Berbamine Analogues(Berbamine Analogues) - 药物靶点：TRPML1_在研适应症：病毒感染_专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点

TRPML1

作用机制

TRPML1激动剂(mucolipin 1 agonists)

治疗领域

感染

在研适应症

病毒感染

非在研适应症-

原研机构

Protheragen, Inc.

在研机构

Protheragen, Inc.

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 Berbamine Analogues 相关的临床结果

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100 项与 Berbamine Analogues 相关的转化医学

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100 项与 Berbamine Analogues 相关的专利（医药）

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1

项与 Berbamine Analogues 相关的文献（医药）

2012-08-01·European Journal of Medicinal Chemistry1区 · 医学

Synthesis of berbamine acetyl glycosides and evaluation of antitumor activity

1区 · 医学

Article

作者: Rongzhen Xu ; Yanli Cui ; Jingfeng Ouyang ; Minghan Xu ; Yongping Yu ; Jianwei Mao

A series of berbamine glycosides was designed, synthesized and evaluated as a new class of antitumor agents. An efficient glycosylation route was developed for berbamide derivatives. The newly synthesized glycosides were evaluated for their cytotoxic activity in vitro against a human leukemia cell line K562, a human lung adenocarcinoma cell line A549 and mouse lymphocytic leukemia cells L1210. In contrast to berbamine most of its glycosides manifested potent cytotoxic activities. The acetyl glycosyl berbamine 5a, 5d caused distinct improvement against K562, A549 and L1210. It is suggested that the acetyl D-glucose residue has affinity to these cancer cells.

100 项与 Berbamine Analogues 相关的药物交易

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