This is a randomized, double-blind, placebo-controlled, 2 arm crossover study conducted over 11 weeks, with participants randomised to a product for 4 weeks, followed by a 3-week washout period before completing the second product for 4 weeks, to study the effectiveness of a grape seed extract on circulatory measures in healthy adults.

开始日期2024-10-30

申办/合作机构

RDC Clinical Pty Ltd

IRCT20240528061937N1 / Recruiting临床3期IIT

Investigating the effect of Grape Seed on sperm parameters and sperm DNA fragmentation rate in infertile men

开始日期2024-08-07

申办/合作机构

Arak University of Medical Sciences

NCT06576700 / RecruitingN/A

Effect of Procyanidins in the Leaky Gut Repairing Associated with Inflammatory Bowel Disease

The goal of this clinical trial is to learn if the Grape Seed Extract Ecovitis, featuring low monomeric catechins content and a high concentration of oligo-polymeric procyanidins, could modulate the Gut Microbiota composition of Ulcerative Colitis patients during the remission phase. The main questions it aims to answer are:
Does Ecovitis improve the microbiota composition in patients with Ulcerative colitis? Is the intestinal permeability affected? What about the variation in the quality of life?
Participants will:
Take 2 capsules/day of Ecovitis for eight weeks Visit the clinic two times for checkups, serum collection, and Questionaire.

开始日期2024-06-15

申办/合作机构

University of Padua

100 项与葡萄籽提取物相关的临床结果

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100 项与葡萄籽提取物相关的转化医学

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100 项与葡萄籽提取物相关的专利（医药）

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1,127

项与葡萄籽提取物相关的文献（医药）

2024-12-01·Biological Trace Element Research

Grape Seed Proanthocyanidins Protect Pancreatic β Cells Against Ferroptosis via the Nrf2 Pathway in Type 2 Diabetes

Article

作者: Wang, Hao ; Zhang, Liyuan ; Yang, Ruirui ; Lu, Heng ; Li, Haiyan ; Wang, Tongling ; Ding, Yusong ; Zhang, Haowei

AbstractPancreatic β cell damage is the primary contributor to type 2 diabetes mellitus (T2DM); however, the underlying mechanism remains nebulous. This study explored the role of ferroptosis in pancreatic β cell damage and the protective effects of grape seed proanthocyanidin extract (GSPE). In T2DM model rats, the blood glucose, water intake, urine volume, HbA1c, and homeostasis model assessment-insulin resistance were significantly increased, while the body weight and the insulin level were significantly decreased, indicating the successful establishment of the T2DM model. MIN6 mouse insulinoma β cells were cultured in high glucose and sodium palmitate conditions to obtain a glycolipid damage model, which was administered with GSPE, ferrostatin-1 (Fer-1), or nuclear factor erythroid 2-related factor 2 (Nrf2) small interfering (si) RNA. GSPE and Fer-1 treatment significantly improved pancreatic β-cell dysfunction and protected against cell death. Both treatments increased the superoxide dismutase and glutathione activity, reduced the malondialdehyde and reactive oxygen species levels, and improved iron metabolism. Furthermore, the treatments reversed the expression of ferroptosis markers cysteine/glutamate transporter (XCT) and glutathione peroxidase 4 (GPX4) caused by glycolipid toxicity. GSPE treatments activated the expression of Nrf2 and related proteins. These effects were reversed when co-transfected with si-Nrf2. GSPE inhibits ferroptosis by activating the Nrf2 signaling pathway, thus reducing β-cell damage and dysfunction in T2DM. Therefore, GSPE is a potential treatment strategy against T2DM.Graphical Abstract

2024-11-01·Clinics and Research in Hepatology and Gastroenterology

Co-exposure to different bacterial species’ lipopolysaccharides with the NASH diet exacerbates NASH and liver fibrosis progression in mice

Article

作者: Chiu, Chien-Chao ; Wu, Wei-Kai ; Chen, Yi-Hsun ; Lee, Yen-Peng ; Chuang, Hsiao-Li ; Chang, Yung-Chi ; Wu, Ming-Shiang

BACKGROUND AND AIMWith the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become a public health concern, but its progression mechanism remains unclear. Experimental models mimicking human NAFLD/steatohepatitis (NASH) are crucial. This study simulates gut microbiota imbalance effects on NASH and liver fibrosis.METHODSWe used different bacterial sources of lipopolysaccharide (LPS), including Escherichia coli (GEC) and Salmonella abortus equi (GSE), combined with a Gubra Amylin NASH (GAN) diet to induce NASH and liver fibrosis.RESULTSThe GSE group showed significantly higher serum alanine aminotransferase, hydroxyproline, CD68-positive cells, α-smooth muscle actin, glial fibrillary acidic protein, and TNF-α, COL1A1, TGF-β, and NLRP3 expressions compared to the the GAN group. The GSE group also had higher Erysipelotrichaceae, Akkermansiaceae, and Bacteroidaceae family numbers.CONCLUSIONSThe GAN diet with LPS treatment successfully induced NASH and fibrosis making this model useful for preclinical NASH drug testing.

2024-11-01·International Journal of Food Microbiology

Antimicrobial resistance induction potential of grapefruit seed extract on multi-species biofilm of E. coli in food industry

Article

作者: Kim, Unji ; Oh, Se-Wook

Biofilm formation in natural environments involving complex multi-structural arrangements hinders challenges in antimicrobial resistance. This study investigated the antimicrobial resistance potential of grapefruit seed extract (GSE) by examining the formation of mono-, dual-, and multi-species biofilms. We also explored the counterintuitive effect in response to GSE at various concentrations, including minimum inhibitory concentration (MIC) and sub-MIC (1/2 and 1/4 MIC). The results of the swimming and swarming motility tests revealed increased motility at the sub-MIC of GSE. The crystal violet assay demonstrated increased biofilm formation in multi-species biofilms, highlighting the synergistic effect of Escherichia coli, Salmonella Typhimurium, and Listeria monocytogenes. At the MIC concentration of GSE, field emission scanning electron microscopy (FE-SEM) revealed cell morphology damage, while sub-MIC increased biofilm formation and architectural complexity. Multi-species biofilms demonstrated greater biofilm-forming ability and antimicrobial resistance than mono-species biofilms, indicating synergistic interactions and enhanced resilience. These findings highlight the importance of understanding biofilm dynamics and antimicrobial resistance to ensure environmental safety.

项与葡萄籽提取物相关的新闻（医药）

2021-01-26

·BioSpace

New Study Concludes Xlear Kills and/or Deactivates SARS-CoV-2; Efficacy Against New Variants

Jan. 26, 2021 09:15 UTC EVANSTON, Ill.--(BUSINESS WIRE)-- A new in vitro study done collaboratively by Utah State University and Northwestern University finds Xlear components (grapefruit seed extract and xylitol) significantly eliminates SARS-CoV-2, the virus that causes COVID-19. The imaging research study component was performed at the BioCryo facility of Northwestern University’s NUANCE Center. This press release features multimedia. View the full release here: Using electron microscopy, we have visual evidence showing that xylitol and grapefruit seed extract (GSE) counters the virus. The GSE kills the virus, while the xylitol prevents the virus from attaching to the cell walls. The image shows SARS-CoV-2 viruses outside the cell and never attached, thereby preventing infection (Photo: Business Wire) The study tested SARS-CoV-2 virus titers and LRV against a single concentration of Xlear nasal spray. According to the Study, “After a 25-minute contact time, the nasal spray reduced virus from 4.2 to 1.7 log10 CCID50 per 0.1 mL, a statistically significant reduction (P<0.001) of 2.5 log10 CCID50.” The Northwestern/Utah State Study is the newest in a string of studies to reach the conclusion that Xlear is effective against the SARS-CoV-2. However, the study breaks new ground in two vital respects: “First, we conclude, in addition to countering SARS-CoV-2, Xlear is likely effective in preventing the spread of future H1N1 viruses, including the emerging SARS-CoV-2 variants, along with other viral epidemics. Given the more transmissible variants we now face, this is critical now,” said Professor Mark Cannon, Feinberg School of Medicine, Northwestern University. “Second, using electron microscopy, we have visual evidence showing that xylitol and GSE counters the virus. The GSE kills the virus, while the xylitol prevents the virus from attaching to the cell walls. The image (attached) shows SARS-CoV-2 viruses outside the cell and never attached, thereby preventing infection,” added Dr. Cannon. The study postulates that xylitol acts as a decoy target for SARS-CoV-2, preventing virus attachment to the core protein on the cell wall. The collaborative study concludes: “Because there are no risk factors in using the X/GSE combination therapy, and [Xlear] nasal spray is over the counter available without prescription, and [Xlear] allows for comfortable long term mask wearing, adoption of this preventive anti-viral therapy should be encouraged.” Full study: For more information on Xlear (including where to obtain): View source version on businesswire.com: Contacts Jeff Gulko 617.304.7339 jeff@thegulkogroup.com Source: Xlear Smart Multimedia Gallery Photo Using electron microscopy, we have visual evidence showing that xylitol and grapefruit seed extract (GSE) counters the virus. The GSE kills the virus, while the xylitol prevents the virus from attaching to the cell walls. The image shows SARS-CoV-2 viruses outside the cell and never attached, thereby preventing infection (Photo: Business Wire) View this news release and multimedia online at:

100 项与葡萄籽提取物相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
乳腺癌	临床2期	美国	City of Hope National Medical Center	2006-04-15
结直肠癌	临床前	美国	University of Colorado Denver	2008-05-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01267227 (CTgov)	临床2/3期	高脂血症 \| 应激氧化	80	Pterostilbene 125 mg twice daily (High Dose)	(鬱夢窪膚選鬱齋艱繭網) = 鹽製鬱鹹選醖獵蓋憲蓋鑰簾餘餘醖觸廠憲範願 (糧襯憲選遞鏇鹽艱獵範, 鹽鹹襯製鹽鹹膚觸糧蓋 ~ 壓膚範糧網鏇襯鏇壓鹹) 更多	-	2013-05-03
				Pterostilbene 50 mg twice daily (Low Dose)	(鬱夢窪膚選鬱齋艱繭網) = 遞衊艱願餘鹽醖壓衊選鑰簾餘餘醖觸廠憲範願 (糧襯憲選遞鏇鹽艱獵範, 構餘繭獵構簾蓋壓鏇獵 ~ 簾繭選獵窪觸選鹽衊膚) 更多