BACKGROUNDMethamphetamine (METH) is a psychostimulant with high abuse liability that affects the monoamine neurotransmitter systems, particularly the dopamine system. Currently there are no effective medications for the treatment of METH abuse to restore METH-induced dopaminergic dysfunction. The Jitai tablet (JTT), a commercial traditional Chinese medicinal preparation, has been shown to modulate the dopaminergic function both in heroin addicts and in morphine-dependent rats. The purpose of this study was to investigate, in a rodent model, whether JTT can protect against METH-induced neurotoxicity, and/or restore METH-damaged dopaminergic function.METHODSImmunohistochemical staining and/or autoradiography staining were used to detect tyrosine hydroxylase (TH) expression in the substantia nigra, and to examine the levels of dopamine transporter (DAT), dopamine D2 receptor (D2R) and TH levels in the striatum. Using a stereotyped behavior rating scale, we evaluated the inhibitory effect of JTT on METH-induced behavioral sensitization.RESULTSRepeated METH administration induced obvious stereotyped behavior and neurotoxicity on the dopaminergic system. Pre-treatment with JTT significantly attenuated METH-induced stereotyped responses, and interdicted METH-induced changes in the levels of DAT, D2R and TH expression. Treatment with JTT after METH administration restored DAT, D2R and TH expression to normal levels.CONCLUSIONSOur results indicated that JTT protects against METH-induced neurotoxicity and restores the dopaminergic function, and thus might be a potential treatment for the dopaminergic deficits associated with METH abuse.

2017-04-10·Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

[Changes and the impact on immune function of opioid-dependent subjects by Jitai tabelets during the withdrawal stage].

Article

作者: Sun, L ; Liang, J C ; Fan, H Y ; Deng, Y P ; Li, X X

目的： 探讨阿片类物质依赖者戒断期间免疫功能的变化和济泰片的影响。 方法： 采用随机、双盲、安慰剂平行对照试验，受试者分别给予济泰片、济泰片联合丁丙诺啡、安慰剂治疗，戒断前、戒断后第14天检测血清中免疫球蛋白（IgM、IgA、IgG）、T细胞亚群（CD(3)(+)、CD(4)(+)、CD(8)(+)、CD(4)(+)/CD(8)(+)比例）以及细胞因子（IL-2、IFN-γ、IL-4、IFN-γ/IL-4比例）水平。 结果： 戒断前，阿片类物质依赖者IgM水平为（1.67±0.87）g/L，IL-2、IFN-γ、IL-4占CD(3)(+)CD(8)(-)细胞比例分别为（14.44±13.50）%、（20.23±15.10）%、（1.97±1.59）%，高于健康对照，差异有统计学意义（P<0.05）；CD(3)(+)T细胞水平为（47.01±13.62）%，低于健康对照，差异有统计学意义（P<0.05）；其余免疫学指标与健康对照相比差异无统计学意义（P>0.05）。安慰剂戒断第14天，IL-4水平降至正常水平，IFN-γ/IL-4比例升高3.43倍（P<0.05），IgA、IgG、CD(4)(+)T细胞水平及CD(4)(+)/CD(8)(+)比例在正常范围内波动；其余免疫学指标与戒断前相比差异无统计学意义（P>0.05）。与安慰剂相比，济泰片可减小戒断期间IgG、IgM水平的波动，并使戒断第14天时IgM水平恢复正常；济泰片联合丁丙诺啡可使IL-4水平异常升高0.54倍，IFN-γ/IL-4比例降低至正常（P>0.05）。药物干预不影响戒断期间其余免疫指标的变化。 结论： 戒断时免疫功能有一定程度的损害，济泰片治疗有助于损伤的修复。.

2015-09-01·Psychopharmacology3区 · 医学

Longitudinal changes of dopamine transporters in heroin users during abstinence

3区 · 医学

Article

作者: Yangping Deng ; Mei Han ; Guangming Zhang ; Shasha Xu ; Yuankai Wang ; Daxu Fu ; Ying Liu ; Xingdang Liu ; Yiyun Huang ; Rongbin Lv ; Jie Yuan ; Zhirui Guo ; Yu Li

RATIONALEChronic exposure to heroin results in decreased dopamine transporter levels. Jitai tablets, a traditional Chinese medicine, have been effective at increasing striatal dopamine transporter availability after 6 months of treatment. However, it remains unknown how long the heroin-induced impairment persists and whether dopamine transporter can be normalized following long-term abstinence or treatment.OBJECTIVESThis study was to evaluate the time course of dopamine transporter changes in heroin users undergoing long-term abstinence and treatment with Jitai tablets for 1 year.METHODSSingle-photon emission computed tomography using [(99m)Tc]TRODAT-1 was performed on 64 heroin users and 20 healthy subjects to assess striatal dopamine transporter availability at baseline, 3, 6, and 12 months. Heroin users were randomly assigned to treatment with either placebo or Jitai tablets. Depression and anxiety scores were measured before each imaging session.RESULTSCompared with healthy controls, significant reduction in dopamine transporter availability was found in heroin users at baseline in both the right (by ∼ 31.6%) and left striatum (by ∼ 33.2%). At 6 months, dopamine transporter availability was significantly higher in Jitai tablet-treated group than placebo group in the bilateral striatum (p < 0.01). At 12 months, dopamine transporter levels in both groups were upregulated substantially from baseline but still not recovered to normal levels in the left striatum (p < 0.05). Depression and anxiety scores significantly decreased at 3, 6, and 12 months (p < 0.05).CONCLUSIONSOur results confirmed that heroin abuse induces pronounced, long-term reduction in dopamine transporter. Treatment with Jitai tablets appears to stimulate recovery.

100 项与 Jitai 相关的药物交易

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