SIPI-644(SIPI-644) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用方式-

作用机制-

治疗领域

心血管疾病

在研适应症-

非在研适应症

心律失常

原研机构

上海医药工业研究院有限公司

在研机构-

非在研机构

上海医药工业研究院有限公司

权益机构-

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)无进展

特殊审评-

结构/序列

分子式C24H29ClN2O5

InChIKeyQJLGYXDDDCIZDH-UHFFFAOYSA-N

CAS号114460-32-1

关联

100 项与 SIPI-644 相关的临床结果

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100 项与 SIPI-644 相关的转化医学

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100 项与 SIPI-644 相关的专利（医药）

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6

项与 SIPI-644 相关的文献（医药）

1988-03-01·Zhongguo yao li xue bao = Acta pharmacologica Sinica

[Anti-arrhythmic action of 4'-methyl-7-([2-hydroxy-3-(beta-propinamidoethyl)amino]propoxy) flavone hydrochloride (SIPI-644)].

Article

作者: Pan, X X ; Chen, J C ; Min, Y

Zhongguo Yiyao Gongye Zazhi

Effects of SIPI-644 on aconitine-induced ventricular arrhythmias in rats

作者: Chen, Jiechun ; Min, Yang

Intraduodenal (i.d.) administration of SIPI-644 (I) at 50, 100, and 200 mg/kg increased the threshold doses of aconitine for inducing ventricular premature beats, short ventricular tachycardia, ventricular tachycardia, and ventricular fibrillation, in rats.However, its antiarrhythmic effect did not parallel the i.d. dose of SIPI-644.The i.v. ED₅₀ of SIPI-644 and amiodarone determined on aconitine-induced arrhythmia in rats were 12.3 and 27.8 mg/kg, resp.The i.v. therapeutic index of SIPI-644 and amiodarone were 11.7 and 5.3, resp.

Zhongguo Yaoli Xuebao

Antiarrhythmic action of 4'-methyl-7-{[2-hydroxy-3-(β-propionamidoethyl)amino]propoxy}flavone hydrochloride (SIPI-644)

作者: Pan, Xianxin ; Chen, Jiechun ; Min, Yang

SIPI 644 (I) was active against aconitine-, ouabain-, and BaCl₂-induced cardiac arrhythmias in rats and guinea pigs.I was more active than the closely related flavone SIPI 549.Depending on the model, I was sometimes more and sometimes less active than amiodarone.The acute i.v. LD₅₀ values of I and SIPI 549 in mice were 144 and 92 mg/kg, resp.

100 项与 SIPI-644 相关的药物交易

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