Evaluation of the Necessity of Long-term Pharmacological Treatment With Antipsychotics for the Prevention of Relapse in Long-term Stabilized Schizophrenic Patients: a Randomized, Single-blind, Longitudinal Trial

The main objective of the trial is to evaluate, how long an antipsychotic relapse-prevention should be continued and to which time a patient with schizophrenia is protected enough, so that a withdrawal or reduction of the medication seems appropriate. Relapse is defined as primary outcome.

开始日期2015-02-01

申办/合作机构

Technische Universität München

100 项与培拉嗪丙二酸氢盐相关的临床结果

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100 项与培拉嗪丙二酸氢盐相关的转化医学

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100 项与培拉嗪丙二酸氢盐相关的专利（医药）

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项与培拉嗪丙二酸氢盐相关的文献（医药）

2021-04-30·Psychiatria Polska4区 · 医学

Fałszywie dodatnie wyniki testów narkotykowych u pacjentów przyjmujących leki psychotropowe – przegląd literatury

4区 · 医学

Review

作者: Padała, Olga ; Masternak, Sebastian ; Karakuła-Juchnowicz, Hanna

2016-12-01·Arthritis Research & Therapy2区 · 医学

Screening for peptides targeted to IL-7Rα for molecular imaging of rheumatoid arthritis synovium

2区 · 医学

ArticleOA

作者: Sauvage, Sébastien ; Devalckeneer, Aude ; Burtea, Carmen ; Muller, Robert N ; Beckers, Marie-Claire ; Salmon, Isabelle ; Vander Elst, Luce ; Sanli, Tuba ; Laurent, Sophie ; Fanfone, Deborah ; Lauwerys, Bernard R ; Rorive, Sandrine

BACKGROUNDInterleukin-7 receptor alpha (IL-7Rα) represents a biomarker with potential applications in rheumatoid arthritis (RA) diagnosis and therapy. We have therefore searched by phage display potential IL-7Rα specific peptides with the primary goal being to develop in vivo molecular imaging tools.METHODSIL-7Rα-targeted peptides were searched within a disulfide-constrained combinatorial phage displayed library of random linear heptapeptides. The apparent dissociation constant (K_d) and half maximal inhibition constant (IC₅₀) were estimated for phage clones and synthesized peptides by ELISA. We used 5-Aza-2'-deoxycytidine (ADC)-stimulated Jurkat cells and human synovial tissue from patients with RA for in vitro characterization of peptides. For molecular imaging studies performed by magnetic resonance imaging (MRI), experimental arthritis was induced in DBA/1 male mice by immunization with an emulsion of complete Freund's adjuvant and type II collagen from chicken sternal cartilage.RESULTSAfter several steps of phage display and peptide screening, two IL-7Rα-specific heptapeptides (P258 and P725) were selected from the initial library, based on their affinity for the target (extracellular domain of IL-7Rα, which contains a fibronectin type III repeat-like sequence). P258 (a linear peptide obtained by removing the Cys-constraint) had the lowest affinity for fibronectin itself and was therefore proposed for molecular imaging. After grafting to ultra-small superparamagnetic particles of iron oxide (USPIO), P258 produced a strong negative contrast on MRI in mice with collagen-induced arthritis (CIA), even at 2 hours post injection. The co-localization of USPIO-P258 with IL-7Rα-expressing cells in the synovial tissue from CIA mice and its ability to discriminate the level of IL-7R expression and the disease severity confirmed its efficacy as an in vivo IL-7Rα imaging agent. Interestingly, the cyclic peptide (P725), which was less adequate for molecular imaging because of higher affinity for fibronectin, had a strong ability to compete with IL-7 for the IL-7Rα binding sites, making it a potential candidate for blocking applications. Accordingly, P725 prevented the signal transducer and activator of transcription 5 (STAT5) activation induced by IL-7 in ADC-stimulated Jurkat cells.CONCLUSIONSThe two peptides identified in this work demonstrate that IL-7Rα targeting in RA presents potential applications for in vivo molecular imaging and putative blocking purposes.

1980-01-01·Archiv der Pharmazie

Bestimmung der Bindung von Perazin und Perazinsulfoxid an Humanserumalbumin

Article

作者: Hassan Mohamed‐Ali ; Abdelwahab Kinawi ; Brigitte Lüth

100 项与培拉嗪丙二酸氢盐相关的药物交易

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