更新于：2024-11-21

Azatadine Maleate

马来酸阿扎他定

更新于：2024-11-21

概要

概要

基本信息

药物类型

小分子化药

别名

11-(1-Methyl-4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine、6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine、Azatadine maleate (USP)

+ [3]

靶点

Histamine receptor

作用机制

组胺受体家族拮抗剂

治疗领域

免疫系统疾病感染耳鼻咽喉疾病+ [1]

在研适应症-

非在研适应症

过敏性鼻炎

原研机构

Merck & Co., Inc.

在研机构-

非在研机构

Schering Corp.

最高研发阶段撤市

首次获批日期

美国 (1977-03-29),

过敏性鼻炎

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构

分子式C24H26N2O4

InChIKeyKGCJWSUJYBJBBW-BTJKTKAUSA-N

CAS号3978-86-7

查看全部结构式(2)

关联

100 项与马来酸阿扎他定相关的临床结果

登录后查看更多信息

100 项与马来酸阿扎他定相关的转化医学

登录后查看更多信息

100 项与马来酸阿扎他定相关的专利（医药）

登录后查看更多信息

104

项与马来酸阿扎他定相关的文献（医药）

2022-01-01·Profiles of Drug Substances, Excipients and Related Methodology

Loratadine

Review

作者: AlMasoud, Najla ; Abdel-Aziz, Hatem A ; Alshammari, Munif Farhan M ; Bakheit, Ahmed H ; AlRabiah, Haitham

Loratadine, 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester, is an antihistamine drug with long-acting effects and has limited selectivity for peripheral H1 receptors. It is widely used for the prevention of allergic diseases such as rhinitis chronic urticaria, and asthma. This chapter discusses, by a critical extensive review of the literature, the description of loratadine in terms of its names, formulae, elemental composition, appearance, methods of preparation. The profile contains physicochemical properties of Loratadine, including pKa value, solubility and X-ray powder diffraction. In addition, it involves Fourier transform infrared spectrometry, nuclear magnetic resonance spectroscopy and mass spectroscopy for functional groups and structural confirmation of. The chapter also includes methods of analysis of the drug such as compendial, titrimetric, electrochemical, spectroscopic, chromatographic and capillary electrophoretic methods. The chapter also covers clinical applications of the drug such as its uses, doses, ADME profiles and mechanism of action.

2019-06-01·Acta Crystallographica Section C Structural Chemistry4区 · 化学

Monoclinic and orthorhombic forms of (RS)-(E)-4-[2-(4-chlorobenzylidene)hydrazinyl]-6,11-dimethyl-6,11-dihydro-5H-benzo[b]pyrimido[5,4-f]azepine: synthesis, concomitant polymorphism and supramolecular assembly mediated by C—H...N, C—H...π(arene) and C—Cl...π(arene) interactions

4区 · 化学

Article

作者: Glidewell, Christopher ; Acosta Quintero, Lina M ; Palma, Alirio ; Cobo, Justo ; Choquesillo-Lazarte, Duane

The title compound, C21H20ClN5, has been synthesized in two steps from (RS)-4-chloro-6,11-dimethyl-6,11-dihydro-5H-benzo[b]pyrimido[5,4-f]azepine and characterized by 1H and 13C NMR spectroscopy and by high-resolution mass spectrometry. Crystallization from hexane–ethyl acetate yields approximately equal quantities of a monoclinic polymorph in the space group Cc, (I), and an orthorhombic polymorph in the space group Pna21, (II). The molecules in polymorphs (I) and (II) show small differences in their molecular conformations, particularly in the shape of the azepine ring and the orientation of the chlorophenyl substituent. The molecules in polymorph (I) are linked by C—H...N and C—H...π(arene) hydrogen bonds to form sheets, which are linked into a three-dimensional framework structure by C—Cl...π(arene) interactions. There are no C—Cl...π(arene) interactions between the molecules in polymorph (II) and the supramolecular assembly takes the form of sheets built from C—H...N and C—H...π(arene) hydrogen bonds. Comparisons are made with some related structures.

2018-11-01·Pakistan journal of pharmaceutical sciences

Report: A comparative study of loratidine physiochemical properties from different brands.

Article

作者: Naveed, Safila ; Dilshad, Huma

Loratidine is a piperidine derivative resemble to azatadine long acting non sedating commonly used for the treatment of allergic condition like watery or itchy eyes, runny nose, chronic urticaria or throat itching. In the present study different brands of loratidine were evaluated for the weight variation, hardness, friability, disintegration time and dissolution. Dissolution release study performed by using paddle method (USP 2) in 900 ml of 0.1N HCl at 50 rpm. The physicochemical of loratidine did not give any variation. By this study we conclude that all parameter for physicochemical properties like weight variation, hardness of tablets, friability, their disintegration time and the dissolution release study for all the brands of loratidine that are available in Karachi meet the British pharmacopoeia (BP) and United State pharmacopoeia (USP) specification for quality control analysis.Weight variation, hardness and friability value requirement was complied by all brands .Disintegration time for all brands was less than 15 minutes complying the BP/USP recommendation. All brands showed more than 80% drug release within 45 minutes. The present findings suggest that almost all the brands of loratidine meet the BP/USP specification for QC analysis.

100 项与马来酸阿扎他定相关的药物交易

登录后查看更多信息