Abstract::Neem gum, a biocompatible and biodegradable polysaccharide, has broad applications in
drug delivery and tissue engineering. Its hydrophilic and bioadhesive properties make it ideal for
controlled drug release and scaffold fabrication. This review examines the role of neem and its derivatives
in pharmaceutical formulations, wound healing, and regenerative medicine, while addressing
stability, scalability, and regulatory considerations. Future directions include the integration of
nanotechnology and chemical modifications for enhanced biomedical applications. Neem gum has
been developed into various forms, including hydrogels, nanoparticles, films, and coatings, for targeted
drug delivery and tissue regeneration. Its antimicrobial, antioxidant, and anti-inflammatory
properties enhance wound healing and infection control, but challenges like batch variability and
mechanical limitations remain. Neem gum is a promising natural biomaterial for pharmaceutical and
biomedical applications. Further research on stability, large-scale processing, and clinical validation
is essential for commercialisation and clinical use.