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更新于：2025-03-20

Sulfamethizole

磺胺甲二唑

更新于：2025-03-20

概要

基本信息

药物类型

小分子化药

别名

Sulfamethizole (JP17/USP/INN)、Sulfamethylthiadiazole

+ [3]

靶点

bacterial DHPS

作用方式

抑制剂

作用机制

bacterial DHPS抑制剂(细菌二氢叶酸合成酶抑制剂)

治疗领域

感染泌尿生殖系统疾病

在研适应症-

非在研适应症

泌尿道感染

原研机构

Pfizer Inc.

在研机构-

非在研机构

Wyeth-Ayerst Laboratories

最高研发阶段撤市

首次获批日期

美国 (1953-10-28),

泌尿道感染

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C9H10N4O2S2

InChIKeyVACCAVUAMIDAGB-UHFFFAOYSA-N

CAS号144-82-1

关联

100 项与磺胺甲二唑相关的临床结果

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100 项与磺胺甲二唑相关的转化医学

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100 项与磺胺甲二唑相关的专利（医药）

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2,233

项与磺胺甲二唑相关的文献（医药）

2025-03-01·Talanta

Voltammetric methodology for the quality control and monitoring of sulfamethoxazole removal from water

Article

作者: Pazos, Marta ; Caruncho-Pérez, Sara ; Sanromán, M Ángeles ; Bernárdez, Nuria ; González-Romero, Elisa

Sulfamethoxazole is an antibiotic that is among the drugs most frequently found in waters around the world because of its habitual consumption and its high chemical stability that prevents it from being eliminated from the environment. In this study, an electroanalytical methodology based on differential pulse voltammetry is developed for the analysis of sulfamethoxazole at trace levels in water. After the optimization of the instrumental parameters a linear range from 6.59 to 96.27 μM was found with limits of detection and quantification of 1.98 and 6.59 μM, respectively, with an RSD below 6 %. Moreover, several validation studies involving different pH values, water samples and instrumentation-techniques were performed in order to ensure the robustness of the method. For this purpose, the peak area was used as quantitative variable since it is not affected by the pH of the medium even if there is any modification of this parameter during the experiments. Furthermore, the effect of other drug such as trimethoprim on the analytical signal of sulfamethoxazole was also evaluated. Once the method was developed it was tested on the quality control of Soltrim®, obtaining recoveries between 98 and 102 %. Lastly, the voltammetric method was applied for the in situ monitoring of sulfamethoxazole's removal from water samples, specifically by anodic oxidation and electro-Fenton treatments. While the former was coupled to an adsorption process, the latter was carried out with different iron sources including commercial medicines that can be found in wastewater. The problem of significant variation in pH during the treatment was solved by working with the peak area, and so obtaining valid and reliable kinetic data. Although anodic oxidation proved to be faster considering the calculated k_obs, electro-Fenton turned out to be more efficient in eliminating the drug, achieving the disappearance of its analytical signal in only 30 min of treatment.

2025-03-01·Environmental Research

Nitrogen transformation and bacterial community response in O3-SBR process for treating nitrogen-containing heterocyclic antibiotics

Article

作者: Liu, Siyang ; Pu, Chuan ; Zhang, Jiayue ; Cao, Gang ; Lu, Gang ; Guo, Junjie

Nitrogen heterocyclic antibiotics (NHAs) pollution poses a significant threat to aquatic ecosystems. Ozonation (O₃) pretreatment is beneficial for the removal of total nitrogen (TN) in antibiotics by facilitating subsequent biological treatment. However, nitrogen transformation and bacterial community responses when treating NHAs by O₃-coupled biological processes remain unclear. This study utilized an O₃-coupled sequencing batch reactor (O₃-SBR) to evaluate its treatment efficacy on three typical NHAs, namely fluconazole, sulfamethizole, and acyclovir, and explored nitrogen transformation and the effects of oxidation products (NHAs-OPs) on bacterial communities. The results showed that the O₃-SBR process was more effective for treating NHAs than using O₃ or SBR alone. O₃ pretreatment converted nitrogen in difficult-to-degrade NHAs into inorganic nitrogen and other organic nitrogen compounds, improving the biodegradability of NHAs. Subsequently, NHAs-OPs were used as the nitrogen/carbon source for SBR. Unlike the low TN removal rate of 14.4-23.4% observed when treating pure NHAs wastewater, the TN and total organic carbon removal rates of the SBR treating NHAs-OPs wastewater reached 62.4-85.2% and 65.2-86.4%, respectively. High-throughput sequencing analysis revealed that the enhanced efficacy of the SBR process may be attributed to the dominance of bacterial genera adapted to NHAs-OPs within the system. Additionally, the abundance of denitrification functions under NHAs-OPs stress was found to be higher than that of nitrification functions. These results provide new theoretical support for the treatment of antibiotic production wastewater.

2025-03-01·Journal of Hazardous Materials

Impact of adaptation time on lincomycin removal in riverbank filtration: A long-term sand column study

Article

作者: Hu, Shengchao ; Huang, Yangrui ; Qi, Weixiao ; Chen, Zhanyan ; Liu, Huijuan ; Wang, Li ; Chen, Bi ; Zhao, Jian

Riverbank filtration (RBF) is an effective pretreatment technology for drinking water, removing organic micropollutants (OMPs) mainly through biodegradation. Despite documented improvements in OMP removal with extended adaptation time, the mechanisms remain poorly understood. This study assessed the removal of 128 OMPs over 82 d in a simulated RBF system, identified those with improved removal, and analyzed their properties. Additionally, microbial community shifts after 400 d of lincomycin exposure were studied to understand the underlying mechanisms. We found that the removal efficiencies of 24 OMPs, including lincomycin and fluconazole, improved by 3-77 % over 82 d while being positively correlated with the presence of tertiary amides and secondary sulfonamides. Lincomycin removal efficiency rose from 20 % to 95 % over 68 days and stayed high. We identified eight potential degradation products of lincomycin, occurring primarily via hydroxylation, N-demethylation, and amide hydrolysis. Additionally, lincomycin notably increased the abundances of specific antibiotic-resistant bacteria (e.g., Thiobacillus, 8.3-fold) and ammonia-oxidizing archaea (e.g., Nitrososphaera, 46.8-fold). The β-lactam resistance gene in Thiobacillus and the amoA gene in Nitrososphaera may enhance lincomycin's removal by promoting its hydrolysis and hydroxylation. Overall, this study provides insights into OMP biodegradation mechanisms and the impact of ng/L levels of lincomycin on microbial communities.

100 项与磺胺甲二唑相关的药物交易

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