HRT-003(HRT-003) - 药物靶点：BCAM_在研适应症：镰状细胞血症_专利_临床

概要

基本信息

药物类型

小分子化药

别名

HRT-003

靶点

BCAM

作用机制

BCAM inhibitors(Lutheran blood group glycoprotein inhibitors)

治疗领域

遗传病与畸形血液及淋巴系统疾病其他疾病

在研适应症

镰状细胞血症

非在研适应症-

原研机构

HARTIS Pharma SA初创企业

在研机构

HARTIS Pharma SA初创企业

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 HRT-003 相关的临床结果

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100 项与 HRT-003 相关的转化医学

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100 项与 HRT-003 相关的专利（医药）

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3

项与 HRT-003 相关的文献（医药）

2011-06-01·Journal of glaucoma3区 · 医学

3区 · 医学

Article

作者: Aung, Tin ; Koh, Victor ; Wong, Wan-Ling ; Wong, Tien Y ; Loon, Seng Chee

PURPOSE:

To examine the correlation and agreement of stereometric parameters between Heidelberg Retinal Tomograph version 2 (HRT-2) and HRT-3 in a normal Asian population.

METHODS:

This was a population-based study using data from the Singapore Malay Eye Study. Participants underwent a standardized and complete ophthalmic examination. A confocal laser ophthalmoscope using HRT-2 was used to take retinal images by 2 trained operators. Disc contours were drawn by a single experienced ophthalmologist. Without modifying the contours, the exact images were then exported and analyzed with HRT-3 software. Paired t tests were used to compare mean differences, whereas interclass correlations and Bland-Altman plots were used to assess agreement and trend of Moorfields regression analysis parameters between HRT-2 and HRT-3.

RESULTS:

A total of 2960 Malay participants [mean age, 58.3 y (SD 10.9); 50.5% female] were included. Average disc size was 2.15 μm. Interclass correlations and Bland-Altman plots showed good agreement between HRT-2 and HRT-3. However, global disc area, rim area, cup area, cup-disc area ratio, rim-disc area ratio, and rim volume were significantly different between HRT-2 and HRT-3, with all area and rim volume measurements using HRT-2 were approximately 4% larger compared with HRT-3. Analysis of HRT-2 and HRT-3 parameters from different sectors of the scans showed an inconsistent change in measurement values. Cup shape measurement was significantly different in the temporal region compared with the nasal region of the optic nerve head.

CONCLUSIONS:

There was good correlation between the 2 HRT versions and conversion equations were possible to calibrate HRT-3 parameters from HRT-2 measurements in Asian eyes. However, HRT-2 and HRT-3 showed significant differences in stereometric parameters. Further studies are needed to determine the impact of such differences and in comparative accuracy of HRT-2 versus HRT-3 for diagnosis and monitoring of glaucoma.

2010-03-01·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft4区 · 医学

Vergleich der SOCT mit Laser-Scanning-Ophthalmoskopie

4区 · 医学

Article

作者: J. Nawrocki ; J. Michalewski ; Z. Michalewska

BACKGROUND:

The aim of this prospective study was to analyze the specificity and sensitivity of HRT 3 compared with spectral optical coherence tomography (SOCT) in differentiating full-thickness macular holes, lamellar macular holes, and macular pseudoholes.

MATERIAL AND METHODS:

In 128 patients with a diagnosis made by SOCT of full-thickness macular hole, lamellar macular hole, or macular pseudohole, 161 eyes were examined with the HRT 3 Retina Module, and the results were compared.

RESULTS:

Using SOCT, full-thickness macular holes were diagnosed in 80 eyes, pseudoholes in 15 eyes, and lamellar macular holes in 66 eyes. Using HRT, full-thickness macular holes were diagnosed in 81 eyes, and pseudoholes and lamellar macular holes (non-full-thickness macular holes) were diagnosed in 80 eyes. In 160/161 cases, the diagnosis with HRT 3 was correct. Compared with SOCT, HRT 3 has a specificity of 98.7% and a sensitivity of 100% in differentiating full-thickness from non-full-thickness macular holes.

CONCLUSION:

The HRT 3 macular module enables diagnosis of macular holes. Full-thickness macular holes could be differentiated from non-full-thickness macular holes; however, lamellar macular holes could not be differentiated from macular pseudoholes.

2009-07-01·Arteriosclerosis, thrombosis, and vascular biology1区 · 医学

1区 · 医学

Article

作者: Collins, Nora ; Guha, Shaunta ; Cahill, Paul A. ; Liu, Weimin ; Redmond, Eileen M. ; Morrow, David ; Walls, Dermot ; Sweeney, Catherine ; Cullen, John P. ; Birney, Yvonne A.

Objective— Notch, VEGF, and components of the Hedgehog (Hh) signaling pathway have been implicated in vascular morphogenesis. The role of Notch in mediating hedgehog control of adult vascular smooth muscle cell (SMC) growth and survival remains unexplored. Methods and Results— In cultured SMCs, activation of Hh signaling with recombinant rShh (3.5 μg/mL) or plasmid encoded Shh increased Ptc1 expression, enhanced SMC growth and survival and promoted Hairy-related transcription factor (Hrt) expression while concomitantly increasing VEGF-A levels. These effects were significantly reversed after Hh inhibition with cyclopamine. Shh-induced stimulation of Hrt-3 mRNA and SMC growth and survival was attenuated after inhibition of Notch-mediated CBF-1/RBP-Jk-dependent signaling with RPMS-1 while siRNA knockdown of Hrt-3 inhibited SMC growth and survival. Recombinant VEGF-A increased Hrt-3 mRNA levels while siRNA knockdown abolished rShh stimulated VEGF-A expression while concomitantly inhibiting Shh-induced increases in Hrt-3 mRNA levels, proliferating cell nuclear antigen (PCNA), and Notch 1 IC expression, respectively. Hedgehog components were expressed within intimal SMCs of murine carotid arteries after vascular injury concomitant with a significant increase in mRNA for Ptc1, Gli 2 , VEGF-A, Notch 1, and Hrts. Conclusion— Hedgehog promotes a coordinate regulation of Notch target genes in adult SMCs via VEGF-A.

100 项与 HRT-003 相关的药物交易

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