氢化可的松/苯佐卡因/次没食子酸铋/苯扎氯铵(Hydrocortisone/Benzocaine/Bismuth Subgallate/Benzalkonium Chloride)

概要

基本信息

药物类型

小分子化药

别名

Bismuth subgallate、basic bismuth 3,4,5-trihydroxybenzoate、gallic acid bismuth basic salt

+ [1]

靶点

GR x Nav1.8

作用机制

GR激动剂(糖皮质激素受体激动剂)、Nav1.8阻滞剂(X型钠通道蛋白α亚基阻滞剂)

治疗领域

心血管疾病消化系统疾病

在研适应症

肛裂痔疮

非在研适应症-

原研机构

Chemo Ibérica SA

在研机构

Chemo Ibérica SA

非在研机构-

最高研发阶段批准上市

首次获批日期

土耳其 (1997-08-01),

肛裂痔疮

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构

分子式C7H5BiO6

InChIKeyJAONZGLTYYUPCT-UHFFFAOYSA-K

CAS号99-26-3

查看全部结构式(4)

关联

4

项与氢化可的松/苯佐卡因/次没食子酸铋/苯扎氯铵相关的临床试验

IRCT20141025019669N17 / Recruiting临床3期IIT

The effect of oral gallic acid supplementation on antioxidant status in people with major depression

开始日期2021-04-04

申办/合作机构

Mazandaran University of Medical Sciences

TCTR20200304005 / Completed临床1期

Study the pharmacokinetic of Catechin, Gallic acid and Chlorogenic acidof jelly from Kimchi juice in healthy volunteer

开始日期2020-07-20

申办/合作机构

Mark One Innovation Center Co. Ltd.

IRCT20080901001155N32 / Completed临床3期IIT

Comparision of H.pylori eradication rate in quadriple regimen Bismuth subcytrate , Pantazol,Amoxicillin, Formilid and Probiotic(Lactobacillus reuteri)” with quadriple regimen Bismuth subcytrate, Pantazol,Amoxicillin, Formilid and placebo.

开始日期2019-12-22

申办/合作机构-

100 项与氢化可的松/苯佐卡因/次没食子酸铋/苯扎氯铵相关的临床结果

登录后查看更多信息

100 项与氢化可的松/苯佐卡因/次没食子酸铋/苯扎氯铵相关的转化医学

登录后查看更多信息

100 项与氢化可的松/苯佐卡因/次没食子酸铋/苯扎氯铵相关的专利（医药）

登录后查看更多信息

4,264

项与氢化可的松/苯佐卡因/次没食子酸铋/苯扎氯铵相关的文献（医药）

2024-12-06·Journal of Biomolecular Structure and Dynamics

Permeability of antioxidants through a lipid bilayer model with coarse-grained simulations

Article

作者: Glossman-Mitnik, Daniel ; Aceves-Luna, Hugo ; Flores-Holguín, Norma

Oxidative stress caused by pollution and lifestyle changes causes an excess of free radicals that react chemically with cell constituents leading to irreversible damage. There are molecules known as antioxidants that reduce the levels of free radicals. Some pigments of fruits and vegetables known as anthocyanins have antioxidant properties. Their interaction with the cell membrane becomes a crucial step in studying these substances. In this research, molecular dynamics simulations, particularly, coarse-grained molecular dynamics (CGMD) were used. This technique aims to replace functional groups with corresponding beads that represent their level of polarity and affinities to other chemical groups. Also, umbrella sampling was carried out to obtain free energy profiles that describe well the orientation and location of antioxidants in a membrane considering Trolox, Cyanidin, Gallic Acid, and Resveratrol molecules to study the structural effects they cause on it. It was concluded in this study that an antioxidant when crossing the membrane does not cause either damage to the structural properties or the loss of packing and stratification of phospholipids. it was also observed that the most reactive part of the molecules could easily approach area A prone to lipid oxidation, which can describe the antioxidant capacity of these molecules.Communicated by Ramaswamy H. Sarma.

2024-11-01·Environmental Toxicology

GSK‐3β/Notch‐1 Activation Promotes Radiation‐Induced Renal Damage: The Role of Gallic Acid in Mitigation of Nephrotoxicity

Article

作者: Abdel‐Naby, Doaa H. ; Abd El‐Rahman, Sahar S. ; El‐Sheikh, Marwa M. ; El‐Hamoly, Tarek

ABSTRACTDespite the therapeutic advances in treating malignancies, the efficient radiotherapeutic approaches with deprived adverse reactions still represent a potential clinical inquiry. The current study aims to elucidate the role of gallic acid (GA) in modifying the hazardous renal cytotoxicity induced by acute exposure to radiation. The MTT test was used to evaluate the viability of Vero cells exposed to 2 Gy gamma radiation with or without incubation of GA. In an in vivo model, male Wistar rats were divided into four experimental groups (n = 6): Control, Irradiated (IRR, 5 Gy), GA (100 mg/kg, i.p.) + IRR, and Glycogen synthase kinase inhibitor (GSKI, 3 mg/kg, i.p.) + IRR. Based on the MTT toxicity assay, from 0 and up to 5 μM dosages of GA did not demonstrate any cytotoxicity to Vero cells. The optimal GA dose that could protect the cells from radiation was 5 μM. Furthermore, GA exerted a protective effect from gamma radiation on renal tissue as indicated by corrected renal functions, decreased LDH level in serum, and balanced oxidative status, which is indicated by decreased tissue contents of NOx and TBARS with a significant increase of reduced GSH. These outcomes were inferred by the upregulation of nuclear factor erythroid 2‐related factor 2 (Nrf2) expression. The overall molecular impact of radiation in damaging the renal tissue may be explained by modifying the upstream AKT activity and its downstream targets GSK‐3β/Notch‐1. Here, we concluded that the anticipated adverse reaction in the course of radiation exposure could be protected by daily administration of GA.

2024-11-01·Food Chemistry

A new plant-based probiotic from juá: Source of phenolics, fibers and antioxidant properties

Article

作者: da Silva Campelo Borges, Graciele ; Fernandes, Flávio Gomes ; Magnani, Marciane ; Dos Santos Lima, Marcos ; da Costa, Whyara Karoline Almeida ; de Lima Costa, Igor Henrique

The objective of this study was to evaluate the viability of juá pulp for fermentation by monoculture L. casei (Lc - 01) and L. acidophilus (La - 05) and co-culture (25 and 37 °C) for 72 h. Viable strain values (> 7 log CFU/g), pH reduction (below 3.7), fructose and glucose and increased of lactic acid showed that the pulp of juá served as a good matrix for fermentation. Catechin, epicatechin, epigallocatechin procyanidin B1, and gallic acid were the main phenolics that contributed to antioxidant activity. Fermentation by mono or co-culture increased or reduced the content of phenolics and antioxidant activity. Results showed that culture, time and temperature have effects in the fermentation of juá pulp. The co-cultivation of La - 05 + Lc - 01 contributed to improving the bioaccessibility of gallic acid (72.9%) of the jua pulp. Finding indicate juá pulp as a promising substrate to obtaining a new probiotic plant-based fermented beverage.

100 项与氢化可的松/苯佐卡因/次没食子酸铋/苯扎氯铵相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
-	氢化可的松/苯佐卡因/次没食子酸铋/苯扎氯铵	R01AD60	DB13909

研发状态

10 条最早获批的记录,

登录

后查看更多信息

适应症	国家/地区	公司	日期
肛裂	土耳其	Chemo Ibérica SA	1997-08-01
痔疮	土耳其	Chemo Ibérica SA	1997-08-01

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


AACR2010	N/A	膀胱癌	-	Gallic acid	鬱艱餘顧鑰鏇窪構網壓(壓鑰遞壓糧醖製獵艱鏇) = 鑰積糧壓蓋壓顧憲製鏇選獵遞製壓繭簾鏇簾夢 (衊觸繭膚願顧衊選窪壓 )	-	2010-04-15