AbstractObjectivesTo evaluate the influence of implant‐abutment interface (IAI) placement depth on bone remodeling around implants with two different types of tapered internal IAI: screwed‐in (SI) and tapped‐in (TI) connections in dogs.Materials and methodsEight weeks post mandibular tooth extraction in six beagle dogs, two SI implants (OsseoSpeed™, Astra Tech, DENTSPLY) and two TI implants (Integra‐CP™, Bicon LLC) were placed in one side of the mandible. The four experimental groups were as follows: (i) SI‐placed equicrestally (SIC); (ii) TI‐placed equicrestally (TIC); (iii) SI‐placed 1.5 mm subcrestally (SIS); and (iv) TI‐placed 1.5 mm subcrestally (TIS). Healing abutments were connected 12 weeks after implant placement. Sixteen weeks later, the dogs were sacrificed and histomorphometric analysis was performed. Histometrical outcomes were evaluated using a nonparametric Brunner–Langer model.ResultsMean distance from the IAI to first bone‐implant contact (IAI‐fBIC) was 0.88 mm (median: 0.77; SD: 0.54) for SIC group, 1.23 mm (median: 1.22; SD: 0.66) for TIC group, 0.41 mm (median: 0.31; SD: 0.36) for SIS group, and 0.41 mm (median: 0.26; SD: 0.45) for TIS group. Subcrestal groups showed lower IAI‐fBIC compared with equicrestal groups (P < 0.001). Connective tissue presented similar measurements regardless of the IAI placement depth and IAI type (P > 0.05), but the epithelium length and peri‐implant soft tissue length in subcrestal groups were significant larger than that in the equicrestal groups (P < 0.001 and P = 0.004, respectively).ConclusionSubcrestal implant placement with tapered internal IAI is beneficial for bone contact with the implant neck, and concurrently, it may not increase the soft tissue inflammation around IAI.

2005-10-01·Acta Anaesthesiologica Scandinavica4区 · 医学

Effects of PentaLyte^® and Voluven^® hemodilution on plasma coagulation kinetics in the rabbit: role of thrombin‐fibrinogen and factor XIII‐fibrin polymer interactions

4区 · 医学

Article

作者: Nielsen, V G

Background: Hydroxyethyl starch (HES) administration has resulted in decreased hemostasis and fibrinogen (FI)‐thrombin‐(FIIa)‐Factor XIII (FXIII) interactions. I proposed to determine the hemostatic effect of hemodilution with PentaLyte® (6% HES, mean molecular weight 220 kDa) and Voluven® (6% HES, 130 kDa).Methods: Rabbits were intravenously administered 20 ml/kg PentaLyte® or Voluven® (n = 8 per fluid) over 10 min. Plasma was obtained prior to, 1 min and 1 h after hemodilution. Thrombelastography was performed, with clot initiation (R, sec), clot propagation (α, degrees), and clot strength (shear elastic modulus, G, dynes/cm2) determined over 20 min. Celite‐activated samples had either no additions or addition of FI, FIIa or activated FXIII (FXIIIa) to restore protein content to pre‐diluted values.Results and conclusions: While there were no significant differences between the groups, R significantly decreased 1 h after hemodilution compared with values observed before and 1 min after hemodilution, whereas α and G significantly decreased 1 min after hemodilution and then significantly, but only partially, increased 1 h after hemodilution compared with pre‐dilution values. Addition of FI, FIIa and FXIIIa significantly decreased R in both groups. α and G 1 min after hemodilution were significantly enhanced by FI, FIIa, FXIIIa in both groups; however, 1 h after hemodilution, rabbits administered PentaLyte® had α and G enhanced only by FI and FXIIIa addition, whereas animals administered Voluven® had α and G significantly enhanced by FI addition. PentaLyte® and Voluven® hemodilution initially diminishes FIIa‐FI and FXIIIa‐fibrin, but within an hour primarily inhibit FXIIIa‐fibrin interactions in the rabbit.

2003-10-01·The Journal of Trauma: Injury, Infection, and Critical Care

The Effect of the Bovine Hemoglobin Oxygen Therapeutic HBOC-201 on Human Neutrophil Activation In Vitro

Article

作者: Deborah L. Mueller ; Patricia S. Dixon ; Delio P. Ortegon ; Kathryn K. Crow ; Jeffrey D. Kerby

BACKGROUNDWe previously demonstrated that HBOC-201 is an efficient resuscitation fluid. However, little is known about its immunomodulatory effects. The goal of this study was to investigate human neutrophil activation after exposure to HBOC-201 and other low-volume resuscitation fluids.METHODSWhole blood from 10 healthy volunteers was serially diluted with HBOC-201, 7.5% hypertonic saline (HTS), 7.5% hypertonic saline-6% dextran 70 (HSD), Hextend, or PentaLyte. After an incubation period, samples were analyzed for oxidative burst and CD11b expression using flow cytometry.RESULTSIncreases in both CD11b and oxidative burst activity were noted in samples diluted with HBOC-201, Hextend, PentaLyte, and lactated Ringer's solution. Samples maximally diluted with HBOC-201 demonstrated increased CD11b expression when compared with lactated Ringer's solution and Hextend (196.11% vs. 22.68% and 33.97%; p = 0.018 and p = 0.033).CONCLUSIONAlthough differences were noted only at the highest dilutions, further studies investigating the effects of HBOC-201 are warranted.

100 项与 PentaLyte 相关的药物交易

登录后查看更多信息