Dihydroxychromone 4c(Konkuk University)(Dihydroxychromone 4c(Konkuk University))

概要

基本信息

药物类型

小分子化药

别名-

靶点

HELQ

作用方式

抑制剂

作用机制

HELQ inhibitors(helicase, POLQ like inhibitors)

治疗领域

感染其他疾病

在研适应症-

非在研适应症

严重急性呼吸综合征

原研机构

Konkuk University

在研机构-

非在研机构

Konkuk University

权益机构-

最高研发阶段无进展药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 Dihydroxychromone 4c(Konkuk University) 相关的临床结果

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100 项与 Dihydroxychromone 4c(Konkuk University) 相关的转化医学

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100 项与 Dihydroxychromone 4c(Konkuk University) 相关的专利（医药）

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1

项与 Dihydroxychromone 4c(Konkuk University) 相关的文献（医药）

2009-08-01·Bioorganic & Medicinal Chemistry Letters4区 · 医学

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives

4区 · 医学

Article

作者: Youhoon Chong ; Jin Moo Lee ; Chaewoon Lee ; Dong-Eun Kim ; Yong-Joo Jeong ; Na-Ra Lee

Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were prepared. Based on SAR study, an extended feature of the pharmacophore model of SARS-CoV NTPase/helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit.

100 项与 Dihydroxychromone 4c(Konkuk University) 相关的药物交易

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