19ISP(19ISP) - _专利_临床

概要

基本信息

药物类型

预防性疫苗、mRNA疫苗

别名-

靶点-

作用方式-

作用机制-

治疗领域

感染其他疾病

在研适应症-

非在研适应症

莱姆病

原研机构

Yale University

在研机构-

非在研机构

Yale University

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 19ISP 相关的临床结果

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100 项与 19ISP 相关的转化医学

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100 项与 19ISP 相关的专利（医药）

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2

项与 19ISP 相关的文献（医药）

2021-11-17·Science Translational Medicine1区 · 医学

mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent

1区 · 医学

Article

作者: Lynn, Geoffrey ; Weissman, Drew ; Pal, Utpal ; Strank, Norma Olivares ; Wu, Ming-Jie ; DePonte, Kathleen ; Arora, Gunjan ; Pardi, Norbert ; Sajid, Andaleeb ; Narasimhan, Sukanya ; Kurokawa, Cheyne ; Fikrig, Erol ; Tang, Xiaotian ; Matias, Jaqueline

An Ixodes scapularis saliva mRNA vaccine induces tick resistance and prevents Borrelia burgdorferi infection in guinea pigs.

Scientific Reports

mRNA vaccination of rabbits alters the fecundity, but not the attachment, of adult Ixodes scapularis

Article

作者: Mesquita, Emily ; Tam, Ying K ; Pardi, Norbert ; Cui, Yingjun ; Matias, Jaqueline ; Muramatsu, Hiromi ; Weissman, Drew ; Lynn, Geoffrey E ; Dwivedi, Garima ; Fikrig, Erol ; Alameh, Mohamad G ; DePonte, Kathleen

Abstract19ISP is a nucleoside-modified mRNA-lipid nanoparticle vaccine that targets 19 Ixodes scapularis proteins. We demonstrate that adult I. scapularis have impaired fecundity when allowed to engorge on 19ISP-immunized rabbits. 19ISP, therefore, has the potential to interrupt the tick reproductive cycle, without triggering some of the other effects associated with acquired tick resistance. This may lead to the development of new strategies to reduce I. scapularis populations in endemic areas.

100 项与 19ISP 相关的药物交易

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