ML095(ML095) - 药物靶点：ALPP_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点

ALPP

作用方式

抑制剂

作用机制

ALPP抑制剂(alkaline phosphatase, placental inhibitors)

治疗领域

肿瘤内分泌与代谢疾病泌尿生殖系统疾病

在研适应症-

非在研适应症

睾丸肿瘤

原研机构

Sanford Burnham Prebys Medical Discovery Institute

在研机构-

非在研机构

Sanford Burnham Prebys Medical Discovery Institute

权益机构-

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C13H14N2O3

InChIKeyKRFQWVXRVPHWCH-UHFFFAOYSA-N

CAS号1135683-24-7

关联

100 项与 ML095 相关的临床结果

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100 项与 ML095 相关的转化医学

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100 项与 ML095 相关的专利（医药）

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2

项与 ML095 相关的文献（医药）

2010-01-01·Bioorganic & Medicinal Chemistry3区 · 医学

Design and synthesis of selective inhibitors of Placental Alkaline Phosphatase

3区 · 医学

Article

作者: Thomas Chung ; Ana Maria Simão ; José Luis Millán ; Eduard Sergienko ; Ying Su ; John R. Cashman ; Marion Lanier

Placental Alkaline Phosphatase (PLAP) is a tissue-restricted isozyme of the Alkaline Phosphatase (AP) superfamily. PLAP is an oncodevelopmental enzyme expressed during pregnancy and in a variety of human cancers, but its biological function remains unknown. We report here a series of catechol compounds with great affinity for the PLAP isozyme and significant selectivity over other members of the AP superfamily. These selective PLAP inhibitors will provide small molecule probes for the study of the pathophysiological role of PLAP.

Placental Alkaline Phosphatase (PLAP) Luminescent HTS assay - Probe 2

作者: Xochella Garcia ; Sonoko Narisawa ; Justin Rascon ; Thomas Dy Chung ; José Luis Millán ; Ying Su ; John Cashman ; Ana Maria Simao ; Russell Dahl ; Derek Stonich ; Eduard Sergienko ; Brock Brown ; Marion Lanier

Placental alkaline phosphatase (PLAP) is highly expressed in primate placental tissue. Its biological function and relevance are still unknown, but PLAP-like enzymes are detected in serum of patients with primary testicular tumors, in particular seminoma and other cancers. Consequently, the identification of PLAP-specific inhibitors with selectivity over tissue non-specific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) may provide the necessary tools to characterize its biological role. Currently, inhibitors of PLAP lack either potency or selectivity. The small molecule probe ML095 (CID-25067483) is a biochemical inhibitor of PLAP, and will be useful to elucidate the key biological functions and natural substrates of human PLAP.

100 项与 ML095 相关的药物交易

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