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更新于：2025-12-04
Cefmetazole Sodium
头孢美唑钠
更新于：2025-12-04
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1979-08-27), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C15H17N7NaO5S3 |
InChIKeyQTNLVCQCRNPXAJ-PBCQUBLHSA-N |
CAS号56796-39-5 |
关联
5
项与 头孢美唑钠 相关的临床试验JPRN-jRCTs061200055
Exploratory study on pharmacokinetics of cefmetazole in over-weight or under-weight patients as prophylactic antibiotics for surgical site infection after lower gastrointestinal surgery
JPRN-jRCTs061190025
Exploratory study on pharmacokinetics and optimum dosing regimen of cefmetazole, flomoxef and ceftolozane-tazobactam as prophylaxis for surgical site infection by ESBL-producing Escherichia coli after lower gastrointestinal surgery
JPRN-UMIN000028155
The effectiveness of de-escalation to cefmetazole for bacteremia. Open-label randomized non-inferiority trial - De-escalation to cefmetazole
100 项与 头孢美唑钠 相关的临床结果
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100 项与 头孢美唑钠 相关的转化医学
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100 项与 头孢美唑钠 相关的专利（医药）
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1,163
项与 头孢美唑钠 相关的文献（医药）2025-12-01JOURNAL OF INFECTION AND CHEMOTHERAPY
Campylobacter fetus meningitis and bacteremia: A case report in a post–liver transplant and post–splenectomy patient and a restructured literature review
Review
作者: Kubo, Taketo ; Kitaya, Shiori ; Yanagi, Masahiro ; Issiki, Ryosuke ; Kanamori, Hajime ; Otani, Hatsumi ; Takahashi, Yoshinori ; Oshima, Megumi
BACKGROUND:
Campylobacter fetus is a rare but serious pathogen, mainly affecting immunocompromised patients. Central nervous system infections, particularly meningitis, are uncommon; only one case has been reported after liver transplantation and none after splenectomy.
CASE PRESENTATION:
We report meningitis and bacteremia caused by C. fetus subsp. fetus (Cff) in a 70-year-old man with liver transplantation and splenectomy for hepatitis C virus-related cirrhosis, on long-term immunosuppression. He presented with intermittent fever; blood cultures grew C. fetus, and cerebrospinal fluid (CSF) cultures confirmed it. Therapy was changed from cefmetazole to meropenem and vancomycin, then de-escalated to high-dose ampicillin. After 23 days of antibiotics, he fully recovered without sequelae.
LITERATURE REVIEW:
The literature review included 36 adult cases identified through a PubMed search and our own case. Seventy-eight percent were male, with a median age of 49 years. Sixteen percent were immunocompromised, while 41 % were otherwise healthy. Exposure risks were reported in 43 %, though absent in 54 %. Of 38 isolates, 24 were subspeciated: Cff was most frequent (18/24, 75 %), followed by C. fetus subsp. intestinalis and venerealis (2 each), and single isolates of jejuni and Spirillum serpens. Relapse occurred in 22 %, and mortality was 5 %.
CONCLUSION:
C. fetus meningitis is rare and diagnostically challenging but should be considered in immunocompromised patients, including those with post-transplantation or post-splenectomy status. Infection may occur even without clear exposure. Both blood and CSF cultures are essential, with blood cultures often positive earlier. Prompt diagnosis and targeted therapy are crucial for favorable outcomes, and long-term follow-up is recommended due to relapse risk.
2025-12-01Clinical Journal of Gastroenterology
Extra-intestinal Edwardsiella tarda infection presenting as sequential cholecystitis and cholangitis: a case report
Article
作者: Oka, Yusuke ; Tokutake, Koujiro ; Kondo, Shohei ; Wada, Shuichi ; Ozawa, Yoshiki ; Ito, Tetsuya ; Yoshimura, Keigo ; Kimura, Takefumi ; Yamashita, Yuki ; Mori, Hiromitsu
BACKGROUND:
Edwardsiella tarda (E. tarda) is a rare human pathogen. Extra-intestinal infections of E. tarda are particularly uncommon, with only one case of recurrent cholangitis caused by E. tarda reported to date.
CASE PRESENTATION:
A 77-year-old man suffered acute calculous cholecystitis 5 days after eating eel and raw fish. Culture results from bile obtained via percutaneous gallbladder drainage revealed E. tarda infection, and an 8-day course of intravenous cefmetazole led to clinical resolution. However, the patient returned with fever and laboratory signs of obstructive cholangitis 5 weeks later. Contrast-enhanced computed tomography showed a migrated gallstone in the distal common bile duct. Endoscopic retrograde cholangiopancreatography drained the purulent bile, and cultures from the bile and blood were again positive for E. tarda. A 10-day course of cefmetazole, along with biliary stent placement resulted in complete recovery.
CONCLUSION:
E. tarda can cause relapsing biliary tract infections despite appropriate initial treatment. Clinicians should consider this rare pathogen in cases of recurrent cholangitis, especially for patients with recent consumption of raw or undercooked aquatic animals. A detailed dietary history and targeted microbiological testing are essential for accurate diagnosis and management.
2025-10-01SCIENCE PROGRESS
Compatibility and stability of seven selected cephalosporin antibiotics during extended infusion
Article
作者: Zhang, Liting ; Dong, Zhanjun ; Fan, Liju ; Wang, Yao ; An, Jing ; Guo, Xinjian
Objective:
To investigate the physical and chemical stability of cefminox sodium, cefuroxime sodium, cefoxitin sodium, ceftizoxime sodium, cefmetazole sodium, ceftazidime and cefamandole nafate when continuously infused with 0.9% sodium chloride (NS) and 5% glucose (GS).
Methods:
Seven cephalosporin antibiotics were reconstituted in 50 and 100 mL of NS and GS, and stored at room temperature. Samples were collected at 0, 2, 4, 8, and 24 hours to evaluate changes in appearance, pH, insoluble particle count, and drug content.
Results:
The admixture solutions of cefuroxime with both solvents turned yellow at 8 hours. The relative percentage content of the low-concentration group in NS dropped to 82.97% at 24 hours. When cefamandole nafate was admixed with NS, contents of both high and low concentrations dropped below 90% at 8 hours and below 60% at 24 hours. The pH change of the high-concentration group exceeded 1.0 pH unit at 24 hours. For cefoxitin sodium, the pH change of all concentration groups admixed with both solvents exceeded 1.0 pH unit at 24 hours. The high-concentration group in NS declined to 87.72%. The admixture solutions of cefminox with both solvents showed slight discoloration at 24 hours. When cefminox was admixed with GS, the contents of both concentration groups dropped below 90% at 2 hours. All other drug–solvent–concentration combinations had all indicators within the specified limits.
Conclusion:
When admixed with NS, cefmetazole, ceftazidime, and ceftizoxime are stable for 24 hours continuous infusion; cefoxitin and cefminox for up to 8 hours; and cefuroxime and cefamandole nafate for 4 hours. When admixed with GS, cefmetazole, ceftazidime, and ceftizoxime are stable for 24 hours; cefoxitin for up to 8 hours; cefuroxime for 4 hours; and cefminox has a stability period of less than 2 hours, so GS is not recommended as it is continuous infusion solvent.
100 项与 头孢美唑钠 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 淋病 | 美国 | 1989-12-11 | |
| 细菌感染 | 日本 | 1979-08-27 |
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