伪人参皂苷GQ(Pseudo-Ginsenoside GQ) - 药物靶点：VDCCs_在研适应症：稳定型心绞痛_专利_临床

概要

基本信息

药物类型

小分子化药

别名

PGQ

靶点

VDCCs

作用机制

VDCCs阻滞剂(电压门控性钙通道复合体阻滞剂)

治疗领域

神经系统疾病心血管疾病

在研适应症

稳定型心绞痛

非在研适应症-

原研机构

在研机构

非在研机构

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)临床2期

特殊审评-

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关联

3

项与伪人参皂苷GQ 相关的临床试验

CTR20191009 / Recruiting临床2期

评价伪人参皂苷GQ 注射液用于治疗稳定性心绞痛患者的有效性和安全性Ⅱa期探索性临床试验

初步探索伪人参皂苷GQ注射液用于治疗稳定性心绞痛患者的有效性和安全性，为后续临床研究提供依据。

开始日期2019-05-22

申办/合作机构

吉林大学再生医学科学研究所

[+1]

CTR20130380 / Completed临床1期

伪人参皂苷GQ注射液多次给药、安慰剂对照、随机双盲，耐受性和药代动力学的Ⅰ期临床研究

评价伪人参皂苷GQ注射液多次给药在健康受试者中的安全性、耐受性及药代动力学特征。

开始日期2013-09-03

申办/合作机构

吉林大学再生医学科学研究所

[+1]

CTR20131074 / Completed临床1期

伪人参皂苷GQ注射液单次给药、安慰剂对照、随机双盲，耐受性和药代动力学的Ⅰ期临床研究

评价伪人参皂苷GQ（PGQ）注射液单次给药在健康受试者中的安全性、耐受性及药代动力学特征。

开始日期2012-06-21

申办/合作机构

吉林大学再生医学科学研究所

[+1]

100 项与伪人参皂苷GQ 相关的临床结果

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100 项与伪人参皂苷GQ 相关的转化医学

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100 项与伪人参皂苷GQ 相关的专利（医药）

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8

项与伪人参皂苷GQ 相关的文献（医药）

2024-01-01·International Immunopharmacology

Pseudoginsenoside GQ mitigates chronic intermittent hypoxia-induced cognitive damage by modulating microglia polarization

Article

作者: Zhang, Yating ; Teng, Bo ; Tong, Weifang ; Wang, Hongyan ; Wang, Sanchun ; Tian, Yanhua

Obstructive sleep apnea (OSA), a state of sleep disruption, is characterized by recurrent apnea, chronic intermittent hypoxia (CIH) and hypercapnia. Previous studies have showed that CIH-induced neuroinflammatory plays a crucial role in cognitive deficits. Pseudoginsenoside GQ (PGQ) is a new oxytetracycline-type saponin formed by the oxidation and cyclization of the 20(S) Rg3 side chain. Rg3 has been found to afford anti-inflammatory effects, while whether PGQ plays a role of anti-neuroinflammatory remains unclear. The purpose of this study was to investigate whether PGQ attenuates CIH-induced neuroinflammatory and cognitive impairment and the possible mechanism it involves. We found that PGQ significantly ameliorated CIH-induced spatial learning deficits, and inhibited microglial activation, pro-inflammatory cytokine release, and neuronal apoptosis in the hippocampus of CIH mice. In addition, PGQ pretreatment promoted microglial M1 to M2 phenotypic transition in IH-induced BV-2 microglial, as well as indirectly inhibited IH-induced neuronal injury via modulation of microglia polarization. Furthermore, we noted that activation of HMGB1/TLR4/NF-κB signaling pathway induced by IH was inhibited by PGQ. Molecular docking results revealed that PGQ could bind to the active sites of HMGB1 and TLR4. Taken together, this work supports that PGQ inhibits M1 microglial polarization via the HMGB1/TLR4/NF-κB signaling pathway, and indirectly exerts neuroprotective effects, suggesting that PGQ may be a potential therapeutic strategy for cognitive impairment accompanied OSA.

2019-01-01·Journal of Ginseng Research2区 · 医学

High frequency somatic embryogenesis and plant regeneration of interspecific ginseng hybrid between Panax ginseng and Panax quinquefolius

2区 · 医学

ArticleOA

作者: Kondeti, Subramanyam ; Chang Kim, Young ; Han, Jung Yeon ; Kim, Jong Youn ; Kim, Dong Hwi ; Adhikari, Prakash Babu ; Choi, Yong Eui ; Ahn, Chang Ho

BACKGROUNDInterspecific ginseng hybrid, Panax ginseng × Panax quenquifolius (Pgq) has vigorous growth and produces larger roots than its parents. However, F₁ progenies are complete male sterile. Plant tissue culture technology can circumvent the issue and propagate the hybrid.METHODSMurashige and Skoog (MS) medium with different concentrations (0, 2, 4, and 6 mg/L) of 2,4-dichlorophenoxyacetic acid (2,4-D) was used for callus induction and somatic embryogenesis (SE). The embryos, after culturing on GA₃ supplemented medium, were transferred to hormone free ½ Schenk and Hildebrandt (SH) medium. The developed taproots with dormant buds were treated with GA₃ to break the bud dormancy, and transferred to soil. Hybrid Pgq plants were verified by random amplified polymorphic DNA (RAPD) and inter simple sequence repeat (ISSR) analyses and by LC-IT-TOF-MS.RESULTSWe conducted a comparative study of somatic embryogenesis (SE) in Pgq and its parents, and attempted to establish the soil transfer of in vitro propagated Pgq tap roots. The Pgq explants showed higher rate of embryogenesis (~56% at 2 mg/L 2,4-D concentration) as well as higher number of embryos per explants (~7 at the same 2,4-D concentration) compared to its either parents. The germinated embryos, after culturing on GA₃ supplemented medium, were transferred to hormone free ½ SH medium to support the continued growth and kept until nutrient depletion induced senescence (NuDIS) of leaf defoliation occurred (4 months). By that time, thickened tap roots with well-developed lateral roots and dormant buds were obtained. All Pgq tap roots pretreated with 20 mg/L GA₃ for at least a week produced new shoots after soil transfer. We selected the discriminatory RAPD and ISSR markers to find the interspecific ginseng hybrid among its parents. The F₁ hybrid (Pgq) contained species specific 2 ginsenosides (ginsenoside Rf in P. ginseng and pseudoginsenosides F₁₁ in P. quinquefolius), and higher amount of other ginsenosides than its parents.CONCLUSIONMicropropagation of interspecific hybrid ginseng can give an opportunity for continuous production of plants.

2018-06-01·The American Surgeon™4区 · 医学

Ultrasound-Guided Breast-Conservative Surgery Decreases the Rate of Reoperations for Palpable Breast Cancer

4区 · 医学

Article

作者: Latteri, Stefania ; Graceffa, Giuseppa ; Priola, Roberta ; Cipolla, Calogero ; Latteri, Mario A. ; Fricano, Martina ; Vieni, Salvatore

The purpose of this study is to verify whether the performance of ultrasound-guided quadrantectomy (USGQ) versus palpation-guided quadrantectomy (PGQ) can reduce the incidence of positive margins and if it can change the attitude of the surgeon. A retrospective study was conducted on 842 patients underwent quadrantectomy for breast cancer, 332 of them underwent USGQ, whereas 550 underwent PGQ. The histological type of the tumors and the margin status obtained with the histological examination were compared. The histological examination of the surgical specimen showed involvement of the margins in 24/842 patients (2.85%), 22 (2.61%) of them belonged to the PGQ group, and two to the USGQ group (P = 0.0011). The highest rate of microscopically positive margins was, statistically significant, for carcinoma in situ, when compared with patients with invasive carcinoma (0.0001). USGQ technique showed several advantages compared with PGQ. In fact, the former notes a lower positive margin rate and, consequently, a lower rate of reintervention. In addition, it may change the surgeon's attitude by causing him to remove another slice of margin to ensure more histological negativity. It should be the gold standard technique for breast-conservative surgery of palpable tumors.

100 项与伪人参皂苷GQ 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
心绞痛	临床2期	中国	吉林大学	2019-06-25
稳定型心绞痛	临床2期	中国	吉林华康药业股份有限公司	2019-05-22
稳定型心绞痛	临床2期	中国	吉林大学再生医学科学研究所	2019-05-22