葡萄籽提取物(Grape Seed Extract) - 在研适应症：乳腺癌，结直肠癌_专利_临床

概要

基本信息

药物类型

中药

别名

GSE、GSPE、Grape seed extract

+ [3]

靶点-

作用机制-

治疗领域

肿瘤皮肤和肌肉骨骼疾病消化系统疾病

在研适应症

乳腺癌结直肠癌

非在研适应症-

原研机构-

在研机构

University of Colorado Denver

City of Hope National Medical Center

Beckman Research Institute of The City of Hope

+ [1]

非在研机构-

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

关联

13

项与葡萄籽提取物相关的临床试验

NCT06440252 / Not yet recruiting临床3期

The Effectiveness of a Grape Seed Extract on Circulatory Measures in Healthy Adults: a Randomised, Double-blind, Placebo-controlled Crossover Study

This is a randomized, double-blind, placebo-controlled, 2 arm crossover study conducted over 11 weeks, with participants randomised to a product for 4 weeks, followed by a 3-week washout period before completing the second product for 4 weeks, to study the effectiveness of a grape seed extract on circulatory measures in healthy adults.

开始日期2024-10-30

申办/合作机构

RDC Clinical Pty Ltd

IRCT20240528061937N1 / Recruiting临床3期IIT

Investigating the effect of Grape Seed on sperm parameters and sperm DNA fragmentation rate in infertile men

开始日期2024-08-07

申办/合作机构

Arak University of Medical Sciences

NCT06576700 / RecruitingN/AIIT

Effect of Procyanidins in the Leaky Gut Repairing Associated with Inflammatory Bowel Disease

The goal of this clinical trial is to learn if the Grape Seed Extract Ecovitis, featuring low monomeric catechins content and a high concentration of oligo-polymeric procyanidins, could modulate the Gut Microbiota composition of Ulcerative Colitis patients during the remission phase. The main questions it aims to answer are:
Does Ecovitis improve the microbiota composition in patients with Ulcerative colitis? Is the intestinal permeability affected? What about the variation in the quality of life?
Participants will:
Take 2 capsules/day of Ecovitis for eight weeks Visit the clinic two times for checkups, serum collection, and Questionaire.

开始日期2024-06-15

申办/合作机构

University of Padua

100 项与葡萄籽提取物相关的临床结果

登录后查看更多信息

100 项与葡萄籽提取物相关的转化医学

登录后查看更多信息

100 项与葡萄籽提取物相关的专利（医药）

登录后查看更多信息

1,127

项与葡萄籽提取物相关的文献（医药）

2024-12-01·Biological Trace Element Research

Grape Seed Proanthocyanidins Protect Pancreatic β Cells Against Ferroptosis via the Nrf2 Pathway in Type 2 Diabetes

Article

作者: Wang, Hao ; Zhang, Liyuan ; Yang, Ruirui ; Lu, Heng ; Wang, Tongling ; Li, Haiyan ; Ding, Yusong ; Zhang, Haowei

AbstractPancreatic β cell damage is the primary contributor to type 2 diabetes mellitus (T2DM); however, the underlying mechanism remains nebulous. This study explored the role of ferroptosis in pancreatic β cell damage and the protective effects of grape seed proanthocyanidin extract (GSPE). In T2DM model rats, the blood glucose, water intake, urine volume, HbA1c, and homeostasis model assessment-insulin resistance were significantly increased, while the body weight and the insulin level were significantly decreased, indicating the successful establishment of the T2DM model. MIN6 mouse insulinoma β cells were cultured in high glucose and sodium palmitate conditions to obtain a glycolipid damage model, which was administered with GSPE, ferrostatin-1 (Fer-1), or nuclear factor erythroid 2-related factor 2 (Nrf2) small interfering (si) RNA. GSPE and Fer-1 treatment significantly improved pancreatic β-cell dysfunction and protected against cell death. Both treatments increased the superoxide dismutase and glutathione activity, reduced the malondialdehyde and reactive oxygen species levels, and improved iron metabolism. Furthermore, the treatments reversed the expression of ferroptosis markers cysteine/glutamate transporter (XCT) and glutathione peroxidase 4 (GPX4) caused by glycolipid toxicity. GSPE treatments activated the expression of Nrf2 and related proteins. These effects were reversed when co-transfected with si-Nrf2. GSPE inhibits ferroptosis by activating the Nrf2 signaling pathway, thus reducing β-cell damage and dysfunction in T2DM. Therefore, GSPE is a potential treatment strategy against T2DM.Graphical Abstract

2024-11-01·Science of The Total Environment

Spatiotemporally non-stationary evolution of groundwater levels in Poyang Lake Basin driven by meteorological and hydrological factors.

Article

作者: Qiu, Baozhong ; Lu, Chengpeng ; Liu, Bo ; Chen, Jing ; Liu, Yu ; Wang, Jianliang ; Wu, Chengcheng ; Shu, Longcang ; Zhang, Yong

The complex relationship between wet-dry transition in the Poyang Lake basin and groundwater storage significantly affects the lake's hydrology, downstream ecological state, and overall security along the Yangtze River in China. There is, however, a notable lack of systematic exploration into how various factors drive spatiotemporal variability in groundwater level (GWL). Using local indicators of spatial association (LISA), spatial non-stationarity models, and multi-source data, our analysis explores the spatial distribution of GWL and quantifies the influence of driving factors on its spatiotemporal non-stationarity at annual and monthly scales. We also compare driving factor contributions in hilly, plain, and local areas within the Poyang Lake basin. Our findings reveal significant local clustering of GWL, indicating substantial spatial autocorrelation and geographic heterogeneity in GWL. Influencing factors exhibit non-stationary effects on GWL at spatial and temporal scales, with precipitation (P), ground surface elevation (GSE), and soil moisture (SM) being primary contributors, generally exerting positive effects. SM contributes most during dry years and normal periods. P and the Palmer Drought Severity Index (PDSI) have greater impacts in hilly areas, while GSE shows the opposite trend. Rainfall is a source of groundwater recharge, with a lagged response observed in GWL to rainfall in this basin. The lag time is about 1-2 months. Evapotranspiration is not the dominant discharge pathway. The decrease in GWL during the dry season is mainly due to reduced precipitation recharge and increased lateral groundwater discharge from areas of high hydraulic head to areas of low hydraulic head.

2024-11-01·International Journal of Food Microbiology

Antimicrobial resistance induction potential of grapefruit seed extract on multi-species biofilm of E. coli in food industry

Article

作者: Kim, Unji ; Oh, Se-Wook

Biofilm formation in natural environments involving complex multi-structural arrangements hinders challenges in antimicrobial resistance. This study investigated the antimicrobial resistance potential of grapefruit seed extract (GSE) by examining the formation of mono-, dual-, and multi-species biofilms. We also explored the counterintuitive effect in response to GSE at various concentrations, including minimum inhibitory concentration (MIC) and sub-MIC (1/2 and 1/4 MIC). The results of the swimming and swarming motility tests revealed increased motility at the sub-MIC of GSE. The crystal violet assay demonstrated increased biofilm formation in multi-species biofilms, highlighting the synergistic effect of Escherichia coli, Salmonella Typhimurium, and Listeria monocytogenes. At the MIC concentration of GSE, field emission scanning electron microscopy (FE-SEM) revealed cell morphology damage, while sub-MIC increased biofilm formation and architectural complexity. Multi-species biofilms demonstrated greater biofilm-forming ability and antimicrobial resistance than mono-species biofilms, indicating synergistic interactions and enhanced resilience. These findings highlight the importance of understanding biofilm dynamics and antimicrobial resistance to ensure environmental safety.

100 项与葡萄籽提取物相关的药物交易

登录后查看更多信息

研发状态

10 条进展最快的记录,

登录

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
乳腺癌	临床2期	美国	City of Hope National Medical Center	2006-04-15
结直肠癌	临床前	美国	University of Colorado Denver	2008-05-01

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01267227 (CTgov)	临床2/3期	高脂血症 \| 应激氧化	80	Pterostilbene 125 mg twice daily (High Dose)	(鏇夢憲鑰鬱艱醖願築艱) = 構繭網醖膚鏇遞襯蓋艱獵獵蓋齋鏇憲網構窪鹽 (鹹獵膚齋淵鹽製選簾醖, 積鹽膚願積鹽願窪襯積 ~ 鹹淵觸窪網觸膚選艱構) 更多	-	2013-05-03
				Pterostilbene 50 mg twice daily (Low Dose)	(鏇夢憲鑰鬱艱醖願築艱) = 蓋築願艱襯積網衊鑰鏇獵獵蓋齋鏇憲網構窪鹽 (鹹獵膚齋淵鹽製選簾醖, 艱膚糧鹽構糧鬱簾網廠 ~ 願壓鏇鏇襯構齋齋夢構) 更多