PPIB siRNA(AstraZeneca)(PPIB siRNA(AstraZeneca)) - 药物靶点：PPIB_专利_临床

概要

基本信息

药物类型

siRNA

别名-

靶点

PPIB

作用机制

PPIB modulators(Cyclophilin B modulators)

治疗领域-

在研适应症-

非在研适应症-

原研机构

AstraZeneca PLC

在研机构

AstraZeneca PLC

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构

使用我们的RNA技术数据为新药研发加速。

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关联

100 项与 PPIB siRNA(AstraZeneca) 相关的临床结果

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100 项与 PPIB siRNA(AstraZeneca) 相关的转化医学

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100 项与 PPIB siRNA(AstraZeneca) 相关的专利（医药）

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1

项与 PPIB siRNA(AstraZeneca) 相关的文献（医药）

Nature Communications

The structural basis for the collagen processing by human P3H1/CRTAP/PPIB ternary complex

Article

作者: Zhao, Jie ; Wang, Qian ; Cao, Mi ; Li, Shaobai ; Xia, Ying ; Peng, Junjiang ; Ma, Peixiang ; Li, Wenguo ; Qin, An ; Rao, Bing ; Cao, Yu ; Yao, Deqiang ; Shen, Yafeng ; Liao, Rijing

Collagen posttranslational processing is crucial for its proper assembly and function. Disruption of collagen processing leads to tissue development and structure disorders like osteogenesis imperfecta (OI). OI-related collagen processing machinery includes prolyl 3-hydroxylase 1 (P3H1), peptidyl-prolyl cis-trans isomerase B (PPIB), and cartilage-associated protein (CRTAP), with their structural organization and mechanism unclear. We determine cryo-EM structures of the P3H1/CRTAP/PPIB complex. The active sites of P3H1 and PPIB form a face-to-face bifunctional reaction center, indicating a coupled modification mechanism. The structure of the P3H1/CRTAP/PPIB/collagen peptide complex reveals multiple binding sites, suggesting a substrate interacting zone. Unexpectedly, a dual-ternary complex is observed, and the balance between ternary and dual-ternary states can be altered by mutations in the P3H1/PPIB active site and the addition of PPIB inhibitors. These findings provide insights into the structural basis of collagen processing by P3H1/CRTAP/PPIB and the molecular pathology of collagen-related disorders.

100 项与 PPIB siRNA(AstraZeneca) 相关的药物交易

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