A Phase II/III, Multicenter, Open Label, Randomized Clinical Trial Evaluating ABX-CBL When Compared to Atgam as Second Line Therapy in Patients With Steroid Resistant Acute Graft Versus Host Disease

Trial evaluating the improvement in survival at 180 days of two therapies (Atgam versus ABX-CBL, a monoclonal antibody) in patients with acute graft versus host disease that does not respond to steroid therapy.

开始日期1999-10-01

申办/合作机构

Abgenix, Inc.

[+1]

100 项与加维莫单抗相关的临床结果

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100 项与加维莫单抗相关的转化医学

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100 项与加维莫单抗相关的专利（医药）

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项与加维莫单抗相关的文献（医药）

2023-01-01·Frontiers in microbiology

Fecal microbiota transplantation from HUC-MSC-treated mice alleviates acute lung injury in mice through anti-inflammation and gut microbiota modulation.

Article

作者: Lu, Huadong ; Cui, Enhai ; Chen, Na ; Wang, Bin ; Lv, Lu ; Li, Liqin ; Hua, Feng ; Chen, Wenyan

IntroductionAcute lung injury (ALI) is a severe respiratory tract disorder facilitated by dysregulated inflammation, oxidative stress and intestinal ecosystem. Fecal microbiota transplantation (FMT) is a rapid method for gut microbiota (GM) reconstruction. Furthermore, our previous studies have confirmed that human umbilical cord mesenchymal stromal cells (HUC-MSCs) can alleviate ALI by improving GM composition. Therefore, we aimed to explore the efficacy and mechanism of FMT from HUC-MSCs-treated mice on ALI.MethodsIn brief, fresh feces from HUC-MSCs-treated mice were collected for FMT, and the mice were randomly assigned into NC, FMT, LPS, ABX-LPS, and ABX-LPS-FMT groups (n = 12/group). Subsequently, the mice were administrated with antibiotic mixtures to deplete GM, and given lipopolysaccharide and FMT to induce ALI and rebuild GM. Next, the therapeutic effect was evaluated by bronchoalveolar lavage fluid (BALF) and histopathology. Immune cells in peripheral blood and apoptosis in lung tissues were measured. Furthermore, oxidative stress- and inflammation-related parameter levels were tested in BALF, serum, lung and ileal tissues. The expressions of apoptosis-associated, TLR4/NF-κB pathway-associated, Nrf2/HO-1 pathway related and tightly linked proteins in the lung and ileal tissues were assessed. Moreover, 16S rRNA was conducted to assess GM composition and distribution.ResultsOur results revealed that FMT obviously improved the pathological damage of lung and ileum, recovered the immune system of peripheral blood, decreased the cell apoptosis of lung, and inhibited inflammation and oxidative stress in BALF, serum, lung and ileum tissues. Moreover, FMT also elevated ZO-1, claudin-1, and occludin protein expressions, activating the Nrf2/HO-1 pathway but hindering the TLR4/NF-κB pathway. Of note, the relative abundances of Bacteroides, Christensenella, Coprococcus, and Roseburia were decreased, while the relative abundances of Xenorhabdus, Sutterella, and Acinetobacter were increased in the ABX-LPS-FMT group.ConclusionFMT from HUC-MSCs-treated mice may alleviate ALI by inhibiting inflammation and reconstructing GM, additionally, we also found that the TLR4/NF-κB and Nrf2/HO-1 pathways may involve in the improvement of FMT on ALI, which offers novel insights for the functions and mechanisms of FMT from HUC-MSCs-treated mice on ALI.

2022-12-31·OncoImmunology2区 · 医学

Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1

2区 · 医学

ArticleOA

作者: Quixabeira, Dafne C. A. ; Heiniö, Camilla ; Santos, Joao M. ; Havunen, Riikka ; Kudling, Tatiana V. ; Hemminki, Akseli ; Cervera-Carrascon, Victor ; Grönberg-Vähä-Koskela, Susanna ; Clubb, James H.A. ; Kanerva, Anna ; Anttila, Marjukka ; Basnet, Saru

Intratumoral immunotherapies are entering clinical use but concerns remain regarding their effects on non-injected tumors. Here, we studied the impact of local treatment with an adenovirus coding for TNFa and IL-2 on systemic antitumor response in animals receiving aPD-1 (anti-programmed cell death protein 1) therapy. Using bilateral murine melanoma models, we tested systemic tumor response to combined therapy with anti-PD-1 and an adenovirus coding for TNFa and IL-2 ("virus"). Virus was given intratumorally (to one of the two tumors only) and aPD-1 monoclonal antibody systemically. We evaluated both tumors' response to treatment, overall survival, metastasis development, and immunological mechanisms involved with response. Consistent tumor control was observed in both injected and non-injected tumors, including complete response in all treated animals receiving aPD-1+ virus therapy. Mechanistically, virus injections enabled potent effector lymphocyte response locally, with systemic effects in non-injected tumors facilitated by aPD-1 treatment. Moreover, adenovirus therapy demonstrated immunological memory formation. Virus therapy was effective in preventing metastasis development. Local treatment with TNFa and IL-2 coding adenovirus enhanced systemic response to aPD-1 therapy, by re-shaping the microenvironment of both injected and non-injected tumors. Therefore, our pre-clinical data support the rationale for a trial utilizing a combination of aPD-1 plus virus for the treatment of human cancer.

2022-06-01·Annals of Surgery1区 · 医学

Perioperative Broad-spectrum Antibiotics are Associated With Decreased Surgical Site Infections Compared to 1st–3rd Generation Cephalosporins After Open Pancreaticoduodenectomy in Patients With Jaundice or a Biliary Stent

1区 · 医学

Article

作者: Banulescu, Mihaela ; Maker, Ajay V ; Torres, Carolina ; Maker, Vijay K ; Kone, Lyonell B

Objective:Compare the effectiveness of 1st-3rd generation cephalosporins (1st-3rdCE) to broad-spectrum antibiotics in decreasing surgical site infections (SSI) after pancreatectomy.Summary of Background Data:SSI is one of the most common complications after pancreatic surgery. Various antibiotic regimens are utilized nationwide with no clear guidelines for pancreatectomy. As we await results of a recently initiated prospective trial, this study retrospectively evaluates over 15,000 patients using the same administrative data abstraction tools as in the trial.Methods:All relevant clinical variables were collected from the 2016–2018 targeted-pancreatectomy database from the American College of Surgeon National Surgical Quality Improvement Program. Preoperative antibiotics were initially collected as first-generation cephalosporin, second or third-generation cephalosporin, and broad-spectrum antibiotics (Broad-abx).Results:Of the 15,182 patients who completed a pancreatic surgery between 2016 and 2018, 6114 (40%) received a first-generation cephalosporin, 4097 (27%) received a second or third-generation cephalosporin, and 4971 (33%) received Broad-abx. On multivariate analysis, Broad-abx was associated with a decrease in all-type SSI compared to 1st-3rdCE (odds ratio = 0.73–0.77, P < 0.001) after open pancreaticoduodenectomy (PD). There was no difference in SSI between antibiotic-types after distal pancreatectomy. Subgroup multivariate analysis of open PD revealed decrease in all-type SSI with Broad-abx amongst patients with jaundice and/or biliary stent only, regardless of wound protector use (odds ratio = 0.69–0.70, P < 0.001). Propensity score matching of open PD patients with jaundice and/or biliary stent confirmed a decrease in all-type SSI (19% vs 24%, P = 0.001), and organ-space SSI (12% vs 16%, P < 0.001).Conclusion:Broad-abx are associated with decreased SSI after open PD and may be preferred specifically for patients with preoperative biliary stent and/ or jaundice.

100 项与加维莫单抗相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	加维莫单抗	-	DB06545

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
类固醇难治性移植物抗宿主病	临床3期	美国	SangStat Medical Corp.	1999-10-01
移植物抗宿主病	临床3期	-	Genzyme Corp.	-
移植物抗宿主病	临床3期	-	Abgenix, Inc.	-
移植物抗宿主病	临床3期	美国	-	-
银屑病	临床3期	-	Abgenix, Inc.	-
银屑病	临床3期	-	Genzyme Corp.	-
肾移植排斥反应	临床3期	-	Abgenix, Inc.	-
肾移植排斥反应	临床3期	-	Genzyme Corp.	-
类风湿关节炎	临床3期	-	Genzyme Corp.	-
类风湿关节炎	临床3期	-	Abgenix, Inc.	-

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


START Program (ASH2007)	N/A	急性转化期慢性粒细胞性白血病	157	Dasatinib 70 mg BID	廠膚範觸獵顧艱遞顧壓(壓範構鑰構憲製構淵鑰) = Cytopenias were noted for the majority of patients, and were manageable; grade 3-4 febrile neutropenia was recorded in 8% of patients 艱窪衊艱齋繭鹽憲襯觸 (築鑰齋膚夢糧選積膚構 ) 更多	-	2007-11-16
				Cbi