Cyclin B1/WT-1/CEF peptide-loaded dendritic cell vaccine(Baylor Scott & White Research Institute (BSWRI))(Cyclin B1/WT-1/CEF peptide-loaded dendritic cell vaccine(Baylor Scott & White Research Institute (BSWRI)))

概要

基本信息

药物类型

合成肽疫苗、治疗性疫苗、树突状细胞疫苗

别名-

靶点

CCNB1 x WT1

作用机制

CCNB1抑制剂(cyclin B1 inhibitors)、WT1抑制剂(Wilms瘤基因l抑制剂)

治疗领域

肿瘤皮肤和肌肉骨骼疾病

在研适应症

乳腺癌

非在研适应症-

原研机构

Baylor Scott & White Research Institute

在研机构

Baylor Scott & White Research Institute

非在研机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

1

项与 Cyclin B1/WT-1/CEF peptide-loaded dendritic cell vaccine(Baylor Scott & White Research Institute (BSWRI)) 相关的临床试验

NCT02018458 / Completed临床1/2期IIT

Pilot Safety Trial of Preoperative Chemotherapy Combined With Dendritic Cell Vaccine in Patients With Locally Advanced, Triple-Negative Breast Cancer or ER-Positive, Her2-Negative Breast Cancer

The primary objective of this study is to determine the safety and feasibility of combining cyclin B1/WT-1/CEF (antigen)-loaded DC vaccination with preoperative chemotherapy.
The secondary objectives of this trial are to determine pathologic complete response rates; disease-free survival; to assess immune biomarkers of immunity (antigen-specific CD8+ T cell immunity and TH2 T cells) in breast cancer biopsy specimens and blood samples in patients receiving DC vaccinations; and to assess the feasibility of immunizing LA TNBC and ER+/HER2- BC patients with patient-specific tumor antigens.

开始日期2014-05-01

申办/合作机构

Baylor Research Institute

100 项与 Cyclin B1/WT-1/CEF peptide-loaded dendritic cell vaccine(Baylor Scott & White Research Institute (BSWRI)) 相关的临床结果

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100 项与 Cyclin B1/WT-1/CEF peptide-loaded dendritic cell vaccine(Baylor Scott & White Research Institute (BSWRI)) 相关的转化医学

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100 项与 Cyclin B1/WT-1/CEF peptide-loaded dendritic cell vaccine(Baylor Scott & White Research Institute (BSWRI)) 相关的专利（医药）

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100 项与 Cyclin B1/WT-1/CEF peptide-loaded dendritic cell vaccine(Baylor Scott & White Research Institute (BSWRI)) 相关的药物交易

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