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项与 Anti-TM4SF1-CAR-T-cell therapy (Shanghai Biomed-union Biotechnology) 相关的临床试验A Clinical Study on the Safety and Efficacy of Chimeric Antigen Receptor T-cell Therapy for the TM4SF1- and EpCAM-positive Recurrent/Refractory Solid Tumors
Transmembrane 4 L Six Family Member 1 (TM4SF1) and Epithelial cell adhesion molecule (EpCAM) are both highly expressed in many epithelial-derived solid tumors.
The Chimeric Antigen Receptor T-cells (CAR-T) that target TM4SF1 or EpCAM have been generated respectively in our good manufacturing practices (GMP) facility and their anti-tumor effects have been demonstrated in multiple in vitro and in vivo studies.
Clinical studies are proposed here to evaluate the anti-tumor activity of these cell therapy products for treatment of patients with TM4SF1 or EpCAM positive tumors. In this study, the safety, tolerance, and preliminary efficacy of CART-TM4SF1 and CART-EpCAM cells will be examined inpatients with refractory/recurrent advanced pancreatic cancer, colorectal cancer, gastric cancer or lung cancer. And 9 patients for each cancer will be evaluated.
Clinical and immunological responses will be evaluated about 30 days and last up to 2 years after CAR-T cell infusion.
100 项与 Anti-TM4SF1-CAR-T-cell therapy (Shanghai Biomed-union Biotechnology) 相关的临床结果
100 项与 Anti-TM4SF1-CAR-T-cell therapy (Shanghai Biomed-union Biotechnology) 相关的转化医学
100 项与 Anti-TM4SF1-CAR-T-cell therapy (Shanghai Biomed-union Biotechnology) 相关的专利(医药)
100 项与 Anti-TM4SF1-CAR-T-cell therapy (Shanghai Biomed-union Biotechnology) 相关的药物交易