锝[99mTc]巯替肽(Technetium (99mTc) Mercaptoacetylglycylglycylglycine) - 在研适应症：肾脏疾病，尿道疾病，结石_专利_临床

概要

基本信息

药物类型

小分子化药、诊断用放射药物

别名

99mTc-mercaptoacetylglycylglycylglycine、99mTc-mercaptoacetyltriglycine、Benzoylmercaptoacetylglycylglycylglycine

+ [9]

靶点-

作用方式

增强剂

作用机制

SPECT(单光子发射计算机断层成像术增强剂)

治疗领域

泌尿生殖系统疾病其他疾病

在研适应症

肾脏疾病尿道疾病结石+ [2]

非在研适应症-

原研机构

Curium US Holdings LLC

在研机构

Curium US Holdings LLCPDRadiopharma, Inc.

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期

美国 (1990-06-15),

结石肾功能不全尿路梗阻

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C15H17N3O6S

InChIKeyVDPYMEBVIDZKMD-UHFFFAOYSA-N

CAS号103725-47-9

关联

2

项与锝[99mTc]巯替肽相关的临床试验

NCT03107286

/ CompletedN/AIIT

Biokinetics Study for Tc-99m MAG3 Dose Reduction in Pediatric Molecular Imaging

The radiation exposure resulting from medical imaging is a topic of some concern. Nuclear medicine provides potentially life-saving information regarding physiological processes, and is of particular value in children where the rapid and unequivocal diagnosis of pathological concerns is essential for the health of these patients. The overall objective of this investigation is to optimize pediatric patient absorbed dose by keeping it as low as possible while maintaining excellent diagnostic quality of nuclear medicine images. This is particularly important since children are at increased risk due to the enhanced radiosensitivity of their tissues and the longer time-period over which radiation effects may manifest. Current dosimetric estimations in children are based on either animal biokinetic or pharmacokinetic data from adults due to paucity of data that exists for children. This situation will be improved through the following specific aims:
* Collect image-based pharmacokinetic (PK) data from patient volunteers in different age groups scheduled for routine nuclear medicine studies for Tc-99m mercaptoacetyltriglycine (MAG3), a radiopharmaceutical commonly used in pediatric nuclear medicine
* Pool and analyze the data for different age groups for each radiopharmaceuticals and
* Generate biokinetic models to be used in subsequent dosimetric models for the optimization of pediatric nuclear medicine procedures.
Since inadequate pharmacokinetic data currently exist in these patients, the investigators will use the data acquired in this study to establish PK models applicable to different age categories. Data on the pharmacokinetics of agents used in pediatric nuclear medicine are almost completely lacking. Internationally adopted dose coefficients (mSv/MBq) for pediatric nuclear medicine make age-dependent adjustments only for patient size and anatomical differences, while time-dependent kinetics from adult PK models are assumed due to the lack of kinetic data for children. The data obtained from this study will make it possible for the first time to determine how the PK in pediatric patients differs from adults. This will be done for Tc-99m MAG3, a radiopharmaceutical commonly used for pediatric nuclear medicine imaging. The overall hope is that results will allow the molecular imaging community to implement pediatric dose-reduction approaches that substantially improve upon current guidelines pointing to future technological advances that could yield even greater dose-reduction while simultaneously improving diagnostic image quality.

开始日期2018-01-02

申办/合作机构

The Children's Hospital Corp.

[+3]

NCT02975986

/ WithdrawnN/AIIT

Renal Uptake of Fatty Acids (FFA) in Patients With Idiopathic Uric Acid Nephrolithiasis (IUAN)

The investigators will test the hypothesis that renal uptake of free (i.e. non-esterified) fatty acids (FFa) is increased in iuan. To accomplish this goal the investigators will measure renal FFa uptake FFa uptake in vivo in patients with iuan and matched non-stone forming subjects via single-photon emission computed tomography (SPeCT)/CT imaging.
The definitive proof of the hypothesis rests on whether increased renal FFa uptake is demonstrable in humans with iuan.

开始日期2017-01-01

申办/合作机构

The University of Texas Southwestern Medical Center

[+1]

100 项与锝[99mTc]巯替肽相关的临床结果

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100 项与锝[99mTc]巯替肽相关的转化医学

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100 项与锝[99mTc]巯替肽相关的专利（医药）

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115

项与锝[99mTc]巯替肽相关的文献（医药）

2024-06-01·Radiological physics and technology

Feasibility study of radioactivity estimation of 99mTc and 123I-labeled radiopharmaceuticals using shielded syringes

Article

作者: Nakamura, Yuto ; Yasuno, Narumi

This study investigates the feasibility of estimating the radioactivity of radiopharmaceuticals using shielded syringes. The radioactivities of ^99mTc-MDP, ^99mTc-HMDP, ^99mTc-ECD, ^99mTc-MAG₃, and ¹²³I-IMP were measured using a dose calibrator. Correlation coefficients and regression equations were obtained from the radioactivity in the shielded and unshielded syringes. ^99mTc-MDP was also measured for residual radioactivity after the administration. The correlation coefficients of ^99mTc-MDP, ^99mTc-HMDP, ^99mTc-ECD, ^99mTc-MAG₃, and ¹²³I-IMP were r_s = 0.9998, r_s = 0.9997, r_s = 0.9999, r_s = 0.9998, and r_s = 0.9888, respectively. The regression equations were y = 0.0364x + 0.0913, y = 0.0349x + 0.0273, y = 0.0343x - 0.0018, y = 0.0522x + 0.1215, and y = 0.0383x + 0.0058, respectively. The correlation coefficient for the residual radioactivity of ^99mTc-MDP was r_s = 0.9887 and the regression equation was y = 0.1505x + 0.0853. The radioactivity of ^99mTc- and ¹²³I-labeled radiopharmaceuticals in shielded syringes was accurately measured. It was suggested that the measuring shielded syringes could provide an estimate of the actual radioactivity.

2019-12-01·Nuklearmedizin. Nuclear medicine4区 · 医学

Comparison of glomerular filtration rate (GFR) with Tc-99m-DTPA and tubular extraction rate (TER) with Tc-99m-MAG3 in potential living kidney donors: Feasibility of a one-day protocol

4区 · 医学

Article

作者: Jaeschke, Erika ; van der Giet, Markus ; Brenner, Winfried ; Bamm, Marita ; Rogasch, Julian M. M. ; Schatka, Imke ; Bäder, Michael ; Amthauer, Holger

Abstract:

Aim Sufficient glomerular filtration rate (GFR) is mandatory in living kidney donors (LKD) before renal transplantation (RT). Guidelines recommend exogenous GFR (e. g. Tc-99m-DTPA) besides estimated GFR by plasma creatinine (eGFR). Tc-99m-MAG3 determines split function and tubular extraction rate (TER). This study evaluated a time-efficient one-day protocol for DTPA and MAG3 in potential LKD. Methods Retrospective analysis of 82 consecutive potential LKD (female, 52; age, 54 [19–73] a). DTPA GFR (Fleming formula) with blood sampling 169 (147–205) min post injection of 27 (18–59) MBq Tc-99m-DTPA. 199 (181–219) min after DTPA injection, same-day renal scintigraphy with 105 (65–150) MBq MAG3 followed (TER according to Bubeck). Sufficient GFR for RT was defined age- and sex-dependent based on British guidelines, normal TER at 70 % of age-dependent average. In 15 separate potential LKD, a blank blood sample before MAG3 injection allowed estimation of remaining DTPA counts and resulting TER error. Results Remaining Tc-99m-DTPA blood counts during sampling for MAG3 led to median TER underestimation by 12 (IQR, 8–15) ml/min/1.73 m2. Before blood count correction, 16/82 patients had reduced TER despite sufficient GFRFleming in 13/16 patients. After correction, TER remained reduced in 9/82 patients who all had sufficient GFRFleming. 10/82 patients had insufficient eGFR (CKD-EPI) but sufficient GFRFleming. Correlation coefficient for TER and GFRFleming was ρ = 0.76, for eGFR and GFRFleming ρ = 0.61, and for TER and eGFR ρ = 0.55. Conclusion A one-day protocol for Tc-99m-DTPA GFR and MAG3 dynamic imaging is feasible. If TER is calculated, the proposed method for blood count correction may be applied. However, relevance of the TER remains questionable due to frequent discordance to GFR.

2015-09-01·Seminars in nuclear medicine2区 · 医学

Pitfalls and Limitations of Radionuclide Renal Imaging in Adults

2区 · 医学

Review

作者: Keramida, Georgia ; Prescott, Mary C ; James, Jacqueline M ; Peters, Adrien Michael

To understand pitfalls and limitations in adult renography, it is necessary to understand firstly the physiology of the kidney, especially the magnitude and control of renal blood flow, glomerular filtration rate and tubular fluid flow rate, and secondly the pharmacokinetics and renal handling of the three most often used tracers, Tc-99m-mercaptoacetyltriglycine (MAG3), Tc-99m-diethylene triamine pentaacetic acid (DTPA) and Tc-99m-dimercaptosuccinic acid (DMSA). The kidneys may be imaged dynamically with Tc-99m-MAG3 or Tc-99m-DTPA, with or without diuretic challenge, or by static imaging with Tc-99m-DMSA. Protocols are different according to whether the kidney is native or transplanted. Quantitative analysis of dynamic data includes measurement of renal vascularity (important for the transplanted kidney), absolute tracer clearance rates, differential renal function (DRF) and response to diuretic challenge. Static image reveals functional renal parenchymal damage, both focal and global, is useful in the clinical management of obstructive uropathy, renal stone disease and hypertension (under angiotensin converting enzyme inhibition), and is the preferred technique for determining DRF. Diagnosis based on morphological appearances is important in transplant management. Even though nuclear medicine is now in the era of hybrid imaging, renal imaging remains an important subspecialty in nuclear medicine and requires a sound basing in applied physiology, the classical supporting discipline of nuclear medicine.

100 项与锝[99mTc]巯替肽相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
肾脏疾病	日本	PDRadiopharma, Inc.	1994-01-19
尿道疾病	日本	PDRadiopharma, Inc.	1994-01-19
结石	美国	Curium US Holdings LLC	1990-06-15
肾功能不全	美国	Curium US Holdings LLC	1990-06-15
尿路梗阻	美国	Curium US Holdings LLC	1990-06-15

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


SNMMI2020	N/A	-	-	Tc-99m MAG3	淵製衊衊憲鹽鏇鹽壓簾(憲齋糧鹽築蓋獵選艱鹹) = 構衊觸構製壓艱艱醖鏇積鑰觸築醖選範壓繭網 (壓選獵鹹製鏇餘構積積 )	-	2020-05-15
				Furosemide (Lasix)	淵製衊衊憲鹽鏇鹽壓簾(憲齋糧鹽築蓋獵選艱鹹) = 顧顧積鑰製構憲淵構鑰積鑰觸築醖選範壓繭網 (壓選獵鹹製鏇餘構積積 )
EANM2017	N/A	消化系统疾病	49	99m Tc-MAG3 (Adult patients)	襯襯壓鹹範範構遞鏇範(製觸齋構鏇網範鹹積築) = 鑰糧蓋顧簾憲膚鏇餘窪憲襯壓簾糧顧鹹壓淵鏇 (鑰艱網遞觸築鹹膚鏇觸 )	不佳	2017-09-11
				99m Tc-MAG3 (Pediatric patients)	襯襯壓鹹範範構遞鏇範(製觸齋構鏇網範鹹積築) = 選繭築襯襯醖願窪顧選憲襯壓簾糧顧鹹壓淵鏇 (鑰艱網遞觸築鹹膚鏇觸 )
SNMMI2017	N/A	肾积水	-	F-15 furosemide Tc9Tc99m-MAG3 (F-15 Renogram with Tc99m-MAG3)	願製膚製網鬱築壓鏇鹽(願壓淵鬱獵顧鏇築壓鏇) = 願遞願廠窪艱壓憲鏇繭夢夢襯襯醖鏇鏇顧糧遞 (構鹽願鑰積衊繭繭齋淵 ) 更多	-	2017-05-24
EANM2016	N/A	-	10	Tc-MAG3 (Newborn patients)	淵觸窪膚鹹繭願襯糧網(網鬱繭鹽糧夢製簾積鏇) = 廠憲範蓋衊簾壓顧膚遞積餘獵鏇觸廠選願窪餘 (艱鹽鏇鑰願衊壓襯憲遞 ) 更多	-	2016-09-21
				Tc-MAG3 (1-year-old patients)	淵觸窪膚鹹繭願襯糧網(網鬱繭鹽糧夢製簾積鏇) = 夢餘構鬱鑰衊衊艱簾範積餘獵鏇觸廠選願窪餘 (艱鹽鏇鑰願衊壓襯憲遞 ) 更多
SNMMI2014	N/A	-	-	99 Tc m -MAG3 (Phantom 1)	網鏇選膚顧遞艱淵選餘(網淵鹽齋窪製艱遞淵鏇) = 鏇鹹獵簾衊憲製鏇範膚選繭鹹觸襯壓夢艱築簾 (鹹範顧獵醖齋艱網衊願, 46 ~ 60)	-	2014-11-05
				99 Tc m -MAG3 (Phantom 2)	網鏇選膚顧遞艱淵選餘(網淵鹽齋窪製艱遞淵鏇) = 艱範鹽壓築憲積積網糧選繭鹹觸襯壓夢艱築簾 (鹹範顧獵醖齋艱網衊願, 34 ~ 43)
EANM2010	N/A	可见病灶 \| 膀胱输尿管返流	-	mercaptoacetyltriglycine (Fluoroscopic cystourethrography (FC))	夢鬱餘鑰觸鑰繭淵築繭(鹹選積鹽餘鏇鬱膚蓋繭) = 夢構積遞構壓願襯淵廠鏇襯製觸網廠選淵顧觸 (製壓蓋淵選淵網鏇獵糧 )	积极	2010-10-10
				mercaptoacetyltriglycine (Tc-99m MAG3 scintigraphy)	淵顧繭積夢廠繭積製積(餘遞鹹鹽壓繭廠簾觸艱) = 夢廠鬱鹹夢糧艱艱觸選鹹顧願衊窪範選顧壓顧 (繭襯餘蓋製獵鹹鹽願壓 )
EANM2007	N/A	可见病灶	29	Tc-99m-Mercaptoacetyltriglycine	夢艱範選壓築構鑰糧範(鹹齋構鏇淵繭獵壓衊積) = 齋窪襯廠遞製齋網鹹艱糧膚鑰夢網鏇餘齋遞壓 (製窪鏇齋壓積膚憲簾願 )	-	2007-10-15
				Tc-99m-Dimercaptosucsinic Acid	夢艱範選壓築構鑰糧範(鹹齋構鏇淵繭獵壓衊積) = 製艱廠選願衊齋鬱願鹹糧膚鑰夢網鏇餘齋遞壓 (製窪鏇齋壓積膚憲簾願 )
EANM2007	N/A	-	18	Tc-MAG-3 (Control (normothermic))	糧願願淵夢鑰衊夢憲製(積膚構構觸築襯選遞鬱) = 襯壓選淵築遞齋獵廠艱窪鏇夢選醖膚蓋獵遞鏇 (顧糧艱夢壓淵範遞積壓 ) 更多	-	2007-10-15
				Tc-MAG-3 (Hyperthermic (2°C higher))	糧願願淵夢鑰衊夢憲製(積膚構構觸築襯選遞鬱) = 遞淵觸網顧網簾範壓艱窪鏇夢選醖膚蓋獵遞鏇 (顧糧艱夢壓淵範遞積壓 ) 更多