甘露醇/脯氨酸(Mannitol/Proline) - 药物靶点：Free radicals_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Prodarsan

靶点

Free radicals

作用方式

调节剂

作用机制

Free radicals调节剂(自由基调节剂)

治疗领域

神经系统疾病遗传病与畸形内分泌与代谢疾病+ [2]

在研适应症-

非在研适应症

科凯恩氏综合症

原研机构

Pharming Group NV

在研机构-

非在研机构

Pharming Group NV

DNage BV

最高研发阶段终止临床1/2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C6H14O6

InChIKeyFBPFZTCFMRRESA-KVTDHHQDSA-N

CAS号69-65-8

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关联

1

项与甘露醇/脯氨酸相关的临床试验

NCT01142154

/ Completed临床1/2期

A Phase I/II Crossover Study To Evaluate and Compare the Pharmacokinetics of a Single IV Dose of D-Mannitol (Osmitrol®10%) to Single and Multiple, Escalating Doses of Liquid, Oral Prodarsan™ in Patients With Cockayne Syndrome

This study is to compare the exposure of orally administered Prodarsan to the intravenous dosed Osmitrol (10% solution) in Cockayne Syndrome (CS) patients. Also the pharmacokinetics of single and multiple orally dosed Prodarsan will be evaluated and compared to intravenous dose of Osmitrol in CS patients.

开始日期2010-06-01

申办/合作机构

DNage BV

100 项与甘露醇/脯氨酸相关的临床结果

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100 项与甘露醇/脯氨酸相关的转化医学

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100 项与甘露醇/脯氨酸相关的专利（医药）

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37

项与甘露醇/脯氨酸相关的文献（医药）

2022-04-27·mSphere2区 · 生物学

The Stickland Reaction Precursor trans -4-Hydroxy- l -Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia

2区 · 生物学

ArticleOA

作者: Kountz, D. J. ; Rivera, A. J. ; Huang, Y. Y. ; Stewart, A. K. ; Fletcher, J. R. ; Thanissery, R. ; Shen, A. ; Parsons, R. J. ; Reed, A. D. ; Theriot, C. M. ; Balskus, E. P.

Proline is an essential environmental amino acid that C. difficile uses to support growth and cause significant disease. A posttranslationally modified form, hydroxyproline, is highly abundant in collagen, which is degraded by host proteases in response to C. difficile toxin activity.

1982-01-01·Acta cientifica venezolana

[5'nucleotidase activity in the venom of Bothrops atrox (L.) Jergón].

Article

作者: Yarlequé, A ; Heredia, V ; Campos, S

1981-06-01·Indian journal of biochemistry & biophysics

Characteristics of proline transport in the spheroplasts isolated from Candida albicans cells.

Article

作者: Singh, M ; Jayakumar, A ; Baquer, N Z ; Verma, R S ; Prasad, R

1

项与甘露醇/脯氨酸相关的新闻（医药）

2009-08-14

·BioSpace

Pharming Group Gets U.S. Okay for Prodarsan Trial

Reuters -- Biotechnology company Pharming Group on Friday said the U.S. Food and Drug Administration accepted its investigational new drug application for Prodarsan, permitting a clinical trial to proceed.

100 项与甘露醇/脯氨酸相关的药物交易

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