Comparitive study between dexmedetomidine and fentanyl as adjuvants to continuous ropivacaine epidural infusion for post-operative analgesia in abdominal cancer surgeries - NIL

开始日期2024-11-02

申办/合作机构

Indira Gandhi Medical College

CTRI/2024/09/074396

/ Not yet recruitingN/AIIT

An observational study to evaluate relation of intrapartum VAS scores with postpartum depression - Nil

开始日期2024-09-29

申办/合作机构

Indira Gandhi Medical College

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4,569

项与 Himachal Pradesh University 相关的文献（医药）

2025-03-01·International Journal of Biological Macromolecules

Development of agar-alginate marine polysaccharides-based hydrogels for agricultural applications to reduce environmental hazards

Article

作者: Singh, Jasvir ; Sharma, Vikrant ; Vishavnath ; Singh, Baljit

In order to meet global food requirement, innovation in agricultural techniques and pesticide delivery system will be required for sustainable food supply with minimal harmful impact on environment. This article discusses the synthesis of hydrogels for use in controlled release formulations (CRFs) to increase agricultural output while reducing ecotoxicity and health risks. These hydrogels were designed by graft-copolymerization reaction of polyacrylamide and polyvinyl sulfonic acid onto agar-alginate marine polysaccharides. Copolymers were characterized by SEM, AFM, XRD, FTIR and ¹³C NMR. One gram of copolymeric hydrogels absorbed 14.80 ± 0.53 g of water. The glyphosate herbicide was released in a slow regulated manner over 72 h which is useful to avoid herbicide loss through leaching, evaporation and to reduce environmental hazards. The herbicide released via a non-Fickian diffusion mechanism and release profile was best described by the Korsmeyer-Peppas kinetic model. The release of herbicide from hydrogels occurred slowly and consistently in simulated soil conditions for a prolonged period. A soil adsorption studies of herbicide revealed a reduction in ground water ubiquity score (GUS) for glyphosate encapsulated hydrogels as compared to commercial formulations. Soil water retention was enhanced by the addition of hydrogel in the soil. The degradation of these CRFs can provide micronutrients (N and S) to improve soil quality and minimize the risk of water pollution by reducing the leaching of herbicides.

2025-03-01·International Journal of Biological Macromolecules

Functionalization of almond gum through covalent and non-covalent interactions for biomedical applications

Article

作者: Sharma, Priyanka ; Sharma, Vikrant ; Singh, Baljit

The versatile properties of carbohydrate polymers make them a relevant, promising precursor to design innovative materials for use in biomedical applications. Recent research mainly focuses on the development of the polysaccharide based functional materials. Hydrogel derived materials are a source of great motivation for the development of drug delivery (DD) carriers with inherent therapeutic potential. Herein, almond gum-based hydrogels were synthesized for the delivery of the anticancer drug methotrexate after impregnation to improve the DD profile. Hydrogels were characterized by FESEM, EDS, AFM, ¹³C NMR, FTIR, TGA, DSC, XRD, mechanical strength & biomedical assay. The optimized network hydrogel exhibited a mesh size of 19.764 mm and a cross-linking density of 5.002 × 10^-5 mol/cm³ of the hydrogels. Morphological features revealed irregular, uneven internal morphology of hydrogels in FE-SEM. The inclusion of sulphated and amide polymers in hydrogels was found in elemental composition (C = 60.72 %, O = 29.79 %, N = 6.63 % and S = 2.86 %) of hydrogels inferred from EDS. Spectroscopic characterization by FT-IR and ¹³C NMR confirmed the inclusion of PVP and PVSA through grafting reaction. The crosslinked product formed was found thermally stable and amorphous in nature through TGA and XRD analysis. The sustained release was found through supramolecular interactions and release complied a non-Fickian mechanism for drug diffusion (n = 0.73) and the release profile was best described by the Hixson-Crowell kinetic model in colonic pH. The hydrogels were mucoadhesive in nature and required 144 ± 10.54 mN force for the separation of hydrogels from the mucosal surface during the adhesion test. Hydrogel illustrated antioxidant activity (32.68 ± 0.83 μg GAE) during their radical scavenging test by FC reagent assay. Drug encapsulated hydrogels demonstrated antimicrobial efficacy against microbes. The results of physico-chemical and biomedical properties of hydrogels suggested their suitability for biomedical uses.

2025-02-11·Journal of Biomolecular Structure and Dynamics

Unveiling the molecular interactions and antimicrobial activity of cetyl pyridinium bromide in ternary systems with short tetraalkylammonium bromide salts

Article

作者: Negi, Kiran ; Chauhan, Suvarcha

Physicochemical properties of a surfactant cetyl pyridinium bromide (CPB) (0.2-2 mmol kg^-1) has been investigated by the addition of greener additives, that is, aqueous tetraalkylammonium bromide (TAAB) salts at different concentrations (0.005, 0.010 and 0.015 mol kg^-1) by employing techniques viz: conductivity, fluorescence and UV-visible spectra. In contrast to spectroscopic analysis, which was conducted at room temperature (298.15 K), conductivity measurements were made at various temperatures (298.15, 303.15, 308, and 313.15 K). The obtained electrical conductivity data has been used to compute the critical micelle concentration (cmc), which was also obtained from the UV-Visible and fluorescence methods. It is important to mention that the cmc values obtained from these methods are found to be in good agreement. Various thermodynamic parameters (__-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__ΔGmo, __-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__ΔHmo, and __-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__ΔSmo) have been calculated using conductivity data, the interpretation of which reveals that the interactions between CPB and TAAB are found to be both electrostatic and hydrophobic, however, hydrophobic interactions are found to be dominant in the ternary system. Additionally, the impact of TAAB on the antimicrobial activities of CPB has been evaluated by measuring the zone of inhibition, which explains why the CPB-TAAB system is more effective against gram-positive bacteria (Bacillus cereus and Staphylococcus aureus) than gram-negative bacteria (Escherichia coli and Salmonella typhi).Communicated by Ramaswamy H. Sarma.

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