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更新于：2025-05-07

LIOTRIX (T4;T3)

更新于：2025-05-07

概要

概要

基本信息

药物类型

小分子化药

别名

EUTHROID-0.5、EUTHROID-1、EUTHROID-2

+ [7]

靶点-

作用方式-

作用机制-

治疗领域-

在研适应症-

非在研适应症-

原研机构

Allergan Sales LLC

在研机构-

非在研机构

Allergan Sales LLCParke-Davis & Co. Ltd.

权益机构-

最高研发阶段撤市

首次获批日期

美国 (1969-11-21)

最高研发阶段(中国)-

特殊审评-

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关联

100 项与 LIOTRIX (T4;T3) 相关的临床结果

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100 项与 LIOTRIX (T4;T3) 相关的转化医学

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100 项与 LIOTRIX (T4;T3) 相关的专利（医药）

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项与 LIOTRIX (T4;T3) 相关的文献（医药）

1983-12-01·American Journal of Clinical Pathology4区 · 医学

A Case of Peliosis Hepatis in Association with Tamoxifen Therapy

4区 · 医学

Article

作者: Loomus, Gerald N. ; Bota, Robert A. ; Aneja, Pravin

A 58-year-old white woman was admitted to Sinai Hospital of Detroit in May 1981 with complaints of substernal pain radiating to the right upper abdominal quadrant and right shoulder. An episode of chest pain two months prior to admission had been diagnosed as pulmonary embolism,, and warfarin was used to elevate the prothrombin time to a therapeutic range. The other medication taken included liotrix for hypothyroidism. A modified radical mastectomy was performed for a diagnosis of adenocarcinoma of the right breast in October 1977. One of 17 axillary lymph nodes dissected was positive for metastasis. The estrogen receptor protein was elevated to 53.3 fmol at that time. The chest x-ray, metastatic bone survey, and liver scan were normal. There was no history of alcohol abuse, jaundice, blood transfusion, trauma, nor treatment with any androgenic steroid. The physical examination on the present admission revealed that the woman had stable vital signs. The abdomen was soft, nondistended, with no guarding or rigidity, but with tenderness in the upper right quadrant. No organs or masses were palpable, and there were no signs of external blood loss. Shortly after admission, however, the blood pressure dropped, and deep clinical shock developed. Her hemoglobin dropped from 14 g/dL to 10.3 g/dL. On admission, surgical consultation was obtained, and the following studies were done: SMA-12, electrolytes, CPK, chest x-ray, and electrocardiogram results were within normal limits. Ventilation perfusion scan of the lungs showed no defects. Flat films of the abdomen indicated peritoneal fluid. The patient was taken to surgery, where a massive rupture of the right lobe of liver was found. Right lobe hepatectomy was done and the hepatic bed packed with gel foam. The patient had a stormy postoperative course. Vital signs could not be maintained, in spite of transfusions of 13 units of blood, 3 units of fresh frozen plasma, and platelets. She died 36 hours postoperatively.

1981-02-01·Journal of Pharmaceutical Sciences3区 · 医学

Reversed-Phase High-Performance Liquid Chromatographic Analysis of Liothyronine Sodium and Levothyroxine Sodium in Tablet Formulations: Preliminary Studies on Dissolution and Content Uniformity

3区 · 医学

Article

作者: Rao S. Rapakax ; Vadlamani K. Prasad ; Patrick W. Knight

Levothyroxine sodium was estimated from tablet formulations of levothyroxine sodium and liotrix (liothyronine sodium-levothyroxine sodium combination tablet). The procedures consisted of the addition of 3,3-,5-triiodothyronine as the internal standard to the pulverized sample, followed by an acidic butanol extraction, evaporation, and injection onto a muBondapak reversed-phase high-performance liquid chromatographic column. The eluent was methanol-water-phosphoric acid (50:50:0.1), and the effluent was monitored by UV detection at 254 nm. A standard linear calibration curve was obtained for direct standard solutions equivalent to 18-225 micrograms of levothyroxine sodium/tablet. The procedure is sensitive enough for single-tablet analysis. Using this procedure, content uniformity studies were performed on liothyronine sodium tablets, levothyroxine sodium tablets, and liotrix tablets. The procedure also was adapted for conducting dissolution studies on levothyroxine sodium tablets in deionized water using the rotating-paddle method.

1978-01-01·American Journal of Health-System Pharmacy

Drug Therapy Reviews: Management of Hypothyroidism

Review

作者: Cobb, William E. ; Jackson, Ivor M. D.

The therapeutic management of hypothyroidism caused by deficient thyroid hormone production is discussed. The therapeutic use of the following thyroid agents is reviewed: levothyroxine sodium, Thyroid USP, thyroglobulin, liotrix, and liothyronine sodium. Myxedema coma, neonatal hypothyroidism, primary hypothyroidism, and secondary and tertiary hypothyroidism are specific hypothyroid states for which drug therapy is discussed. Levothyroxine sodium is the preferred agent because of consistent potency, restoration of normal, constant serum levels of thyroxine (T4) and triiodothyronine (T3) and ease of interpretation of thyroid hormone levels. Other agents, because they contain T3, result in postabsorptive elevated T3 serum concentrations that may cause thyrotoxic symptoms and reduction of T4 levels. This, in turn, may give rise to misleading estimates of thyroid dosage. Patients with the sick euthyroid or low T3 syndromes are not candidates for thyroid hormone therapy.

100 项与 LIOTRIX (T4;T3) 相关的药物交易

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