P2X7 receptor antagonists(Chengdu University)(P2X7 receptor antagonists(Chengdu University)) - 药物靶点：P2X7 receptor_在研适应症：慢性肾病_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Compound 13a(Chengdu University)

靶点

P2X7 receptor

作用机制

P2X7 receptor拮抗剂(嘌呤P2X7受体拮抗剂)

治疗领域

泌尿生殖系统疾病

在研适应症

慢性肾病

非在研适应症-

原研机构

成都大学

在研机构

成都大学

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)临床前

特殊审评-

结构

分子式C21H17F3N6O3S2

InChIKeyJRMLTYBLQKCPLC-GFCCVEGCSA-N

CAS号3046388-17-1

关联

100 项与 P2X7 receptor antagonists(Chengdu University) 相关的临床结果

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100 项与 P2X7 receptor antagonists(Chengdu University) 相关的转化医学

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100 项与 P2X7 receptor antagonists(Chengdu University) 相关的专利（医药）

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1

项与 P2X7 receptor antagonists(Chengdu University) 相关的文献（医药）

2009-03-01·Behavioural Brain Research3区 · 心理学

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders

3区 · 心理学

Article

作者: Richard R. Harris ; Ana M. Basso ; Michael W. Decker ; Natalie A. Bratcher ; Lynne E. Rueter ; Michael F. Jarvis

The purinergic P2X(7) receptor is a ligand-gated ion channel found on peripheral macrophages and microglia in the nervous system. Activation of P2X(7) receptors results in the rapid release of interleukin-1 beta (IL-1 beta). Cytokines like IL-1 beta are suggested to be involved in the pathophysiology of depression. The aim of this study was to behaviorally profile P2X(7) receptor knockout (KO) mice in behavioral models of depression- and anxiety-like behaviors. P2X(7) receptor KO and wild type (WT) mice were tested in multiple models including; forced swim test, tail suspension test, elevated plus maze, novelty suppressed feeding, spontaneous locomotor activity, and food intake. P2X(7) receptor KO mice exhibited an antidepressant-like profile in tail suspension test and forced swim test; an effect that was not associated with changes in spontaneous locomotor activity. In addition, P2X(7) receptor KO mice showed higher responsivity to a subefficacious dose of the antidepressant drug imipramine (15 mg/kg) in forced swim test. No significant differences between genotypes were observed in models of anxiety. These data support the relevance of pro-inflammatory cytokines in depressive-like states, and suggest that P2X(7) receptor antagonists could be of potential interest for the treatment of affective disorders.

100 项与 P2X7 receptor antagonists(Chengdu University) 相关的药物交易

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