Purified Tuberculin (Nippon BCG Seizo KK)(Purified Tuberculin (Nippon BCG Seizo KK))

概要

基本信息

药物类型

其他体内诊断药物、变应原提取物

别名

Freeze Dried Tuberculin Purified Protein Derivative (PPD)、一般診断用精製ツベルクリン（ＰＰＤ）

靶点-

作用机制

结核菌素皮试诊断

治疗领域

其他疾病

在研适应症

诊断试剂

非在研适应症-

原研机构

Japan BCG Laboratory KK

在研机构

Japan BCG Laboratory KK

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1975-01-29),

诊断试剂

最高研发阶段(中国)-

特殊审评-

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关联

3

项与 Purified Tuberculin (Nippon BCG Seizo KK) 相关的临床试验

TCTR20200604014 / Completed临床3期IIT

Intralesional measles, mumps, rubella (MMR) vaccine versus tuberculin purified protein derivative (PPD) in the treatment of palmoplantar and periungual warts: A randomized controlled trial

开始日期2020-06-02

申办/合作机构

Ramathibodi Hospital

CTRI/2019/07/020070 / Not yet recruitingN/AIIT

To Compare the efficacy and safety of Intradermal versus Intralesional Purified Protein Derivative (PPD) for treatment of Common warts in children

开始日期2019-07-14

申办/合作机构

Himachal Pradesh University

CTRI/2014/12/005244 / Recruiting临床4期IIT

A double blind randomized control trial to compare the effectiveness, safety and tolerability of bacillus-calmette-guerin (BCG) vaccine and purified protein derivative (PPD) of tuberculin antigen in the treatment of multiple viral warts.

开始日期2014-05-05

申办/合作机构

Kolkata Medical College

100 项与 Purified Tuberculin (Nippon BCG Seizo KK) 相关的临床结果

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100 项与 Purified Tuberculin (Nippon BCG Seizo KK) 相关的转化医学

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100 项与 Purified Tuberculin (Nippon BCG Seizo KK) 相关的专利（医药）

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48

项与 Purified Tuberculin (Nippon BCG Seizo KK) 相关的文献（医药）

2024-05-01·JID Innovations

Systematic Review of Intralesional Therapies for Cutaneous Warts

Review

作者: Brenner, Rebecca L ; Welsh, Darby ; Keffer, Storm ; Mullen, Sarah A ; Mueller, Jenna ; Whitley, Melodi Javid ; Myers, Emma L ; Nguyen, Kim T ; Harper, Tara A

Intralesional therapies are used for recalcitrant warts, but no Food and Drug Administration-approved treatment exists nor is there consensus regarding the most efficacious therapy. Therefore, this systematic review aims to summarize efficacy and adverse events reported in 62 randomized controlled trials (RCTs) of intralesional therapies for cutaneous warts. The most studied intralesional therapies included measles, mumps, rubella (MMR) vaccine (n = 24 studies), purified protein derivative (PPD) (n = 19 studies), vitamin D3 (n = 15 studies), and Candida antigen (n = 14 studies). Most studies included adult and pediatric patients or adults alone, with only 4 studies on pediatric patients alone. MMR vaccine was the most studied treatment (n = 853 patients). MMR had a complete response rate of 27-90%. The next most common treatment, PPD, had a complete response rate of 45-87%. Other treatments included Candida antigen and vitamin D3, with complete response rates of 25-84% and 40-96%, respectively. The most frequent side effects were injection-site reactions and flu-like symptoms. This systematic review represents a useful summary of intralesional therapy RCTs for clinician reference. This study also highlights the lack of large multi-institutional RCTs, despite many patients being treated for this widespread problem.

2023-03-01·Journal of Cutaneous Medicine and Surgery

Efficacy of Cryotherapy Combined With Intralesional Purified Protein Derivative (PPD) Versus Intralesional PPD Monotherapy in the Treatment of Multiple Common Warts

Article

作者: Hassan, Hiba A. ; Gomaa, Ahmed S. ; Tawfik, Yasmin M. ; Awad, Sara M.

IntroductionIntralesional antigen immunotherapy represents a promising therapeutic approach for the treatment of different types of warts, particularly if multiple and/or recalcitrant.Aimto investigate the efficacy and safety of combined cryotherapy with intralesional purified protein derivative (PPD) immunotherapy in the treatment of multiple common warts.MethodsFifty patients were randomly divided into two groups (25 patients each): Group A: receiving intralesional PPD immunotherapy for the largest wart, while group B: receiving cryotherapy for all warts plus intralesional PPD for the largest wart. Treatments were performed every 2 weeks for a maximum of four sessions. Photographs were taken at baseline and at each visit and clinical response was evaluated by the reduction in number and size of warts. Adverse effects were recorded.ResultsThere was a significant reduction in size and number of warts in both groups ( P < .001), with no significant difference between the two groups. Complete clearance of the lesions was observed in 48% of patients in group A and 44% in group B ( P = .39). Higher rates of near complete/complete response were achieved after fewer sessions (2, 3 sessions) in group B ( P = .002). Blistering was common after cryotherapy. Higher rate of hypopigmentation was noticed after combined treatment than after PPD monotherapy (56%, 8% respectively; P < .001), which resolved gradually.ConclusionBoth intralesional PPD alone and combined cryotherapy with PPD are safe and effective in clearing of common warts. Cryotherapy may be a successful adjunct to intralesional PPD immunotherapy that helps in reducing the number of treatment sessions. The study protocol was registered at ClinicalTrials.gov with ID: NCT04288817

2023-01-01·Dermatology

Intralesional Measles, Mumps, Rubella Vaccine versus Tuberculin Purified Protein Derivative Injections in the Treatment of Palmoplantar and Periungual Warts: A Double-Blind Randomized Controlled Trial

Article

作者: Pomsoong, Cherrin ; Namasondhi, Amornrut ; Thadanipon, Kunlawat ; Anuntrangsee, Tanaporn ; Kositkuljorn, Chaninan ; Rutnin, Suthinee

Background: Palmoplantar and periungual warts tend to be recalcitrant. Intralesional immunotherapy can provide high efficacy with additional benefit to distant warts. However, evidence on comparative effects between intralesional immunotherapy with measles, mumps, rubella vaccine (MMR) and tuberculin purified protein derivative (PPD) and roles of dermoscopy in predicting treatment outcomes in palmoplantar/periungual warts is limited. Objectives: The study aimed to compare efficacy and safety of intralesional MMR and PPD injections in treatment of palmoplantar/periungual warts and explore associations between dermoscopic findings and treatment outcomes. Methods: We conducted a double-blind randomized controlled trial involving 40 patients with palmoplantar/periungual warts who were equally assigned to receive MMR or PPD. Intralesional injection was done every 2 weeks until clearance or maximum of 5 treatments. Results: Complete resolution was higher in MMR than PPD group (90.0% vs. 80.0% in index lesion and 81.3% vs. 54.6% in distant lesions, respectively), although the differences were statistically nonsignificant. Dermoscopic findings were not significantly associated with complete resolution. Local swelling, i.e., the most common adverse event, occurred more frequently in PPD (40.0%) than MMR group (10.0%). Conclusion: This study suggests that intralesional immunotherapy with either MMR or PPD is efficacious in palmoplantar/periungual warts, with MMR showing a trend toward higher clearance and lower adverse events.

100 项与 Purified Tuberculin (Nippon BCG Seizo KK) 相关的药物交易

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