Comparative evaluation of ultrasound guided PECS block of the two concentration of levobupivacaine with adjuvant dexmedetomidine in patients undergoing modified radical mastectomy - NIL

开始日期2024-08-30

申办/合作机构

Indira Gandhi Medical College

CTRI/2024/07/070693 / Not yet recruitingN/AIIT

To study the incidence of adverse events during intrahospital transport of critically ill patients A prospective observational study - Nil

开始日期2024-07-31

申办/合作机构

Indira Gandhi Medical College

100 项与 Himachal Pradesh University 相关的临床结果

登录后查看更多信息

0 项与 Himachal Pradesh University 相关的专利（医药）

登录后查看更多信息

4,710

项与 Himachal Pradesh University 相关的文献（医药）

2024-12-11·International Journal of Polymeric Materials and Polymeric Biomaterials

Smart mucoadhesive 3-D network hydrogels for use in localized impregnated anticancer drug delivery

作者: Singh, Baljit ; Sharma, Vikrant ; Sharma, Prerna ; Kapil, Disha

Recently, bioactive dietary fibers (DFs) have been explored for various benefits to human health because of their therapeutic activities.Role of DF psyllium (arabinoxylan (Ax)) has been established for curing colon cancer.Herein, methotrexate (MXT), an anti-neoplastic agent, was impregnated into network hydrogels developed from DF psyllium, through graft copolymerization reactions for its sustained colon-specific drug delivery (DD).Copolymers were characterized through SEM, AFM, FTIR, C¹³-NMR and TGA anal.Smart hydrogels demonstrated antioxidant (39.40 ± 0.78% free radical scavenging in the DPPH assay), biocompatible (1.16 ± 0.22% hemolysis value in blood-polymer interactions), and mucoadhesive (7.0 ± 0.1 mN detachment force from the mucous membrane) properties.Sustained diffusion of MXT in colonic conditions occurred with a Fickian mechanism, and release profile obeyed the Korsmeyer-Peppas kinetic model.Overall, findings suggested the suitability of DF psyllium-based DD carriers for colon with enhanced potential.

2024-12-01·Environmental Research

Coexistence of microplastics and heavy metals in soil: Occurrence, transport, key interactions and effect on plants

Review

作者: Kajal, Sanjay ; Thakur, Sveta

Microplastics (MPs) pollution has raised serious environmental concerns due to its widespread generation and discharge across global ecosystems. It is estimated that approximately 400 million metric tons of plastic are produced annually, with 54% ending up as waste. The MPs account for a significant portion of this pollution. These MPs interact with heavy metals (HMs) in terrestrial ecosystems, such as cadmium (Cd), lead (Pb), and arsenic (As), which are introduced through various industrial activities at rates of thousands of tons per year. Such interactions may cause synergistic or antagonistic effects on plants. Recent studies suggest that MPs and HMs exposure impacts various physiological and biochemical pathways in plants, thereby increasing the toxicity symptoms. However, the existing scholarly understanding of the coupled effect of HMs and MPs on plants is limited, highlighting the need to explore these complex dynamics further. Through a comprehensive analysis of current research, this review underscores various pathways of MPs and HMs infiltration mechanisms, detailing their penetration, translocation, and bioaccumulation within plants. The physiological and biochemical effects of both pollutants on plants are deliberated individually and in combination. The review reveals that the co-existence of these contaminants results in a multifaceted environmental challenge, affecting overall plant growth, yield, and quality in ways that differ from individual exposure. Building on recent advancements, this article is expected to delineate the complex interactions between MPs, HMs, and plants and enhance the current understanding of the intricate interplay between them.

2024-11-01·International Journal of Biological Macromolecules

Sustainable and facile fabrication of chitosan-coated silver-doped zinc oxide nanocomposites exploiting Bergera koenigii foliage for enhanced photocatalysis and antibacterial activity

Article

作者: Singh, Amritpal ; Kumar, Rajesh ; Kumar, Santosh ; Montaño, Victor Emmanuel Alvarez ; Tanuj ; Sharma, Subhash ; Kalra, Neerja

Industrial and academic chemical pollutants such as Eriochrome Black-T (EBT) and murexide dyes are widely used in academic institution as well as industries, when eluted into rivers, delineate the ill effect on human and aquatic life. Herein, green and ecofriendly synthesis of silver doped-Zinc oxide nanoparticles (Ag/ZnO NPs) and chitosan coated Ag/ZnO nanoparticles (CS/Ag/ZnO NPs) using Bergera koenigii extract to solve environmental issues have been reported for the first time. Spherical and agglomerated particles with crystalline flakes like morphology of Ag/ZnO NPs and CS/Ag/ZnO NPs respectively have been ascertained by Scanning electron morphology (SEM) analyses and XRD. XRD analysis revealed the average crystallite size of 42.16 nm and 48.45 nm for Ag/ZnO NPs with 5 % and 10 % Ag concentration respectively, lesser than crystallite size of 47.394 nm and 52.38 nm for CS-5 % Ag/ZnO NC and CS-10 % Ag/ZnO NC respectively. All the synthesized NPs and NC demonstrated remarkable antibacterial potential against both gram +ve and gram -ve bacteria. Additionally, all the materials showed very high time-dependent photocatalytic degradation activity (>98 %) of EBT and murexide in 12 min. Remarkably, all active nano-catalysts exhibit high durability, and displayed recyclability for >8 cycles. In nutshell, chitosan coated nano-catalyst showed drastic improvement in photocatalytic and antibacterial activities.

100 项与 Himachal Pradesh University 相关的药物交易

登录后查看更多信息

100 项与 Himachal Pradesh University 相关的转化医学

登录后查看更多信息