BACKGROUND:Polyphenols have the potential to reduce the risk of many metabolic disorders. Lily bulbs are rich in polyphenols; however, its effects on lipid metabolism remain unclear. The present study aimed to explore the effects of lily bulbs polyphenols (LBP) on oxidative stress and lipid metabolism.
RESULTS:A total of 14 polyphenolic compounds in LBP were identified by HPLC/DAD/ESI-MS. Total phenolic compound in LBP was 53.76 ± 1.12 g kg-1 dry weight. In cellular experiments, LBP attenuated the disruption of mitochondrial membrane potential, impeded ROS production, alleviated oxidative stress and reduced lipid accumulation in OA-induced HepG2 cells. In vivo studies, LBP significantly inhibited body weight gain, reduced lipid levels in serum and liver, and improved oxidative damage in high fat diet (HFD)-fed mice in a dose-dependent manner. Moreover, LBP ameliorated hepatic steatosis and suppressed the expression of hepatic lipogenesis related genes (SREBP-1c, FAS, ACC1 and SCD-1), while promoted lipolysis genes (SRB1 and HL) and lipid oxidation genes (PPARα and CPT-1) in HFD-fed mice.
CONCLUSION:It was concluded that LBP is a potential complementary therapeutic alternative in the development of functional foods to curb obesity and obesity-related diseases such as metabolic syndrome. This article is protected by copyright. All rights reserved.