重组人白介素-11 (上海三生国健)(Recombinant human interleukin-11(Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.))

概要

基本信息

药物类型

白细胞介素、生物类似药

别名

Oprelvekin biosimilar (Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.)、Xin Mei Ge、oprelvekin

+ [3]

靶点

IL-11RA

作用机制

IL-11RA刺激剂(白细胞介素-11受体α刺激剂)、血小板生成刺激剂

治疗领域

血液及淋巴系统疾病

在研适应症

血小板减少症

非在研适应症-

原研机构

三生国健药业（上海）股份有限公司

在研机构

三生国健药业（上海）股份有限公司

非在研机构-

最高研发阶段批准上市

首次获批日期

中国 (2005-04-26),

血小板减少症

最高研发阶段(中国)批准上市

特殊审评-

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序列信息

Sequence Code 13648

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关联

2

项与重组人白介素-11 (上海三生国健) 相关的临床试验

ChiCTR-IOR-16008358 / RecruitingIIT

The special advantages of TCM from TCM strong province construction disease breakthrough project (chronic heart failure)

开始日期2016-05-01

申办/合作机构-

ChiCTR-IPR-15006397 / Recruiting临床4期IIT

Recombinant human interleukin-11 (Teer Kang) combined with glucocorticoid treatment of immune thrombocytopenia: a randomized controlled study

开始日期2015-06-15

申办/合作机构-

100 项与重组人白介素-11 (上海三生国健) 相关的临床结果

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100 项与重组人白介素-11 (上海三生国健) 相关的转化医学

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100 项与重组人白介素-11 (上海三生国健) 相关的专利（医药）

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4

项与重组人白介素-11 (上海三生国健) 相关的文献（医药）

2015-11-01·Experimental and Therapeutic Medicine4区 · 医学

Effects and mechanism of Xin Mai Jia in a rabbit model of atherosclerosis

4区 · 医学

Article

作者: Lu, Jun-Xiu ; Qiu, LE-LE ; Yin, Ya-Ling ; Jia, Mei ; Wan, Guang-Ming ; Wan, Guang-Rui ; Zhu, Mo-Li ; Qi, Heng-Tian ; Ma, Li-Juan ; Zhao, Fan-Rong

The aim of this study was to investigate the protective effects of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rabbits and to explore the underlying mechanisms in order to provide experimental evidence for the clinical application of XMJ. An intraperitoneal injection of vitamin D3, combined with a high-fat diet and sacculus injury, was utilized to establish the AS rabbit model. Following the oral administration of lovastatin, Zhibituo and different dosages of XMJ, respectively, blood was drawn from each rabbit for the detection of blood rheological indicators, such as serum lipids. The pathological changes in the right common carotid artery were observed. Vascular function experiments and the expression detection of common carotid artery-related proteins by immunohistochemistry were conducted. XMJ was observed to decrease the blood lipid levels of the AS rabbits; increase the concentration of high-density lipoprotein and apolipoprotein A; decrease blood viscosity, erythrocyte sedimentation rate and hematocrit; elevate the levels of endothelial nitric oxide synthase (eNOS) and Na⁺/H⁺ exchanger 1 in vascular tissues and decrease the levels of angiotensin II receptor, type 1 (AT-1) and endothelin-1 (ET-1). In conclusion, XMJ was shown to lower the blood lipid levels of the experimental AS rabbits, improve the abnormal changes in hemorheology, increase the eNOS content in the vascular tissue, decrease the AT-1 and ET-1 levels and increase the endothelium-dependent vasodilation reaction. XMJ therefore has an anti-AS effect.

Genetics and Molecular Research

Effect of Xin Mai Jia on atherosclerosis in rats

Article

作者: Zhao, F R ; Wan, G M ; Pan, G P ; Guo, Z G ; Wang, Q Q ; Jia, M ; Li, P ; Lei, G L ; Wan, G R

We investigated the therapeutic effect of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rats. Rat models of AS were established by peritoneally injecting vitamin D, feeding a high-fat diet, and inducing balloon injuries in rats. The stomachs of the rats were irrigated continuously for 10 weeks with XMJ. Blood lipid- and hemorheology-related indices of blood samples were detected. Pathological changes in the right common carotid arterial tissues were also determined. The protein expression levels of endothelial nitric oxide synthase, angio-tensin-1, and endothelin-1 were determined by western blotting. XMJ reduced cholesterol, trigylecride, and low-density lipoprotein levels as well as blood viscosity, sedimentation, and hematocrit. Furthermore, XMJ alleviated vascular endothelial injury and reduced/eliminated atherosclerotic plaques. In contrast, XMJ significantly increased the endothelium-dependent relaxing response of the AS rat models. The western blotting results showed that XMJ upregulated endothelial nitric oxide synthase but downregulated angiotensin-1 and endothelin-1. XMJ prevented the development of AS by regulating blood lipid levels, hemorheology, and vascular function.

Foods

Mei-Gin Formula Ameliorates Obesity through Lipolysis, Fatty Oxidation, and Thermogenesis in High-Fat Diet-Induced Obese Rats

Article

作者: Lin, Jiun-Ling ; Wong, Yue-Ching ; Cheng, Ming-Ching ; Chang, Wei-Tang ; Tsai, Chun-Tse ; Huang, Shih-Chien ; Cheng, Hsin-Lin ; Hsu, Chin-Lin

Obesity is a metabolic dysfunction characterized by excessive body fat deposition as a consequence of an energy imbalance. Novel therapeutic strategies have emerged that are safe and have comparatively low side effects for obesity treatment. Functional foods and nutraceuticals have recently received a great deal of attention because of their components with the properties of antimetabolic syndrome. Based on our previous in vitro and in vivo investigations on anti-adipogenesis activity and improved body fat accumulation in serials, the combination of three ingredients (including bainiku-ekisu, black garlic, and Mesona procumbens Hemsl), comprising the Mei-Gin formula (MGF), was eventually selected as a novel inhibitor that exhibited preventive effects against obesity. Herein, we verify the anti-obesity effects of MGF in obese rats induced by a high-fat diet and discuss the potential molecular mechanisms underlying obesity development. Oral administration of MGF significantly suppressed the final body weight, weight change, energy and water intake, subcutaneous and visceral fat mass, liver weight, hepatic total lipids and triglycerides (TG), and serum levels of TG, triglycerides (TC), low-density lipoprotein cholesterol (LDL-C), alanine transaminase (AST), uric acid, and ketone bodies and augmented fecal total lipids, TG, and cholesterol excretion in the high-dose MGF-supplemented groups. Furthermore, the corresponding lipid metabolic pathways revealed that MGF supplementation effectively increased lipolysis and fatty acid oxidation gene expression and attenuated fatty acid synthesis gene expression in the white adipose tissue (WAT) and liver and it also increased mitochondrial activation and thermogenic gene expression in the brown adipose tissue (BAT) of rats with obesity induced by a high-fat diet (HFD). These results demonstrate that the intake of MGF can be beneficial for the suppression of HFD-induced obesity in rats through the lipolysis, fatty oxidation, and thermogenesis pathway. In conclusion, these results demonstrate the anti-obesity efficacy of MGF in vivo and suggest that MGF may act as a potential therapeutic agent against obesity.

100 项与重组人白介素-11 (上海三生国健) 相关的药物交易

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