Drotaverine acephyllinate(Drotaverine acephyllinate) - 药物靶点：nAChRα1/β1/δ/γ_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Depogen

靶点

nAChRα1/β1/δ/γ

作用方式

拮抗剂

作用机制

AChR拮抗剂(乙酰胆碱受体α1/β1/δ/γ复合体拮抗剂)

治疗领域

心血管疾病

在研适应症-

非在研适应症

外周血管疾病

原研机构

Sanofi

在研机构-

非在研机构

Nippon Zoki Pharmaceutical Co. Ltd.

SanofiChinoin Zrt.

权益机构-

最高研发阶段终止临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C33H41N5O8

InChIKeyOUKQYSCCWVCDKU-UHFFFAOYSA-N

CAS号61954-97-0

关联

100 项与 Drotaverine acephyllinate 相关的临床结果

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100 项与 Drotaverine acephyllinate 相关的转化医学

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100 项与 Drotaverine acephyllinate 相关的专利（医药）

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50

项与 Drotaverine acephyllinate 相关的文献（医药）

2018-12-01·Molecular Catalysis

Domino reactions of vinyl ethynyl ketones with 1-aryl-3,4-dihydroisoquinolines — Search for selectivity

作者: Alexander Golovanov ; Leonid Voskressensky ; Alexey Varlamov ; Tatiana Borisova ; Alexander Titov ; Ahmad Shaabani ; Arina Obydennik ; Maria Matveeva

An efficient domino reaction for synthesizing pyrrolo[2,1-a]isoquinolines from 1-aryl-3,4-dihydroisoquinolines and vinyl ethynyl ketones was reported.The chem. selectivity of vinyl ethynyl ketones; i.e., adduct formation by the double or triple bond were also reported.The reaction outcome depends on the solvent, temperature, microwave irradiation and catalyst.Donor substituents in the initial isoquinolines provided a regioselective addition to double or triple bonds.

2017-12-01·SYNTHESIS-STUTTGART

Domino Reactions of 1-Aroyl-3,4-dihydroisoquinolines with α,β-Unsaturated Aldehydes

作者: Varlamov, Alexey ; Voskressensky, Leonid ; Anikina, Lada ; Titov, Alexander ; Astakhov, Grigorii ; Borisova, Tatiana ; Matveeva, Maria ; Dyachenko, Svetlana

An efficient synthesis of pyrrolo[2,1-a]isoquinolines by a domino reaction from a variety of 3,4-dihydropyrrolo[2,1-a]isoquinolines and α,β-unsaturated aldehydes in the absence of catalyst in good yields under microwave irradiation, is reported.

2017-03-01·TETRAHEDRON LETTERS

A facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinolines

作者: Maria D. Matveeva ; Alexey V. Varlamov ; Tatiana N. Borisova ; Svetlana V. Dyachenko ; Alexander A. Titov ; Viktor N. Khrustalev ; Alexander V. Aksenov ; Leonid G. Voskressensky

The facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinolines from the reaction of 1-aroyl-3,4-dihydroisoquinolines and sym. alkynes in toluene is described.The novel compounds contain functional groups that are suitable for further modification.

100 项与 Drotaverine acephyllinate 相关的药物交易

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