A Randomized, Double-Blind, Controlled, Clinical Trial to Evaluate the Risk of Developing Essential Fatty Acid Deficiency in Pediatric Patients, Including Neonates, Receiving Either Clinolipid (Lipid Injectable Emulsion, USP) 20% or Standard-of-Care Soybean Oil-Based Lipid Emulsion (Part A)

This will be a descriptive study designed to evaluate the propensity for hospitalized pediatric patients treated adequately with Clinolipid or standard of care (Intralipid) from 7 up to 90 days to develop Essential Fatty Acid Deficiency (EFAD). Additionally, this study design will evaluate the safety and efficacy of using Clinolipid or Intralipid in a pediatric population.

开始日期2021-01-22

申办/合作机构

Baxter Healthcare Ltd

NCT02476994 / Terminated临床4期

This will be a descriptive study designed to evaluate the propensity for hospitalized pediatric patients treated adequately with Clinolipid or standard of care for up to 90 days to develop Essential Fatty Acid Deficiency (EFAD). Additionally, this study design will evaluate the safety and efficacy of using Clinolipid in a pediatric population.

开始日期2015-05-01

申办/合作机构

Baxter Healthcare Ltd

100 项与 Olive oil;Soybean oil 相关的临床结果

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100 项与 Olive oil;Soybean oil 相关的转化医学

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100 项与 Olive oil;Soybean oil 相关的专利（医药）

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4,404

项与 Olive oil;Soybean oil 相关的文献（医药）

2024-02-15·Heliyon

Possible effects of cannabidiol (CBD) administration on the vocal activity of healthy domestic dogs upon their temporary separation from caregivers.

Article

作者: Nobuo Masataka

Recent human clinical studies indicate that cannabidiol (CBD), the primary non-addictive component of cannabis, possesses considerable therapeutic potentials. The purpose of the present study was to explore the possibility of effects of CBD administration on behaviors of healthy domestic dogs. It is well-known that when temporarily separated from their caregivers, they may show an increase in vocalization. Here the effects of CBD administration upon such vocal activity were assessed. Ten 4- to 7-year-old healthy dogs experienced temporary separation from their caregivers twice, once following the administration of CBD at 2.0 mg/kg/day over a 2-week-period, and once following the administration of the same amount of olive oil as placebo over the same length of period. When the behavioral assessment was conducted by computing the total duration of any vocal activity exhibited by the dogs before the separation from their caregivers and after the separation, it was found that all of the 10 participant dogs vocalized more often when being left alone (after the separation) than when being with their caregivers (before the separation), whether they had received the administration of CBD or placebo. Following the CBD administration, however, the degree of such increase was significantly less robust than that following the placebo administration (p < 0.01). As one of the possible explanations for the results. the author hypothesizes anxiolytic effects of CBD in healthy domestic dogs, as has been reported in humans.

2024-02-12·Current aging science

Neuroprotective Effects of Curcumin against Chronic ChlorpyrifosInduced Oxidative Damage in Rat Brain Tissue.

Article

作者: Tahereh Farkhondeh ; Mahmoud Zardast ; Shahnaz Rajabi ; Mahdi Abdollahi-Karizno ; Babak Roshanravan ; Jalal Havangi ; Michael Aschner ; Saeed Samarghandian

BACKGROUND:

Chlorpyrifos (CPF) is an organophosphate pesticide that inhibits acetylcholinesterase (AChE) activity. Investigations have also focused on its neurotoxicity, which is independent of AChE inhibition. Here, we evaluated the effect of CPF on oxidative indices in the brain tissue and explored the protective effect of curcumin (Cur) against its toxicity.

METHODS:

Forty male Wistar rats were divided into five groups, each consisting of eight rats (n = 8) per group. Animals were administrated by oral gavage for 90 days with the following treatments: control (C), CPF, CPF + CUR 25 mg/kg, CPF + CUR50, and CPF + cur 100 received olive oil, CPF, CPF plus 25 mg/kg of CUR, CPF plus 50 mg/kg of CUR, and CPF plus 100 mg/kg of CUR, respectively. After anesthetization, animal brain tissues were obtained for assessment of oxidative stress indices.

RESULTS:

The concentration of MDA significantly increased in the brains of the CPF group as compared to the control group (p < 0.01). Also, a significant decrease in MDA concentrations was observed in the brains of rats in the CPF + Cur 100 group compared to the CPF group (p < 0.05). A significant decrease was noted in the GSH concentration in the brains of the CPF group compared to the control group (p < 0.05). Treatment with Cur at 100 mg/kg exhibited a significant increase in GSH concentrations in the brains of the CPF-exposed group compared to the CPF group without Cur administration (p < 0.05). The concentration of NO exhibited a significant increase in the brains of the CPF group when compared to the control group (p < 0.05). Also, a significant decrease in NO concentration was observed in the brain tissue of the CPF + Cur 100 group compared to the CPF group (p < 0.05).

CONCLUSION:

Our data establish that chronic exposure to CPF induced oxidative stress in brain tissue, which was reversed by CUR administration. Additional experimental and clinical investigations are needed to validate the efficacy of CUR as a potential antidote for CPF poisoning.

2024-02-08·Journal of the science of food and agriculture

Partial replacement of saturated fats in liver Pâté by an olive Oil-in-Water emulsion containing β-Glucan shows No compromise in sensory and storage oxidation of lipids and protein.

Article

作者: Marzena Zając ; Mirosław M Kasprzak ; Joanna Tkaczewska ; Wiktor Berski ; Anna Stępień ; Charles Odilichukwu R Okpala ; Jacek Domagała

BACKGROUND:

The consumption of olive oil has been shown to have a positive effect on preventing obesity and hypertension. At the same time, it is recommended to avoid processed meat products as they contain saturated fats. The inclusion of highly unsaturated lipids in food products can lead to rapid oxidation and deterioration of sensory characteristics. The objective of the current work was to encapsulate olive oil and incorporate it into traditional Polish liver pâté. The oil-in-water emulsions were formulated with varying levels of oat β-glucan and were evaluated for droplet size, pH, encapsulation efficiency and rheology. The liver pâtés made using the emulsions with and without β-glucan were then evaluated for pH, texture, colour, lipid and protein oxidation, thermal stability and sensory properties.

RESULTS:

The results allowed to show that the oil-in-water emulsions had a 100% encapsulation rate of olive oil after 30 days of storage at 4°C, regardless of the presence of β-glucan. Although the texture of the emulsion-enriched liver pâté was different from the control, this difference was reduced when β-glucan was added to the emulsion and then to the pâté matrix.

CONCLUSION:

Replacing 50% of animal fat with an olive oil emulsion enriched with β-glucan did not result in any compromise of sensory properties, increase lipid or protein oxidation. These results suggest that it is possible to replace saturated lipids with omega-3 rich olive oil. This article is protected by copyright. All rights reserved.

项与 Olive oil;Soybean oil 相关的新闻（医药）

2023-11-13

·PRNewswire

North American Olive Oil Association Announces Nation's Most Comprehensive Olive Oil Testing Study

Effort to Bolster Consumer Confidence as Heat and Drought Conditions Raise Prices NEPTUNE, N.J., Nov. 13, 2023 /PRNewswire/ -- The North American Olive Oil Association (NAOOA), whose members represent over half the olive oil sold in the United States, today announced plans to commission the nation's most comprehensive, rigorous olive oil testing study to date. In the spirit of collaboration, NAOOA has invited other industry stakeholders to provide both strategic and financial support for this important project. The announcement comes as drought in Europe and elsewhere in the Mediterranean has caused lower yields and tightening global olive oil supplies. These market conditions are expected to keep olive oil prices at historic highs for the coming months. In light of these circumstances, the NAOOA testing study is intended to further strengthen consumer confidence in the authenticity and quality of the olive oil they buy. "Our industry has successfully undertaken an ambitious, years-long effort to significantly improve the quality of olive oil in the American marketplace. As a result, consumers today can have tremendous confidence in the integrity of the olive oil available in U.S. stores," said Joseph R. Profaci, executive director of the NAOOA. "As prices climb due to current market conditions, we think it's even more important to assure consumers that they're getting the quality and authenticity they deserve. That's why we're launching this testing effort, which sets a new, even higher standard for our industry. The NAOOA has conducted random, off-the-shelf testing of both members' and non-members' products for years, but this study will vastly broaden those efforts." This study's aim is to create a new benchmark for olive oil testing, further strengthening the quality of olive oil industrywide. The NAOOA has asked Tassos C. Kyriakides, Ph.D., assistant professor of biostatistics at the Yale School of Public Health, to design and oversee a sampling protocol that will set the standard for the industry, with the following proposed elements: Largest Sample Size: The program will test over 200 samples, which is more than any single domestic study conducted previously. Retail Samples: The program will test olive oil purchased directly from supermarkets and other retail outlets – not from samples supplied directly from producers. Foodservice Samples: The program will sample olive oils from wholesalers who supply restaurants and other foodservice outlets. Geographic Diversity: Olive oils will be tested proportionately from across the country to reflect geographic distribution. Branded and Private Label: The testing will encompass both proprietary brands and private label products. Sampling by Independent Sampling Agencies: The sampling will be conducted by independent sampling agencies unaffiliated with the olive oil industry in accordance with strict protocols based on regulatory guidance. Testing in Independent, Accredited Lab: The testing will be conducted in an independent lab accredited by the International Olive Council (IOC), an organization chartered by the United Nations more than 60 years ago to oversee standards for the production and quality of olive oil around the world. Full Physico-Chemical and Organoleptic Testing: Each sample will be subject to full chemical and organoleptic (sensory) testing of all parameters that are included in the proposed federal standard of identity for olive oil (including PPP and DAGs). Inclusive of All Grades: The study will test all olive oil grades and types commonly available to U.S. consumers (i.e., extra virgin, regular and light-tasting). "Olive oil is one of the healthiest foods people can eat, but consumers who lack confidence in it will sadly turn to other, less healthful oils," said Dr. Kyriakides. "That's why this testing program is so important. It's designed to test olive oil at a scale and level of transparency never seen before, so consumers can continue to feel great about buying this incredibly healthy food." The testing program will begin sampling in early 2024 to coincide with the first major shipments of olive oil from the most recent northern hemisphere growing season. The study is being announced in advance in part to deter any potential misconduct by bad actors seeking to capitalize on current market conditions. For any oil that fails to meet authenticity standards, the NAOOA intends to notify the responsible parties and take any responsive actions deemed appropriate under the circumstances, up to and including notification of government authorities and/or initiating direct legal action. Despite current market conditions, olive oil continues to deliver tremendous value for consumers. Olive oil supports heart and brain health and can protect against a host of diseases from certain cancers to dementia. Olive oil is also good for the planet, as it's produced from a permanent crop (i.e., a long-living tree versus a crop that has to be replanted every year) with relatively low water requirements. The global production of olive oil absorbs the carbon emissions of a city of 7 million people every year. About the North American Olive Oil Association The North American Olive Oil Association is committed to supplying North American consumers with quality products in a fair and competitive environment; to fostering a clear understanding of the different grades of olive oil; and to expounding the benefits of olive oil in nutrition, health, and the culinary arts. Contact: [email protected] SOURCE North American Olive Oil Association

2021-06-18

·GlobeNewswire

Specialized Formula Medical Nutrition Market to Grow at an

New York, US, June 18, 2021 (GLOBE NEWSWIRE) -- Straits Research has recently added a new report on the global specialized formula medical nutrition market which is expected to grow at a 6.84 % CAGR during the forecast period 2021 to 2029. The rise in prevalence of chronic diseases such as cancer, diabetes, cardiovascular diseases, Coronary Obstructive Pulmonary Disorders (COPD), along with the rising geriatric population, growing prevalence of preterm births, and accelerated demand for home healthcare is expected to drive the growth of the global specialized formula medical nutrition market Specialized medical nutrition formulas are therapeutic compositions specifically formulated for the dietary management of patients. Technological advancements in diagnostic processes, improvement in the hospital infrastructure, and post-delivery extra care are some of the factors fueling the demand for different medical nutrition products. Download Report (PDF with Insights, Charts, Tables, Figures) @ Further, manufacturers are paying close attention to rising consumer concerns regarding growing nutritional requirements. Increasing risk of chronic illnesses at the older age and malnutrition prevalence in developing countries has compelled market players to come up with products to meet individual nutritional needs. For instance, in 2019, Baxter International Inc. announced the launch of Clinolipid (20% Lipid Injectable Emulsion) in the U.S. in 2019 at the ASPEN Nutrition Science & Practice Conference. The product is aimed at diversifying the parenteral nutrition (PN) product portfolio and help malnourished patients. Specialized Formula Medical Nutrition Market by Type COVID-19 Scenario COVID-19 has modified the way we function. Isolation and Stay-Put Orders have pushed the general populace to adopt a digitally-dependent lifestyle. - The COVID-19 pandemic had a significant impact on the on market trade segment and medical nutrition Industry. - Medical nutrition products manufacturers and best supplement manufacturers usa are comprehending strategies to revive from the current situation by means of reshaping their sales channels as well as product innovation. - The duration of the virus outbreak remains a key factor in assessing the overall impact of the pandemic. However, the global Specialized Formula Medical Nutrition and Shaver industry is expected to stabilize after 2021. Key Highlights of Advanced Medical Nutrition Get Details Insight @ Growing Geriatric Population Supported by Rising Prevalence of Lifestyle Paddles the Wheels of Global Market The geriatric population has been rising around the world. For instance, as per the World Health Organization (WHO) reports: » The global population aged 60 years and above is expected to cross 2 billion by 2050, up from 900 million in 2015. » By 2050, China alone is expected to be home to 120 million people aged 80 years and older, whereas the global geriatric population is expected to surpass 434 million. Thus, this generates a constant yet high demand for therapeutic and management options. How Big is the American Market in Terms of Revenue? The analysis indicates that the Americas' regional market has the largest adoption of specialized formula medical nutrition for all applications. Thus, the market generates the highest revenue with a sizeable market share amongst all regions in the global market. The number of new cancer cases is forecasted to grow by 70% during 2025 and 2035, as per WHO Statistics, 2019. Moreover, the rise in the women workforce is driving the demand for infant specialized nutrition products. In 2018, 75,978,000 women were present in the labor force, accounting for 46.9% of the total workforce in the U.S., according to the Catalyst organization. Lack of time to feed the infant and work lifestyle has compelled women to opt for high nutritional products for their children. Get Regional Analysis and Trends @ Detailed Table of Content 1 Introduction 2 Clinical Management Systems Methodology 2.1 Primary Research 2.2 Research Methodology 2.3 Assumptions & Exclusions 2.4 Secondary Data Sources 3 Market Overview 3.1 Report Segmentation & Scope 3.2 Value Chain Analysis: Global Specialized Formula Medical Nutrition Market 3.3 Key Market Trends 3.3.1 Drivers 3.3.2 Restraints 3.3.3 Opportunities 3.4 Porter’s Five Forces Analysis 3.7 Impact of COVID-19 on Global Specialized Formula Medical Nutrition Market4 Type Overview 4.1 Introduction 4.2 Infant Medical Nutrition Products 4.3 Enteral Medical Nutrition Products 4.4 Parenteral Medical Nutrition Products 5 Application Overview 5.1 Introduction 5.2 Adult 5.3 Geriatric 5.4 Pediatric/Infants 6 Regional Overview 6.2 North America 6.3 Europe 6.4 Asia Pacific 6.5 Middle East & Africa 7 Company Profile 7.1 Abbott Laboratories 7.2 B. Braun Melsungen AG 7.3 Fresenius Kabi AG 7.4 Danone Nutricia 7.5 Medifood GmbH 7.6 Mead Johnson & Company LLC 7.7 Others We have provided a detailed analysis on the specialized formula medical nutrition market with medical nutrition products countries, including world's best nutrition company in U.S., vitamin manufacturing companies in Canada, Mexico, advanced medical nutrition in Germany, France, medical nutrition products in U.K, Italy, patient nutrition in hospital in Japan, food supplement factory in Australia, China, Pakistan, India, the Philippines, Spain, Turkey, Netherlands, vitamin manufacturers in Russia, South Africa, Brazil, and Argentina. Specialized Formula Medical Nutrition Market: Information by Type (Infant Medical Nutrition Products), Application (Pediatric/Infants, Geriatric), and Region — Forecast till 2029 Buy Full Research Report @ Similar Reports We Have on Healthcare IT MMA Equipment, Merchandise, and Nutrition Market: Information by Product (Equipment, Nutrition, and Merchandise) and Region — Forecast till 2029 Oncology Nutrition Market: Information by Cancer Type (Head, Blood, Pancreas, Breast, Neck, and Stomach and Gastrointestinal Cancer), and Region-Forecast till 2029 Cereal Bar Market: Information by Type (Breakfast Bar, Snacks Bar, Health and Wellness Bar, Energy and Nutrition Bar), Composition, Packaging, Sales Channel), and Region — Forecast till 2029 Dietary Supplements Market: Information by Form (Soft Gel/ Pills, Liquid), Application (Sports Nutrition, Weight Loss), Ingredient, End-Use, Sales Channel, and Region — Forecast till 2029 Nutraceutical Products Market: Information by Type (Dietary Supplements, Functional Beverages, Functional Food), Form, Distribution Channel, and Region — Forecast Till 2027 Personalized Medicine Market: Information by Type and Application with Study, Opportunities, & Forecast till 2029 About Straits Research StraitsResearch is a market intelligence company providing global business information reports and services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insight for thousands of decision makers. Straits Research provides the actionable market research data specially designed and presented for the decision making and ROI. Regardless of whether you're looking at business sectors in the next town or crosswise over continents, we understand the significance of being acquainted with what customers purchase. We overcome the issues of our customers by recognizing and deciphering just the target group, while simultaneously generating leads with the highest precision. We seek to collaborate with our customers to deliver a broad spectrum of results through a blend of market and business research approaches. So let's put our minds together. We'll make your vision a reality and help you grow.

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100 项与 Olive oil;Soybean oil 相关的药物交易

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研发状态

适应症	最高研发状态	国家/地区	公司
膳食补充剂	批准上市	美国更多	Baxter Healthcare Corp. 更多

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临床结果

适应症

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04555044 (CTgov)	临床4期	必需脂肪酸缺乏症	101	Clinolipid (Clinolipid (Lipid Injectable Emulsion) 20%)	糧憲艱簾繭顧鏇鏇窪網(構醖膚衊鏇遞網範簾憲) = 鹹襯襯網遞糧齋簾齋繭繭蓋壓襯窪鑰艱鹽壓觸 (構襯繭獵製簾衊廠糧顧, 構鏇鹹鹹鏇選淵鹹鑰齋 ~ 網顧襯淵鑰範構鹹鑰築) 更多	-	2023-12-27
				Intralipid (Intralipid (SOC Soybean Oil-based Lipid Emulsion))	糧憲艱簾繭顧鏇鏇窪網(構醖膚衊鏇遞網範簾憲) = 築鑰窪壓鏇糧構憲壓獵繭蓋壓襯窪鑰艱鹽壓觸 (構襯繭獵製簾衊廠糧顧, 網齋餘衊積願積艱選衊 ~ 遞艱鹹鑰製糧衊壓艱選) 更多
NCT02476994 (CTgov)	临床4期	必需脂肪酸缺乏症	1	Clinolipid (Clinolipid (Lipid Injectable Emulsion, USP) 20%)	構艱廠鑰窪構繭築艱齋(醖衊淵鑰醖鹽醖艱廠窪) = 範築觸鬱顧憲顧窪願廠齋廠獵鬱觸膚鹹壓糧選 (齋鹹鹽選網獵積顧餘衊, 遞構壓繭網糧選鑰網憲 ~ 廠壓淵淵齋築醖鏇製齋) 更多	-	2017-12-05
				Intralipid (Intralipid 20% (Lipid Injectable Emulsion, USP))	構艱廠鑰窪構繭築艱齋(醖衊淵鑰醖鹽醖艱廠窪) = 鏇鏇膚網獵獵餘獵獵憲齋廠獵鬱觸膚鹹壓糧選 (齋鹹鹽選網獵積顧餘衊, 齋鏇鑰衊鏇鬱鑰簾膚繭 ~ 簾鏇網憲簾觸憲遞廠衊) 更多
PREDIMED (Pubmed \| Am J Kidney Dis)	N/A	-	785	MedDiet + olive oil	(淵齋築繭積壓壓醖蓋夢) = 夢選築壓醖繭齋簾願艱壓觸鏇餘繭選蓋衊艱顧 (鏇構餘蓋壓艱鏇鬱範齋, 3.2 ~ 6.2)	不佳	2012-09-01
				Mediterranean Diets (MedDiet + nuts)	(淵齋築繭積壓壓醖蓋夢) = 齋齋壓鏇製簾構簾衊齋壓觸鏇餘繭選蓋衊艱顧 (鏇構餘蓋壓艱鏇鬱範齋, 1.9 ~ 5.0)