盐酸美贝维林(Mebeverine Hydrochloride) - 药物靶点：mAChRs_在研适应症：胃痉挛，肠易激综合征_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Mebeverine、Mebeverine hydrochloride (USAN)、CSAG-144

+ [4]

靶点

mAChRs

作用机制

mAChRs拮抗剂(毒蕈碱型乙酰胆碱受体家族拮抗剂)

治疗领域

消化系统疾病

在研适应症

胃痉挛肠易激综合征

非在研适应症-

原研机构-

在研机构-

非在研机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)批准上市

特殊审评-

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结构

分子式C25H36ClNO5

InChIKeyPLGQWYOULXPJRE-UHFFFAOYSA-N

CAS号2753-45-9

关联

16

项与盐酸美贝维林相关的临床试验

IRCT20190706044111N37 / Suspended

A randomized, open label, single dose, crossover, bioequivalence study of Mebeverin 135mg tablet of Amin Pharm. Co., IRAN in comparison of Duspatalin 135mg tablet of Abbott in 24 healthy adult subjects under fasting condition

开始日期2024-10-22

申办/合作机构

Amin Pharmaceutical Co.

IRCT20210519051345N52 / RecruitingIIT

Fasted-state in vivo bioequivalence study of Mebeverine ER 200 mg capsule manufactured by AaniDarman Co. compared with innovator product

开始日期2024-04-11

申办/合作机构

Tabriz University of Medical Sciences

NCT05867550 / Completed临床4期IIT

To Compare the Efficacy of (Rifaximin + Mebeverine), (Rifaximin + Amitriptyline), and (Rifaximin + Psyllium Husk) in Irritable Bowel Syndrome Associated With Diarrhea

The goal of this clinical trial is to compare the efficacy of four different drugs in combination for management of irritable bowel syndrome (IBS)-associated diarrhea. The main question to answer is:
Is there a significant difference in effect of different drug combinations in management of irritable bowel syndrome with diarrhea?
Participants will be divided into 3 treatment groups.
Each group will be given a combination of drugs for 2 weeks
At the end of study, efficacy of different drug combinations and their potential side effects will be compared between the treatment groups

开始日期2023-01-03

申办/合作机构

Bahria University

100 项与盐酸美贝维林相关的临床结果

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100 项与盐酸美贝维林相关的转化医学

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100 项与盐酸美贝维林相关的专利（医药）

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205

项与盐酸美贝维林相关的文献（医药）

2024-02-01·Biotechnology journal

3D‐QSAR pharmacophore modeling, virtual screening, molecular docking, MD simulations, in vitro and in vivo studies to identify potential anti‐hyperplasia drugs

Article

作者: Akbar, Muhammad Yasir ; Khan, Dildar ; Wang, Hao ; Haq, Ihsan-Ul ; Chen, Jian-Zhong ; Khan, Muhammad Zafar Irshad

2024-01-01·Sudebno-meditsinskaia ekspertiza

Development of selective method for identifying mebeverine in hair

Article

作者: Balabanova, O L ; Vikman, P S ; Strelova, O Yu ; Grebenyuk, A N

2024-01-01·Sudebno-meditsinskaia ekspertiza

Development of selective method for mebeverine detection in blood

Article

作者: Balabanova, O L ; Vikman, P S ; Strelova, O Yu ; Grebenyuk, A N

100 项与盐酸美贝维林相关的药物交易

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