A Phase 3, Prospective, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Chenodeoxycholic Acid (CDCA), With an Open-Label Cohort, in Newly Diagnosed Participants With Cerebrotendinous Xanthomatosis (CTX)

This study is designed to demonstrate the beneficial effect of CDCA in the treatment of CTX-associated diarrhea in approximately 10 participants aged 2-75 years old with newly diagnosed CTX or suspected CTX who have never received treatment with CDCA.

开始日期2024-05-27

申办/合作机构

Leadiant Biosciences, Inc.

NCT06180057

/ Completed临床1期

Randomized, Two-way, Two-period, Single Oral Dose, Open-label, Crossover, Bioequivalence Study to Compare Chenodeoxycholic Acid Capsules (250mg Chenodeoxycholic Acid) [Dose: 1 x 02 Capsules] Versus Chenodeoxycholic Acid Leadiant 250 mg Hard Capsules (250mg Chenodeoxycholic Acid) [Dose: 1 x 02 Capsules] in Healthy Subjects Under Fasting Conditions

Randomized, two-way, two-period, single oral dose, open-label, crossover, bioequivalence study to compare Chenodeoxycholic acid capsules (250mg chenodeoxycholic acid) [dose: 1 x 02 capsules] versus Chenodeoxycholic acid leadiant 250 mg hard capsules (250mg chenodeoxycholic acid) [dose: 1 x 02 capsules] in healthy subjects under fasting conditions.

开始日期2022-06-12

申办/合作机构-

EUCTR2021-003823-14-NL

/ Recruiting临床4期

Pharmacokinetic cross-over study of compounded chenodeoxycholic acid.

开始日期2021-11-16

申办/合作机构-

100 项与鹅去氧胆酸相关的临床结果

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100 项与鹅去氧胆酸相关的转化医学

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100 项与鹅去氧胆酸相关的专利（医药）

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7,437

项与鹅去氧胆酸相关的文献（医药）

2026-02-01·CARBOHYDRATE POLYMERS

Integrated microbial and metabolic coordination orchestrates antler growth induced by guar gum and xylo-oligosaccharides

Article

作者: Li, Zhipeng ; Zhu, Yuhang ; Ma, Cuiliu ; Deng, Ruijia ; Sang, Jianan ; Nan, Weixiao ; Wang, Tao ; Li, Songze ; Si, Huazhe

Antlers are a unique mammalian bone organ characterized by rapid growth, a process critically dependent on nutrient availability and the gastrointestinal tract microbiome. Polysaccharides and oligosaccharides shape microbiome output, but their roles in antler development remain unclear. Here, the strongest short-chain fatty acid effect was found with guar gum (GG) and xylo-oligosaccharides, which altered the rumen microbiome in vitro incubations with six polysaccharides and oligosaccharides. GG enriched Lachnospiraceae and Oscillospiraceae, and glycoside hydrolase families, enhancing butyrate biosynthesis and amino acid catabolism, while xylo-oligosaccharides selectively enriched Selenomonadaceae, supporting vitamin and fatty acid biosynthesis in vivo in the rumen. GG increased the fecal microbiome involved in bile acid deconjugation and dihydroxylation. Targeted metabolomics demonstrated that GG elevated the circulating levels of bile acids (chenodeoxycholic acid, deoxycholic acid, taurohyodeoxycholic acid) and osteogenic factors (IGF-1, BMP2, FGF2), and resulted in free fatty acid changes in the serum. Transcriptomics and RT-PCR revealed activation of angiogenic pathways in reserve mesenchyme and osteogenic signaling in mineralized cartilage of antlers. In vitro assays demonstrated that taurohyodeoxycholic acid significantly promoted osteogenic differentiation of mesenchymal cells. Our results revealed the distinct microbial adaptations of specific carbohydrates and elucidated a "GIT-antler" axis intervention for enhancing bone growth in mammals.

2026-01-01·MICROBIAL PATHOGENESIS

Lithocholic acid exerts antiviral activity against porcine epidemic diarrhea virus by enhancing TGR5-mediated type III interferon production

Article

作者: He, Haiyan ; Zhang, Chunhong ; Shen, Haiyan ; Zhang, Kunli ; Nie, Jingjing ; Jia, Aiqing ; Qu, Yunzhi ; Liu, Zhicheng ; Zhang, Jianfeng

BACKGROUND:

Porcine epidemic diarrhea virus (PEDV), a highly infectious porcine virus, leads to high mortality in newborn piglets. Bile acids (BAs) are synthesized in the liver and metabolized in the intestines by gut microbiota. These acids can regulate cellular immunity and influence viral infection processes.

AIM:

To assess the antiviral activity of four BAs-cholic acid (CA), chenodeoxycholic acid (CDCA), deoxycholic acid (DCA), and lithocholic acid (LCA) against PEDV in IPEC-J2 cells.

METHODOLOGY:

We investigated the effects of 24-h pretreatment with the four aforementioned BAs at varying concentrations on PEDV replication in IPEC-J2 cells through quantitative polymerase chain reaction (qPCR), Western blotting, and TCID₅₀ assay.

RESULTS:

BA exposure inhibited PEDV N protein expression to varying degrees. qPCR and Western blotting to measure PEDV N protein and mRNA expression at varying LCA concentrations (1, 5, or 10 μM) revealed that LCA demonstrated significant anti-PEDV activity in a concentration-dependent manner (p < 0.05). Time-of-addition assay confirmed that LCA predominantly inhibits PEDV infection at the replication stage. Thus, LCA activates transcription of the type III interferon (IFN) gene, 2'-5'-oligoadenylate synthetase 1 gene, and IFN-stimulated gene 15 (ISG15). Moreover, 24-h pretreatment with 100 nM SBI-115 (receptor inhibitor) and LCA blocked Takeda G protein-coupled receptor 5 in IPEC-J2 cells, effectively inhibiting type III interferon and ISG15 expression and promoting PEDV proliferation.

CONCLUSION:

LCA primarily targets Takeda G protein-coupled receptor 5 by inducing type III interferon, inhibiting PEDV proliferation. Therefore, LCA may be included in therapeutic strategies targeting PEDV. These results collectively highlight the potential of LCA as a therapeutic agent against PEDV by targeting the viral replication process, providing a novel strategy to control PEDV infections.

2026-01-01·BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

α,ω-Hexadecanedioic acid induces proton-translocating decoupling at complex III via Q-cycle disruption: evidence from kinetic and structural analyses

Article

作者: Samartsev, Victor N ; Dubinin, Mikhail V ; Khoroshavina, Ekaterina I ; Pavlova, Svetlana I ; Chulkov, Alexander V

This study investigates the interaction between α,ω-hexadecanedioic acid (HDA (D)) and сomplex III (E_III) electron transport chain in liver mitochondria, focusing on DE_III complex formation during succinate and glutamate/malate oxidation. A key emphasis is placed on the "idling" state of DE_III, where electron transfer occurs without proton translocation. The decoupling effect of HDA was quantified using three parameters: 1) K_d^ap and K_d^∗: apparent dissociation constants of the DE_III complex, calculated based on the total HDA concentration and the HDA quantity within the mitochondrial effective volume, respectively; 2) J_Dmax: the maximal mitochondrial respiration rate under saturating HDA concentrations (as [HDA] approaches infinity); 3) K_0.5: the HDA concentration at which the decoupling effect (J_D-J₄) equals half of its maximal value (J_Dmax-J₄), where J₄ represents the mitochondrial respiration rate in State 4. Methodologies for parameter determination were established through HDA concentration-dependent respiration profiles. Key findings reveal that K_d^ap remains substrate-independent but in contrast to K_d^∗ varies with mitochondrial protein concentration. In contrast, K_0.5 and J_Dmax/J₄ were significantly higher during succinate oxidation compared to glutamate/malate. Classical protonophores 3,5-di(tret-butyl)-4-hydroxybenzylidenemalononitrile (SF6847) and 2,4-dinitrophenol (DNP), as well as chenodeoxycholic acid (CDCA) at low concentrations, increased K_d^ap without affecting J_Dmax/J₄, suggesting reduced HDA efficacy. Molecular docking identified potential HDA binding sites on сomplex III. Based on these findings, we discuss a possible mechanism underlying the decoupling action (intrinsic uncoupling of complex III) of HDA by shuttling its protonated and anionic forms.

151

项与鹅去氧胆酸相关的新闻（医药）

2025-12-10

·胖胖细胞笔记

Mirum 6.2亿美金收购Bluejay，加码罕见肝病领域全球领导力

点击上方蓝字关注我们 2025年12月8日，专注于罕见病治疗的行业领军企业Mirum Pharmaceuticals（纳斯达克代码：MIRM）宣布与专注于病毒性和肝脏疾病的私营生物技术公司Bluejay Therapeutics达成最终收购协议。此次收购将为Mirum的罕见肝病产品线增添治疗慢性丁型肝炎病毒（HDV）的后期候选药物brelovitug的全球权益，进一步巩固其在罕见病领域的全球领导地位。收购核心亮点：一款潜力重磅药物+高度协同效应brelovitug：HDV治疗的突破性候选药物 brelovitug是一款具有突破性潜力的全人源单克隆抗体，拥有FDA突破性疗法认定以及欧洲药品管理局（EMA）的PRIME认定和孤儿药资格。其核心优势显著：作用机制：靶向乙肝病毒（HBV）和丁型肝炎病毒（HDV）表面抗原（HBsAg），能够中和并清除相关病毒粒子，同时耗尽含HBsAg的亚病毒颗粒，从根源上抑制病毒复制。临床数据亮眼：在Ⅱ期研究中，展现出强大的抗病毒活性，HDV RNA应答率达到100%，同时改善了患者的肝酶水平，且安全性良好，最常见的不良事件仅为注射部位红斑。研发进展明确：目前正处于全球Ⅲ期AZURE注册临床试验阶段，该试验包含多项开放标签研究，主要终点为病毒学和生化联合应答，预计2026年下半年公布顶线数据，2027年有望提交生物制品许可申请（BLA）并实现上市。战略协同：精准契合Mirum核心优势此次收购并非简单的资产补充，而是基于双方在罕见肝病领域的高度契合： Mirum在罕见肝病领域拥有深厚的专业知识和成熟的全球商业化能力，旗下已有LIVMARLI®、CHOLBAM®等多款获批产品，通过volixibat等项目与关键医疗服务提供者建立了稳固合作关系，可为brelovitug的后续研发和商业化提供强大支持。收购后，brelovitug将成为Mirum未来18个月内第四个潜在注册申报项目，进一步丰富其罕见肝病管线，强化公司在该领域的竞争壁垒。HDV：亟待攻克的“最严重病毒性肝炎” 丁型肝炎病毒（HDV）是一种需与乙肝病毒（HBV）共感染的病毒，被称为“最严重的病毒性肝炎”，其危害程度令人触目惊心：疾病进展迅猛：感染HDV后，患者极易快速发展为肝纤维化、肝硬化、肝功能失代偿，且患肝癌的风险显著增加，近半数患者在确诊后10年内会因肝脏相关疾病死亡。患者群体庞大且缺乏治疗手段：仅在美国和欧洲，HDV患者就约有23万人，而目前全球绝大多数国家（包括美国）尚无FDA批准的治疗方案，存在巨大的未满足医疗需求。交易细节：6.2亿美金基础对价+2亿美金里程碑根据最终协议，此次收购的交易结构包括三部分：基础对价：Mirum将以2.5亿美金现金和3.7亿美金Mirum普通股（约合520万股，每股定价71.2085美金）收购Bluejay全部流通股，基础交易总额达6.2亿美金；里程碑付款：若达到预设的销售目标，Bluejay股东还可获得最高2亿美金的现金里程碑付款；配套融资：Mirum同时与现有及新的医疗健康投资者达成私募配售协议，通过发行普通股及预融资权证（部分投资者选择）募集约2亿美金（扣除承销费用前），所得资金将用于收购后的临床研发和商业化活动。私募配售的普通股定价为每股68.48美金，预融资权证对应的普通股行权价为每股0.0001美金，实际发行价相当于68.4799美金/股。目前，该交易已获得双方董事会批准，预计将于2026年第一季度完成交割，尚需满足监管审批及其他惯例成交条件。交割后，Mirum将拥有brelovitug的全球权益，同时将评估Bluejay其他在研项目的战略选项。双方表态：聚焦患者，共推创新疗法落地 Mirum Pharmaceuticals首席执行官Chris Peetz表示：“此次收购完全契合我们的核心战略——通过严谨的研发、监管创新和卓越的商业化能力，为罕见病患者带来高影响力的药物。brelovitug充分利用了我们在罕见肝病领域的深厚积累，以及通过volixibat和LIVMARLI项目建立的合作网络。Bluejay团队在brelovitug的研发上取得了令人钦佩的成就，我们期待在此基础上，将这款重要的新疗法带给HDV患者。” Bluejay Therapeutics创始人兼首席执行官Keting Chu认为：“Bluejay的成立使命是为病毒性和肝脏疾病患者开发变革性疗法。在FDA和EMA等监管机构的支持下，我们的团队仅用四年时间就将brelovitug从临床候选药物推进至全球Ⅲ期试验。brelovitug有望重新定义HDV治疗，而Mirum在罕见病领域的领导力、对罕见肝病患者群体的承诺以及商业化专长，使其成为推动该项目全球落地的理想合作伙伴。”关于双方公司Mirum Pharmaceuticals 作为全球领先的罕见病公司，Mirum拥有全球化的获批产品组合和广泛的在研管线，专注于为被忽视的疾病领域带来突破性药物。其商业化产品包括用于阿拉吉勒综合征（ALGS）和进行性家族性肝内胆汁淤积症（PFIC）的LIVMARLI®、用于胆汁酸合成障碍的CHOLBAM®、用于脑腱黄瘤病（CTX）的CTEXLI®；在研管线涵盖用于原发性硬化性胆管炎（PSC）和原发性胆汁性胆管炎（PBC）的IBAT抑制剂volixibat，以及用于脆性X综合征（FXS）的PDE4D抑制剂MRM-3379。Bluejay Therapeutics Bluejay是一家临床阶段生物制药公司，致力于为严重病毒性和肝脏疾病开发潜在的救命疗法。除了brelovitug（针对HDV和慢性乙肝CHB），公司还在推进多项创新项目，包括 proprietary TLR9激动剂（cavrotolimod）和肝脏靶向HBV转录抑制剂（BJT-628），目标是开发慢性乙肝的联合治疗方案，实现功能性治愈。原文链接https://ir.mirumpharma.com/news-events/news/news-details/2025/Mirum-Pharmaceuticals-Enters-into-Definitive-Agreement-to-Acquire-Bluejay-Therapeutics-Expanding-Global-Leadership-in-Rare-Disease/default.aspx 图片和部分素材来自网络，如果侵权联系删除，请转给更多有需要的人，点关注不迷路

并购孤儿药突破性疗法申请上市

2025-12-09

·生物医药科研笔记

IF＞10 文献速递∣2025年12月胆汁酸研究动态（上）

-♥点击蓝字关注♥- 01 论文 1. 约氏乳杆菌通过调控胆汁酸与活性氧抑制高脂饮食诱导的结直肠癌 Gut Check: Lactobacillus johnsonii Harnesses Bile Acids and Reactive Oxygen Species to Suppress High-Fat Diet-Induced Colorectal Cancer. 结直肠癌是全球最常见且致命的恶性肿瘤之一，其发病率与高脂饮食（HFD）等生活方式因素密切相关。尽管流行病学研究已将HFD与结直肠癌风险上升关联，但个体易感性差异显著，其内在驱动机制仍不清楚。最新研究范式已从单纯关注膳食组成转向探讨宿主-微生物互作及微生物代谢谱在HFD驱动结直肠癌个体风险差异中的作用。在本期《Cancer Research》中，Liu等将约翰逊乳杆菌（Lactobacillus johnsonii）鉴定为一种保护性菌株，可抑制HFD诱导的肿瘤发生。该菌通过促进结合型胆汁酸向鹅去氧胆酸的转化，触发线粒体功能障碍，进而提升活性氧（ROS）生成并诱导细胞凋亡，从而抑制结直肠癌发展。这些临床前发现为胆汁酸代谢、肠道菌群与致癌作用交汇的机制提供了新见解，并为未来探索基于益生菌的癌症预防策略奠定了转化研究基础。参见Liu等在本期第4600页的相关研究如下：IF＞10 文献速递∣2025年9月胆汁酸研究动态（下） Lactobacillus johnsonii Synthesizes Chenodeoxycholic Acid to Reduce Susceptibility to High-Fat Diet-Induced Colorectal Cancer 定植约翰逊乳杆菌（Lactobacillus johnsonii）菌可显著提高高脂饮食（HFD）暴露小鼠的肠腔内鹅去氧胆酸（CDCA）水平，从而延缓HFD诱导的结直肠癌进展。机制上，L. johnsonii通过胆盐水解酶将结合型胆汁酸转化为CDCA；CDCA诱导线粒体功能障碍与氧化应激，促进细胞凋亡，有效抑制肿瘤发生。研究结果确立了肠道菌群作为HFD诱导癌症易感性差异的中介，并提出一种可抑制肿瘤发生的益生菌干预策略，为减缓HFD相关结直肠癌进展提供了可行路径。 2. 肠道菌群通过调控猪脱氧胆酸-TGR5轴维持骨量 Gut microbiota preserves bone mass through modulating the hyodeoxycholic acid-TGR5 axis. 背景：骨质疏松症是一种与年龄相关的疾病。肠道菌群（GM）稳态与骨骼健康之间的关联已得到广泛证实，但其失调如何导致老年性骨质疏松的机制尚不明确。本研究旨在探讨肠道菌群、胆汁酸（BAs）及其对骨量的影响之间的关系。结果：通过16S rRNA测序以及非靶向与靶向代谢组学分析发现，老年小鼠肠道菌群多样性降低，并伴有胆汁酸谱的改变。与年轻小鼠相比，老年小鼠中戈氏副拟杆菌（Parabacteroides goldsteinii）的丰度及猪去氧胆酸（HDCA）水平显著下降，且两者均与骨量呈强正相关。进一步研究发现，无论是否采取措施阻止食粪行为，将老年小鼠与年轻小鼠共笼饲养均未能改变其肠道菌群组成或逆转与年龄相关的骨量丢失。然而，将年轻小鼠的肠道菌群移植给老年小鼠（而非单独移植戈氏副拟杆菌）可以重构老年小鼠的肠道菌群，并通过抑制骨吸收来维持骨量。机制上，HDCA在体外可抑制破骨细胞成熟，在体内则通过激活G蛋白偶联胆汁酸受体（TGR5）发挥骨保护作用。研究表明，HDCA处理可导致TGR5内化，从而在体内抑制P65的核转位。TGR5基因敲除削弱了HDCA对骨微结构的影响，证实了上述发现。结论：本研究确定了肠道菌群-HDCA-TGR5轴是影响骨量的关键通路，靶向干预HDCA为骨质疏松症提供了潜在的治疗策略。 3. 生命早期微生物组来源的胆汁酸特征及其与胰岛自身免疫的关联 Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity 最新研究揭示，肠道微生物能将多种氨基酸与胆汁酸结合，形成微生物共轭胆汁酸。然而，其调节机制及健康效应尚不明确。本研究分析了生命早期微生物共轭胆汁酸的谱式特征及其与胰岛自身免疫的关联。对303份纵向收集（3至36月龄）的粪便样本中的110种微生物胆汁酸进行了定量分析，样本来源于后续出现一种或多种胰岛自身抗体的儿童，以及始终未出现自身抗体的对照儿童。识别出这些胆汁酸酰胺化物具有明显的年龄依赖性变化轨迹，并将其与肠道微生物组组成相关联。研究发现，熊去氧胆酸与脱氧胆酸共轭物的水平改变与胰岛自身免疫相关，并调控了免疫刺激脂多糖诱导的单核细胞活化以及Th17/Treg细胞平衡。这些发现表明，微生物共轭胆汁酸影响免疫发育与1型糖尿病风险。图1. 研究概述。分析了来自具有HLA遗传性T1D风险儿童的纵向粪便样本系列中的微生物共轭胆汁酸，样本收集时间点为3、6、12、18、24及36月龄。这些儿童在随访期间，后续分别发展为：(i) 多种胰岛自身抗体阳性，(ii) 单一胰岛自身抗体阳性，或 (iii) 始终保持自身抗体阴性。图中关于体外实验、微生物（以红色标记）、结肠及质谱仪的示意图使用BioRender绘制。 02 综述 4. 添加糖、肠道菌群与宿主健康 Added sugars, gut microbiota, and host health 过量摄入添加糖是一项全球性公共卫生问题，已明确其与心血管代谢疾病及其他慢性病密切相关。新近证据表明，肠道菌群可能介导高糖摄入带来的危害。本综述总结了动物与人体研究中关于添加糖摄入对肠道菌群多样性及组成影响的证据，并探讨了糖诱导的微生物变化与健康结局之间可能的机制联系。添加糖（包括葡萄糖、果糖和蔗糖）可能改变肠道微生物多样性，富集利用糖的类群，并减少产短链脂肪酸的细菌。这些微生物变化可能损害肠道屏障完整性，在炎症条件下增加肠腔氧气及替代电子受体的水平，降低短链脂肪酸产量，改变胆汁酸与氨基酸代谢，并促进内毒素跨肠道屏障进入血液循环。总体上，这些通路可能将添加糖摄入与肠易激综合征、肥胖、肝脏脂肪变性、糖尿病及心血管疾病联系起来。然而，不同研究中关于添加糖引起肠道菌群改变的结果并不一致，这可能与糖的剂量和形式（液体 vs. 固体）以及人群在基础饮食、宿主遗传和肠道微生物生态学方面的差异有关。未来研究应聚焦于机制探索、个体对添加糖应答差异的特征分析，以及通过临床研究评估饮食或治疗干预能否逆转糖诱导的肠道菌群变化并改善宿主健康结局。胆汁酸代谢肠道菌群通过胆汁酸解偶联和7α-脱羟基化作用代谢宿主胆汁酸，生成能够通过FXR-FGF19与Takeda G蛋白偶联受体5通路传递信号的代谢物，从而调节脂质与葡萄糖代谢。一项人群研究发现，含糖饮料摄入量较高与肠道中携带胆汁盐水解酶（可解偶联初级胆汁酸）和7α-脱羟基化酶的真杆菌属和梭菌属丰度降低相关。这两类菌群丰度的下降进一步与血清中熊去氧胆酸及甘氨熊去氧胆酸水平升高相关，而这两种胆汁酸与含糖饮料摄入量、不良血糖特征及较高的糖尿病风险呈正相关。 5. 实体瘤中的 FGF19：分子机制、代谢重编程和新兴治疗机会 FGF19 in Solid Tumors: Molecular Mechanisms, Metabolic Reprogramming, and Emerging Therapeutic Opportunities 成纤维细胞生长因子19（FGF19）是小鼠FGF15的人类直系同源物，是一种内分泌型FGF。它通过FGFR4-β-Klotho受体复合物传递信号，调节胆汁酸合成、葡萄糖与脂质代谢以及产热作用。除了在代谢稳态中的生理功能外，FGF19的异常表达日益被证实与实体肿瘤的发生和进展相关。从机制上讲，FGF19驱动信号级联反应，以维持肿瘤细胞的增殖、侵袭和代谢重编程，同时促进上皮-间质转化、血管生成和免疫抑制，从而助推转移进程。这些多效性功能凸显了FGF19作为一个极具潜力的治疗靶点。目前，数种靶向FGFR4的抑制剂已进入临床评估阶段。然而，相关疗法仍面临挑战，包括靶点相关的毒性、有限的选择性以及适应性耐药等。综述将探讨FGF19塑造肿瘤生物学的分子机制，评估当前靶向FGF19-FGFR4轴治疗策略的研究现状，并展望未来的发展方向，例如合理的药物联用和代谢干预。深入理解FGF19信号传导、肿瘤微环境与全身代谢之间的相互作用，对于挖掘其在精准肿瘤学中的潜力至关重要。图2. FGF19/15基因表达调控。胆汁酸激活FXR，与RXR形成异二聚体，转录诱导FGF19；同时上调SHP，后者经抑制HNF4α/LRH-1介导的CYP7A1表达减少胆汁酸合成，形成负反馈。PXR和内质网应激因子ATF4增强FGF19转录；GATA4与KLF15则抑制之。Diet1过表达可适度升高FGF19 mRNA，并在转录后水平增加蛋白输出。miR-710和miR-9-3p短暂抑制FGF19，而CO通过下调miR-710解除抑制。Brd4结合启动子进一步促进FGF19/15表达。图 3. FGF19的多重代谢调节作用 (A) 胆汁酸代谢：胆汁酸激活法尼醇X受体，促使FGF19生成增加。FGF19随后经门静脉转运至肝细胞，与FGFR4及β-Klotho结合，最终抑制胆汁酸合成途径中的关键酶——胆固醇7α-羟化酶的转录。 (B) 葡萄糖代谢：FGF19可改善葡萄糖耐量与胰岛素敏感性，参与促进肝脏糖原合成并抑制糖异生。此外，它能增强脂肪细胞中GLUT4的转位，从而促进葡萄糖的摄取与利用。 (C) 脂质代谢：FGF19-FGFR4信号通路与肝脏甘油三酯水平降低及线粒体β-氧化增强相关，可能影响整体脂质稳态。 (D) 产热代谢：FGF19可激活棕色脂肪组织，导致能量消耗增加与脂肪细胞体积减小。本图由MedPeer.cn生成。参考资料： [1] Dalal, Prarthana J, and Yatrik M Shah. “Gut Check: Lactobacillus johnsonii Harnesses Bile Acids and Reactive Oxygen Species to Suppress High-Fat Diet-Induced Colorectal Cancer.” Cancer research vol. 85,23 (2025): 4579-4581. doi:10.1158/0008-5472.CAN-25-3546 [2] Zheng, Xuan-Qi et al. “Gut microbiota preserves bone mass through modulating the hyodeoxycholic acid-TGR5 axis.” Gut microbes vol. 17,1 (2025): 2593088. doi:10.1080/19490976.2025.2593088 [3] Lamichhane, Santosh et al. “Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity.” Nature communications, 10.1038/s41467-025-66619-6. 3 Dec. 2025, doi:10.1038/s41467-025-66619-6 [4] Zhang, Yanbo et al. “Added sugars, gut microbiota, and host health.” Gut microbes vol. 17,1 (2025): 2592431. doi:10.1080/19490976.2025.2592431 [5] Xu, Jiayi et al. “FGF19 in Solid Tumors: Molecular Mechanisms, Metabolic Reprogramming, and Emerging Therapeutic Opportunities.” Theranostics vol. 16,1 345-397. 1 Jan. 2026, doi:10.7150/thno.121601 ———END——— 内容原创，转载请写明来源于【生物医药科研笔记】期待您的分享点赞关注具体内容以英文文献为准，中文解读仅供参考。免责声明：本公众号的原创文章相关知识产权归生物医药科研笔记所有，如需转载或引用文中内容（包括但不限于文字、图片等）请后台留言联系编者，获得授权后方可发布，未经授权严禁私自转载、删减、洗稿。本公众号的转载文章和观点仅代表原作者个人观点，不代表生物医药科研笔记立场，所有内容仅供行业学习交流，不构成任何建议，无商业用途。我们尊重原创和版权，如有疏忽误引用您的版权内容，请及时联系我们处理！

2025-12-08

·北京医学感染与传染研究

癌症研究 85卷 13-23期、15、18（1-3）期增刊

Cancer Res[Jour] AND 85[volume] AND 13[issue] 癌症研究 85卷 13期 https://aacrjournals.org/cancerres/issue/ Editorial(社论) 1 Cancer Research in the Age of Big Data 大数据时代的癌症研究 Christine A. Iacobuzio-Donahue Cancer Res (2025) 85 (13): 2347 In the Spotlight(焦点) 2 Leveraging Whole-Exome Sequencing and Mutational Signatures to Detect Homologous Recombination Deficiency in Cancer 利用全外显子组测序和突变特征检测癌症同源重组缺陷 Joonoh Lim; Young Seok Ju Cancer Res (2025) 85 (13): 2348–2350 3 Cells Keep Diverse Company in Diseased Tissues 细胞在疾病组织中保持多样性 Kieran R. Campbell; Aleksandrina Goeva Cancer Res (2025) 85 (13): 2351–2352 Cancer Research Landmarks(癌症研究里程碑) 4 Paving a Path to Clinical Impact with Radiomics: Enabling Reproducibility and Reach 为放射组学的临床影响铺平道路：实现可重复性和可及性 Mohamad El-Jammal; Caroline Chung Cancer Res (2025) 85 (13): 2353–2355 Reviews(综述) 5 Artificial Intelligence–Driven Cancer Diagnostics: Enhancing Radiology and Pathology through Reproducibility, Explainability, and Multimodality 人工智能驱动的癌症诊断：通过可再现性、可解释性和多模态增强放射学和病理学 Pegah Khosravi; Thomas J. Fuchs; David Joon Ho Cancer Res (2025) 85 (13): 2356–2367 6 Illuminating the Noncoding Genome in Cancer Using Artificial Intelligence 利用人工智能阐明癌症中的非编码基因组 Maria del Mar Alvarez-Torres; Xi Fu; Raul Rabadan Cancer Res (2025) 85 (13): 2368–2375 7 Leveraging Artificial Intelligence for Neoantigen Prediction 利用人工智能进行新抗原预测 Jing Zeng; Zhengjun Lin; Xianghong Zhang; Tao Zheng; Haodong Xu; Tang Liu Cancer Res (2025) 85 (13): 2376–2387 Cancer Biology(癌症生物学) 8 Dissecting FAP+ Cell Diversity in Pancreatic Cancer Uncovers an Interferon-Response Subtype of Cancer-Associated Fibroblasts with Tumor-Restraining Properties 剖析胰腺癌中FAP+细胞多样性揭示具有肿瘤抑制特性的癌症相关成纤维细胞干扰素应答亚型 Joshua Cumming; Parniyan Maneshi; Mitesh Dongre; Tala Alsaed; Mohammad Javad Dehghan-Nayeri; Agnes Ling; Kristian Pietras; Cedric Patthey; Daniel Öhlund Cancer Res (2025) 85 (13): 2388–2411 9 Targeting LTBP2 Derived from Cancer-Associated Fibroblasts Sensitizes Esophageal Squamous Cell Carcinoma to Chemotherapy 靶向来自癌症相关成纤维细胞的LTBP2使食管鳞状细胞癌对化疗敏感 Jiarong Zhan; Mengqing Li; Lei Li; Ting-Ting Zeng; Jun Liu; Qingyun Chen; Chen Jiang; Xin Wang; Dan Xie; Xin-Yuan Guan; Ying-Hui Zhu Cancer Res (2025) 85 (13): 2412–2428 10 Chronic Stress Stimulates Protumor Macrophage Polarization to Propel Lung Cancer Progression 慢性应激刺激前体巨噬细胞极化促进肺癌进展 Cuilan Liu; Hengwei Du; Guoxing Yu; Jingjing Qi; Hongliang Dong; Ruiqi Hu; Fei Wang; Bingjie Cui; Weiwei Chen; Qian Zhang; Chen Li; Ran Gao; Clemens A. Schmitt; Jiong Deng; Yong Yu; Jing Du Chronic stress facilitates lung cancer immune evasion by inducing M2-like macrophage polarization, supporting the potential of combination therapies targeting both tumor cells and the immune microenvironment for treating stress-related cancers. Cancer Res (2025) 85 (13): 2429–2447 Cancer Immunology(癌症免疫学) 11 Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin 氨通过降低成熟穿孔素抑制自然杀伤细胞和T细胞的抗肿瘤活性 Joanna Domagala; Tomasz M. Grzywa; Iwona Baranowska; Magdalena Justyniarska; Ryan Tannir; Agnieszka Graczyk-Jarzynka; Aleksandra Kusowska; Maria Lecka; Marcin Poreba; Klaudyna Fidyt; Katsiaryna Marhelava; Zofia Pilch; Lea K. Picard; Tomasz Wegierski; Kamil Jastrzebski; Marta Krawczyk; Marta Klopotowska; Monika Granica; Doris Urlaub; Szymon Hajduk; Alexandra Neeser; Spencer Moros; Pawel Kozlowski; Malgorzata Bobrowicz; Marta Miaczynska; Leyuan Ma; Carsten Watzl; Magdalena Winiarska Cancer Res (2025) 85 (13): 2448–2467 12 Mannose Enhances Immunotherapy Efficacy in Ovarian Cancer by Modulating Gut Microbial Metabolites 甘露糖通过调节肠道微生物代谢物提高卵巢癌免疫治疗效果 Chen Zhang; Yiying Wang; Mengdi He; Chenyang Wang; Kankan Cao; Yujing Zhong; Xueling Wang; Moran Yang; Guodong Zhang; Jiaqi Lu; Huan Yi; Haiou Liu; Congjian Xu Cancer Res (2025) 85 (13): 2468–2484 Translational Cancer Biology(癌症转化生物学) 13 SCD1 Inhibition Blocks the AKT–NRF2–SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma SCD1抑制阻断AKT-NRF2-SLC7A11通路诱导肺腺癌脂质代谢重塑和铁蛋白沉积 Utsav Sen; Charles Coleman; Nishant Gandhi; Vrinda Jethalia; Deniz Demircioglu; Andrew Elliott; Ari M. Vanderwalde; Omar Hayatt; Elisa de Stanchina; Balazs Halmos; Patrick C. Ma; Mirela Berisa; Dan Hasson; Triparna Sen Cancer Res (2025) 85 (13): 2485–2503 Computational Cancer Biology and Technology(癌症计算生物学与技术) 14 HRProfiler Detects Homologous Recombination Deficiency in Breast and Ovarian Cancers Using Whole-Genome and Whole-Exome Sequencing Data HRProfiler使用全基因组和全外显子组测序数据检测乳腺癌和卵巢癌的同源重组缺陷 Ammal Abbasi; Christopher D. Steele; Erik N. Bergstrom; Azhar Khandekar; Akanksha Farswan; Rana R. McKay; Nischalan Pillay; Ludmil B. Alexandrov Cancer Res (2025) 85 (13): 2504–2513 15 Combining Spatial Transcriptomics, Pseudotime, and Machine Learning Enables Discovery of Biomarkers for Prostate Cancer 将空间转录组学、伪时间和机器学习相结合，有助于发现癌症前列腺生物标志物 Martin Smelik; Daniel Diaz-Roncero Gonzalez; Xiaojing An; Rakesh Heer; Lars Henningsohn; Xinxiu Li; Hui Wang; Yelin Zhao; Mikael Benson Cancer Res (2025) 85 (13): 2514–2526 16 Multitask Deep Learning Based on Longitudinal CT Images Facilitates Prediction of Lymph Node Metastasis and Survival in Chemotherapy-Treated Gastric Cancer 基于纵向CT图像的多任务深度学习有助于预测癌症化疗后淋巴结转移和存活率 Bingjiang Qiu; Yunlin Zheng; Shunli Liu; Ruirui Song; Lei Wu; Cheng Lu; Xianqi Yang; Wei Wang; Zaiyi Liu; Yanfen Cui Cancer Res (2025) 85 (13): 2527–2536 Convergence Science(融合医学) 17 Eco-Evolutionary Guided Pathomic Analysis Detects Biomarkers to Predict Ductal Carcinoma In Situ Upstaging 生态进化指导的病理分析检测生物标志物以预测导管癌原位升级 Yujie Xiao; Manal Elmasry; Ji Dong K. Bai; Andrew Chen; Yuzhu Chen; Brooke Jackson; Joseph O. Johnson; Prateek Prasanna; Chao Chen; Mehdi Damaghi Evolutionary dynamics of the various niches composing the tumor ecosystem can be harnessed for predicting cancer progression, demonstrating how eco-evolutionary–designed approaches can guide biomarkers discovery studies in the era of digital pathology Cancer Res (2025) 85 (13): 2537–2547 Cancer Res[Jour] AND 85[volume] AND 14[issue] 癌症研究85卷 14期 https://aacrjournals.org/cancerres/issue/ In the Spotlight(焦点) 1 Pan-Cancer Spatial Profiling Reveals Conserved Subtypes and Niches of Cancer-Associated Fibroblasts 泛癌症空间谱揭示了癌症相关成纤维细胞的保守亚型和生态位 Hani Jieun Kim; Travis Ruan; Alexander Swarbrick Cancer Res (2025) 85 (14): 2555–2557 In Focus(焦点) 2 Bacterial Therapeutics: Addressing the Affordability Gap in Cancer Therapy 细菌疗法：解决癌症治疗的可负担性差距 Kejsi Prifti; Chiswili Yves Chabu; Koichi S. Kobayashi; Jianxun Song; Arum Han; Paul de Figueiredo Cancer Res (2025) 85 (14): 2558–2560 Review(综述) 3 AXL Tyrosine Kinases: A Growing Isoform Family That Promotes Cancer Pathogenesis AXL酪氨酸激酶：促进癌症发病的一个不断增长的异构体家族 May Eriksen Gjerstad; Pia Aehnlich; Pascal Gelebart; Emmet Mc Cormack Cancer Res (2025) 85 (14): 2561–2573 Cancer Biology(癌症生物学) 4 The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer 综合应激反应途径协调肺癌中多个免疫检查点的转化控制 Shayna Thomas-Jardin; Shruthy Suresh; Ariana Arce; Nicole Novaresi; Qing Deng; Emily Stein; Lisa Thomas; Cheryl Lewis; Chul Ahn; Bret M. Evers; Esra A. Akbay; Maria E. Salvatierra; Wei Lu; Khaja Khan; Luisa M. Solis Soto; Ignacio I. Wistuba; John D. Minna; Kathryn A. O’Donnell Cancer Res (2025) 85 (14): 2574–2590 5 Cis-Regulatory Alterations in FOXP4 Modulate Esophageal Cancer Susceptibility Induced by Chronic Alcohol Exposure FOXP4顺式调控改变可调节慢性酒精暴露诱导的食管癌易感性 Siyuan Niu; Jialing Ma; Shasha Liu; Yueping Li; Xinying Yue; Miaoxin Pan; Lina Song; Yutong Wu; Zifei Yang; Yuqian Tan; Linglong Gu; Chaolong Wang; Jiang Chang Cancer Res (2025) 85 (14): 2591–2607 6 Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness 原位细胞系来源的异种移植物的大规模表征鉴定TGFβ信号作为乳腺癌形态和侵袭性的关键调节因子 Catrin Lutz; Xue Chao; Bim de Klein; Jinhyuk Bhin; Madelon Badoux; Timo Eijkman; Apostolos P. Nikolakopoulos; Stefan J. Hutten; Natalie Proost; Bjørn Siteur; Marieke van de Ven; Ji-Ying Song; Jacco van Rheenen; Jessica Morgner; Stefan Prekovic; Jos Jonkers Cancer Res (2025) 85 (14): 2608–2625 7 Loss of SMARCA4 Leads to Intron Retention and Generation of Tumor-Associated Antigens in Small Cell Carcinoma of the Ovary, Hypercalcemic Type SMARCA4的缺失导致高钙血症型卵巢小细胞癌内含子保留和肿瘤相关抗原的产生 Elizabeth A. Raupach; Apurva M. Hegde; Krystine Garcia-Mansfield; Marice Alcantara; David L. Rose; Rebecca F. Halperin; Krystal A. Orlando; Jessica D. Lang; Ritin Sharma; Victoria David-Dirgo; Salvatore J. Facista; Rayvon Moore; Rochelle Kofman; Zoe N. Jensen; Victoria L. Zismann; Anthony N. Karnezis; Yemin Wang; Lynda B. Bennett; Timothy G. Whitsett; Marcin Kortylewski; William P.D. Hendricks; David G. Huntsman; Lorna Rodriguez-Rodriguez; Bernard E. Weissman; Jeffrey M. Trent; Patrick Pirrotte Cancer Res (2025) 85 (14): 2626–2642 Cancer Immunology(癌症免疫学) 8 Fes-Deficient Macrophages Prime CD8+ T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy 缺铁性巨噬细胞激活CD8+T细胞以刺激抗肿瘤免疫并提高免疫治疗效果 Brian J. Laight; Danielle Harper; Natasha Dmytryk; Connie S. Zhang; Changnian Shi; Andrew Garven; Richard W. Nauman; Jacob Kment; Faizah Alotaibi; Ivan Shapovalov; Victoria Hoskin; Yan Gao; Jeffery Mewburn; Caitlyn Vlasschaert; Ami Wang; Julian Simonetti; David LeBrun; Kathrin Tyryshkin; David M. Berman; Amber L. Simpson; Charles H. Graham; Andrew W. Craig; Sameh Basta; Madhuri Koti; Peter A. Greer Cancer Res (2025) 85 (14): 2643–2658 9 Antigen Cross-Presentation by Type-2 Innate Lymphoid Cells Facilitates the Activation of Antitumor CD8+ T Cells 2型先天淋巴细胞的抗原交叉呈递促进了抗肿瘤CD8+ T细胞的激活 Jihyun Kim; Seung Geun Song; Suhyun Park; Young Gyun Ko; Jongho Ham; TaeSoo Kim; Sang-Jun Ha; Yong-Soo Bae; Doo Hyun Chung; Hye Young Kim Cancer Res (2025) 85 (14): 2659–2678 10 Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors 靶向细胞内天然RNA传感系统克服实体瘤对CAR-T细胞治疗的耐药性 Nardine Soliman; Tatiana Nedelko; Giada Mandracci; Stefan Enssle; Vincent Grass; Julius C. Fischer; Florian Bassermann; Hendrik Poeck; Sebastian Kobold; Nadia El Khawanky; Simon Heidegger Cancer Res (2025) 85 (14): 2679–2693 Cancer Metabolism and Molecular Mechanisms(癌症代谢与分子机制) 11 Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation 异常CircTMEM45A通过m5c介导的NLRP3激活促进食管鳞状细胞癌的炎症进展 Lingjiao Meng; Haotian Wu; Jiaxiang Wu; Ping’an Ding; Jinchen He; Tongkun Li; Xiaoman Niu; Meixiang Sang; Lihua Liu Cancer Res (2025) 85 (14): 2694–2713 Therapeutic Development and Chemical Biology(治疗学发展和生物化学) 12 A Cyanobacteria-Derived RNA Aptamer Resensitizes Prostate Cancer to Hormone Therapy 蓝藻衍生的RNA适体使前列腺癌对激素治疗重新敏感 Carlos D. Cruz-Hernández; Bethany Smith; Sandrine Billet; Manish Thiruvalluvan; Gabrielle Gonzales; David M. Underhill; Ekihiro Seki; Shelly C. Lu; Neil A. Bhowmick Cancer Res (2025) 85 (14): 2714–2725 Translational Cancer Biology(癌症转化生物学) 13 Genomic and Single-Cell Analyses Characterize Patient-Derived Tumor Organoids to Enable Personalized Therapy for Head and Neck Squamous Cell Carcinoma 基因组和单细胞分析表征患者来源的肿瘤类器官，以实现头颈部鳞状细胞癌的个性化治疗 Jung Hyun Um; Yueyuan Zheng; Qiong Mao; Chehyun Nam; Hua Zhao; Yoon Woo Koh; Su-Jin Shin; Young Min Park; De-Chen Lin Cancer Res (2025) 85 (14): 2726–2742 14 Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification 种系和体细胞变异的整合提高了慢性淋巴细胞白血病的风险分层 Aubrey K. Hubbard; Derek W. Brown; Jie Liu; Irenaeus C. Chan; Weiyin Zhou; Giulio Genovese; Alexander DePaulis; Sruthi Srinivasan; Shu-Hong Lin; Batel Blechter; Ian D. Buller; Qinglin Zeng; Yin Cao; Wen-Yi Huang; Neal D. Freedman; Haoyu Zhang; Diptavo Dutta; Stephen J. Chanock; Kelly L. Bolton; Mitchell J. Machiela Cancer Res (2025) 85 (14): 2743–2752 Computational Cancer Biology and Technology(癌症计算生物学与技术) 15 A Machine Learning–Based Strategy Predicts Selective and Synergistic Drug Combinations for Relapsed Acute Myeloid Leukemia 基于机器学习的策略预测复发急性髓性白血病的选择性和协同药物组合 Yingjia Chen; Liye He; Aleksandr Ianevski; Kristen Nader; Tanja Ruokoranta; Nora Linnavirta; Juho J. Miettinen; Markus Vähä-Koskela; Ida Vänttinen; Heikki Kuusanmäki; Mika Kontro; Kimmo Porkka; Krister Wennerberg; Caroline A. Heckman; Anil K. Giri; Tero Aittokallio Cancer Res (2025) 85 (14): 2753–2768 Cancer Res[Jour] AND 85[volume] AND 15[issue] 癌症研究85卷 15期 https://aacrjournals.org/cancerres/issue/ In the Spotlight(焦点) 1 Ferreting Out Ferroptosis: Extending the Mechanism of Action of RSL3 to the Selenoproteome in Colorectal Cancer 摆脱脱铁症：将RSL3的作用机制扩展到结直肠癌的硒蛋白组 Sarah P. Short Cancer Res (2025) 85 (15): 2775–2777 2 Unlocking the Therapeutic Potential of the cGAS–STING Pathway through TREX1 Targeting 通过TREX1靶向释放cGAS-STING通路的治疗潜力 Brent A. Hanks Cancer Res (2025) 85 (15): 2778–2780 3 The Genetic Footprint of Tobacco Smoking: Unraveling the Mutational Signatures in Head and Neck Cancer 吸烟的遗传足迹：揭示头颈癌的突变特征 Kaito Mimura; Kenichi Yoshida Cancer Res (2025) 85 (15): 2781–2783 In Focus(焦点) 4 Charting New Paths in Cancer Research: Insights from the Frontiers in Cancer Science Conference 2024 绘制癌症研究的新路径：来自2024年癌症医学会议前沿的见解 Giang Le Minh; Sasidharan Swarnalatha Lucky; Shazib Pervaiz; Kristijan Ramadan; Joe Yeong; Sin Tiong Ong; Vaidehi Krishnan; Chit Fang Cheok; Wee Joo Chng; Sanjay De Mel; Xiaomeng Wang; Anand D. Jeyasekharan; Chartsiam Tipgomut; Li Ren Kong; Kanaga Sabapathy; Cheng Ean Chee; Koji Itahana; Reshma Taneja; Soo-Chin Lee Cancer Res (2025) 85 (15): 2784–2787 Cancer Biology(癌症生物学) 5 Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer RSL3肿瘤抑制机制的重新表征确定硒蛋白组作为结直肠癌的可药物途径 Stephen L. DeAngelo; Liang Zhao; Sofia Dziechciarz; Myungsun Shin; Sumeet Solanki; Andrii Balia; Marwa O. El-Derany; Cristina Castillo; Yao Qin; Nupur K. Das; Hannah N. Bell; Joao A. Paulo; Yuezhong Zhang; Nicholas J. Rossiter; Elizabeth C. McCulla; Jianping He; Indrani Talukder; Billy Wai-Lung Ng; Zachary T. Schafer; Nouri Neamati; Joseph D. Mancias; Markos Koutmos; Yatrik M. Shah Cancer Res (2025) 85 (15): 2788–2804 6 Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression 胰腺神经内分泌肿瘤分泌载脂蛋白E诱导尖端内皮细胞重塑肿瘤-间质比率并促进肿瘤进展 Xin Lou; Yihua Shi; Faming Zhao; Xiaowu Xu; Yan Wang; Yi Qin; Wuhu Zhang; Zeng Ye; Fei Wang; Tian Ding; Desheng Jing; Guixiong Fan; Yue Zhang; Xuemin Chen; Jie Chen; Xianjun Yu; Junfeng Xu; Shunrong Ji Cancer Res (2025) 85 (15): 2805–2819 7 Modeling the PAX5P80R Mutation Reveals HIF2α Activation as a Common Feature and Therapeutic Target in B-cell Acute Lymphoblastic Leukemia PAX5P80R突变建模揭示HIF2α激活是B细胞急性淋巴细胞白血病的共同特征和治疗靶点 Manon Bayet; Vincent Fregona; Mathieu Bouttier; Clémence Rouzier; Jérémy Bigot; Laura Jamrog; Sylvie Hebrard; Naïs Prade; Stéphanie Lagarde; Christine Didier; Stéphanie Gachet; Marie Passet; Laetitia Largeaud; Marlène Pasquet; Ahmed Amine Khamlichi; Emmanuelle Clappier; Eric Delabesse; Cyril Broccardo; Bastien Gerby Cancer Res (2025) 85 (15): 2820–2837 8 Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression 吸烟通过诱导GAPDH琥珀酰化改变细胞代谢促进肺癌进展 Kun Wang; Jingzhuo Li; Hai Zhang; Hongyan Ma; Hong-Yong Cui; Huai-Qiang Ju; Jing Zhang; Qing-zhi Ma; Ming Zhao; Qing-mei Zeng; Jie Zou; Xiu-Xuan Sun; Gang Nan; Meirui Qian; Lin Jing; Yiming Li; Cai-feng Xiong; Qiu-zi Yang; Hao Wang; Jian-Li Jiang; Zhi-Nan Chen; Liang Chen; Wan Huang Cancer Res (2025) 85 (15): 2838–2857 Cancer Immunology(癌症免疫学) 9 Targeting Innate Immune Checkpoint TREX1 Is a Safe and Effective Immunotherapeutic Strategy in Cancer 靶向先天免疫检查点TREX1是一种安全有效的癌症免疫治疗策略 Cong Xing; Xintao Tu; Wanwan Huai; Zhen Tang; Kun Song; Devon Jeltema; Kennady Knox; Nicole Dobbs; Kun Yang; Nan Yan Cancer Res (2025) 85 (15): 2858–2875 10 Systemic Inactivation of TREX1 Induces Selective Inflammation of the Tumor Microenvironment and Invigorated T-cell–Mediated Tumor Control TREX1的系统失活诱导肿瘤微环境的选择性炎症和活化T细胞介导的肿瘤控制 Emilija Marinkovic; Minyi Chen; Nadja Schubert; Elif Dogan Dar; Tanja Poth; Janet Y. Leung; Jack Lohre; Jennifer M. Sahni; Christine Tun; Pavithra Rajeswaran; Tanja Mehlo-Jensen; Olivia Perng; C. Mark Hill; Pallavur Sivakumar; Michael J. Barnes; Rohit Malik; Rayk Behrendt; Axel Roers Cancer Res (2025) 85 (15): 2876–2889 Therapeutic Development and Chemical Biology(治疗学发展和生物化学) 11 Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells 结合多重CRISPR/Cas9-Nickase和PARP抑制剂有效精确地靶向癌细胞 Soyoung Lee; Kyunghwan Kim; Hye-Jin Jeong; Subin Choi; Himchan Cheng; Dayoung Kim; Soomin Heo; Jinhee Mun; Minjong Kim; Eunjin Lee; Yoon Ji Choi; Seon-gyeong Lee; Eun A Lee; Yewon Jang; Kayeong Lim; Heon Seok Kim; Euihwan Jeong; Seung-Jae Myung; Deok-Beom Jung; Chang Sik Yu; In Ho Song; M. Ryan Corces; Joo H. Kang; Kyungjae Myung; Taejoon Kwon; Tae-Eun Park; Jinmyoung Joo; Seung Woo Cho Cancer Res (2025) 85 (15): 2890–2904 Cancer Landscapes(癌症特征) 12 Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients 体细胞突变时间的综合表征揭示了中国患者肺腺癌的进化轨迹 Na Qin; Zhoufeng Wang; Xianfeng Xu; Yuan Xie; Yingjia Chen; Wenxin Luo; Pan Tang; Xin Wang; Lingfeng Bi; Linnan Gong; Zhe Li; Congcong Chen; Kai Wang; Songwei Guo; Zihuan Zhao; Jun Xiang; Meng Zhu; Yue Jiang; Yuanlin He; Juncheng Dai; Rong Yin; Cheng Wang; Zhibin Hu; Hongxia Ma; Weimin Li; Hongbing Shen Cancer Res (2025) 85 (15): 2905–2920 Computational Cancer Biology and Technology(癌症计算生物学与技术) 13 Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm 细胞可塑性的表观遗传力通过一对多基因型-表型范式驱动癌症耐药性 Erica A. Oliveira; Salvatore Milite; Javier Fernandez-Mateos; George D. Cresswell; Erika Yara-Romero; Georgios Vlachogiannis; Bingjie Chen; Chela T. James; Lucrezia Patruno; Gianluca Ascolani; Ahmet Acar; Timon Heide; Inmaculada Spiteri; Alex Graudenzi; Giulio Caravagna; Andrea Bertotti; Trevor A. Graham; Luca Magnani; Nicola Valeri; Andrea Sottoriva Cancer Res (2025) 85 (15): 2921–2938 Convergence Science(融合医学) 14 Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations 具有片段重复的肿瘤抑制基因容易发生体细胞缺失和结构变异 Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred Sze Lok Cheng; Maggie Haitian Wang; Wei Kang; Ka-Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew Tak Vai Chan; Xiansong Wang; William Ka Kei Wu Cancer Res (2025) 85 (15): 2939–2952 Corrections(更正) 15 Correction: N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression 更正：N6甲基腺苷受体YTHDF1通过增强NOTCH1表达促进肝细胞癌的恶性和治疗耐药性 Xinyue Zhang; Tianhong Su; Yifan Wu; Yuhong Cai; Lina Wang; Cong Liang; Lei Zhou; Shiyan Wang; Xiao-Xing Li; Sui Peng; Ming Kuang; Jun Yu; Lixia Xu Cancer Res (2025) 85 (15): 2953 16 Correction: Inhibition of NF-κB-Dependent Signaling Enhances Sensitivity and Overcomes Resistance to BET Inhibition in Uveal Melanoma 更正：抑制NF-κB依赖的信号传导增强了葡萄膜黑色素瘤对BET抑制的敏感性并克服了抗性 Grazia Ambrosini; Catherine Do; Benjamin Tycko; Ronald B. Realubit; Charles Karan; Elgilda Musi; Richard D. Carvajal; Vivian Chua; Andrew E. Aplin; Gary K. Schwartz Cancer Res (2025) 85 (15): 2954 Cancer Res[Jour] AND 85[volume] AND 15_Supplement[issue] 癌症研究85卷 15期增刊 https://aacrjournals.org/cancerres/issue/ Abstracts: Frontiers in Cancer Science 2024; November 13-15, 2024; Singapore 摘要：《2024年癌症医学前沿》；2024年11月13日至15日；新加坡 LIGHTNING TALK ABSTRACTS（闪电演讲摘要） 1 Abstract LT01: Identifying Optimal Tumour-specific Promoters for CRISPR/Cas9 Engineering of Armoured CAR T Cells with Enhanced Safety and Efficacy 摘要LT01：鉴定用于增强安全性和有效性的装甲CAR - T细胞CRISPR/Cas9工程的最佳肿瘤特异性启动子 Kah Min Yap; Amanda X. Y. Chen ... Cancer Res (2025) 85 (15_Supplement): LT01 2 Abstract LT02: CRISPR-Cas9 as a Novel Cancer Gene Therapy Approach against Pancreatic Cancers 摘要LT02：CRISPR-Cas9作为一种新的癌症基因治疗胰腺癌的方法 Selina Shiqing K. Teh; Kirsten Bowland ... Cancer Res (2025) 85 (15_Supplement): LT02 3 Abstract LT03: Cell confinement by micropatterning induces phenotypic changes in cancer-associated fibroblasts 摘要LT03：微模式诱导的细胞隔离可诱导癌症相关成纤维细胞的表型改变 Aleksandr Mitriashkin; Josephine Yu Yan Yap ... Cancer Res (2025) 85 (15_Supplement): LT03 4 Abstract LT07: HEPATOCTYE-MACROPHAGE CROSSTALK VIA THE PGRN-EGFR AXIS MODULATES ADAR1-MEDIATED IMMUNITY IN THE LIVER 摘要LT07：通过PGRN-EGFR轴的肝-巨噬细胞交联调节肝脏中ADAR1介导的免疫 Wei Liang Gan; Xi Ren ... Cancer Res (2025) 85 (15_Supplement): LT07 5 Abstract LT08: Advancing Targeted Gene Therapy: Leveraging Dumbbell-Shaped DNA for Cell-Specific Precision in Cancer, Virus Infection and Mitochondrial Disease 摘要LT08：推进靶向基因治疗：利用哑铃形DNA在癌症、病毒感染和线粒体疾病中实现细胞特异性精确性 Pei She Loh (Rachel); Sushmita Poddar ... Cancer Res (2025) 85 (15_Supplement): LT08 6 Abstract LT10: Molecular mechanisms of SOCS1-mediated tumor suppression in prostate cancer 摘要LT10：SOCS1介导的前列腺癌症肿瘤抑制的分子机制 Awais Ullah Ihsan; Mozhdeh Namvarpour ... Cancer Res (2025) 85 (15_Supplement): LT10 POSTER PRESENTATION ABSTRACTS(海报展示摘要)（略） Cancer Res[Jour] AND 85[volume] AND 16[issue] 癌症研究 85卷 16期 https://aacrjournals.org/cancerres/issue/ In the Spotlightt(焦点) 1 A Spotlight on Oxidative Metabolism in Oncogenic Transformation and Cell Competition 氧化代谢在肿瘤转化和细胞竞争中的作用 Yogaspoorthi J. Subramaniam; Eugenia Piddini Cancer Res (2025) 85 (16): 2961–2962 In Focus(焦点) 2 Tumor–Immune Cell Interactions in Cancer Progression 癌症进展中的肿瘤-免疫细胞相互作用 Xiaoxue Zhou; Feng Xie; Long Zhang Cancer Res (2025) 85 (16): 2963–2966 Review(综述) 3 Informatics at the Frontier of Cancer Research 癌症研究前沿的信息学 Kathleen Noller; Taxiarchis Botsis; Pablo G. Camara; Lauren Ciotti; Lee A.D. Cooper; Jeremy Goecks; Malachi Griffith; Brian J. Haas; Trey Ideker; Rachel Karchin; Despina Kontos; Jiaying Lai; Daniel Marcus; Clifford A. Meyer; Kristen Naegle; Sarthak Pati; Bjoern Peters; Dexter Pratt; Benjamin J. Raphael; Michael Reich; Guergana K. Savova; Carrie Wright; Elana J. Fertig; Spyridon Bakas Cancer Res (2025) 85 (16): 2967–2986 Priority Report(优先报告) 4 SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition SMAD4缺乏促进胰腺癌进展并赋予TGFβ抑制的易感性 Gilbert Z. Murimwa; Natalie E. Williams; Dina Alzhanova; Amir Mohammadi; Jill M. Westcott; Francisca Beato; Ruifan Dai; Luis Nivelo; Francesca Rossi; Henry K. Fleming; Alexandra F. Tassielli; Zeynep Yazgan; Jason E. Toombs; Jason B. Fleming; Aatur D. Singhi; Cecilia G. Ethun; Huocong Huang; Rolf A. Brekken Cancer Res (2025) 85 (16): 2987–2996 Cancer Biology(癌症生物学) 5 SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer SMARCA4缺失会加剧RNA聚合酶II的转录暂停现象，并增加R环的形成，从而抑制卵巢癌中BRCA1介导的DNA损伤修复 Xianbing Zhu; Zheng Fu; Giulio Aceto; Jonathan St-Germain; Kexin Liu; Azadeh Arabzadeh; Yuxuan Qi; Yibo Xue; Leora Witkowski; Elise Graulich; Jutta Steinberger; Selim Misirlioglu; Nicklas Bassani; Racim Sansal; Amber Yasmeen; Geneviève Morin; Jingjie Guo; Anie Monast; Virginie Pilon; Alica Valachová; Kitty Pavlakis; Lili Fu; Walter H. Gotlieb; W. Glenn McCluggage; David Huntsman; Alexander J.R. Bishop; Douglas A. Levine; Morag Park; Yemin Wang; Brian Raught; William D. Foulkes; Sidong Huang Cancer Res (2025) 85 (16): 2997–3014 Cancer Immunology(癌症免疫学) 6 Reactivating cGAS–STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in NRAS-Mutant Tumors 通过靶向 SOS1 重新激活 cGAS–STING信号传导在 NRAS突变肿瘤中增强抗肿瘤免疫力 Jia-Lu Shan; Kai-Ming Zhang; Wen-Qing Zhong; Xiao-Yu Yang; Zhi-Ling Li; Yun Huang; Tian Du; Dong Yang; Jia-Hong Tang; Yu-Hong Chen; Hai-Liang Zhang; Xiao-Feng Zhu; Rong Deng Cancer Res (2025) 85 (16): 3015–3031 Cancer Metabolism and Molecular Mechanisms(癌症代谢与分子机制) 7 Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer 全基因组CRISPR筛选揭示mTOR抑制在头颈癌中启动铁蛋白自噬和铁凋亡 Keiichi Koshizuka; Xingyu Wu; Kuniaki Sato; Pham Thuy Tien Vo; Gosia M. Murawska; Tomohiko Ishikawa; Zhiyong Wang; Alfredo A. Molinolo; Edward A. Dennis; Cherie-Ann O. Nathan; Prashant Mali; J. Silvio Gutkind Cancer Res (2025) 85 (16): 3032–3051 8 MYLK-AS1 Enhances Glutamine Metabolism to Promote EGFR Inhibitor Resistance in Non–Small Cell Lung Cancer MYLK-AS1 通过增强谷氨酰胺代谢促进 EGFR 抑制剂耐药性在非小细胞肺癌中的作用 Tianyu Qu; Lei Song; Jiali Xu; Xiyi Lu; Dandan Yin; Jiali Dai; Chen Zhang; Renhua Guo; Erbao Zhang Cancer Res (2025) 85 (16): 3052–3071 Translational Cancer Biology(转化癌症生物学) 9 CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer CARM1介导的MAP2K4甲基化增强MAP2K4的致癌功能，并在三阴性乳腺癌中构成可靶向的依赖性 Eui-Jun Kim; Yidan Wang; Yu-Lin Chen; Min Ma; Peng Liu; Megan S. Bacabac; Jingjing Zhou; Christopher J. Fry; Jordan R. Hoffman; Menggang Yu; Lingjun Li; Aussie Suzuki; Shulin Li; Wei Xu Cancer Res (2025) 85 (16): 3072–3088 10 Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma 开发一种抗CD99抗体使弥漫性中线胶质瘤能够被靶向治疗 Ilango Balakrishnan; Krishna Madhavan; Angela Pierce; Joshua Michlin; Breauna Brunt; Senthilnath Lakshmanachetty; Dong Wang; John DeSisto; Zachary James Nuss; Nathan Davidson; Faye Walker; Ammu Suresh; Andrew Donson; Bridget Sanford; Kenneth L. Jones; Etienne P. Danis; Siddhartha S. Mitra; Adam L. Green; Nathan Dahl; Rajeev Vibhakar; Sujatha Venkataraman Cancer Res (2025) 85 (16): 3089–3110 11 AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer AREG和EREG是胃食管癌对EGFR抑制反应的预测性生物标志物 Daniela Conticelli; Marco Volante; Filippo Pietrantonio; Claudia Orrù; Martina Olivero; Alessia Nottegar; Felice Borghi; Gian L. Baiocchi; Giovanni Crotti; Uberto Fumagalli Romario; Giovanni De Manzoni; Rossella Reddavid; Roberta Porporato; Dinçer Kılıç; Rebecca Ghione; Erika Calabrò; Russell Petty; Simona Corso; Silvia Giordano; Cristina Migliore Cancer Res (2025) 85 (16): 3111–3122 Cancer Landscapes（癌症特征） 12 Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer 基因组分析揭示肠化生和胃癌的进化特征 Xianfeng Xu; Caiwang Yan; Lijun Bian; Zhe Li; Yuhui Yu; Xia Zhu; Yun Gao; Hao Xu; Fengyuan Li; Yao Liu; Ping Sun; Zheng Wang; Yao Fu; Yue Jiang; Juncheng Dai; Hongxia Ma; Zhibin Hu; Hongbing Shen; Gang Li; Cheng Wang; Guangfu Jin Cancer Res (2025) 85 (16): 3123–3138 Convergence Science(融合医学) 13 Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy 数学建模和关联分析解读肠道微生物组对癌症免疫治疗的影响 Andreas G. Hadjigeorgiou; Constantinos Harkos; Aditya K. Mishra; Golnaz Morad; Sarah B. Johnson; Nadim J. Ajami; Jennifer A. Wargo; Lance L. Munn; Triantafyllos Stylianopoulos; Rakesh K. Jain Cancer Res (2025) 85 (16): 3139–3155 14 Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer 适应体积压缩驱动肝癌细胞抗凋亡和侵袭性表型 Xiangyu Gong; Noriyoshi Ogino; M. Fátima Leite; Dingyao Zhang; Zehua Chen; Ryan Y. Nguyen; Raymond Liu; Emma Kruglov; Kaitlin Flores; Aidan T. Cabral; Gabriel Moreira de M. Mendes; Barbara E. Ehrlich; Michael Mak Cancer Res (2025) 85 (16): 3156–3175 Editor’s Notes(编辑注) 15 Editor’s Note: A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression 编辑注：一种靶向TRIP13的小分子抑制剂抑制多发性骨髓瘤进展 Yingcong Wang; Jing Huang; Bo Li; Han Xue; Guido Tricot; Liangning Hu; Zhijian Xu; Xiaoxiang Sun; Shuaikang Chang; Lu Gao; Yi Tao; Hongwei Xu; Yongsheng Xie; Wenqin Xiao; Dandan Yu; Yuanyuan Kong; Gege Chen; Xi Sun; Fulin Lian; Naixia Zhang; Xiaosong Wu; Zhiyong Mao; Fenghuang Zhan; Weiliang Zhu; Jumei Shi Cancer Res (2025) 85 (16): 3176 16 Editor’s Note: Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation 编者注：细胞表面四跨膜蛋白Tspan8参与了外泌体诱导的内皮细胞活化的分子途径 Irina Nazarenko; Sanyukta Rana; Alexandra Baumann; Jessica McAlear; Andrea Hellwig; Michael Trendelenburg; Günter Lochnit; Klaus T. Preissner; Margot Zöller Cancer Res (2025) 85 (16): 3177 Cancer Res[Jour] AND 85[volume] AND 17[issue] 癌症研究 85卷 17期 https://aacrjournals.org/cancerres/issue/ Obituary（讣告） 1 Eva Klein, MD, PhD, FAACR: In Memoriam (1925–2025) 伊娃·克莱因（Eva Klein）医学博士、哲学博士、美国癌症研究学会会士：缅怀（1925-2025） Maria Teresa Bejarano; Marie Arsenian Henriksson Cancer Res (2025) 85 (17): 3185. In the Spotlight（亮点） 2 Another Slice of the Pie Uncovered: RIT1M90I Is an Actionable Driver in Non–Small Cell Lung Cancer 又一块“蛋糕”被揭开：RIT1M90I是非小细胞肺癌中的可干预驱动因素 Cheng Pei Wu; Aria Vaishnavi Cancer Res (2025) 85 (17): 3186–3188. 3 Bone Voyage: OPN's Path from Skeleton to Systemic Immunosuppression 骨之旅：骨桥蛋白（OPN）从骨骼到全身免疫抑制的路径 Kyoko Hashimoto; Kazuo Okamoto; Hiroshi Takayanagi Cancer Res (2025) 85 (17): 3189–3191. In Focus（聚焦） 4 Lactylation in Cancer: Advances, Challenges, and Future Perspectives 癌症中的乳酸化：进展、挑战与未来展望 Zhi Zong; Long Zhang; Fangfang Zhou Cancer Res (2025) 85 (17): 3192–3195. Priority Report（重点研究简报） 5 RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma RIT1驱动肺腺癌的致癌性转化，是可干预的靶点 Alessandro M. Mozzarelli; Antonio Cuevas-Navarro; Emily G. Shuldiner; Martha Vega; Walid K. Chatila; Jierui Xu; Henry S. Walch; Yuzhe Niu; Dmitri A. Petrov; Nikolaus Schultz; Anatoly Urisman; Charles M. Rudin; Monte M. Winslow; Pau Castel Cancer Res (2025) 85 (17): 3196–3206. Cancer Biology（癌症生物学） 6 RIT1M90I Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy RIT1M90I是肺腺癌发生和靶向治疗耐药的驱动因素 Ashley V. DiMarco; Mirunalini Ravichandran; Jeff Lau; Anthony Lima; Jennifer Lacap; Pablo Saenz-Lopez Larrocha; Eva Lin; Julie Weng; Luca Gerosa; Thomas Hunsaker; Yang Xiao; Monika Miś; Charles Havnar; Wennie Chen; Kai H. Barck; Klara Totpal; Oded Foreman; Nicole M. Sodir; Mark Merchant; Danilo Maddalo Cancer Res (2025) 85 (17): 3207–3218. 7 XPO1R749Q Mutations Co-occur with POLE Mutations in Cancer and Can Be Targeted to Overcome Chemoresistance XPO1R749Q突变与癌症中的POLE突变共存，可成为克服化疗耐药性的靶点 Tulasigeri M. Totiger; Wannasiri Chiraphapphaiboon; Yasmine Baca; Sana Chaudhry; Ryan Q. Notti; Skye Montoya; Monika Chojnacka; Gabriel Gaidosh; Jumana Afaghani; Maurizio Affer; Christopher Armstrong; Paul M. Kavanaugh; Efe Karaca; Jenna Zabroski; Michael Lewis; Alyssa Maye; Jacob Jahn; Rajesh K. Soni; Daniel Bilbao; Phil Walker; Andrew Elliott; Emil Lou; Wafik S. El-Deiry; Jose Antonio Rodriguez; Hai Dang Nguyen; Justin Taylor Cancer Res (2025) 85 (17): 3219–3233. 8 The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR2 C端激酶结构域结合与抑制基序可防止成纤维细胞生长因子受体2（FGFR2）的组成性激活 Daniel Zingg; Chi-Chuan Lin; Julia Yemelyanenko; Lukasz Wieteska; Sjors M. Kas; Onno B. Bleijerveld; Xue Chao; Jinhyuk Bhin; Catrin Lutz; Ellen Wientjens; Sjoerd Klarenbeek; Giulia Zanetti; Stefano Annunziato; Bjørn Siteur; Eline van der Burg; Anne Paulien Drenth; Marieke van de Ven; Lodewyk F.A. Wessels; Maarten Altelaar; John E. Ladbury; Jos Jonkers Cancer Res (2025) 85 (17): 3234–3257. Cancer Immunology（癌症免疫学） 9 Tumor-Specific MHC-II Activates CD4+ and CD8+ T Cells in Head and Neck Squamous Cell Carcinoma to Boost Immunotherapy Efficacy 头颈部鳞状细胞癌中肿瘤特异性主要组织相容性复合体II类分子（MHC-II）激活CD4+和CD8+T细胞，增强免疫治疗疗效 Yuying Zhang; Jinbang Li; Xiaoyu Guo; Zhao Gao; Junchen Pan; Sheng Nong; Jiyuan Ma; Gang Chen; Jiali Zhang Cancer Res (2025) 85 (17): 3258–3274. Cancer Metabolism and Molecular Mechanisms（癌症代谢与分子机制） 10 PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer 过氧化物酶体增殖物激活受体δ（PPARδ）协调胰腺癌对微环境信号的促转移代谢反应 Beatriz Parejo-Alonso; David Barneda; Sara Maria David Trabulo; Sarah Courtois; Sara Compte-Sancerni; Jelena Zurkovic; Laura Ruiz-Cañas; Quan Zheng; Jiajia Tang; Matthias M. Gaida; Ulf Schmitz; Pilar Irun; Laure Penin-Peyta; Shanthini Mary Crusz; Petra Jagušt; Pilar Espiau-Romera; Alba Royo-García; Andrés Gordo-Ortiz; Mariia Yuneva; Meng-Lay Lin; Shenghui Huang; Ming-Hsin Yang; Angel Lanas; Bruno Sainz, Jr; Christoph Thiele; Christopher Heeschen; Patricia Sancho Cancer Res (2025) 85 (17): 3275–3291. 11 TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis TRAF3IP2-AS1缺乏诱导坏死性凋亡，促进胰腺癌肝转移 Yong-Ding Wu; Xiao-Xiao Huang; Hao-Xiang Zhang; Yu Pan; Cheng-Ke Xie; Ge Li; Cai-Feng Lin; Xin-Quan Lin; Zhi-Yuan Li; Yin-Hao Chen; Jian-Fei Hu; Hong-Yi Lin; Shun-Cang Zhu; Zu-Wei Wang; Yi-Feng Tian; Qiao-Wei Li; Cheng-Yu Liao; Shi Chen Cancer Res (2025) 85 (17): 3292–3312. 12 Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression 神经酰胺诱导的代谢应激耗竭延胡索酸，驱动线粒体自噬以介导肿瘤抑制 Natalia V. Oleinik; Firdevs Cansu Atilgan; Mohamed Faisal Kassir; Han Gyul Lee; Alhaji H. Janneh; Wyatt Wofford; Chase Walton; Zdzislaw M. Szulc; Elizabeth G. Hill; Alexander V. Alekseyenko; Huseyin Cimen; Jessica H. Hartman; Christina Voelkel-Johnson; Michael B. Lilly; John J. Lemasters; Norma Frizzell; Xue-Zhong Yu; Shikhar Mehrotra; Besim Ogretmen Cancer Res (2025) 85 (17): 3313–3334. Translational Cancer Biology（癌症转化生物学） 13 Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models 在不同的小鼠肿瘤模型中，膳食纤维对免疫检查点阻断疗效的影响不一致 Asael Roichman; Gabriela Reyes-Castellanos; Ziqing Chen; Zihong Chen; Sarah J. Mitchell; Michael R. MacArthur; Akshada Sawant; Llewelyn Levett; Jesse R. Powers; Victoria Burgo; Maria Gomez-Jenkins; Maria Ibrahim; Xincheng Xu; Beianka Tomlinson; Xiang Hang; Eric G. Pamer; Yong Wei; Yibin Kang; Eileen P. White; Joshua D. Rabinowitz Cancer Res (2025) 85 (17): 3335–3347. 14 NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma 神经纤维蛋白1（NF1）缺失促进表皮生长因子受体（EGFR）激活，使NF1突变型黑色素瘤对EGFR抑制敏感 Milad Ibrahim; Irineu Illa-Bochaca; George Jour; Eleazar Vega-Saenz de Miera; Joseph Fracasso; Kelly Ruggles; Iman Osman; Markus Schober Cancer Res (2025) 85 (17): 3348–3364. Cancer Res[Jour] AND 85[volume] AND 18[issue] 癌症研究 85卷 18期 https://aacrjournals.org/cancerres/issue/ In the Spotlight（聚焦） 1 A New VISTA in Intracellular Checkpoint Signaling in Triple-Negative Breast Cancer 三阴性乳腺癌细胞内检查点信号传导的新“VISTA” Jacqueline J. Tao; Neil Vasan Cancer Res (2025) 85 (18): 3371–3372. 2 The Approaching Darwinian Era in Oncology 肿瘤学中达尔文时代的来临 Robert A. Gatenby Cancer Res (2025) 85 (18): 3373–3375. 3 Catch Me If You Can: Could Y Chromosome Loss Spread in Cancer? 想抓我？没那么容易：Y染色体缺失会在癌症中传播吗？ Zihai Li Cancer Res (2025) 85 (18): 3376–3377. Review（综述） 4 Plasticity and Functional Heterogeneity of Cancer-Associated Fibroblasts 癌症相关成纤维细胞的可塑性与功能异质性 Jacqueline M. Flynn; Nikita Thadani; Erin E. Gallagher; Isabella Azzaro; Cameron M. Bodnar; Colin P. McCarty; Gabriele Romano; Marie R. Webster; Claudia Capparelli Cancer Res (2025) 85 (18): 3378–3398. Cancer Biology（癌症生物学） 5 A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression VISTA的四个氨基酸细胞内基序可阻断癌细胞中的生长受体信号传导以诱导肿瘤抑制 Yan Zhao; Tina Andoh; Fatima Charles; Priyanka Reddy; Kristina Paul; Harsh Goar; Ishrat Durdana; Caiden J. Golder; Ashley N. Hardy; Marisa M. Juntilla; Soo-Ryum Yang; Chien-Yu Lin; Idit Sagiv-Barfi; Benjamin S. Geller; Stephen Moore; Dipti Thakkar; Jerome D. Boyd-Kirkup; Yan Peng; James M. Ford; Melinda L. Telli; Song Zhang; Allison W. Kurian; Robert B. West; Tao Yue; Andrew M. Lipchik; Michael P. Snyder; Joshua J. Gruber Cancer Res (2025) 85 (18): 3399–3415. 6 Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells 线粒体钙单向转运体将乙酰辅酶A代谢和H3K27乙酰化联系起来以维持胶质母细胞瘤干细胞 Guangqin Liu; Haoqian Zhang; Siqi Chen; Jun Gao; Haixin Zhao; Yan Dong; Changwei Liu; Xuechen Wei; Ting Li; Chang Lu; Haizhen Zhu; Dingyi Lu; Shiyu Feng; Teng Li; Weina Zhang; Qing Xia; Jianghong Man; Tao Zhou; Jiayi Chen; Ailing Li; Xin Pan Cancer Res (2025) 85 (18): 3416–3434. Cancer Immunology（癌症免疫学） 7 Prostate Cancer Cells Secrete PD-1 in Exosomes to Enhance Myeloid-Derived Suppressor Cell Activity and Promote Tumor Immune Evasion 前列腺癌细胞在外泌体中分泌PD-1以增强髓源性抑制细胞活性并促进肿瘤免疫逃逸 Jie Zhang; Weiwu Chen; Chen Zhang; Qian He; Xudong Wang; Jiayu Han; Peng Gao; Kunyu Wang; Haoze Xie; Feng Gao; Yining Guo; Wenhao Guo; Haofei Jiang; Jing Le; Ruichen Zang; Sisi Mo; Haobo Fan; Xiaoxiao Zhu; Xinrong Jiang; Fengbin Gao; Yanlan Yu; Guoqing Ding; Yicheng Chen Cancer Res (2025) 85 (18): 3435–3453. 8 FADD Activation in Hepatocellular Carcinoma Potentiates CD8+ T-cell Responses and Sensitizes to Immune Checkpoint Inhibitors 肝细胞癌中FADD的激活可增强CD8+ T细胞反应并增强对免疫检查点抑制剂的敏感性 Jiahuan Lu; Thomas Ting-Hei Chan; Yun Wang; Jingya Wang; Zhewen Xiong; Jingqing Li; Yixuan Zhang; Huanyu Wang; Jintian Chen; Weiqin Yang; Jing Wang; Yalin Tu; Howard H.W. Leung; Raymond Wai Ming Lung; Wei Kang; Man Tong; Dan Michelle Wang; Qi-Nian Wu; Zhao-Lei Zeng; Alfred Sze-Lok Cheng; Ka-Fai To; Anthony W.H. Chan; Jingying Zhou Cancer Res (2025) 85 (18): 3454–3470. Cancer Metabolism and Molecular Mechanisms（癌症代谢与分子机制） 9 Selective Alanine Transporter Utilization Is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer 选择性利用丙氨酸转运体是ARID1A突变型卵巢癌的治疗弱点 Hao Nie; Liping Liao; Rafal J. Zielinski; Javier A. Gomez; Akshay V. Basi; Erin H. Seeley; Lin Tan; Agnes Julia Bilecz; Wei Zhou; Heng Liu; Chen Wang; Shuai Wu; Yuan Qi; Taito Miyamoto; Federica Severi; Aaron R. Goldman; Shengqing Gu; Anil K. Sood; Amir A. Jazaeri; Ronny Drapkin; Daniel T. Claiborne; Nan Zhang; Philip L. Lorenzi; Jared K. Burks; Ernst Lengyel; Eyal Gottlieb; Rugang Zhang Cancer Res (2025) 85 (18): 3471–3489. Therapeutic Development and Chemical Biology（治疗开发与生物化学） 10 A Peptide-Based PROTAC Degrader of BRCA2 Sensitizes Metastatic Castration-Resistant Prostate Cancer to PARP Inhibition 一种基于肽的BRCA2 PROTAC降解剂可使转移性去势抵抗性前列腺癌对PARP抑制剂敏感 Qi Ye; Bohan Ma; Lei Li; Zixi Wang; Mingming Lu; Jialu Kang; Yuzeshi Lei; Shan Xu; Ke Wang; Yanlin Jian; Yizeng Fan; Bin Wang; Jing Liu; Yang Gao; Jian Ma; Lei Li Cancer Res (2025) 85 (18): 3490–3502. Translational Cancer Biology（癌症转化生物学） 11 Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control 适应性治疗利用化疗耐药性卵巢癌的适应性缺陷实现长期肿瘤控制 Helen Hockings; Eszter Lakatos; Weini Huang; Maximilian Mossner; Mohammed A. Khan; Nikolina Bakali; Jacqueline McDermott; Kane Smith; Ann‐Marie Baker; Trevor A. Graham; Michelle Lockley Cancer Res (2025) 85 (18): 3503–3517. 12 CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-Deleted Cancer CRISPR-药物组合筛选确定了针对MTAP缺失型癌症的有效联合治疗方案 Nikola Knoll; Sarah Masser; Blanka Bordas; Richard Y. Ebright; Guangyan Li; Devishi Kesar; Eliana Destefanis; Nicholas Kania; Diego J. Rodriguez; Jayu Jen; Sydney E. Zagar; Caleb Mensah; Zixin Chen; Samuel J. Moffitt; Erhumuoghene M. Enakireru; Yao He; Baomou Feng; Mira K. Chokshi; Cyrus Y. Jin; Srivatsan Raghavan; William R. Sellers; Kathleen M. Mulvaney Cancer Res (2025) 85 (18): 3518–3539. 13 Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors Is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer MTA协同PRMT5抑制剂BMS-986504与KRAS抑制剂联合是治疗MTAP缺失型KRAS突变胰腺癌的有效治疗策略 Kristina Drizyte-Miller; Lars D. Engstrom; Jeffrey A. Klomp; Clint A. Stalnecker; Addison G. Stamey; Khalilah E. Taylor; Mallory K. Roach; Ryan Robb; Laura M. Waters; Andrew Calinisan; Seamus Degan; Wen-Hsuan Chang; Xousaen M. Helu; David Nguyen; Elisa Baldelli; Mariaelena Pierobon; Emanuel F. Petricoin; David M. Briere; Jill Hallin; James G. Christensen; Kirsten L. Bryant; Adrienne D. Cox; Peter Olson; Channing J. Der Cancer Res (2025) 85 (18): 3540–3557. Cancer Landscapes（癌症特征） 14 Multiomic Characterization of Pre- and Post-Neoadjuvant Chemotherapy–Treated Ovarian Cancer Reveals Mediators of Tumorigenesis and Chemotherapy Response 对新辅助化疗治疗前后的卵巢癌进行多组学分析揭示了肿瘤发生和化疗反应的介导因子 Mark C. Valentine; Mary M. Mullen; Emilee N. Kotnik; Matthew A. Powell; Premal H. Thaker; Carolyn K. McCourt; Lindsay M. Kuroki; Andrea R. Hagemann; Rebecca C. Arend; Alex S. Holehouse; Robi Mitra; David G. Mutch; Katherine C. Fuh Cancer Res (2025) 85 (18): 3558–3570. Editor’s Note（编者按） 15 Editor’s Note: Nuclear-Cytoplasmic Partitioning of Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN) Differentially Regulates the Cell Cycle and Apoptosis 编者按：第10号染色体缺失的磷酸酶和张力蛋白同源物（PTEN）的核质分布差异调控细胞周期和细胞凋亡 Ji-Hyun Chung; Charis Eng Cancer Res (2025) 85 (18): 3571. Retraction（撤稿声明） 16 Retraction: Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN) Has Nuclear Localization Signal-Like Sequences for Nuclear Import Mediated by Major Vault Protein 撤稿声明：第10号染色体缺失的磷酸酶和张力蛋白同源物（PTEN）具有由主要穹窿蛋白介导的核定位信号样序列以实现核输入 Ji-Hyun Chung; Margaret E. Ginn-Pease; Charis Eng Cancer Res (2025) 85 (18): 3572. Cancer Res[Jour] AND 85[volume] AND 18_Supplement[issue] 癌症研究 85卷 18期增刊 https://aacrjournals.org/cancerres/issue/85/18_Supplement Abstracts: AACR Special Conference in Cancer Research: Advances in Ovarian Cancer Research; September 19-21, 2025; Denver, CO 摘要：美国癌症研究协会（AACR）癌症研究特别会议：卵巢癌研究进展；2025年9月19 - 21日；美国科罗拉多州丹佛市 GENOMICS 基因组学 KEYNOTE LECTURE 主题演讲 PATHOLOGY 病理学 PATIENT ADVOCACY: CLINICAL TRIALS AND SURVIVORSHIP 患者权益倡导：临床试验与生存者关怀 PRECISION THERAPY 精准治疗 TUMOR HETEROGENEITY 肿瘤异质性 TUMOR IMMUNOLOGY 肿瘤免疫学 TUMOR IMMUNOLOGY (BIOLOGY) 肿瘤免疫学（生物学方向） TUMOR INITIATION 肿瘤发生起始 OTHER TOPICS 其他主题 Cancer Res[Jour] AND 85[volume] AND 18_Supplement_2[issue] 癌症研究 85卷 18期增刊2期 https://aacrjournals.org/cancerres/issue/85/18_Supplement_2 Abstracts: AACR Special Conference in Cancer Research: Discovery and Innovation in Pediatric Cancer—From Biology to Breakthrough Therapies; September 25-28, 2025; Boston, MA 摘要：美国癌症研究协会（AACR）癌症研究特别会议：儿童癌症领域的发现与创新——从生物学研究到突破性疗法；2025年9月25 - 28日；美国马萨诸塞州波士顿市 BIOMARKERS AND INTEGRATION OF MOLECULAR APPROACHES INTO DIAGNOSTICS 生物标志物及分子方法在诊断中的应用整合 CANCER BIOLOGY, TUMOR HETEROGENEITY, EARLY DETECTION AND CTDNA 癌症生物学、肿瘤异质性、早期检测与循环肿瘤DNA（ctDNA） CLINICAL TRIALS 临床试验 DEVELOPMENT IN CANCER AND CANCER EPIGENETICS 癌症发生发展及癌症表观遗传学研究 DISCOVERY AND TRANSLATION OF TARGETS 靶点发现与转化应用 IMMUNOLOGY AND IMMUNO-ONCOLOGY IN CHILDHOOD CANCERS 儿童癌症的免疫学与免疫肿瘤学 MECHANISMS UNDERLYING CHILDHOOD CANCER 儿童癌症的潜在发生机制 OTHER TOPICS 其他主题 Cancer Res[Jour] AND 85[volume] AND 18_Supplement_3[issue] 癌症研究 85卷 18期增刊3期 https://aacrjournals.org/cancerres/issue/85/18_Supplement_3 Abstracts: AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research—Emerging Science Driving Transformative Solutions; September 28 - October 1, 2025; Boston, MA 摘要：美国癌症研究协会（AACR）癌症研究特别会议：胰腺癌研究进展——新兴科学推动变革性解决方案；2025年9月28日 - 10月1日；马萨诸塞州波士顿市 BIOLOGY OF PANCREATIC CANCER PROGRESSION 胰腺癌进展生物学 CLINICAL TRIALS (INCLUDING TRIALS IN PROGRESS) 临床试验（含进行中的试验） HARNESSING THE IMMUNE SYSTEM TO TREAT PANCREATIC CANCER 利用免疫系统治疗胰腺癌 NEW THERAPEUTIC STRATEGIES 新型治疗策略 REVOLUTIONIZING EARLY DIAGNOSIS AND PREVENTION 革新早期诊断与预防手段 SPOTLIGHT ON NEW DRUG DEVELOPMENT 聚焦新药研发 TRANSLATIONAL ADVANCES TO DISSECT PANCREATIC CANCER TREATMENT RESPONSE 转化研究进展：解析胰腺癌治疗反应 TUMOR HETEROGENEITY AND EVOLUTION 肿瘤异质性与演进 OTHER TOPICS 其他主题 Cancer Res[Jour] AND 85[volume] AND 19[issue] 癌症研究 85卷 19期 https://aacrjournals.org/cancerres/issue/ In the Spotlight（焦点） 1 Ceramide Links Alzheimer’s Disease to Decreased Cancer Risk: A Lipid Behind the Enigma of Inverse Comorbidity 神经酰胺：连接阿尔茨海默病与癌症风险降低的纽带——逆共病现象背后的脂质奥秘 Erhard Bieberich Cancer Res (2025) 85 (19): 3579–3581. 2 Generations in Flux: Tracking the Birth of Cellular Heterogeneity in Cancer 代际更迭：追踪癌症细胞异质性的起源 Aaron McKenna Cancer Res (2025) 85 (19): 3582–3583. Review（综述） 3 Challenges and Opportunities in Analyzing Cancer-Associated Microbiomes 分析癌症相关微生物组的挑战与机遇 Minghao Chia; Mihai Pop; Steven L. Salzberg; Niranjan Nagarajan Cancer Res (2025) 85 (19): 3584–3595. Resource Report（资源报告） 4 Pan-Cancer Analyses Refine the Single-Cell Portrait of Tumor-Infiltrating Dendritic Cells 泛癌症分析完善肿瘤浸润树突状细胞的单细胞图谱 Tianyi Ma; Xiaojing Chu; Jinyu Wang; Xiangjie Li; Yu Zhang; Dan Tong; Wenbin Xu; Guohui Dang; Lu Qi; Yuhui Miao; Zemin Zhang; Sijin Cheng Cancer Res (2025) 85 (19): 3596–3613. Cancer Biology（癌症生物学） 5 Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells SOX10缺陷型黑色素瘤中转谷氨酰胺酶-2升高促进肿瘤发生并减少肿瘤内CD4+ T细胞 Signe Caksa; Timothy J. Purwin; Dan A. Erkes; Kristen M. DeRosa; Erica Kitterman; Samantha M. Barnada; Casey D. Stefanski; Haley P. Wilson; Glenn L. Mersky; McKenna Q. Glasheen; Jacob S. Heilizer; Namra Ajmal; Yunguang Sun; Joanna S.Y. Chan; Hallgeir Rui; Inna Chervoneva; Claudia Capparelli; Andrew E. Aplin Cancer Res (2025) 85 (19): 3614–3632. 6 Tumor-Derived CCL16 Normalizes Tumor Vasculature through Macrophage ICAM-1 Receptor and Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma 肿瘤来源的CCL16通过巨噬细胞ICAM-1受体使肿瘤血管正常化并增强肝细胞癌免疫治疗疗效 Kunling Chen; Huolun Feng; Yujie Zhang; Jingyuan Pei; Yuyan Xu; Xiangxu Wei; Zhuohao Chen; Zhoubin Feng; Lei Cai; Yong Li; Liang Zhao; Mingxin Pan Cancer Res (2025) 85 (19): 3633–3650. Cancer Metabolism and Molecular Mechanisms（癌症代谢与分子机制） 7 BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells BBOX1是代谢检查点，介导转移性癌细胞逃逸自然杀伤（NK）细胞的免疫监视 Chuanjie Zhang; Hongchao He; Yi Gao; Jiawei Ding; Hai Huang; Yixun Liu; Hanqing Liu; Jun Xiao; Dan-feng Xu; Zunguo Du; Zhenbo Zhang; Lechi Ye Cancer Res (2025) 85 (19): 3651–3670. 8 Hypoxia-Induced Creatine Uptake Reprograms Metabolism to Antagonize PARP1-Mediated Cell Death and Facilitate Tumor Progression in Hepatocellular Carcinoma 缺氧诱导的肌酸摄取重编程代谢，对抗PARP1介导的细胞死亡并促进肝细胞癌进展 Rui-Zhe Li; Guo-Qiang Pan; Chen Xiong; Zi-Niu Ding; Tuan-Song Zhang; Lun-Jie Yan; Dongxu Wang; Xiaolu Zhang; Xiao-Feng Dong; Yu-Chuan Yan; Yu Zhou; Rui Dong; Zhao-Ru Dong; Tao Li Cancer Res (2025) 85 (19): 3671–3688. 9 TERC Stimulates Fatty Acid Metabolism to Promote Bladder Cancer Progression TERC刺激脂肪酸代谢以促进膀胱癌进展 Chen Chen; Yuting Gao; Renquan Lu; Ying Wu; Yiwen Yao; Ruixin Sun; Junlu Wu; Ping Ji; Wenqiang Quan; Denglong Wu; Zujun Sun; Dong Li Cancer Res (2025) 85 (19): 3689–3705. Therapeutic Development and Chemical Biology（治疗开发与生物化学） 10 Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration 脂质纳米颗粒包裹的编码肿瘤特异性毒素蛋白的mRNA选择性靶向癌细胞并刺激T细胞浸润 Rui Zhou; Lu Han; Jing Wang; Ling Ma; Tingting Zhang; Tianming Qi; Meichen Liu; Yijie Dong; Weiguo Zhang; Shan Cen Cancer Res (2025) 85 (19): 3706–3716. Translational Cancer Biology（癌症转化生物学） 11 Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy 通过抑制帽子依赖性起始来阻断NRF2翻译，使淋巴瘤细胞对铁死亡和嵌合抗原受体（CAR）T细胞免疫治疗敏感 Paola Manara; Austin D. Newsam; Venu Venkatarame Gowda Saralamma; Tyler Andrew Cunningham; Drew Lazenby; J.J.David Ho; Marco Vincenzo Russo; Abdessamad Youssfi Alaoui; Dhanvantri Chahar; Alicia Bilbao Martinez; Nikolai Fattakhov; Alexandra Marie Carbone; Olivia Barbara Farag; Alexa Marie Barroso; Kyle Hoffman; Francesco Maura; Daniel Bilbao; Jonathan H. Schatz Cancer Res (2025) 85 (19): 3717–3736. 12 Carbonic Anhydrase Inhibition Sensitizes Group 3 Medulloblastoma to Radiotherapy 碳酸酐酶抑制使3组髓母细胞瘤对放疗敏感 Cory M. Richman; Alexandra Rasnitsyn; Borja L. Holgado; Maria Vladoiu; Namal Abeysundara; Sandra Majo; Sara Chabi; Lucie J. Taunay; Hiromichi Suzuki; Ichiyo Shibahara; Joonas Haapasalo; Jonelle G. Pallotta; Tajana Douglas; Kaitlin Kharas; Kyle Juraschka; Oliver Ocsenas; Sachin A. Kumar; Kristiina Nordfors; Ana Guerreiro Stücklin; Raul A. Suarez; Jiao Zhang; Xiaochong Wu; Craig Daniels; Livia Garzia; Jüri Reimand; Olivier Saulnier; Thomas E. Merchant; Celio Pouponnot; David R. Raleigh; Michael D. Taylor; Pasqualino De Antonellis Cancer Res (2025) 85 (19): 3737–3751. 13 Oxytocin Receptor Regulates the Hippo/YAP Axis to Drive Hepatocarcinogenesis 催产素受体调控Hippo/YAP轴以驱动肝细胞癌发生 Huijie Yang; Jiayao Cui; Peng Su; Xiujie Cui; Haojie Guo; Penghe Yang; Shuqing Zhang; Chenmiao Zhang; Mingxi Fu; Zhongbo Li; Yinlu Ding; Ting Zhuang; Jian Zhu; Xiaodong Tan Cancer Res (2025) 85 (19): 3752–3770. Cancer Landscapes（癌症特征） 14 Integrated Omics and Multicohort Analyses Identify an Enhancer Variant Linking Ferroptosis to Precision Therapy in Prostate Cancer 整合组学和多队列分析确定一个增强子变异，将铁死亡与前列腺癌精准治疗联系起来 Sheng Ma; Yue Ge; Zequn Lu; Junbiao Zhang; Qin Zhang; Yuzheng Peng; Zirui Xi; Hao Peng; Meng-Yao Xu; Zezhong Xiong; Yuan Gao; Yanan Wang; Le Li; Chunyu Zhang; Zheng Chao; Tengfei Li; Ruiyun Zhang; Qiang Zhang; David A. Horne; Baojun Wang; Xu Gao; Xu Zhang; Jianbo Tian; Jing Li; Meng Jin; Gong-Hong Wei; Zhihua Wang Cancer Res (2025) 85 (19): 3771–3790. Convergence Science（互动医学） 15 Alzheimer's Disease–Associated Amyloid-βPrecursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity 阿尔茨海默病相关淀粉样蛋白-β前体蛋白可防止衰老应激诱导的线粒体自噬和富马酸盐耗竭，从而改善抗肿瘤免疫 Mohamed Faisal Kassir; Han Gyul Lee; Natalia V. Oleinik; Wyatt Wofford; Chase Walton; Firdevs Cansu Atilgan; Alhaji H. Janneh; Paramita Chakraborty; Kubra Calisir; Elif Percin; Silvia G. Vaena; Kalyani Sonawane; Ashish Deshmukh; Narayan R. Bhat; Kumar Sambamurti; Onder Albayram; Ozgur Sahin; Shikhar Mehrotra; Besim Ogretmen Cancer Res (2025) 85 (19): 3791–3811. Editor’s Notes（编者按） 16 Editor’s Note: A Novel L-Asparaginase with low L-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo 编者按：一种低L-谷氨酰胺酶共活性的新型L-天冬酰胺酶对体内T细胞和B细胞急性淋巴细胞白血病均具有高效治疗作用 Hien Anh Nguyen; Ying Su; Jenny Y. Zhang; Aleksandar Antanasijevic; Michael Caffrey; Amanda M. Schalk; Li Liu; Damiano Rondelli; Annie Oh; Dolores L. Mahmud; Maarten C. Bosland; Andre Kajdacsy-Balla; Sofie Peirs; Tim Lammens; Veerle Mondelaers; Barbara De Moerloose; Steven Goossens; Michael J. Schlicht; Kasim K. Kabirov; Alexander V. Lyubimov; Bradley J. Merrill; Yogen Sauntharajah; Pieter Van Vlierberghe; Arnon Lavie Cancer Res (2025) 85 (19): 3812. 17 Editor’s Note: Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway 编者按：沃纳综合征解旋酶在无功能性范可尼贫血通路时对DNA损伤反应起关键作用 Monika Aggarwal; Taraswi Banerjee; Joshua A. Sommers; Chiara Iannascoli; Pietro Pichierri; Robert H. Shoemaker; Robert M. Brosh, Jr. Cancer Res (2025) 85 (19): 3813. Cancer Res[Jour] AND 85[volume] AND 20[issue] 癌症研究 85卷 20期 https://aacrjournals.org/cancerres/issue/ In the Spotlight（聚焦热点） 1 Precision Epigenetic Reprogramming: CoREST Inhibition Sensitizes STK11-Mutant Tumors to Immune Checkpoint Blockade Therapy 精准表观遗传重编码：抑制CoREST使STK11突变肿瘤对免疫检查点阻断疗法敏感 De-Chen Lin; Keyue Shen Cancer Res (2025) 85 (20): 3821–3822. 2 From Harmony to Discord: Multicellular Coordination in Tissues and Its Rewiring in Cancer 从和谐到失调：组织中多细胞协调及其在癌症中的重编码 Merve Dede; Vakul Mohanty; Ken Chen Cancer Res (2025) 85 (20): 3823–3825. Review（综述） 3 P2 Purinergic Receptors in Tumor Immunity 肿瘤免疫中的P2嘌呤能受体 Xin Wang; Shu-Heng Jiang; Mingyue Ma; Shuqi Cai; Dong Song; Bing Han Cancer Res (2025) 85 (20): 3826–3841. Priority Report（优先报道） 4 Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression PROX1的表观遗传去抑制促进神经内分泌前列腺癌进展 Varadha Balaji Venkadakrishnan; Adam Presser; Nathaniel C.E. Voss; James Neiswender; Lisa Brenan; Keira Prenza Sosa; Kenny Weng; Andres M. Acosta; Francisca Vazquez; Himisha Beltran Cancer Res (2025) 85 (20): 3842–3854. Resource Report（资源报道） 5 Genetic Control of tRNA-Derived Fragments Contributes to Cancer Risk tRNA衍生片段的遗传调控对癌症风险的影响 Bin Li; Hanting Li; Yan Li; Zhirui Chen; Danyi Zou; Chunyi He; Songqiang Li; Kexin Hu; Caibo Ning; Yanmin Li; Hui Geng; Shuhui Yang; Chaoqun Huang; Xiaojun Yang; Qiuhong Wang; Xu Zhu; Xiangpan Li; Ying Zhu; Meng Jin; Xiaoping Miao; Jianbo Tian Cancer Res (2025) 85 (20): 3855–3874. Cancer Biology（癌症生物学） 6 HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma HPV E5通过促进头颈部鳞状细胞癌的干细胞样表型，介导对化疗和放疗的耐药性 Souvick Roy; Sayuri Miyauchi; Riley N. Jones; Sangwoo S. Kim; Aldo Venuti; Angad S. Boparai; Loren K. Mell; Theresa Guo; Joseph A. Califano; Andrew B. Sharabi Cancer Res (2025) 85 (20): 3875–3893. 7 SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m6A Modification SRSF9形成相分离凝聚物，通过诱导RNA选择性剪接促进卵巢癌进展，而该过程受m6A修饰抑制 Xinzhao Zuo; Jie Xu; Dan Yang; Chenyue Yang; Xiaoyi Liu; Ningxuan Chen; Haocheng Wang; Xin Luo; Qingya Luo; Yuan Wang; Qinglv Wei; Yu Yang; Hongyan Zhao; Jing Xu; Wei Wang; Tao Liu; Ping Yi Cancer Res (2025) 85 (20): 3894–3909. Cancer Immunology（癌症免疫学） 8 Dasatinib Remodels the Tumor Microenvironment and Sensitizes Small Cell Lung Cancer to Immunotherapy 达沙替尼重塑肿瘤微环境，使小细胞肺癌对免疫治疗敏感 Esther Redin; Nerea Otegui; Mirentxu Santos; Sergio Leon; Miriam Redrado; Diego Serrano; Eva Fernandez de Pierola; Joan Salvador Russo-Cabrera; Irene Ferrer; Maria Olmedo; Angel Diaz-Lagares; Maeva Houry; Silve Vicent; Anna Vilalta; Patricia Mondelo-Macía; Jorge García-González; Luis León-Mateos; Alvaro Gonzalez; Luis Paz-Ares; Rafael López; Miguel F. Sanmamed; Luis Montuenga; Alfonso Calvo Cancer Res (2025) 85 (20): 3910–3929. Cancer Metabolism and Molecular Mechanisms（癌症代谢与分子机制） 9 Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Ste20样激酶的外显子跳跃通过激活烯醇化酶1介导的磷酸烯醇式丙酮酸生成，增强糖酵解和肿瘤进展 Zeyu Chen; Jingyu Liao; Chang Zhu; Ruizhi Chang; Huifang Liang; Zeyang Ding; Zhao Huang; Xiaoping Chen; Junnan Liang; Bixiang Zhang Cancer Res (2025) 85 (20): 3930–3948. 10 PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m6A Methylation to Stabilize PARP1 mRNA PCBP2通过抑制m6A甲基化稳定PARP1 mRNA，介导乳腺癌对奥拉帕利的耐药性 Zhaochang Qi; Lifang He; Zemei Xu; Xi Luo; Likeng Ji; Chenting Lin; Armando E. Giuliano; Xiaojiang Cui; Zihao Deng; Jundong Wu; Stanley Li Lin; Yukun Cui Cancer Res (2025) 85 (20): 3949–3965. Therapeutic Development and Chemical Biology（治疗方法开发与生物化学） 11 TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes STK11-Mutant Tumors to Anti–PD-1 Immunotherapy TNG260是一种小分子CoREST抑制剂，可使STK11突变肿瘤对抗PD-1免疫治疗敏感 Leanne G. Ahronian; Soumyadip Sahu; Minjie Zhang; Ayushi S. Patel; Ke Geng; Reshmee Bhattacharya; Gerald S. Falchook; Jonathan W. Goldman; Alexander I. Spira; Salman R. Punekar; David R. Spigel; Judy S. Wang; Ferdinandos Skoulidis; Janaye Stephens; Mary Meynardie; Jaylen M. Powell; Alfonso Lopez; Michela Ranieri; Magdalena A. Ploszaj; Yi Jer Tan; Yeuan Ting Lee; Yi Yu; Jiehui Deng; Ting Chen; Patrick McCarren; Alice Tsai; Suleman S. Hussain; Brian Doyon; Kenjie Amemiya; Jacques Ermolieff; Preksha Shahagadkar; Nikitha M. Das; Lauren R. Flynn; Julie A. Shields; Laney Danielczyk; Brian J. McMillan; Andre Mignault; Samuel R. Meier; Hsin-Jung Wu; David J. Guerin; Douglas A. Whittington; Chengyin Min; Iga Sienczylo; John P. Maxwell; Heather J. DiBenedetto; Hideo Watanabe; Brian B. Haines; Alan Huang; Adam Crystal; Jannik N. Andersen; Xinyuan Wu; Kwok-Kin Wong Cancer Res (2025) 85 (20): 3966–3982. Translational Cancer Biology（癌症转化生物学） 12 Subtyping-Directed Precision Treatment Refines Traditional One-Size-Fits-All Therapy for HR+/HER2−Breast Cancer 基于分型的精准治疗优化HR+/HER2−乳腺癌的传统“一刀切”疗法 Xiu-Zhi Zhu; Hu-Yun-Long Zhang; Yi-Fan Zhou; Yi-Yu Chen; Tong Fu; Ming-Liang Jin; Ya-Xin Zhao; Yi-Fan Xie; Xiaohua Zeng; Xi Jin; Yi-Zhou Jiang; Zhi-Ming Shao Cancer Res (2025) 85 (20): 3983–3998. 13 Targeting ATP7A-Dependent Copper Metabolic Homeostasis Induces Cuproptosis and Suppresses the Progression of Mutant KRAS-Driven Lung Cancer 靶向ATP7A依赖的铜代谢稳态诱导铜死亡，抑制突变KRAS驱动的肺癌进展 Jian Zhao; Weijie Zhang; Yuanyuan Zeng; Di Lu; Chenkang Ma; Mengzhu Zhang; Xin Cai; Zhifan Huang; Hongli Yang; Jianjun Li; Jianjie Zhu; Jian-An Huang; Zeyi Liu Cancer Res (2025) 85 (20): 3999–4017. Computational Cancer Biology and Technology（癌症计算生物学与技术） 14 Heterogeneous Driving Effects Guide Personalized Tumor Treatments Targeting N6-Methyladenosine 异质性驱动效应指导针对N6-甲基腺苷的个性化肿瘤治疗 Xudong Mao; Zhehao Xu; Xingbo Yang; Shihan Chen; Liyang Li; Zeyi Lu; Haohua Lu; Yudong Lin; Ruyue Wang; Yang Li; Fan Li; Lifeng Ding; Wenqin Luo; Xianjiong Chen; Yi Lu; Ziwei Zhu; Xinyu Zhao; Zhifan Ding; Liqun Xia; Qi Liu; Gonghui Li Cancer Res (2025) 85 (20): 4018–4035. Editor’s Notes（主编评注） 15 Editor’s Note: Circadian Clock Gene Bmal1 Inhibits Tumorigenesis and Increases Paclitaxel Sensitivity in Tongue Squamous Cell Carcinoma 主编评注：昼夜节律基因Bmal1抑制舌鳞状细胞癌的肿瘤发生并增加对紫杉醇的敏感性 Qingming Tang; Bo Cheng; Mengru Xie; Yatao Chen; Jiajia Zhao; Xin Zhou; Lili Chen Cancer Res (2025) 85 (20): 4036. 16 Editor’s Note: MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer 主编评注：MDR1同义多态性改变稳定上皮单层中转运蛋白的特异性和蛋白稳定性 King Leung Fung; James Pan; Shinobu Ohnuma; Paul E. Lund; Jessica N. Pixley; Chava Kimchi-Sarfaty; Suresh V. Ambudkar; Michael M. Gottesman Cancer Res (2025) 85 (20): 4037. Cancer Res[Jour] AND 85[volume] AND 21[issue] 癌症研究 85卷 21期 https://aacrjournals.org/cancerres/issue/ In the Spotlight（聚焦热点） 1 Exploiting AR-Synergistic Metabolic Vulnerabilities in Prostate Cancer 利用前列腺癌中雄激素受体协同的代谢弱点 Jonathan M. Anzules; Mark Sayegh; Yun Rose Li Cancer Res (2025) 85 (21): 4045–4046. 2 Transient Nutrient Sensing Shapes T-cell Exhaustion 瞬时营养感应塑造T细胞耗竭状态 Julian J. Lum Cancer Res (2025) 85 (21): 4047–4048. Review（综述） 3 The Multifaceted Role of Osteopontin in Modulating the Tumor Microenvironment 骨桥蛋白在调节肿瘤微环境中的多面作用 Yu Gu; William J. Muller Cancer Res (2025) 85 (21): 4049–4061. Resource Report（资源报告） 4 An Annotated Biobank of Triple-Negative Breast Cancer Patient-Derived Xenografts Features Treatment-Naïve and Longitudinal Samples during Neoadjuvant Chemotherapy 一个注释完备的三阴性乳腺癌患者来源异种移植生物样本库，包含新辅助化疗期间未经治疗和纵向采集的样本 Amanda L. Rinkenbaugh; Yuan Qi; Shirong Cai; Jiansu Shao; Faiza Baameur Hancock; Sabrina L. Jeter-Jones; Xiaomei Zhang; Emily Powell; Lei Huo; Rosanna Lau; Chunxiao Fu; Rebekah Gould; Petra den Hollander; Elizabeth E. Ravenberg; Jason B. White; Gaiane M. Rauch; Banu Arun; Clinton Yam; Alastair M. Thompson; Gloria V. Echeverria; Stacy L. Moulder; W. Fraser Symmans; Jeffrey T. Chang; Helen Piwnica-Worms Cancer Res (2025) 85 (21): 4062–4080. Cancer Biology（癌症生物学） 5 Gut Microbiota–Mediated Bile Acid Metabolism Regulates Colorectal Cancer Liver Metastasis by Altering Neutrophil Recruitment 肠道微生物群介导的胆汁酸代谢通过改变中性粒细胞招募调节结直肠癌肝转移 Zongmei Zheng; Fuwen Yuan; Jinming Li; Xiangxiang Zhu; Ru Jia; Jiao Wei; Fengjing Jia; Xinxin Hou; Zhaozhou Zhang; Yan Wang; Yanlei Ma; Wei Jia; Ling Zhao Cancer Res (2025) 85 (21): 4081–4098. 6 MYADM Activates RhoA-Mediated Ameboid Migration to Drive Metastasis MYADM激活RhoA介导的变形虫样迁移以驱动肿瘤转移 Yi-Ta Tsai; En-Ting Liu; Ming-Hsin Yang; Chien Chang Kao; Sheue-Fen Tzeng; Yu-Chi Chen; Pei-Wen Hsiao; An-Chieh Feng; Grace S. Shieh; Mong-Hsun Tsai; Shau-Kwaun Chen; Yi-Lin Chiu; Chin Li Chen; Sheng-Tang Wu; En Meng; Wen-Chiuan Tsai; Tai-Kuang Chao; Guang-Huan Sun; Sun-Yran Chang; Mien-Chie Hung; Tai-Lung Cha Cancer Res (2025) 85 (21): 4099–4121. 7 Loss of SETD8 Impairs Mitochondrial Homeostasis to Suppress Leukemia Stem Cell Function in t(8;21) Acute Myeloid Leukemia SETD8缺失损害线粒体稳态，抑制t(8;21)急性髓系白血病中白血病干细胞的功能 Yongwei Su; Shuyi Li; Lei Wang; Yiran Wang; Shujiao He; Xiaotong Li; Jingqiao Qiao; Jingfeng Zhou; Li Yu Cancer Res (2025) 85 (21): 4122–4138. Cancer Immunology（癌症免疫学） 8 Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma That Drives Antitumor Immunity 细胞毒性CD8+ T细胞下调GPX4以促进黑色素瘤中的铁死亡，进而驱动抗肿瘤免疫 Karine Flem-Karlsen; Ronan Talty; Meaghan K. McGeary; Koonam Park; Durga Thakral; Veronica T. Brooks; Andrew J. Daniels; William Damsky; Simon F. Roy; Goran Micevic; Marcus Bosenberg Cancer Res (2025) 85 (21): 4139–4150. 9 METTL14 Enhances Antitumor Immunity through m6A-Dependent Loss of PD-1 METTL14通过m6A依赖性的PD-1缺失增强抗肿瘤免疫 Chang Huang; Xiaodong Wang; Yinmin Gu; Ke Ren; Haojing Zang; Yibi Zhang; Yongbo Pan; Shuwen Cheng; Xiaofeng Zhu; Songzhe Wu; Liqiang Duan; Xiaojun Xu; Qinong Ye; Jian Zeng; Hongbo Hu; Shan Gao Cancer Res (2025) 85 (21): 4151–4163. 10 Intracellular IL1αin Peritumoral Monocytes Induces IL8 Production and Inhibits Mitophagy to Promote Stemness and Metastasis of Hepatocellular Carcinoma 肿瘤周围单核细胞内的IL1α诱导IL8产生并抑制线粒体自噬，促进肝细胞癌的干性和转移 Yong-Hao Ruan et al. Cancer Res (2025) 85 (21): 4164–4181. Cancer Metabolism and Molecular Mechanisms（癌症代谢与分子机制） 11 Caloric Restriction Enhances the Efficacy of Antiandrogen Therapy in Prostate Cancer by Inhibiting Androgen Receptor Translation 热量限制通过抑制雄激素受体转化增强前列腺癌抗雄激素治疗的疗效 Ricardo A. Cordova; May Elbanna; Christopher Rupert; Sabrina A. Orsi; Noah R. Sommers; Angela J. Klunk; Li Shen; Jagannath Misra; Jocelyne N. Hanquier; Maria Tsompana; Yanqing Wang; David W. Goodrich; Ronald C. Wek; Luigi Fontana; Kirk A. Staschke; Roberto Pili Cancer Res (2025) 85 (21): 4182–4197. 12 PRODH2-Mediated Metabolism in the Bone Microenvironment Promotes Breast Cancer Metastasis 骨微环境中PRODH2介导的代谢促进乳腺癌转移 Hui Gong; Yixuan Li; Wen Yang; Zishan Xie; Jiahao Hu; Peihang Li; Rou Xu; Yifan Li; Tianyu Tao; Riqing Li; Shuguang Liu; Yefeng Zhu; Libing Song; Lishan Fang Cancer Res (2025) 85 (21): 4198–4211. 13 The Acetyltransferase ARD1 Induces Glutathione Synthesis to Facilitate Ferroptosis Evasion in Hepatocellular Carcinoma 乙酰转移酶ARD1诱导谷胱甘肽合成，以促进肝细胞癌逃逸铁死亡 Yingyi Liu; Fusheng Liu; Jie Liu; Dongzhi Cairang; Xiaomian Li; Peng Xia; Weijie Ma; Tiangen Wu; Xiangdong Gongye; Zhonglin Zhang; Xi Chen; Wenzhi He; Yufeng Yuan Cancer Res (2025) 85 (21): 4212–4232. Cancer Landscapes（癌症特征） 14 Spatial Multiomics Defines a Shared Tumor Infiltrative Signature at the Resection Margin in High-Grade Gliomas 空间多组学定义高级别胶质瘤切除边缘的共享肿瘤浸润特征 Balagopal Pai; Susana Isabel Ramos; Wan Sze Cheng; Tanvi Joshi; Emine Özen; Lakshmi Shree Kulumani Mahadevan; Thenzing J. Silva-Hurtado; Gabrielle A. Price; Jessica Tome-Garcia; German Nudelman; Sanjana Shroff; Kristin G. Beaumont; Raymund L. Yong; Robert P. Sebra; Elena Zaslavsky; Nadejda M. Tsankova Cancer Res (2025) 85 (21): 4233–4250. 15 Divergent Clonal Evolution and Early Dissemination Promote Genetic Heterogeneity of Metastases in Castration-Resistant Prostate Cancer 不同克隆进化与早期播散促进去势抵抗性前列腺癌转移灶的遗传异质性 Noshad Hosseini; Rahul Mannan; Ryan J. Rebernick; Fengyun Su; Rui Wang; Xuhong Cao; Ana Lako; Dattatreya Mellacheruvu; Jing Hu; Joshi J. Alumkal; Zachery R. Reichert; Rohit Malik; Rohit Mehra; Arul M. Chinnaiyan; Marcin P. Cieslik Cancer Res (2025) 85 (21): 4251–4268. Computational Cancer Biology and Technology（癌症计算生物学与技术） 16 In Silico Digital Twins of Bone Metastasis Enable Investigation of Tumor Progression and Therapy Response 骨转移的计算机数字孪生模型助力肿瘤进展和治疗反应研究 Luca Marsilio; Sergio Barrios; Stefan Maksimovic; Alice Maccarini; Elisa Serafini; Michele Grimaldi; Thomas J. Heyman; Pietro Cerveri; Stefano Casarin; Eleonora Dondossola Cancer Res (2025) 85 (21): 4269–4284. Correction（更正） 17 Correction: Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations 更正：具有片段重复的肿瘤抑制基因易发生体细胞缺失和结构变异 Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred Sze Lok Cheng; Maggie Haitian Wang; Wei Kang; Ka-Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew Tak Vai Chan; Xiansong Wang; William Ka Kei Wu Cancer Res (2025) 85 (21): 4285. Editor’s Note（编者注） 18 Editor’s Note: The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors 编者注：MDM2/MDMX-p53拮抗剂PM2增加野生型p53肿瘤对放疗的敏感性 Diana Spiegelberg; Anja C. Mortensen; Sara Lundsten; Christopher J. Brown; David P. Lane; Marika Nestor Cancer Res (2025) 85 (21): 4286. Cancer Res[Jour] AND 85[volume] AND 22[issue] 癌症研究 85卷 22期 https://aacrjournals.org/cancerres/issue/ In the Spotlight(焦点) 1 Alternatively Spliced Citrate Synthase Supports Colorectal Cancer 选择性剪接的柠檬酸合酶促进结直肠癌发展 Désirée Schatton; Christian Frezza Cancer Res (2025) 85 (22): 4293–4295 2 White Matter Injury Fuels Early Progression of Glioblastoma 白质损伤推动胶质母细胞瘤早期进展 Keon Woo Kim; Hyun Jin Choi; Jeong Ho Lee Cancer Res (2025) 85 (22): 4296–4298 Review(综述) 3 Mismatch Repair as a Dynamic and Clinically Actionable Vulnerability in Cancer 错配修复作为癌症中动态且临床可干预的薄弱环节 Eleonora Piumatti; Pietro Paolo Vitiello; Vito Amodio; Alberto Bardelli; Giovanni Germano Cancer Res (2025) 85 (22): 4299–4314 Resource Reports（资源报告） 4 An Optimized Platform Overcomes Excessive Tumor Immune Rejection Induced by the CRISPR/Cas9 Lentiviral System 优化平台克服CRISPR/Cas9 慢病毒系统诱导的过度肿瘤免疫排斥反应 Yan Shang; Shuaihu Li; Tian Xu; Yihua Sun; Fei Li Cancer Res (2025) 85 (22): 4315–4328 5 Wide-Field Optical Redox Imaging with Leading-Edge Detection Enables Assessment of Treatment Response and Heterogeneity in Patient-Derived Cancer Organoids 具有领先科技检测的宽视野光学氧化还原成像可评估患者来源的癌症类器官的治疗反应和异质性 Amani Gillette; Shirsa Udgata; Alexa E. Schmitz; Jordan N. Stoecker; Jeremy D. Kratz; Dustin A. Deming; Melissa C. Skala Cancer Res (2025) 85 (22): 4329–4340 Cancer Biology(癌症生物学) 6 Metastasis-Initiating Osteosarcoma Subpopulations Establish Paracrine Interactions with Lung and Tumor Cells to Create a Metastatic Niche 转移起始的骨肉瘤亚群与肺细胞和肿瘤细胞建立旁分泌相互作用以创建转移微环境 James B. Reinecke; Leyre Jimenez Garcia; Amanda J. Saraf; John Hinckley; Amy C. Gross; Helene Le Pommellet; Kelly M. Gutpell; Maren Cam; Matthew V. Cannon; Matthew J. Gust; Sophia Vatelle; Berkley E. Gryder; Ruben Dries; Ryan D. Roberts Cancer Res (2025) 85 (22): 4341–4358 7 MYC and p53 Alterations Cooperate through VEGF Signaling to Repress Cytotoxic T-cell and Immunotherapy Responses in Prostate Cancer MYC 和 p53 改变通过 VEGF 信号通路协同抑制前列腺癌中的细胞毒性 T 细胞和免疫治疗反应 Katherine C. Murphy; Kelly D. DeMarco; Lin Zhou; Jessica Peura; Hadiya K. Giwa; Yvette Lopez-Diaz; Yu-Jui Ho; Junhui Li; Shi Bai; Karl Simin; Lihua J. Zhu; Jason R. Pitarresi; Arthur M. Mercurio; Marcus Ruscetti Cancer Res (2025) 85 (22): 4359–4379 8 Lipid Composition Alters Ferroptosis Sensitivity 脂质组成改变铁死亡敏感性 Vivian S. Park; Lauren E. Pope; Justin P. Ingram; Grace A. Alchemy; Julie J. Purkal; Magdalena B. Murray; Sha Jin; Eli Y. Andino-Frydman; Sanjana Singh; Anlu Chen; Priya Narayanan; Sarah Kongpachith; Darren C. Phillips; Scott J. Dixon; Relja Popovic Cancer Res (2025) 85 (22): 4380–4397 9 Condensation of the Golgi Apparatus Activates YAP1 to Promote Gastric Cancer Progression 高尔基体凝聚激活YAP1 以促进胃癌进展 Jinyoung Kim; Chandani Shrestha; Gwangbin Lee; Dasom Jung; Annie Zhao; Junyoung Cho; Ji Hae Nahm; Shinwon Kang; Jung Hwan Yoon; Bum-Ho Bin; Dongwoo Chae; Seung Min Jeong; Eun Kyung Lee; Jiyoon Kim Cancer Res (2025) 85 (22): 4398–4414 Cancer Immunology(癌症免疫学) 10 Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation 表型分析揭示多模式 γδ T 细胞细胞毒性作为克服癌细胞介导的免疫调节的策略 Callum Baird Nattress; Rhianna O’Sullivan; Daniel Fowler; Colin Hutton; Petra Vlckova; Jahangir Sufi; Magdalena Buschhaus; Ewa Basiarz; Maria Ramos Zapatero; Ferran Cardoso Rodriguez; Xiao Qin; Ashley Campbell; Angeliki Kanouta; Vivian S.W. Li; Kerry Chester; John Anderson; Marta Barisa; Jonathan P.H. Fisher; Christopher J. Tape Cancer Res (2025) 85 (22): 4415–4432 11 SPP1+Neutrophils Mediate Resistance to Immune Checkpoint Blockade in BAP1-Inactivated Tumors SPP1+中性粒细胞介导 BAP1 失活肿瘤对免疫检查点阻断的耐药性 Jiahao Shi; Shiyun Huang; Yixiong Zhou; Guopei Zheng; Zhe Zhang; Xianqun Fan; Jianfeng Shen Cancer Res (2025) 85 (22): 4433–4449 Cancer Metabolism and Molecular Mechanisms(癌症代谢与分子机制) 12 A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression 一种柠檬酸合酶剪接变体重编码三羧酸循环以促进结直肠癌进展 Justin Chak Ting Cheung; Lok Wan Ng; Zhongxu Zhu; Bonan Chen; Stephen Li; Mingjing Xu; Xiaofan Ding; Dandan Pu; Yi Hu; Yuqing Ren; Wei Kang; Ming Li; Jason Wing Hon Wong; Xin Wang; Yuen Kit Cheng; Wei Shen Aik; Ka Leung Wong; Simon Siu Man Ng; Nathalie Wong; Yujuan Dong Cancer Res (2025) 85 (22): 4450–4468 13 Neuropeptide Precursor VGF Promotes Neuroendocrine Differentiation and Cancer-Associated Fibroblast Activation in Small Cell Lung Cancer 神经肽前体VGF 促进小细胞肺癌的神经内分泌分化和癌症相关成纤维细胞活化 Wen Ding; Jianzheng Zhu; Jianshan Mo; Shumin Ouyang; Guopin Liu; Yingxue Su; Danyuan Sun; Jiangling Ye; Yanle Wu; Jiayu Yan; Menghan Xue; Peibin Yue; Jin-jian Lu; Libin Wang; Yandong Wang; Xiaolei Zhang Cancer Res (2025) 85 (22): 4469–4484 14 KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma KDM6 去甲基化酶促进 EWSR1::FLI1 驱动的尤文肉瘤致癌重编码 Elisabet Figuerola-Bou; Carla Ríos-Astorch; Enrique Blanco; María Sánchez-Jiménez; Pablo Táboas; Guerau Fernández; Soledad Gómez-González; Oscar Muñoz; Pol Castellano-Escuder; Sara Perez-Jaume; Marta Garcia; Estela Prada; Silvia Mateo-Lozano; Nicolo Riggi; Alexandra Avgustinova; Cinzia Lavarino; Luciano Di Croce; Sara Sánchez-Molina; Jaume Mora Cancer Res (2025) 85 (22): 4485–4503 15 Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation 丙二酰辅酶 A 通过增强脂肪生成和 Ran 激活促进前列腺癌进展及去势抵抗 Yiheng Dai; Lilong Liu; Yongbo Luo; Cai Zhang; Sayu Xiao; Kaixuan Du; Yuanhao Liu; Youmiao Zeng; Zhengfeng Wang; Zhaohui Chen; Ke Chen; Lijie Zhou Cancer Res (2025) 85 (22): 4504–4520 Therapeutic Development and Chemical Biology(治疗学新进展与生物化学) 16 An Fc-Engineered Glycomodified Antibody Supports Proinflammatory Activation of Immune Effector Cells and Restricts Progression of Breast Cancer 一种 Fc工程改造的糖基化修饰抗体支持免疫效应细胞的促炎激活并抑制乳腺癌进展 Alicia M. Chenoweth; Anthony Cheung; Jitesh Chauhan; Rebecca Adams; Gabriel Osborn; Katie Stoker; Melanie Grandits; Roman Laddach; Jennifer Trendell; Blanca Navarro-Llinas; Erin Suriawinata; Amanda Gross; Amanda Clarke; Lev Brown; Judit Cserny; Lenny Moise; Shashi Jatiani; Alexandra McCraw; Benjamina Esapa; Syed Haider; Jelmar Quist; Kristina M. Ilieva; Anna M. Davies; Pablo Romero-Clavijo; Thomas Sénard; Jack Cheeseman; Richard A. Gardner; Daniel I.R. Spencer; Sophia Tsoka; Sheeba Irshad; James M. McDonnell; Anita Grigoriadis; Andrew N.J. Tutt; Sophia N. Karagiannis Cancer Res (2025) 85 (22): 4521–4540 Translational Cancer Biology(癌症转化生物学) 17 Molecular MRI of Dysregulated Zinc Secretion Detects Pancreatic Ductal Adenocarcinoma and Response to KRASG12DInhibitor Treatment 锌分泌失调的分子磁共振成像可检测胰腺导管腺癌及对 KRASG12D 抑制剂治疗的反应 Veronica Clavijo Jordan; Mozhdeh Sojoodi; Farzad Moloudi; Patricia Gonzalez Pagan; Manyu Jin; Pamela Pantazopoulos; Ethan French; Ibrahim Eissa; Jonah Weigand-Whittier; Nicholas Rotile; Mehrad Tavallai; Jill Hallin; Ian Ramsay; Eric M. Gale; Stephen C. Barrett; Nabeel El-Bardeesy; Stuti Shroff; Motaz Qadan; Kenneth K. Tanabe; Peter Caravan Cancer Res (2025) 85 (22): 4541–4557 Convergence Science(融合医学) 18 Modeling Early-Onset Cancer Kinetics Reveals Changes in Underlying Risk and the Impact of Population Screening 早期发病癌症动力学建模揭示潜在风险变化及人群筛查的影响 Navid Mohammad Mirzaei; Chin Hur; Mary Beth Terry; Piero Dalerba; Wan Yang Cancer Res (2025) 85 (22): 4558–4570 Correction(更正) 19 Correction: Myeloma-Modified Adipocytes Exhibit Metabolic Dysfunction and a Senescence-Associated Secretory Phenotype 更正：骨髓瘤修饰的脂肪细胞表现出代谢功能障碍和衰老相关分泌表型 Heather Fairfield; Amel Dudakovic; Casper M. Khatib; Mariah Farrell; Samantha Costa; Carolyne Falank; Maja Hinge; Connor S. Murphy; Victoria DeMambro; Jessica A. Pettitt; Christine W. Lary; Heather E. Driscoll; Michelle M. McDonald; Moustapha Kassem; Clifford Rosen; Thomas L. Andersen; Andre J. van Wijnen; Abbas Jafari; Michaela R. Reagan Cancer Res (2025) 85 (22): 4571 Editor’s Note(编辑注) 20 Editor’s Note: Thioredoxin Is Downstream of Smad7 in a Pathway That Promotes Growth and Suppresses Cisplatin-Induced Apoptosis in Pancreatic Cancer 编者按：硫氧还蛋白是 Smad7 下游通路中的成分，该通路促进胰腺癌生长并抑制顺铂诱导的细胞凋亡 Nicole Boyer Arnold; Knut Ketterer; Jörg Kleeff; Hellmut Friess; Markus W. Büchler; Murray Korc Cancer Res (2025) 85 (22):4572. Cancer Res[Jour] AND 85[volume] AND 23[issue] 癌症研究 85卷 23期 https://aacrjournals.org/cancerres/issue/ In the Spotlight(焦点) 1 Gut Check: Lactobacillus johnsonii Harnesses Bile Acids and Reactive Oxygen Species to Suppress High-Fat Diet–Induced Colorectal Cancer 肠道检查：约翰逊乳杆菌利用胆汁酸和活性氧抑制高脂饮食诱导的结直肠癌 Prarthana J. Dalal; Yatrik M. Shah Cancer Res (2025) 85 (23): 4579–4581 2 Can’t KEEP Up: UXS1 Dependency Exposes a Pyrimidine Vulnerability in KEAP1-Mutant Lung Cancer 难以维持：UXS1依赖性暴露了KEAP1突变型肺癌中嘧啶的薄弱环节 Basma A. Yasseen; Gina M. DeNicola Cancer Res (2025) 85 (23): 4582–4584 Review(综述) 3 From Worms to Tumors: Conserved Strategies of Cellular Arrest and Survival Governing Dormancy 从蠕虫到肿瘤：调控细胞停滞与存活的保守策略主导休眠状态 Veena Prahlad; Irwin H. Gelman Cancer Res (2025) 85 (23): 4585–4599 Cancer Biology(癌症生物学) 4 Lactobacillus johnsonii Synthesizes Chenodeoxycholic Acid to Reduce Susceptibility to High-Fat Diet–Induced Colorectal Cancer 约翰逊乳杆菌合成鹅脱氧胆酸以降低对高脂饮食诱导的结直肠癌的易感性 Chen Liu; Peng Lai; Jiancong Hu; Shengmei Yin; Shuang Guo; Danling Liu; Jing Yu; Dayi Liang; Guangyuan Chen; Mengze Xing; Zhanhao Luo; Xiaosheng He; Junli Gong; Ping Lan; Zhen He Cancer Res (2025) 85 (23): 4600–4615 5 A Multipotent PROX1+ Tumor Stem/Progenitor Cell Population Emerges during Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer 在肠道肿瘤发生过程中出现一种多能PROX1+肿瘤干细胞/祖细胞群体，并介导结直肠癌的放疗抵抗 Pauliina Kallio; Cinzia Bessone; Fatemeh Seyednasrollah; Jefim Brodkin; Marika Lassila; Jenny Högström; Alejandra González-Loyola; Tatiana V. Petrova; Caj Haglund; Kari Alitalo Cancer Res (2025) 85 (23): 4616–4631 6 Extracellular Domain Shedding of TROP2 Activates EGFR Signaling to Drive Prostate Cancer Metastasis TROP2细胞外结构域脱落激活EGFR信号传导，驱动前列腺癌转移 Shiqin Liu; En-Chi Hsu; Merve Aslan; Fernando Garcia-Marques; Michelle Shen; Alifiani B. Hartono; Francisco Solano; Kewei Le; Hyeonji Hwang; Chung S. Lee; Abel Bermudez; Rosalie Nolley; Donna M. Peehl; James D. Brooks; Michael A. Liss; Sharon J. Pitteri; Tanya Stoyanova Cancer Res (2025) 85 (23): 4632–4647 7 SWI/SNF Functions as a Gatekeeper of Enhancer Chromatin Access to Control Progression of Mesenchymal Triple-Negative Breast Cancer SWI/SNF作为增强子染色质可及性的守门人，控制间充质三阴性乳腺癌的进展 Rikkemaja Isahbell J. Møldrup; Mikkel G. Terp; Simon T. Jakobsen; Tina Ravnsborg; Maria S. Madsen; Daniel D. Brown; Laurits R. Sloth; Michael C. Gorry; Steffi Oesterreich; Adrian V. Lee; Henrik J. Ditzel; Ole N. Jensen; Rasmus Siersbæk Cancer Res (2025) 85 (23): 4648–4663 Cancer Immunology(癌症免疫学) 8 Hypoxia Induces Immunosuppression by Silencing STING in Cancer 缺氧通过沉默癌症中的STING诱导免疫抑制 Yuhong Lu; Annali M. Yurkevicz; Yanfeng Liu; Peter M. Glazer Cancer Res (2025) 85 (23): 4664–4680 9 Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti–PD-1 Immunotherapy 使用一种易发生抗体依赖性细胞介导的细胞毒性作用的纳米抗体构建体耗竭IL1R2+肿瘤浸润调节性T细胞，增强抗PD-1免疫疗法的疗效 Sana M. Arnouk; Daliya Kancheva; Helena Van Damme; Guillaume E. Courtoy; Romina Mora Barthelmess; Jolien Van Craenenbroeck; Els Lebegge; Yvon Elkrim; Naela Assaf; Yves Heremans; Aleksandar Murgaski; Timo W.M. De Groof; Emile Clappaert; Ayla Debraekeleer; Jan Brughmans; Gillian Blancke; Máté Kiss; Ramses Forsyth; Wim Waelput; Louis Boon; Nick Devoogdt; Catelijne Stortelers; Nadja van Boxel; Bruno Dombrecht; Lars Vereecke; Cécile Vincke; Geert Raes; Damya Laoui; Jo A. Van Ginderachter Cancer Res (2025) 85 (23): 4681–4700 10 ChREBP-Mediated Choline Deprivation and Chemokine Secretion Shape Tumor-Associated Macrophages to Promote Immune Evasion ChREBP介导的胆碱剥夺和趋化因子分泌塑造肿瘤相关巨噬细胞，促进免疫逃逸 Jianhong Zhao; Baoxiang Chen; Yanrong Deng; Lifang Fan; Siyuan Yin; Haisheng Yu; Yongchang Wei; Jing Dai; Qun Qian; Quanjiao Chen; Xianghai Ren; Xiaoyu Xie; Wenyi Wei; Jinfang Zhang; Congqing Jiang Cancer Res (2025) 85 (23): 4701–4717 Cancer Metabolism and Molecular Mechanisms(癌症代谢与分子机制) 11 PAX3-FOXO1 Drives Targetable Cell State–Dependent Metabolic Vulnerabilities in Rhabdomyosarcoma PAX3-FOXO1驱动横纹肌肉瘤中可靶向的细胞状态依赖性代谢薄弱环节 Katrina I. Paras; Julia S. Brunner; Angela M. Montero; Jacob A. Boyer; Benjamin T. Jackson; Sangita Chakraborty; Abigail Xie; Kristina Guillan; Armaan Siddiquee; Lourdes Pajuelo Torres; Joshua D. Rabinowitz; Andrew L. Kung; Daoqi You; Filemon S. Dela Cruz; Lydia W.S. Finley Cancer Res (2025) 85 (23): 4718–4733 12 CLK2 Regulates the KEAP1/NRF2 and p53 Pathways to Suppress Ferroptosis in Colorectal Cancer CLK2调节KEAP1/NRF2和p53通路以抑制结直肠癌中的铁死亡 Hai-Meng Zhou; Yi Liu; Feng Shi; Hao-Wen Qiu; Le Li; Qi-Peng Shu; Yu-Ying Liu; Bai-Qi Wang; Meng Gao; Run-Lei Du; Shao-Bo Ke; Xiao-Dong Zhang Cancer Res (2025) 85 (23): 4734–4750 13 LHX2 Rewires the Metabolic and Epigenetic Landscape to Drive Tumor Progression in Prostate Cancer LHX2重塑代谢和表观遗传格局以驱动前列腺癌的肿瘤进展 Jun Jiang; Shaojie Liu; Chao Xu; Limin He; Hongji Li; Yike Zhou; Zhengxuan Li; Yu Li; Fa Yang; Yuchen Wei; Tong Lu; Keying Zhang; Jingliang Zhang; Pang Wang; Li Guo; Changhong Shi; Weihong Wen; Rui Zhang; Donghui Han; Weijun Qin Cancer Res (2025) 85 (23): 4751–4768 14 Long-Chain Fatty Acid Redistribution Induced by SLC27A2 Deficiency Facilitates Hypoxic Adaptation and Immunosuppression in Hepatocellular Carcinoma SLC27A2缺乏诱导的长链脂肪酸重新分布促进肝细胞癌的缺氧适应和免疫抑制 Chuli Fu; Wenyun Fu; Zuotian Huang; Xiaoyan He; Teng Wei; Wen Jin; Geyan Wu; Zhengwei Zhao; Kunxiong Guo; Jincui Yang; Jing Li; Shuhui Xu; Xuelong Zheng; Xiaoqiang Chen; Ling Ran; Xiaoli Pan; Kezhen Zong; Zhongjun Wu; Junyao Xu; Guang-Rong Yan; Qiangnu Zhang Cancer Res (2025) 85 (23): 4769–4786 15 tRF-21LeuTAA Promotes Oxidative Stress by Altering Glutathione Metabolic Enzymes to Support Prostate Cancer Progression tRF-21LeuTAA通过改变谷胱甘肽代谢酶促进氧化应激，以支持前列腺癌进展 Xiaoyu Guo; Jinjing Zhong; Jingyu Qian; Xiuyi Pan; Xinyue Zhang; Xueqin Chen; Hao Zeng; Ni Chen; Ling Nie; Ting Yu; Qiao Zhou Cancer Res (2025) 85 (23): 4787–4805 Translational Cancer Biology(癌症转化生物学) 16 Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in KEAP1-Mutant Lung Cancer UXS1缺失选择性地耗竭嘧啶，并在KEAP1突变型肺癌中诱导复制压力 Melat T. Gebru; Timothy E. Hoffman; Aaron Boudreau; Ngoc Vu; Fei Han; Putianqi Wang; Eddie Folk; Xiumin Wu; James Newton; Kelly D. Foster-Duke; Jessica Gajda; Sammy Villa; Nianxin Yang; Celeste M. Sandoval; Christian Grant; Samatha E. Wildeboer; Wayne R. Buck; Jonathan A. Hickson; Ari J. Firestone; Michael Kort; Bryson D. Bennett; J. Brad Shotwell; Noel S. Wilson; David Stokoe Cancer Res (2025) 85 (23): 4806–4824 17 KRAS Inhibition Activates an Actionable CD24 “Do Not Eat Me” Signal in Pancreatic Cancer KRAS抑制在胰腺癌中激活可操作的CD24“不要吃我”信号 Yongkun Wei; Minghui Liu; Er-Yen Yen; Jun Yao; Zhenzhen Xun; Phuoc T. Nguyen; Xiaofei Wang; Zecheng Yang; Abdelrahman Yousef; Dean Pan; Yanqing Jin; Ching-Fei Li; Madelaine S. Theardy; Jangho Park; Yiming Cai; Mitsunobu Takeda; Matthew Vasquez; Elizabeth M. Park; David H. Peng; Yong Zhou; Hong Zhao; Timothy P. Heffernan; Andrea Viale; Huamin Wang; Stephanie S. Watowich; Han Liang; Dan Zhao; Ronald A. DePinho; Wantong Yao; Haoqiang Ying Cancer Res (2025) 85 (23): 4825–4838 Convergence Science(融合医学) 18 Spatial Cross-talk Modeling of the Tumor Microenvironment Identifies CCR5-Mediated Glia-to-Glia Signaling as a Key Regulator of Brain Metastatic Progression 肿瘤微环境的空间交叉对话建模确定CCR5介导的神经胶质细胞-神经胶质细胞信号传导作为脑转移进展的关键调节因子 Ju Young Ahn; Wenjuan Dong; Akshjot Puri; Matthew Vasquez; Raksha Raghunathan; Li Yang; Jianting Sheng; Hong Zhao; Stephen T.C. Wong Cancer Res (2025) 85 (23): 4839–4855

AACR会议临床结果临床1期

100 项与鹅去氧胆酸相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D00163	鹅去氧胆酸	A05AA01	DB06777

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
脑腱黄瘤病	美国	Mirum Pharmaceuticals, Inc.	2025-02-21
先天性胆汁酸合成障碍	欧盟	Leadiant GmbH	2017-04-10
先天性胆汁酸合成障碍	冰岛	Leadiant GmbH	2017-04-10
先天性胆汁酸合成障碍	列支敦士登	Leadiant GmbH	2017-04-10
先天性胆汁酸合成障碍	挪威	Leadiant GmbH	2017-04-10
胆结石	美国	Leadiant Biosciences, Inc.	1983-07-28
胆石症	日本	Fujimoto Pharmaceutical Corp.	1983-05-27
胆汁淤积	中国	天津康宝天然药物有限公司	-

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
脂质沉积	临床3期	美国	Leadiant Biosciences, Inc.	2022-08-10
帕金森病	临床前	巴基斯坦	National University of Sciences & Technology	2025-05-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04270682 (Trial 1, FDA_CDER) 人工标引	临床3期	脑腱黄瘤病	26	CTEXLI 250 mg	鬱憲衊鹽憲鏇鬱餘醖餘(網鬱範範艱顧壓鑰構齋) = 膚窪獵觸淵淵選積齋製糧鹹積廠憲壓遞鏇選繭 (製顧壓選鏇壓窪廠顧窪, 3.9) 更多	积极	2025-02-21
NCT04270682 (Trial 1, FDA_CDER) 人工标引	临床3期	脑腱黄瘤病	26	Placebo	鬱憲衊鹽憲鏇鬱餘醖餘(網鬱範範艱顧壓鑰構齋) = 觸鏇鏇積範鹹醖糧窪鹹糧鹹積廠憲壓遞鏇選繭 (製顧壓選鏇壓窪廠顧窪, 5.6) 更多	积极	2025-02-21
NCT04270682 (Trial 1, CTgov)	临床3期	脑腱黄瘤病	19	CDCA Weight-Based Dose TID	鏇餘顧積襯範網淵壓襯(衊鏇膚夢艱憲淵繭獵衊) = 廠廠淵壓壓壓獵蓋蓋鬱鹽襯壓範壓糧鬱糧廠糧 (製蓋廠鑰鑰繭壓餘遞艱, 憲鏇憲憲簾醖觸觸鹽築 ~ 憲鹽觸齋齋積鏇糧遞鹹) 更多	-	2024-10-28
NCT04640571 (CTgov)	临床4期	-	18	Metformin (Metformin)	簾窪顧製構窪選淵網鹹(範積襯壓窪獵鏇繭淵構) = 夢鏇醖廠築鬱憲蓋齋鏇壓選膚壓醖淵願齋艱餘 (鏇願構廠觸窪夢淵夢餘, 34.1) 更多	-	2024-07-16
NCT04640571 (CTgov)	临床4期	-	18	placebo+enalaprilat+pravastatin+valacyclovir+CDCA (Placebo)	簾窪顧製構窪選淵網鹹(範積襯壓窪獵鏇繭淵構) = 獵鹹觸願膚鏇繭夢鏇糧壓選膚壓醖淵願齋艱餘 (鏇願構廠觸窪夢淵夢餘, 24.7) 更多	-	2024-07-16
NCT03168555 (BACH, CTgov)	临床4期	胆石症 \| 胆汁酸吸收不良（BAM）	23	chenodeoxycholic acid	膚鑰齋積鏇網觸窪範廠 = 夢憲淵遞糧鹽構糧構艱鹽觸蓋鏇願簾糧齋襯遞 (鹽構壓壓築觸鬱憲餘鹹, 糧製壓艱繭餘積網窪繭 ~ 衊餘鏇鏇廠構齋齋鏇簾)	-	2022-05-19