Summit Pharmaceuticals International Corp.

CRISPR/Cas9 genome editing technology contributes to the expansion of the creation of novel disease model TOKYO & DUBLIN--(BUSINESS WIRE)-- Ricoh Company, Ltd. today announced a non-exclusive licensing agreement in the USA and Japan with ERS Genomics Limited ("ERS Genomics") for access to the foundational CRISPR/Cas9 genome editing technology patents managed by ERS Genomics. CRISPR/Cas9 stands as a breakthrough gene editing technology, enabling modification of targeted genome sequences with ease. The technology is an essential tool in drug discovery research and finds application across various fields. In 2022, Ricoh completed the acquisition of Elixirgen Scientific, Inc. (Baltimore, Maryland, USA). Elixirgen Scientific possesses core technologies in rapid and efficient differentiation*1 of human iPS cells*2, and mRNA*3 design, production, and management. We aim to predict the mechanism of action of candidate drugs for patients with varied genetic backgrounds and to improve the speed and efficiency of mRNA design by combining these core technologies with CRISPR/Cas9 genome editing technology. Through manipulations such as genetic editing of cells to enhance or diminish specific functions, it becomes possible to create highly reliable disease models, including those for rare diseases. This advancement is anticipated to lead to shorter drug development timelines and increased success rates. Ricoh has been expanding the application areas of Elixirgen Scientific's technology by leveraging our cultivated expertise in digital and artificial intelligence technologies. This initiative aims to accelerate personalized medicine*4, drug discovery research and regenerative medicine. Ricoh continues to contribute to the acceleration of drug development research through the diverse solutions provided by Elixirgen Scientific. Summit Pharmaceuticals International Corporation (Chiyoda-ku, Tokyo, Japan), a subsidiary of Sumitomo Corporation (Chiyoda-ku, Tokyo, Japan), is the exclusive representative of ERS Genomics in Japan. *1 Differentiation: The process in which a cell becomes specialized in order to perform a specific function, as in case of a liver cell, a blood cell or a neuron. *2 Induced pluripotent stem (iPS) cell: iPS cells, artificially created pluripotent stem cells, have the capability to differentiate into various cell types. *3 mRNA (messenger ribonucleic acid): mRNA is the RNA that carries the genetic information of DNA and functions as the instructions for protein synthesis. *4 Personalized medicine: Providing optimal treatment based on the individual's health status, genetic information, and other personal characteristics. View source version on businesswire.com: Contacts Dr Ben Rutter Zyme Communications Tel: +44(0)7920 770 935 Email: ben.rutter@zymecommunications.com Source: ERS Genomics View this news release online at:

PARIS & TOKYO--( BUSINESS WIRE )--Summit Pharmaceuticals International (Head Office: Chiyoda-ku, Tokyo; Chief Executive Officer: Katsuya Okuyama; hereinafter “SPI”) has signed an exclusive distributorship agreement in Japan with EVERZOM, SAS*. (hereinafter “EVERZOM”), a France-based company providing exosome manufacturing service. Exosomes are vesicles of thirty to hundreds of nanometers in size, surrounded by a lipid bilayer membrane secreted from cells, and contain proteins, microRNAs, and other substances inside. Exosomes are known to play important role as a communication mediator between cells, and have been found to have certain effects on the human body, exemplified in likes of tissue repair. Focusing on this function, exosomes are beginning to be studied/used by multiple universities, bio-tech, and pharmaceuticals for several purposes such as for the prevention of skin sagging, as well as for the treatment of joint injury, with its goal set to be established as one of the main therapeutic modalities for the next generation of breakthrough biotherapeutics. SPI has focused on the market potential of exosomes from early on, and has provided various services based on the keywords like “cells for exosome production” and “analysis and exploration of molecules encapsulated in exosomes,” etc. Now, with the addition of EVERZOM’s exosome production service, SPI is able to further support research and development of exosomes from various aspects especially for exosome manufacturing, engineering, quality control and regulatory advices. EVERZOM is a Contract Development and Manufacturing Organization (CDMO) specialized in exosomes, which spun out from the CNRS Laboratory at the University of Paris Cité in 2019. Only few CDMOS in the world are capable of producing exosomes, and EVERZOM is one of them, with having its strength in the patented technology to produce large quantities of exosomes in a short period of time by stimulating cells with turbulence, and the company is already working with several European companies on joint development with a view to future use in pharmaceutical applications. In addition, a GMP-certified manufacturing facility is scheduled to begin its operations in the fall of 2023. SPI is committed to working with EVERZOM to further promote and develop exosome research in Japanese market. *EVERZOM Website: https://everzom.com/

PARIS & TOKYO--(BUSINESS WIRE)-- Summit Pharmaceuticals International (Head Office: Chiyoda-ku, Tokyo; Chief Executive Officer: Katsuya Okuyama; hereinafter “SPI”) has signed an exclusive distributorship agreement in Japan with EVERZOM, SAS*. (hereinafter “EVERZOM”), a France-based company providing exosome manufacturing service. This press release features multimedia. View the full release here: Exosomes are vesicles of thirty to hundreds of nanometers in size, surrounded by a lipid bilayer membrane secreted from cells, and contain proteins, microRNAs, and other substances inside. Exosomes are known to play important role as a communication mediator between cells, and have been found to have certain effects on the human body, exemplified in likes of tissue repair. Focusing on this function, exosomes are beginning to be studied/used by multiple universities, bio-tech, and pharmaceuticals for several purposes such as for the prevention of skin sagging, as well as for the treatment of joint injury, with its goal set to be established as one of the main therapeutic modalities for the next generation of breakthrough biotherapeutics. SPI has focused on the market potential of exosomes from early on, and has provided various services based on the keywords like “cells for exosome production” and “analysis and exploration of molecules encapsulated in exosomes,” etc. Now, with the addition of EVERZOM’s exosome production service, SPI is able to further support research and development of exosomes from various aspects especially for exosome manufacturing, engineering, quality control and regulatory advices. EVERZOM is a Contract Development and Manufacturing Organization (CDMO) specialized in exosomes, which spun out from the CNRS Laboratory at the University of Paris Cité in 2019. Only few CDMOS in the world are capable of producing exosomes, and EVERZOM is one of them, with having its strength in the patented technology to produce large quantities of exosomes in a short period of time by stimulating cells with turbulence, and the company is already working with several European companies on joint development with a view to future use in pharmaceutical applications. In addition, a GMP-certified manufacturing facility is scheduled to begin its operations in the fall of 2023. SPI is committed to working with EVERZOM to further promote and develop exosome research in Japanese market. *EVERZOM Website: View source version on businesswire.com: Contacts Press: Florence Portejoie – Fportejoie@fp2com.fr Source: EVerZom View this news release online at: