A novel pyridazinone derivative as a nonprostanoid PGI2 agonist
4区 · 医学
Article
作者: Seki, J. ; Okitsu, O. ; Tsubaki, K. ; Hattori, K. ; Taniguchi, K. ; Tabuchi, S. ; Tanaka, H. ; Sakane, K.
A novel optically pure pyridazinone derivative was synthesized and identified as a nonprostanoid PGI2 agonist. It inhibited ADP-induced aggregation of human platelets with an IC50 value of 0.081 microM and has high oral bioavailability (56%) with a long half-life (4.3 h) in rats.