients who meet the eligibility criteria.

开始日期2020-11-04

申办/合作机构

Baylor College of Medicine

[+3]

100 项与 Anti-SARS Cov-2 T Cell(Baylor College of Medicine) 相关的临床结果

登录后查看更多信息

100 项与 Anti-SARS Cov-2 T Cell(Baylor College of Medicine) 相关的转化医学

登录后查看更多信息

100 项与 Anti-SARS Cov-2 T Cell(Baylor College of Medicine) 相关的专利（医药）

登录后查看更多信息

项与 Anti-SARS Cov-2 T Cell(Baylor College of Medicine) 相关的文献（医药）

Sensors3区 · 工程技术

Construction of Fluorescent Immunosensor Quenchbody to Detect His-Tagged Recombinant Proteins Produced in Bioprocess

3区 · 工程技术

ArticleOA

作者: Ning, Xuerao ; Kitaguchi, Tetsuya ; Ueda, Hiroshi ; Yasuda, Takanobu

With the widespread application of recombinant DNA technology, many useful substances are produced by bioprocesses. For the monitoring of the recombinant protein production process, most of the existing technologies are those for the culture environment (pH, O2, etc.). However, the production status of the target protein can only be known after the subsequent separation and purification process. To speed up the monitoring of the production process and screening of the higher-yield target protein variants, here we developed an antibody-based His-tag sensor Quenchbody (Q-body), which can quickly detect the C-terminally His-tagged recombinant protein produced in the culture medium. Compared with single-chain Fv-based Q-body having one dye, the Fab-based Q-body having two dyes showed a higher response. In addition, not only was fluorescence response improved but also detection sensitivity by the mutations of tyrosine to tryptophan in the heavy chain CDR region. Moreover, the effect of the mutations on antigen-binding was successfully validated by molecular docking simulation by CDOCKER. Finally, the constructed Q-body was successfully applied to monitor the amount of anti-SARS CoV-2 nanobody secreted into the Brevibacillus culture media.

100 项与 Anti-SARS Cov-2 T Cell(Baylor College of Medicine) 相关的药物交易

登录后查看更多信息